CHEMBL1774386


SMILES O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1
InChIKey LRBUVURCWWAQQT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 463.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 5.27 5.27 5.27 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.5 8.0 8.27 ChEMBL
D3 DRD3 Human Dopamine A pKd 10.4 10.46 10.52 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.94 5.94 5.94 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.84 5.3 6.02 ChEMBL
D2 DRD2 Human Dopamine A pKd 10.52 10.52 10.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 6.37 6.37 6.37 ChEMBL