RO 116 1148


SMILES CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2
InChIKey VBFBEYXWJLASJA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 332.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Mouse 5-Hydroxytryptamine A pKi 9.3 9.3 9.3 Guide to Pharmacology
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 9.1 9.1 9.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database