DAMGO


SMILES OCCNC(=O)[C@@H](N(C(=O)CNC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)C)C)Cc1ccccc1
InChIKey HPZJMUBDEAMBFI-WTNAPCKOSA-N
Sequence YAGFG

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 6
Rotatable bonds 13
Molecular weight (Da) 513.3

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 10TM 8EFQ 9PU5 8K9K 10TL 9PUD 6DDE 6DDF 9WST 9WSV 8K9L 9ODM 9ODN 8Y73 8Y72

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Human Opioid A pKi 6.5 6.5 6.5 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.3 9.3 9.3 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 8.7 8.7 8.7 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 5.9 5.9 5.9 Guide to Pharmacology
μ OPRM Mouse Opioid A pKi 8.64 8.86 9.08 ChEMBL
CCK2 GASR Human Cholecystokinin A pKi 7.96 7.96 7.96 ChEMBL
δ OPRD Rat Opioid A pKi 5.57 6.15 6.74 ChEMBL
κ OPRK Guinea pig Opioid A pKd 6.29 6.29 6.29 ChEMBL
κ OPRK Guinea pig Opioid A pKi 5.24 5.49 5.74 ChEMBL
μ OPRM Rat Opioid A pKi 7.8 8.76 9.28 ChEMBL
δ OPRD Human Opioid A pKi 5.82 6.43 9.18 ChEMBL
δ OPRD Human Opioid A pKd 5.73 5.73 5.73 ChEMBL
κ OPRK Human Opioid A pKi 5.48 6.27 6.57 ChEMBL
μ OPRM Human Opioid A pKi 5.66 8.72 9.55 ChEMBL
NOP OPRX Guinea pig Opioid A pKi 7.57 7.57 7.57 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pEC50 6.61 7.71 8.48 ChEMBL
μ OPRM Mouse Opioid A pIC50 7.12 8.09 8.86 ChEMBL
CCK2 GASR Human Cholecystokinin A pEC50 8.57 8.57 8.57 ChEMBL
δ OPRD Rat Opioid A pEC50 7.31 7.31 7.31 ChEMBL
δ OPRD Rat Opioid A pIC50 6.14 6.14 6.14 ChEMBL
μ OPRM Rat Opioid A pIC50 7.44 8.3 9.0 ChEMBL
μ OPRM Rat Opioid A pEC50 6.31 7.41 9.59 ChEMBL
δ OPRD Human Opioid A pEC50 6.4 7.28 8.16 ChEMBL
δ OPRD Human Opioid A pIC50 8.84 8.84 8.84 ChEMBL
κ OPRK Human Opioid A pEC50 5.36 5.38 5.4 ChEMBL
μ OPRM Human Opioid A pIC50 7.7 8.74 9.53 ChEMBL
μ OPRM Human Opioid A pEC50 6.42 7.81 9.68 ChEMBL
κ OPRK Mouse Opioid A pEC50 5.4 5.4 5.4 ChEMBL
δ OPRD Mouse Opioid A pIC50 5.81 5.91 6.02 ChEMBL