senktide


SMILES CSCC[C@@H](C(=O)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)O)CC(=O)O)Cc1ccccc1)C)Cc1ccccc1)CC(C)C
InChIKey HMHYXLVEFVGOPM-QKUYTOGTSA-N
Sequence DFFGLM

Chemical properties

Hydrogen bond acceptors 10
Hydrogen bond donors 8
Rotatable bonds 26
Molecular weight (Da) 841.4

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 8JBF

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK3 NK3R Rat Tachykinin A pKd 7.9 8.5 9.1 Guide to Pharmacology
NK3 NK3R Human Tachykinin A pKi 7.1 7.85 8.6 Guide to Pharmacology
NK3 NK3R Mouse Tachykinin A pKi 7.6 7.8 8.0 Guide to Pharmacology
NK3 NK3R Human Tachykinin A pKi 8.5 8.5 8.5 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK3 NK3R Rat Tachykinin A pEC50 7.9 8.35 8.8 Guide to Pharmacology
NK3 NK3R Guinea pig Tachykinin A pEC50 9.3 9.3 9.3 Guide to Pharmacology
NK3 NK3R Guinea pig Tachykinin A pIC50 7.92 7.92 7.92 ChEMBL
NK3 NK3R Rat Tachykinin A pIC50 7.96 7.96 7.96 ChEMBL
NK3 NK3R Rat Tachykinin A pEC50 7.89 9.28 10.64 ChEMBL
NK1 NK1R Guinea pig Tachykinin A pEC50 4.46 4.46 4.46 ChEMBL
NK3 NK3R Human Tachykinin A pEC50 7.96 8.79 10.54 ChEMBL
NK3 NK3R Human Tachykinin A pIC50 7.25 7.8 9.0 ChEMBL