ArrestinDb

amisulpride

SMILES	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC
InChIKey	NTJOBXMMWNYJFB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	6
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	369.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	D₂ D₄

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.5	6.0	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.0	5.22	5.45	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.76	5.76	5.76	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.87	5.87	5.87	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	5.7	5.7	5.7	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.08	5.61	6.13	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.29	8.29	8.29	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.2	6.2	6.2	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.13	7.51	7.89	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.1	8.1	8.1	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.5	6.5	6.5	ChEMBL
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.38	5.62	5.87	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.27	8.27	8.27	Drug Central
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	7.6	7.77	7.94	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.87	7.42	7.94	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.1	8.1	8.1	Drug Central
A₁	AA1R	Rat	Adenosine	A	pKi	5.0	5.0	5.0	PDSP Ki database
AT₁	AGTR1	Human	Angiotensin	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	7.9	7.88	8.0	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pKi	8.52	8.71	8.89	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	7.68	8.25	8.77	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.07	8.07	8.07	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	7.9	8.21	8.52	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pKi	7.4	7.4	7.4	Guide to Pharmacology
D₃	A0A4W2FUW7	Hybrid cattle	Dopamine	A	pKi	8.54	8.64	8.74	PDSP Ki database
D₃	DRD3	Rat	Dopamine	A	pKi	8.42	8.44	8.46	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.07	8.07	8.07	Drug Central
D₃	DRD3	Rat	Dopamine	A	pKi	8.13	8.13	8.13	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	8.62	8.62	8.62	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.4	8.43	8.46	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	5.63	5.63	5.63	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	8.25	8.25	8.25	Drug Central
D₅	DRD5	Human	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
EP₃	PE2R3	Human	Prostanoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
EP₄	PE2R4	Human	Prostanoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₁	HRH1	Guinea pig	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₂	HRH2	Human	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₄	HRH4	Human	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.95	5.95	5.95	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.81	5.81	5.81	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.0	5.0	5.0	PDSP Ki database
κ	OPRK	Human	Opioid	A	pKi	5.0	5.0	5.0	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.0	5.0	5.0	PDSP Ki database

Showing 1 to 68 of 68 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
D₂	DRD2	Human	Dopamine	A	pIC50	8.52	8.52	8.52	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.4	4.4	4.4	ChEMBL

Showing 1 to 2 of 2 entries

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Main reference

amisulpride

Chemical properties

Drug properties

Database connections

Bioactivities