ACTH-(1-24)


SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C
InChIKey ZOEFCCMDUURGSE-SQKVDDBVSA-N
Sequence SYSMEHFRWGKPVGKKRRPVKVYP

Chemical properties

Hydrogen bond acceptors 39
Hydrogen bond donors 39
Rotatable bonds 93
Molecular weight (Da) 2931.6

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC2 ACTHR Mouse Melanocortin A pKd 9.1 9.1 9.1 Guide to Pharmacology
MC2 ACTHR Human Melanocortin A pKi 8.08 8.08 8.08 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC4 MC4R Human Melanocortin A pEC50 9.19 9.19 9.19 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 8.04 8.04 8.04 Drug Central