endomorphin-2 (Human)


SMILES Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)Cc1ccccc1)N
InChIKey XIJHWXXXIMEHKW-LJWNLINESA-N
Sequence YPFF

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 5
Rotatable bonds 12
Molecular weight (Da) 571.3

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pKi 8.5 8.5 8.5 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 7.97 7.97 7.97 ChEMBL
δ OPRD Rat Opioid A pKi 5.02 5.19 5.64 ChEMBL
κ OPRK Guinea pig Opioid A pKi 5.11 5.34 5.57 ChEMBL
μ OPRM Rat Opioid A pKi 7.72 8.53 9.31 ChEMBL
δ OPRD Human Opioid A pKi 5.1 5.24 5.47 ChEMBL
μ OPRM Human Opioid A pKi 8.09 8.57 9.16 ChEMBL
κ OPRK Human Opioid A pKi 5.28 5.62 5.95 ChEMBL
NK1 NK1R Rat Tachykinin A pKi 8.06 8.06 8.06 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pIC50 7.62 7.7 7.78 ChEMBL
δ OPRD Mouse Opioid A pIC50 6.29 6.93 7.82 ChEMBL
δ OPRD Rat Opioid A pIC50 4.99 4.99 4.99 ChEMBL
μ OPRM Rat Opioid A pIC50 8.46 9.0 9.16 ChEMBL
μ OPRM Rat Opioid A pEC50 6.42 6.73 7.11 ChEMBL
μ OPRM Human Opioid A pEC50 7.2 8.25 10.4 ChEMBL