TRV023


SMILES CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC
InChIKey QDAXGBOWJLPIHQ-UHFFFAOYSA-N
Sequence GRVYKHPA

Chemical properties

Hydrogen bond acceptors 13
Hydrogen bond donors 13
Rotatable bonds 28
Molecular weight (Da) 940.5

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 6OS1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Human Angiotensin A pKi 8.64 8.64 8.64 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Human Angiotensin A pEC50 5.68 5.68 5.68 Guide to Pharmacology
AT1 AGTRA Rat Angiotensin A pEC50 7.41 7.69 7.96 ChEMBL
AT1 AGTR1 Human Angiotensin A pEC50 7.36 7.36 7.36 ChEMBL