ArrestinDb

pimozide

SMILES	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2
InChIKey	YVUQSNJEYSNKRX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	461.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	D₂

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.8	6.8	6.8	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.19	6.46	7.06	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.51	5.51	5.51	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.1	7.4	7.7	Guide to Pharmacology
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	7.31	7.81	8.23	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.11	7.52	7.84	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.26	5.8	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.47	5.92	6.24	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.2	7.2	7.2	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.15	7.15	7.15	ChEMBL
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.15	7.15	7.15	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.15	7.15	7.15	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	9.3	9.3	9.3	Guide to Pharmacology
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	9.3	9.3	9.3	ChEMBL
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	9.3	9.3	9.3	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	9.3	9.3	9.3	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
D₁	DRD1	Human	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₁	DRD1	Bovine	Dopamine	A	pKi	5.12	5.24	5.39	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.85	5.85	5.85	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	7.6	7.6	7.6	Guide to Pharmacology
D₂	DRD2	Bovine	Dopamine	A	pKi	9.22	9.22	9.22	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.92	7.92	7.93	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKd	7.54	7.54	7.54	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.54	8.86	10.22	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	8.6	8.77	9.42	PDSP Ki database
D₂	DRD2	Bovine	Dopamine	A	pKi	9.09	9.19	9.22	PDSP Ki database
D₂	DRD2	Mouse	Dopamine	A	pKi	9.72	9.72	9.72	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.05	8.05	8.05	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	7.0	7.9	8.8	Guide to Pharmacology
D₂	DRD2	Bovine	Dopamine	A	pKi	8.04	8.04	8.04	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	7.0	7.8	8.6	Guide to Pharmacology
D₃	DRD3	Rat	Dopamine	A	pKi	7.4	7.4	7.4	Guide to Pharmacology
D₃	DRD3	Human	Dopamine	A	pKi	7.96	9.05	9.7	PDSP Ki database
D₃	DRD3	Rat	Dopamine	A	pKi	8.43	8.62	8.82	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.04	8.04	8.04	Drug Central
D₄	DRD4	Rat	Dopamine	A	pKi	7.37	7.45	7.52	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	8.74	8.74	8.74	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	8.06	8.06	8.06	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	6.2	6.2	6.2	Guide to Pharmacology
H₁	HRH1	Human	Histamine	A	pKi	6.16	6.88	7.6	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.17	8.17	8.17	Drug Central
H₄	HRH4	Human	Histamine	A	pKi	5.7	5.7	5.7	ChEMBL
H₄	HRH4	Human	Histamine	A	pKi	8.24	8.24	8.24	Drug Central
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.71	5.71	5.71	PDSP Ki database
M₃	ACM3	Rat	Acetylcholine (muscarinic)	A	pKi	5.71	5.71	5.71	PDSP Ki database
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	8.24	8.24	8.24	Drug Central
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.7	6.7	6.7	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.8	5.8	5.8	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.09	6.09	6.09	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.42	6.42	6.42	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central

Showing 1 to 62 of 62 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.8	4.92	5.05	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.9	5.05	5.2	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.5	4.5	4.5	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	5.42	5.42	5.42	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	8.27	8.27	8.27	Drug Central
κ	OPRK	Human	Opioid	A	pIC50	6.0	6.0	6.0	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	8.22	8.22	8.22	Drug Central
μ	OPRM	Human	Opioid	A	pIC50	6.43	6.43	6.43	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	8.19	8.19	8.19	Drug Central

Showing 1 to 9 of 9 entries

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Main reference

pimozide

Chemical properties

Drug properties

Database connections

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