tramadol


SMILES COc1cccc(c1)C1(O)CCCCC1CN(C)C
InChIKey TVYLLZQTGLZFBW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 263.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 8.03 8.03 8.03 Guide to Pharmacology
κ OPRK Human Opioid A pKi 7.85 7.85 7.85 Guide to Pharmacology
μ OPRM Human Opioid A pKi 5.8 5.8 5.8 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 5.62 5.62 5.62 ChEMBL
δ OPRD Human Opioid A pKi 8.03 8.03 8.03 ChEMBL
κ OPRK Human Opioid A pKi 7.85 7.85 7.85 ChEMBL
μ OPRM Human Opioid A pKi 5.7 5.75 5.8 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pIC50 5.12 5.12 5.12 ChEMBL
μ OPRM Human Opioid A pEC50 5.89 5.89 5.89 ChEMBL