MITOTANE


SMILES Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1
InChIKey JWBOIMRXGHLCPP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 318.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 5.56 5.56 5.56 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.19 6.19 6.19 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.51 5.51 5.51 ChEMBL
A3 AA3R Human Adenosine A pKi 5.38 5.38 5.38 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.25 8.25 8.25 Drug Central
A3 AA3R Human Adenosine A pKi 8.27 8.27 8.27 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.85 4.85 4.85 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.13 5.13 5.13 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 5.85 5.85 5.85 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.32 5.32 5.32 ChEMBL
A3 AA3R Human Adenosine A pIC50 5.13 5.13 5.13 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.9 4.9 4.9 ChEMBL