DPDPE


SMILES O=C1CNC(=O)[C@H](NC(=O)[C@H](Cc2ccc(cc2)O)N)C(C)(C)SSC([C@@H](NC(=O)[C@@H](N1)Cc1ccccc1)C(=O)O)(C)C
InChIKey MCMMCRYPQBNCPH-WMIMKTLMSA-N
Sequence YXGFX

Chemical properties

Hydrogen bond acceptors 9
Hydrogen bond donors 7
Rotatable bonds 7
Molecular weight (Da) 645.2

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 8.8 8.8 8.8 Guide to Pharmacology
δ OPRD Mouse Opioid A pKi 7.9 7.9 7.9 Guide to Pharmacology
μ OPRM Bovine Opioid A pKi 6.34 6.71 7.09 ChEMBL
δ OPRD Mouse Opioid A pKi 9.05 9.05 9.05 ChEMBL
δ OPRD Rat Opioid A pKi 7.75 8.19 8.64 ChEMBL
μ OPRM Rat Opioid A pKi 5.55 5.98 6.36 ChEMBL
δ OPRD Human Opioid A pKi 7.24 8.56 9.3 ChEMBL
μ OPRM Human Opioid A pKi 6.3 6.48 6.85 ChEMBL
μ OPRM Mouse Opioid A pKi 8.53 8.53 8.53 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Mouse Opioid A pEC50 6.9 8.07 8.69 ChEMBL
δ OPRD Mouse Opioid A pIC50 6.21 8.33 8.8 ChEMBL
δ OPRD Rat Opioid A pIC50 8.0 8.43 9.2 ChEMBL
δ OPRD Rat Opioid A pEC50 6.43 7.64 8.85 ChEMBL
κ OPRK Guinea pig Opioid A pIC50 8.68 8.68 8.68 ChEMBL
μ OPRM Rat Opioid A pIC50 5.43 6.11 6.42 ChEMBL
δ OPRD Human Opioid A pEC50 6.9 8.52 10.0 ChEMBL
δ OPRD Human Opioid A pIC50 5.14 8.44 9.85 ChEMBL
μ OPRM Human Opioid A pIC50 6.21 7.51 8.8 ChEMBL
μ OPRM Mouse Opioid A pIC50 5.57 5.57 5.57 ChEMBL