PPTN


SMILES OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F
InChIKey FOECKIWHCOYYFL-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Molecular weight (Da) 475.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
P2Y14 P2Y14 Human P2Y A pKi 10.1 10.1 10.1 Guide to Pharmacology
P2Y14 P2Y14 Rat P2Y A pKi 9.4 9.4 9.4 ChEMBL
P2Y14 P2Y14 Mouse P2Y A pKi 7.46 7.46 7.46 ChEMBL
P2Y14 P2Y14 Human P2Y A pKi 8.64 9.0 9.37 ChEMBL
D3 DRD3 Rat Dopamine A pKi 5.17 5.17 5.17 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.17 5.61 6.05 ChEMBL
δ OPRD Human Opioid A pKi 5.56 5.56 5.56 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
P2Y14 P2Y14 Mouse P2Y A pIC50 7.67 7.67 7.67 ChEMBL
P2Y14 P2Y14 Human P2Y A pIC50 7.72 8.49 9.4 ChEMBL