ArrestinDb

SB 271046

SMILES	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl
InChIKey	LOCQRDBFWSXQQI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	6
Hydrogen bond donors	2
Rotatable bonds	5
Molecular weight (Da)	451.1

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT₆

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.4	6.42	6.47	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.1	6.1	6.1	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.6	6.6	6.6	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.76	5.76	5.76	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.7	5.98	6.28	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	5.4	5.4	5.4	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.9	8.9	8.9	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.89	8.86	9.2	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.4	6.47	8.52	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.92	6.92	6.92	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.6	5.85	6.34	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.88	6.16	6.3	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	6.89	6.89	6.89	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.7	5.7	5.7	ChEMBL

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	8.7	8.7	8.7	ChEMBL

Showing 1 to 1 of 1 entries