ArrestinDb

2-methyl-5-HT

SMILES	Cc1c(CCN)c2c([nH]1)ccc(c2)O
InChIKey	WYWNEDARFVJQSG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	2
Hydrogen bond donors	3
Rotatable bonds	2
Molecular weight (Da)	190.1

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_2A

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.51	5.51	5.51	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.6	5.76	5.92	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.1	6.1	6.1	Guide to Pharmacology
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.04	6.13	6.29	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.28	6.28	6.28	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.7	5.95	6.2	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.91	5.91	5.91	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.77	5.92	6.07	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	6.4	6.4	6.4	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.1	6.1	6.1	Guide to Pharmacology
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.09	6.09	6.09	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	6.4	6.4	6.4	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	6.38	6.38	6.38	PDSP Ki database
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	6.6	6.6	6.6	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.71	6.71	6.71	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	6.5	6.53	6.55	PDSP Ki database
5-HT_2B	5HT2B	Mouse	5-Hydroxytryptamine	A	pKi	5.18	5.18	5.18	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.86	5.86	5.86	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.19	6.19	6.19	ChEMBL
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.84	5.86	5.9	PDSP Ki database
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	6.2	6.75	7.3	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.4	7.03	7.34	ChEMBL
5-HT₆	5HT6R	Mouse	5-Hydroxytryptamine	A	pKi	6.4	6.4	6.4	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.34	7.34	7.34	PDSP Ki database
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	6.25	6.77	7.28	PDSP Ki database
5-HT₇	5HT7R	Guinea pig	5-Hydroxytryptamine	A	pKi	5.9	5.9	5.9	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.9	5.9	5.9	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database

Showing 1 to 31 of 31 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.9	4.9	4.9	ChEMBL

Showing 1 to 1 of 1 entries

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Main reference

2-methyl-5-HT

Chemical properties

Drug properties

Database connections

Bioactivities