PF-04995274


SMILES OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1
InChIKey WLLOFQROROXOMO-GOSISDBHSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 432.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 9.82 9.82 9.82 Guide to Pharmacology
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 9.52 9.52 9.52 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 9.34 9.52 9.82 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pEC50 9.19 9.21 9.23 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pEC50 8.82 9.28 9.7 ChEMBL