nalmefene


SMILES C=C1CC[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)CC2CC2)ccc1O)O
InChIKey WJBLNOPPDWQMCH-MBPVOVBZSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 339.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Guinea pig Opioid A pKi 8.7 8.7 8.7 ChEMBL
δ OPRD Human Opioid A pKi 7.8 7.9 8.03 ChEMBL
δ OPRD Human Opioid A pKd 9.04 9.04 9.04 ChEMBL
κ OPRK Human Opioid A pKi 8.99 9.5 10.08 ChEMBL
μ OPRM Human Opioid A pKi 9.04 9.26 9.62 ChEMBL
μ OPRM Human Opioid A pKd 9.53 9.53 9.53 ChEMBL
δ OPRD Human Opioid A pKd 8.04 8.04 8.04 Drug Central
δ OPRD Human Opioid A pKi 8.1 8.1 8.1 Guide to Pharmacology
κ OPRK Human Opioid A pKi 8.0 8.0 8.0 Drug Central
κ OPRK Human Opioid A pKi 9.5 9.5 9.5 Guide to Pharmacology
μ OPRM Human Opioid A pKd 8.02 8.02 8.02 Drug Central
μ OPRM Human Opioid A pKi 9.5 9.5 9.5 Guide to Pharmacology
δ OPRD Rat Opioid A pKi 8.07 8.07 8.07 Drug Central
μ OPRM Rat Opioid A pKi 8.02 8.02 8.02 Drug Central
μ OPRM Rat Opioid A pKi 9.54 9.54 9.54 ChEMBL
κ OPRK Guinea pig Opioid A pKi 8.06 8.06 8.06 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Human Opioid A pIC50 6.11 6.11 6.11 ChEMBL