butorphanol


SMILES Oc1ccc2c(c1)[C@]13CCCC[C@]3([C@@H](C2)N(CC1)CC1CCC1)O
InChIKey IFKLAQQSCNILHL-QHAWAJNXSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 327.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 9.92 9.92 9.92 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.66 9.75 9.92 ChEMBL
δ OPRD Human Opioid A pKi 8.1 8.1 8.1 Drug Central
κ OPRK Human Opioid A pKi 8.0 8.0 8.0 Drug Central
μ OPRM Human Opioid A pKi 8.0 8.0 8.0 Drug Central
δ OPRD Human Opioid A pKi 7.92 7.92 7.92 ChEMBL
κ OPRK Human Opioid A pKi 9.66 9.83 9.92 ChEMBL
κ OPRK Human Opioid A pKi 9.92 9.92 9.92 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pIC50 7.85 7.85 7.85 ChEMBL
κ OPRK Human Opioid A pEC50 8.54 8.54 8.54 ChEMBL