neuromedin U-8 (Pig)


SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O
InChIKey YUTFGQVEVLPRJQ-AQJXLSMYSA-N
Sequence YFLFRPRN

Chemical properties

Hydrogen bond acceptors 13
Hydrogen bond donors 14
Rotatable bonds 32
Molecular weight (Da) 1111.6

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NMU1 NMUR1 Human Neuromedin U A pKi 8.8 8.8 8.8 Guide to Pharmacology
NMU2 NMUR2 Human Neuromedin U A pKi 9.3 9.3 9.3 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NMU1 NMUR1 Human Neuromedin U A pEC50 9.0 9.5 10.0 Guide to Pharmacology
NMU2 NMUR2 Human Neuromedin U A pEC50 8.5 9.0 9.5 Guide to Pharmacology