compound 16m [PMID: 19931453]


SMILES CC[C@@H]1CCCCN1C(=O)c1cnc(c(c1)Cl)Nc1ccc(nc1)C
InChIKey QABUURICQJOWID-MRXNPFEDSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 358.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.42 7.42 7.42 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.42 7.42 7.42 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.52 7.52 7.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.49 7.49 7.49 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.44 7.47 7.5 ChEMBL