TAK-448


SMILES CN=C(NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)NNC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](Cc1ccc(cc1)O)NC(=O)C)O)CC(=O)N)Cc1ccccc1)CC(C)C)N
InChIKey MWXWMWSUUYXMRA-GRKBUMBKSA-N
Sequence None

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
kisspeptin KISSR Human Kisspeptin A pEC50 8.28 8.28 8.28 Guide to Pharmacology
kisspeptin KISSR Rat Kisspeptin A pEC50 7.44 7.44 7.44 ChEMBL
kisspeptin KISSR Human Kisspeptin A pEC50 8.28 8.28 8.28 ChEMBL