galanin(1-16) (rat/mouse/pig)


SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)O
InChIKey FHTSPMGFAZMZJT-GDGJPEIESA-N
Sequence GWTLNSAGYLLGPHAI

Chemical properties

Hydrogen bond acceptors 22
Hydrogen bond donors 22
Rotatable bonds 48
Molecular weight (Da) 1668.9

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL1 GALR1 Human Galanin A pKi 8.3 8.8 9.3 Guide to Pharmacology
GAL2 GALR2 Human Galanin A pKi 7.89 8.35 8.8 Guide to Pharmacology
GAL3 GALR3 Human Galanin A pKi 6.5 6.5 6.5 Guide to Pharmacology
GAL3 GALR3 Rat Galanin A pKi 7.05 7.17 7.3 Guide to Pharmacology
GAL2 GALR2 Rat Galanin A pKi 7.89 8.31 8.74 Guide to Pharmacology
GAL1 GALR1 Rat Galanin A pKi 8.05 8.54 9.02 Guide to Pharmacology
GAL2 GALR2 Mouse Galanin A pKi 7.93 7.93 7.93 Guide to Pharmacology
GAL1 GALR1 Mouse Galanin A pKi 8.66 8.82 8.99 Guide to Pharmacology
GAL2 GALR2 Human Galanin A pKd 8.3 8.3 8.3 ChEMBL
GAL3 GALR3 Human Galanin A pKd 6.5 6.5 6.5 ChEMBL
GAL1 GALR1 Human Galanin A pKd 8.49 8.49 8.49 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL1 GALR1 Human Galanin A pIC50 9.0 9.11 9.22 Guide to Pharmacology
GAL2 GALR2 Human Galanin A pIC50 8.66 8.66 8.66 Guide to Pharmacology
GAL2 GALR2 Human Galanin A pEC50 7.26 8.32 9.38 Guide to Pharmacology
GAL2 GALR2 Rat Galanin A pEC50 7.03 7.03 7.03 Guide to Pharmacology
GAL2 GALR2 Rat Galanin A pIC50 7.88 8.2 8.52 Guide to Pharmacology
GAL1 GALR1 Rat Galanin A pIC50 9.57 9.57 9.57 Guide to Pharmacology