silodosin


SMILES OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N
InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 13
Molecular weight (Da) 495.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α1A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Human Adrenoceptors A pKi 9.6 10.0 10.4 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 6.5 7.1 7.7 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 6.9 7.8 8.7 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 7.7 7.7 7.7 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.7 8.7 8.7 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 10.4 10.42 10.44 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.98 7.98 7.98 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.06 8.06 8.06 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 7.04 7.04 7.04 ChEMBL
α1B ADA1B Human Adrenoceptors A pIC50 6.27 6.61 6.94 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 9.1 9.1 9.1 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 7.56 7.88 8.2 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 8.72 8.73 8.74 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.04 8.04 8.04 Drug Central