CHEMBL1084009


SMILES O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1
InChIKey BWXAZFCPGFKANL-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 478.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FP PF2R Human Prostanoid A pKi 5.19 5.19 5.19 ChEMBL
EP2 PE2R2 Human Prostanoid A pKi 5.1 5.1 5.1 ChEMBL
EP4 PE2R4 Human Prostanoid A pKi 9.47 9.55 9.64 ChEMBL
TP TA2R Human Prostanoid A pKi 5.17 5.17 5.17 ChEMBL
DP1 PD2R Human Prostanoid A pKi 5.78 5.78 5.78 ChEMBL
EP1 PE2R1 Human Prostanoid A pKi 4.7 4.7 4.7 ChEMBL
EP3 PE2R3 Human Prostanoid A pKi 5.13 5.13 5.13 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pIC50 8.02 8.55 8.89 ChEMBL