fMet-Leu-Phe


SMILES CSCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)CC(C)C)NC=O
InChIKey PRQROPMIIGLWRP-BZSNNMDCSA-N
Sequence MLP

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 14
Molecular weight (Da) 437.2

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Structure pdb 7EUO 7WVU

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FPR2/ALX FPR2 Human Formylpeptide A pKd 6.37 6.37 6.37 Guide to Pharmacology
FPR1 FPR1 Human Formylpeptide A pKi 7.38 7.38 7.38 ChEMBL
FPR1 FPR1 Human Formylpeptide A pKd 8.52 8.52 8.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FPR1 FPR1 Human Formylpeptide A pEC50 10.1 10.15 10.2 Guide to Pharmacology
FPR1 FPR1 Mouse Formylpeptide A pEC50 4.7 4.7 4.7 Guide to Pharmacology
FPR1 FPR1 Mouse Formylpeptide A pEC50 4.64 4.64 4.64 ChEMBL
FPR1 FPR1 Human Formylpeptide A pIC50 7.7 7.7 7.7 ChEMBL
FPR1 FPR1 Human Formylpeptide A pEC50 7.7 8.15 8.46 ChEMBL
FPR2/ALX FPR2 Human Formylpeptide A pEC50 4.69 4.93 5.17 ChEMBL
FPR3 FPR3 Human Formylpeptide A pEC50 5.72 5.72 5.72 ChEMBL