ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155524115	176547	0	None	-1	3	Rat	10.3	pEC50	=	10.3	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4454158	176547	0	None	-1	3	Rat	10.3	pEC50	=	10.3	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4597218	176547	0	None	-1	3	Rat	10.3	pEC50	=	10.3	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	155524115	176547	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4454158	176547	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4597218	176547	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	155524115	176547	0	None	-4	3	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4454158	176547	0	None	-4	3	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4597218	176547	0	None	-4	3	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	46235428	6604	0	None	263	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083162	6604	0	None	263	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	58227401	176451	0	None	2	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4443126	176451	0	None	2	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596409	176451	0	None	2	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	58227401	176451	0	None	-2	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4443126	176451	0	None	-2	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596409	176451	0	None	-2	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	155513612	176320	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	176320	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	176320	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	176320	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	51354300	58889	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	CHEMBL1688946	58889	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	155491015	176495	4	None	-10	4	Mouse	9.0	pEC50	=	9	Functional	Agonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assayAgonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4441731	176495	4	None	-10	4	Mouse	9.0	pEC50	=	9	Functional	Agonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assayAgonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4596734	176495	4	None	-10	4	Mouse	9.0	pEC50	=	9	Functional	Agonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assayAgonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	155513612	176320	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	176320	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	176320	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	176320	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	58227401	176451	0	None	-2	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4443126	176451	0	None	-2	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596409	176451	0	None	-2	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	45257132	3682	10	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	8983	3682	10	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	CHEMBL595180	3682	10	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	155552061	176478	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4543119	176478	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596606	176478	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	155517880	176667	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4445423	176667	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4598198	176667	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	45257132	3682	10	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	8983	3682	10	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	CHEMBL595180	3682	10	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	58227373	176508	0	None	-1	3	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4455324	176508	0	None	-1	3	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596881	176508	0	None	-1	3	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	155513612	176320	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	176320	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	176320	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	176320	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	136030655	56482	0	None	1	3	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632413	56482	0	None	1	3	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	136030655	56482	0	None	-1	3	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632413	56482	0	None	-1	3	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	25068753	188438	19	None	-1	2	Rat	8.0	pEC50	=	8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL502347	188438	19	None	-1	2	Rat	8.0	pEC50	=	8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	10105117	104195	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL309819	104195	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	127051301	140200	0	None	4	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804906	140200	0	None	4	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	136141537	56481	3	None	1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632412	56481	3	None	1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	4024	2015	20	None	-3388	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	9989505	2015	20	None	-3388	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL82298	2015	20	None	-3388	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	58227259	117142	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393556	117142	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	1194	45	3	None	-50	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	23786499	45	3	None	-50	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	CHEMBL26116	45	3	None	-50	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	24797598	61562	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1771001	61562	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	11846299	139220	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
	CHEMBL378788	139220	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
	46228114	200176	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL596551	200176	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	25130576	187626	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL494890	187626	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	25130232	187563	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cn(C)cn3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494576	187563	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cn(C)cn3)nc(N)n2)CC1	10.1021/jm8005959
	25131229	187595	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	CHEMBL494724	187595	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	25130576	187626	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	CHEMBL494890	187626	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	11846635	78680	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
	CHEMBL211242	78680	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
	46228132	202145	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
	CHEMBL609161	202145	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
	25129178	187629	1	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL494910	187629	1	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	1267	3804	49	None	-17	5	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm900526h
	3035905	3804	49	None	-17	5	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm900526h
	CHEMBL260374	3804	49	None	-17	5	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm900526h
	44480708	5775	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(/NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1021/jm900526h
	CHEMBL1078632	5775	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(/NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1021/jm900526h
	53233804	61526	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770966	61526	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	1204	1932	119	None	-1	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	1247	1932	119	None	-1	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	1375	1932	119	None	-1	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	774	1932	119	None	-1	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	CHEMBL90	1932	119	None	-1	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	DB05381	1932	119	None	-1	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	127052293	140238	3	None	10	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805361	140238	3	None	10	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1247	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1375	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	774	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	CHEMBL90	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	DB05381	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	45257131	199908	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	CHEMBL594731	199908	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	56593499	140242	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	3	4	3.2	N#C/N=C(/NCCSc1ccccc1)N[C@H]1CC[C@@H](c2c[nH]cn2)CC1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805392	140242	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	3	4	3.2	N#C/N=C(/NCCSc1ccccc1)N[C@H]1CC[C@@H](c2c[nH]cn2)CC1	10.1021/acs.jmedchem.6b00120
	127050776	140247	0	None	3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805437	140247	0	None	3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	127050431	140315	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806206	140315	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	58227165	117122	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393536	117122	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	25130578	187333	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	251	4	1	5	1.4	CN(C)CCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL493099	187333	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	251	4	1	5	1.4	CN(C)CCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	25129525	187583	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL494648	187583	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	25128833	188402	38	None	-2	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	CHEMBL501882	188402	38	None	-2	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	25128831	172613	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL449157	172613	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	11043445	56479	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL1632410	56479	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	16061839	188418	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	284	3	2	6	1.6	CN1CCN(c2cc(Nc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL502104	188418	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	284	3	2	6	1.6	CN1CCN(c2cc(Nc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	127050431	140315	0	None	3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806206	140315	0	None	3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	54585780	61558	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770998	61558	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	1204	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	1247	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	1375	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	774	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	CHEMBL90	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	DB05381	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	25130914	187254	0	None	15	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
	CHEMBL492677	187254	0	None	15	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
	11957573	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	1250	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	3692	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	CHEMBL19439	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	11957573	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1250	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	3692	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL19439	2010	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1253	2058	7	None	-251	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	132937	2058	7	None	-251	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL19010	2058	7	None	-251	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	10176414	4063	16	None	-25	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1246	4063	16	None	-25	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL281576	4063	16	None	-25	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1204	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1267	3804	49	None	-17	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	3035905	3804	49	None	-17	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	CHEMBL260374	3804	49	None	-17	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	44482032	5732	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	262	7	3	3	1.4	CC(C)CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1078346	5732	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	262	7	3	3	1.4	CC(C)CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	25130581	187225	0	None	3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	CHEMBL492489	187225	0	None	3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	44482029	5636	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1cccnc1	10.1021/jm900526h
	CHEMBL1077737	5636	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1cccnc1	10.1021/jm900526h
	25131234	187662	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccccc3C#N)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL495083	187662	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccccc3C#N)nc(N)n2)CC1	10.1021/jm8005959
	25130235	187587	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	187587	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	25130235	187587	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	CHEMBL494678	187587	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	25130234	187403	0	None	-	1	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	2	6	-0.7	CN1CCN(c2cc(N3CCNC3=O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493663	187403	0	None	-	1	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	2	6	-0.7	CN1CCN(c2cc(N3CCNC3=O)nc(N)n2)CC1	10.1021/jm8005959
	127051986	140304	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806098	140304	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	51354301	58892	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
	CHEMBL1688969	58892	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
	10934158	108577	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL320331	108577	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	10017821	103786	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL308913	103786	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
	1238	2082	13	None	-1258	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	6603865	2082	13	None	-1258	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	CHEMBL11919	2082	13	None	-1258	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	11043445	56479	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632410	56479	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	10945113	109629	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL322256	109629	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	44480707	5763	0	None	5	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	328	8	3	4	2.2	N#C/N=C(/NCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	CHEMBL1078529	5763	0	None	5	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	328	8	3	4	2.2	N#C/N=C(/NCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	10945113	109629	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL322256	109629	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	127052294	140302	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806079	140302	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1247	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1375	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	774	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	CHEMBL90	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	DB05381	1932	119	None	-1	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	10934158	108577	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL320331	108577	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	25129182	187283	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	291	2	1	7	-0.4	CN1CCN(c2cc(N3CCN(C)CC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492869	187283	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	291	2	1	7	-0.4	CN1CCN(c2cc(N3CCN(C)CC3)nc(N)n2)CC1	10.1021/jm8005959
	127052293	140238	3	None	10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805361	140238	3	None	10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	11846634	78009	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	CHEMBL209758	78009	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	11846464	78460	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
	CHEMBL211170	78460	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
	25071319	189062	14	None	1	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL509540	189062	14	None	1	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	44482030	5675	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	338	9	3	3	2.9	CC(CCN/C(=N\C#N)NCCCCc1c[nH]cn1)c1ccccc1	10.1021/jm900526h
	CHEMBL1077860	5675	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	338	9	3	3	2.9	CC(CCN/C(=N\C#N)NCCCCc1c[nH]cn1)c1ccccc1	10.1021/jm900526h
	25131561	187404	0	None	-3	2	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493664	187404	0	None	-3	2	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	135897837	187628	13	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	209	1	2	6	-0.5	CN1CCN(c2cc(O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494909	187628	13	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	209	1	2	6	-0.5	CN1CCN(c2cc(O)nc(N)n2)CC1	10.1021/jm8005959
	127048828	140320	0	None	38	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806255	140320	0	None	38	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	58227255	117125	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393539	117125	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	44568832	187183	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	2	1	6	1.2	CN1CCN(c2cc(-c3ccc(F)nc3F)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492242	187183	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	2	1	6	1.2	CN1CCN(c2cc(-c3ccc(F)nc3F)nc(N)n2)CC1	10.1021/jm8005959
	25128822	187481	0	None	19	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
	CHEMBL494093	187481	0	None	19	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
	1251	2014	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm100064d
	3035842	2014	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm100064d
	CHEMBL18661	2014	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm100064d
	1251	2014	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	3035842	2014	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	CHEMBL18661	2014	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	25149712	178986	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	299	7	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL470790	178986	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	299	7	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1	10.1016/j.bmcl.2010.10.041
	25149335	184225	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL483406	184225	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	1278	2150	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	1279	2150	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	4908365	2150	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	CHEMBL129198	2150	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	127048890	140295	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805995	140295	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	46890548	6584	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083084	6584	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	44481761	5774	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	324	9	3	3	2.4	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccc1	10.1021/jm900526h
	CHEMBL1078631	5774	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	324	9	3	3	2.4	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccc1	10.1021/jm900526h
	51354301	58892	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	CHEMBL1688969	58892	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	155513612	176320	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	176320	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	176320	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	176320	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	1204	1932	119	None	-102	10	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	1932	119	None	-102	10	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	1932	119	None	-102	10	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	1932	119	None	-102	10	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	1932	119	None	-102	10	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	1932	119	None	-102	10	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1248	1424	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	3077	1424	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	90045	1424	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	CHEMBL12344	1424	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	5310982	93612	4	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
	CHEMBL24665	93612	4	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
	1269	121	41	None	-35	6	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse histamine H4 receptorAgonist activity at mouse histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	121	41	None	-35	6	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse histamine H4 receptorAgonist activity at mouse histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	121	41	None	-35	6	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse histamine H4 receptorAgonist activity at mouse histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	53233802	61547	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770987	61547	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
	25131559	187585	0	None	23	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494667	187585	0	None	23	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	1204	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1204	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1247	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1375	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	774	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	CHEMBL90	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	DB05381	1932	119	None	-1	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	44480959	5676	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	206	5	3	3	0.1	N#C/N=C(\N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077861	5676	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	206	5	3	3	0.1	N#C/N=C(\N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	1484519	173896	60	None	-	1	Rat	4.8	pEC50	=	4.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	227	1	1	5	0.5	CN1CCN(c2cc(Cl)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL454007	173896	60	None	-	1	Rat	4.8	pEC50	=	4.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	227	1	1	5	0.5	CN1CCN(c2cc(Cl)nc(N)n2)CC1	10.1021/jm8005959
	21638785	188658	5	None	1	2	Mouse	7.8	pEC50	=	7.8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	CHEMBL503605	188658	5	None	1	2	Mouse	7.8	pEC50	=	7.8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	127051958	140278	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805813	140278	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	25129880	193130	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	2	1	5	2.6	CN1CCN(c2cc(-c3ccc4ccccc4c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL522841	193130	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	2	1	5	2.6	CN1CCN(c2cc(-c3ccc4ccccc4c3)nc(N)n2)CC1	10.1021/jm8005959
	25130231	187704	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	309	2	1	7	1.2	CN1CCN(c2cc(-n3cnc4ccccc43)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL495280	187704	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	309	2	1	7	1.2	CN1CCN(c2cc(-n3cnc4ccccc43)nc(N)n2)CC1	10.1021/jm8005959
	25131228	187594	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL494723	187594	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25128828	188252	2	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	237	4	2	5	1.3	CN(C)CCNc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL499631	188252	2	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	237	4	2	5	1.3	CN(C)CCNc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	58227163	176463	0	None	4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4518374	176463	0	None	4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596491	176463	0	None	4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	25071319	189062	14	None	-1	2	Mouse	7.7	pEC50	=	7.7	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL509540	189062	14	None	-1	2	Mouse	7.7	pEC50	=	7.7	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	1204	1932	119	None	-1	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	1247	1932	119	None	-1	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	1375	1932	119	None	-1	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	774	1932	119	None	-1	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	CHEMBL90	1932	119	None	-1	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	DB05381	1932	119	None	-1	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	25130233	170613	7	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3cn[nH]c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL445091	170613	7	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3cn[nH]c3)nc(N)n2)CC1	10.1021/jm8005959
	25128831	172613	0	None	-1	2	Rat	4.7	pEC50	=	4.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL449157	172613	0	None	-1	2	Rat	4.7	pEC50	=	4.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	25130574	187376	0	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(N)nc(-c3ccc(C#N)cc3)c2)CC1	10.1021/jm8005959
	CHEMBL493461	187376	0	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(N)nc(-c3ccc(C#N)cc3)c2)CC1	10.1021/jm8005959
	44568790	171414	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	2	2	5	1.4	CN[C@@H]1CCN(c2nc(N)nc3c2Cc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL446269	171414	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	2	2	5	1.4	CN[C@@H]1CCN(c2nc(N)nc3c2Cc2ccccc2-3)C1	10.1021/jm800670r
	155552061	176478	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4543119	176478	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596606	176478	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	45257133	199904	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594721	199904	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	11846300	80266	3	None	-2	2	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
	CHEMBL213912	80266	3	None	-2	2	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
	1204	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	3032915	15495	24	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL12160	15495	24	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	53321919	56478	0	None	-50	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632409	56478	0	None	-50	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	10060213	102911	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL306077	102911	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	25128823	192717	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
	CHEMBL521995	192717	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
	25131230	193109	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	329	4	1	7	1.5	COc1cccc(OC)c1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL522679	193109	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	329	4	1	7	1.5	COc1cccc(OC)c1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	10037650	5209	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106158	5209	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	170389	206981	35	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL4634086	206981	35	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL91353	206981	35	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	155513612	176320	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	176320	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	176320	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	176320	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	136141537	56481	3	None	-1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632412	56481	3	None	-1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	136192874	56483	0	None	-3	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632414	56483	0	None	-3	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	46228133	200054	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL595639	200054	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	10197870	5301	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106612	5301	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	10197870	5301	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106612	5301	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10879463	5290	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106570	5290	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	1278	2150	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	1279	2150	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	4908365	2150	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	CHEMBL129198	2150	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	1278	2150	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	1279	2150	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	4908365	2150	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	CHEMBL129198	2150	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	58227260	117132	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393546	117132	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
	11846636	77952	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	CHEMBL209628	77952	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	1204	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	1247	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	1375	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	774	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	CHEMBL90	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	DB05381	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	16061961	199679	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL593103	199679	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	1204	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	1247	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	1375	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	774	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	CHEMBL90	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	DB05381	1932	119	None	-1	10	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	127052635	140207	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805003	140207	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	25130237	187282	2	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	1	1	5	0.4	CN1CCN(c2cc(I)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492864	187282	2	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	1	1	5	0.4	CN1CCN(c2cc(I)nc(N)n2)CC1	10.1021/jm8005959
	127051301	140200	0	None	4	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804906	140200	0	None	4	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	25131555	187179	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3cccnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492227	187179	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3cccnc3)nc(N)n2)CC1	10.1021/jm8005959
	25130914	187254	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL492677	187254	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	10879463	5290	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106570	5290	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	1613	2348	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	205	2348	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	3964	2348	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	CHEMBL831	2348	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	DB00408	2348	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	753256	179350	12	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL473662	179350	12	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1021/jm8005959
	25131560	187346	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cnn(C)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493229	187346	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cnn(C)c3)nc(N)n2)CC1	10.1021/jm8005959
	1223	953	41	None	-21	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	2790	953	41	None	-21	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	CHEMBL14690	953	41	None	-21	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	155512725	176241	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4437371	176241	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4594753	176241	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	10037650	5209	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106158	5209	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	25129881	187182	5	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3ccncc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492241	187182	5	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3ccncc3)nc(N)n2)CC1	10.1021/jm8005959
	44568855	193194	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	285	2	1	5	2.0	CC(C)(C)c1cc(N2CCNCC2)nc(-n2cccc2)n1	10.1021/jm8005959
	CHEMBL523335	193194	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	285	2	1	5	2.0	CC(C)(C)c1cc(N2CCNCC2)nc(-n2cccc2)n1	10.1021/jm8005959
	25128832	172012	0	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	5	1.2	CN1CCN(c2cc(C(C)(C)C)nc(O)n2)CC1	10.1021/jm8005959
	CHEMBL447151	172012	0	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	5	1.2	CN1CCN(c2cc(C(C)(C)C)nc(O)n2)CC1	10.1021/jm8005959
	25071940	187354	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
	CHEMBL493281	187354	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
	127049156	140194	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804837	140194	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	11437850	187661	1	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3cccc(C#N)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL495082	187661	1	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3cccc(C#N)c3)nc(N)n2)CC1	10.1021/jm8005959
	25129883	192723	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ccncc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL522019	192723	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ccncc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25133972	187350	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(-c3ccc(C#N)cc3)cc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493262	187350	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(-c3ccc(C#N)cc3)cc(N)n2)CC1	10.1021/jm8005959
	25130575	187589	1	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.6	CC1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494687	187589	1	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.6	CC1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	25130577	172598	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	4	1	6	1.0	CN(C)CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL449021	172598	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	4	1	6	1.0	CN(C)CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	10773349	8091	1	None	-89	2	Human	4.6	pEC50	=	4.6	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL109130	8091	1	None	-89	2	Human	4.6	pEC50	=	4.6	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	127052634	140309	0	None	6	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806146	140309	0	None	6	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	90667240	109479	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	356	9	3	4	2.8	Cc1[nH]cnc1CCCCN/C(=N\C#N)NCCSc1ccccc1	10.1039/C3MD00245D
	CHEMBL3220642	109479	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	356	9	3	4	2.8	Cc1[nH]cnc1CCCCN/C(=N\C#N)NCCSc1ccccc1	10.1039/C3MD00245D
	25130576	187626	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL494890	187626	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	25128826	188816	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.5	CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL506187	188816	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.5	CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	25130576	187626	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	CHEMBL494890	187626	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	58227157	115917	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3354815	115917	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	1204	1932	119	None	-1	10	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	1247	1932	119	None	-1	10	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	1375	1932	119	None	-1	10	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	774	1932	119	None	-1	10	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	CHEMBL90	1932	119	None	-1	10	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	DB05381	1932	119	None	-1	10	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	1226	2019	20	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
	41376	2019	20	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
	CHEMBL12608	2019	20	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
	25133970	187588	2	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL494679	187588	2	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	25130230	172456	2	None	3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL448085	172456	2	None	3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	1269	121	41	None	-56	6	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptorAgonist activity at rat histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	121	41	None	-56	6	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptorAgonist activity at rat histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	121	41	None	-56	6	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptorAgonist activity at rat histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	44480958	5673	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccncc1	10.1021/jm900526h
	CHEMBL1077859	5673	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccncc1	10.1021/jm900526h
	25131556	188871	7	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL507063	188871	7	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	127051047	140311	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806162	140311	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	45257134	199943	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
	CHEMBL594949	199943	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
	25131231	187187	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(I)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492288	187187	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(I)cc3)nc(N)n2)CC1	10.1021/jm8005959
	10381810	205174	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
	CHEMBL7828	205174	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
	155512725	176241	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4437371	176241	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4594753	176241	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	127052294	140302	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806079	140302	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	1932	119	None	-102	10	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	1932	119	None	-102	10	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	1932	119	None	-102	10	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	1932	119	None	-102	10	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	1932	119	None	-102	10	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	1932	119	None	-102	10	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	25128822	187481	0	None	-19	2	Human	6.5	pEC50	=	6.5	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	CHEMBL494093	187481	0	None	-19	2	Human	6.5	pEC50	=	6.5	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	155491015	176495	4	None	-31	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assayAgonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4441731	176495	4	None	-31	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assayAgonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4596734	176495	4	None	-31	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assayAgonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	46890072	6910	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084355	6910	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46890166	7316	0	None	3	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086105	7316	0	None	3	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	58227373	176508	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4455324	176508	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596881	176508	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	21638785	188658	5	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	CHEMBL503605	188658	5	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	25130911	185230	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	236	2	1	6	-0.1	CN1CCN(c2cc(N(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL485802	185230	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	236	2	1	6	-0.1	CN1CCN(c2cc(N(C)C)nc(N)n2)CC1	10.1021/jm8005959
	16352	117185	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
	CHEMBL339414	117185	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
	1267	3804	49	None	-8	5	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	3035905	3804	49	None	-8	5	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	CHEMBL260374	3804	49	None	-8	5	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	25130579	187712	2	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	238	4	1	5	1.3	CN(C)CCOc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL495341	187712	2	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	238	4	1	5	1.3	CN(C)CCOc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	10678661	5362	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106931	5362	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	46228101	199798	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594022	199798	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	1249	2009	16	None	-18	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	13499360	2009	16	None	-18	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90019	2009	16	None	-18	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1269	121	41	None	35	6	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	121	41	None	35	6	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	121	41	None	35	6	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	25129528	187186	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(Cl)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492287	187186	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(Cl)c3)nc(N)n2)CC1	10.1021/jm8005959
	44568923	193103	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	327	2	1	5	2.3	CN1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL522661	193103	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	327	2	1	5	2.3	CN1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)CC1	10.1021/jm8005959
	67087450	117136	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393550	117136	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	44547127	115918	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3354816	115918	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	58227148	117133	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393547	117133	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	10678661	5362	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106931	5362	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	25131557	193259	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	8	0.3	COc1ncc(-c2cc(N3CCN(C)CC3)nc(N)n2)cn1	10.1021/jm8005959
	CHEMBL523835	193259	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	8	0.3	COc1ncc(-c2cc(N3CCN(C)CC3)nc(N)n2)cn1	10.1021/jm8005959
	25130909	187380	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	CHEMBL493478	187380	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	44478385	5776	6	None	20	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	CHEMBL1078642	5776	6	None	20	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	46890549	6585	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083085	6585	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	44480960	5630	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	248	6	3	3	1.2	CC(C)N/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077636	5630	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	248	6	3	3	1.2	CC(C)N/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	42625303	180766	0	None	-2089	6	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	CHEMBL475621	180766	0	None	-2089	6	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	56954425	82081	0	None	-13	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	584	23	6	4	4.0	N/C(=N\C(=O)CCCCCCCCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165643	82081	0	None	-13	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	584	23	6	4	4.0	N/C(=N\C(=O)CCCCCCCCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	25130913	170187	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	278	2	1	7	-0.4	CN1CCN(c2cc(N3CCOCC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL444484	170187	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	278	2	1	7	-0.4	CN1CCN(c2cc(N3CCOCC3)nc(N)n2)CC1	10.1021/jm8005959
	1274	4064	16	None	-776	4	Rat	4.5	pEC50	=	4.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	3063228	4064	16	None	-776	4	Rat	4.5	pEC50	=	4.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	CHEMBL1196470	4064	16	None	-776	4	Rat	4.5	pEC50	=	4.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	155517880	176667	0	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4445423	176667	0	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4598198	176667	0	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	155552061	176478	0	None	-8	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4543119	176478	0	None	-8	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596606	176478	0	None	-8	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	25129180	187251	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	4	1	6	0.7	CCN(CC)c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL492662	187251	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	4	1	6	0.7	CCN(CC)c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	3228743	187381	5	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL493479	187381	5	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	12769844	109478	0	None	-3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	234	5	3	3	0.7	CN/C(=N/C#N)NCCCCc1nc[nH]c1C	10.1039/C3MD00245D
	CHEMBL3220641	109478	0	None	-3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	234	5	3	3	0.7	CN/C(=N/C#N)NCCCCc1nc[nH]c1C	10.1039/C3MD00245D
	25129181	187252	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	305	3	1	7	-0.0	CN1CCN(c2cc(N3CCC(N(C)C)C3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492663	187252	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	305	3	1	7	-0.0	CN1CCN(c2cc(N3CCC(N(C)C)C3)nc(N)n2)CC1	10.1021/jm8005959
	25128825	187564	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.2	CN1CCC(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494585	187564	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.2	CN1CCC(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	44478385	5776	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/acs.jmedchem.6b00120
	CHEMBL1078642	5776	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/acs.jmedchem.6b00120
	44478385	5776	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1039/C3MD00245D
	CHEMBL1078642	5776	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1039/C3MD00245D
	25129527	187414	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493720	187414	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm8005959
	24798596	199867	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594491	199867	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	127052292	140266	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805663	140266	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1274	4064	16	None	7	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	3063228	4064	16	None	7	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	CHEMBL1196470	4064	16	None	7	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	11846465	141932	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
	CHEMBL387054	141932	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
	25131559	187585	0	None	-23	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494667	187585	0	None	-23	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	25131561	187404	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493664	187404	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	46235428	6604	0	None	-263	3	Mouse	7.4	pEC50	=	7.4	Functional	Intrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083162	6604	0	None	-263	3	Mouse	7.4	pEC50	=	7.4	Functional	Intrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	1269	121	41	None	35	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	121	41	None	35	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	121	41	None	35	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	136030655	56482	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632413	56482	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	25129523	187287	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492884	187287	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25129523	187287	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
	CHEMBL492884	187287	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
	70692530	75691	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
	CHEMBL2047474	75691	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
	91613	17987	34	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL12620	17987	34	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
	58227326	117128	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393542	117128	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
	58227373	176508	0	None	-3	3	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4455324	176508	0	None	-3	3	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596881	176508	0	None	-3	3	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	25071004	192718	0	None	1	2	Mouse	8.4	pEC50	=	8.4	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL521996	192718	0	None	1	2	Mouse	8.4	pEC50	=	8.4	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	42625303	180766	0	None	-2	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	CHEMBL475621	180766	0	None	-2	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	25128824	193178	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	CHEMBL523225	193178	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	10702196	108568	1	None	-1	2	Human	4.4	pEC50	=	4.4	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL320279	108568	1	None	-1	2	Human	4.4	pEC50	=	4.4	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	56954320	82079	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	472	15	6	4	0.9	N/C(=N\C(=O)CCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165641	82079	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	472	15	6	4	0.9	N/C(=N\C(=O)CCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	1267	3804	49	None	-17	5	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2015.12.035
	3035905	3804	49	None	-17	5	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2015.12.035
	CHEMBL260374	3804	49	None	-17	5	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2015.12.035
	25129524	187184	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	CHEMBL492274	187184	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	25130909	187380	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	CHEMBL493478	187380	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	1278	2150	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	1279	2150	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	4908365	2150	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	CHEMBL129198	2150	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	25128833	188402	38	None	2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	CHEMBL501882	188402	38	None	2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	25129526	187413	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL493719	187413	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	24797248	199866	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594490	199866	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	127050434	140250	0	None	3	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	160	3	4	3	0.2	CC(=N)SCCNC(=N)N	10.1021/acs.jmedchem.6b00120
	CHEMBL3805514	140250	0	None	3	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	160	3	4	3	0.2	CC(=N)SCCNC(=N)N	10.1021/acs.jmedchem.6b00120
	25129169	187181	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	CHEMBL492231	187181	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	24798595	170376	2	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	276	2	1	6	0.8	CN1CCN(c2cc(N3CCCCC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL444782	170376	2	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	276	2	1	6	0.8	CN1CCN(c2cc(N3CCCCC3)nc(N)n2)CC1	10.1021/jm8005959
	90667239	109477	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	8	3	4	2.5	Cc1nc(CCCN/C(=N\C#N)NCCSc2ccccc2)c[nH]1	10.1039/C3MD00245D
	CHEMBL3220640	109477	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	8	3	4	2.5	Cc1nc(CCCN/C(=N\C#N)NCCSc2ccccc2)c[nH]1	10.1039/C3MD00245D
	25130573	186885	2	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL489663	186885	2	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	25130581	187225	0	None	-3	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	CHEMBL492489	187225	0	None	-3	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	25130235	187587	1	None	-4	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	187587	1	None	-4	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	46890546	6515	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082771	6515	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46228143	200083	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL595880	200083	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	117724523	117115	2	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393529	117115	2	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
	25130914	187254	0	None	-15	2	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492677	187254	0	None	-15	2	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25129179	187668	4	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	222	2	2	6	-0.1	CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL495112	187668	4	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	222	2	2	6	-0.1	CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25130236	187701	0	None	1	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	CHEMBL495265	187701	0	None	1	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	25068753	188438	19	None	1	2	Mouse	8.2	pEC50	=	8.2	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL502347	188438	19	None	1	2	Mouse	8.2	pEC50	=	8.2	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	53233805	61524	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770964	61524	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	46890545	7385	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086460	7385	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	1274	4064	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
	3063228	4064	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
	CHEMBL1196470	4064	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
	1274	4064	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activityAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activity	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
	3063228	4064	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activityAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activity	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
	CHEMBL1196470	4064	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activityAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activity	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
	136141537	56481	3	None	-5	3	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632412	56481	3	None	-5	3	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	11313837	2500	8	None	-15848	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	1254	2500	8	None	-15848	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	CHEMBL175782	2500	8	None	-15848	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	10583206	109360	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL321920	109360	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	1204	1932	119	None	-53	10	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	1932	119	None	-53	10	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	1932	119	None	-53	10	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	1932	119	None	-53	10	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	1932	119	None	-53	10	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	1932	119	None	-53	10	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	155513612	176320	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	176320	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	176320	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	176320	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	155512725	176241	0	None	-6	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4437371	176241	0	None	-6	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4594753	176241	0	None	-6	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	58227163	176463	0	None	-4	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4518374	176463	0	None	-4	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596491	176463	0	None	-4	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	25130580	174302	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.6	CNc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	CHEMBL455016	174302	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.6	CNc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	25129878	187335	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	324	3	1	7	1.4	COc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL493103	187335	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	324	3	1	7	1.4	COc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	127052295	140197	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	352	7	3	4	2.4	N#C/N=C(/NCCOc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804862	140197	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	352	7	3	4	2.4	N#C/N=C(/NCCOc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	1932	119	None	-102	10	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	1932	119	None	-102	10	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	1932	119	None	-102	10	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	1932	119	None	-102	10	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	1932	119	None	-102	10	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	1932	119	None	-102	10	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	53233803	61522	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770962	61522	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	25129169	187181	0	None	-1	2	Rat	7.3	pEC50	=	7.3	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	CHEMBL492231	187181	0	None	-1	2	Rat	7.3	pEC50	=	7.3	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	127049856	140245	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805431	140245	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	90667238	109476	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	220	4	3	3	0.3	CN/C(=N/C#N)NCCCc1c[nH]c(C)n1	10.1039/C3MD00245D
	CHEMBL3220639	109476	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	220	4	3	3	0.3	CN/C(=N/C#N)NCCCc1c[nH]c(C)n1	10.1039/C3MD00245D
	565544	109743	11	None	-4466	2	Human	6.3	pEC50	=	6.3	Functional	Inhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptor	ChEMBL	125	2	2	2	0.5	CC(CN)c1cnc[nH]1	10.1021/jm0300025
	CHEMBL322988	109743	11	None	-4466	2	Human	6.3	pEC50	=	6.3	Functional	Inhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptor	ChEMBL	125	2	2	2	0.5	CC(CN)c1cnc[nH]1	10.1021/jm0300025
	10583206	109360	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL321920	109360	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	25130915	187288	1	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL492885	187288	1	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	46228125	199988	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL595215	199988	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	44482028	5624	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccn1	10.1021/jm900526h
	CHEMBL1077580	5624	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccn1	10.1021/jm900526h
	25131232	187290	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	308	2	1	6	1.7	Cc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL492900	187290	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	308	2	1	6	1.7	Cc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	25130235	187587	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	187587	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	25130235	187587	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	CHEMBL494678	187587	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	45257133	199904	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594721	199904	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	25128824	193178	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	CHEMBL523225	193178	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	155517880	176667	0	None	-2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4445423	176667	0	None	-2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4598198	176667	0	None	-2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	45269820	195349	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
	CHEMBL1202326	195349	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
	CHEMBL551790	195349	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
	25071004	192718	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL521996	192718	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	46890022	7046	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	8	3	4	4.3	Cc1cc(OCCCNCC2CCCNC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084869	7046	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	8	3	4	4.3	Cc1cc(OCCCNCC2CCCNC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46228158	202158	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL609289	202158	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	46890547	6516	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082772	6516	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
	1255	3195	19	None	-19	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
	6421522	3195	19	None	-19	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL19173	3195	19	None	-19	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
	9974306	204474	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL72372	204474	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
	10060212	204534	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL72769	204534	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	136192874	56483	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632414	56483	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	1236	2067	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	1237	2067	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	156615	2067	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	CHEMBL268229	2067	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	25129175	187379	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL493477	187379	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	25130914	187254	0	None	15	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492677	187254	0	None	15	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25130908	171851	2	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL446896	171851	2	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	24797775	187245	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492631	187245	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	1204	1932	119	None	-53	10	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	1932	119	None	-53	10	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	1932	119	None	-53	10	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	1932	119	None	-53	10	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	1932	119	None	-53	10	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	1932	119	None	-53	10	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	25130912	188739	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL505061	188739	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1021/jm8005959
	1204	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	25149521	179052	0	None	9	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL471413	179052	0	None	9	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	1204	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	1247	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	1375	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	774	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	CHEMBL90	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	DB05381	1932	119	None	-1	10	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	1267	3804	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	3035905	3804	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	CHEMBL260374	3804	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	1269	121	41	None	35	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	37463	121	41	None	35	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	CHEMBL275443	121	41	None	35	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	1267	3804	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	3035905	3804	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	CHEMBL260374	3804	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	44482031	5642	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	234	6	3	3	0.8	CCN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077756	5642	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	234	6	3	3	0.8	CCN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	46890019	7312	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086085	7312	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	156015638	178272	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4642520	178272	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4650832	178272	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	1278	2150	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	1279	2150	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	4908365	2150	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	CHEMBL129198	2150	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	10978141	5150	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL105803	5150	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	58227127	117129	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393543	117129	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
	44481489	5713	0	None	18	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(\NCCCc1ccccc1)NCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1078210	5713	0	None	18	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(\NCCCc1ccccc1)NCCCc1c[nH]cn1	10.1021/jm900526h
	10419556	5358	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106913	5358	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	11086114	7394	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL108649	7394	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10820930	5799	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL107877	5799	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10106063	109271	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL321860	109271	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10106063	109271	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
	CHEMBL321860	109271	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
	56954318	82078	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	444	13	6	4	0.1	N/C(=N\C(=O)CCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165640	82078	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	444	13	6	4	0.1	N/C(=N\C(=O)CCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	10106063	109271	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL321860	109271	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	10017000	204485	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL72431	204485	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
	1204	1932	119	None	-1	10	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	1932	119	None	-1	10	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	1932	119	None	-1	10	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	1932	119	None	-1	10	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	1932	119	None	-1	10	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	1932	119	None	-1	10	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	136192874	56483	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632414	56483	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	1267	3804	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayInverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
	3035905	3804	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayInverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
	CHEMBL260374	3804	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayInverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
	1239	2033	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1240	2033	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	912	2033	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL268490	2033	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	10978141	5150	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL105803	5150	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	1278	2150	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	1279	2150	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	4908365	2150	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	CHEMBL129198	2150	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	42625303	180766	0	None	-501	6	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	CHEMBL475621	180766	0	None	-501	6	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	10419556	5358	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106913	5358	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	11086114	7394	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL108649	7394	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	155513612	176320	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	176320	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	176320	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	176320	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	25130230	172456	2	None	-3	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL448085	172456	2	None	-3	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	25133971	187349	2	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2nc(N)cc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL493261	187349	2	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2nc(N)cc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	25130229	188755	7	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	271	2	1	7	0.3	CN1CCN(c2cc(-c3cncnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL505346	188755	7	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	271	2	1	7	0.3	CN1CCN(c2cc(-c3cncnc3)nc(N)n2)CC1	10.1021/jm8005959
	56954515	82065	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	546	17	6	6	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165628	82065	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	546	17	6	6	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm201128q
	56954322	82080	0	None	-4	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	500	17	6	4	1.7	N/C(=N\C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165642	82080	0	None	-4	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	500	17	6	4	1.7	N/C(=N\C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	45257131	199908	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	CHEMBL594731	199908	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	11846298	139281	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
	CHEMBL379102	139281	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
	25129176	172761	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2nc(N)ncc2-c2ccccc2)CC1	10.1021/jm8005959
	CHEMBL451108	172761	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2nc(N)ncc2-c2ccccc2)CC1	10.1021/jm8005959
	58227388	117124	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393538	117124	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	1223	953	41	None	-812	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	2790	953	41	None	-812	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	CHEMBL14690	953	41	None	-812	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	10820929	108207	1	None	-30	2	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL319658	108207	1	None	-30	2	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	53233801	61545	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770985	61545	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
	58227252	117130	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393544	117130	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
	1204	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1204	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1247	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1375	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	774	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	CHEMBL90	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	DB05381	1932	119	None	-53	10	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1274	4064	16	None	-199	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	3063228	4064	16	None	-199	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	CHEMBL1196470	4064	16	None	-199	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	25130236	187701	0	None	-1	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	CHEMBL495265	187701	0	None	-1	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	1267	3804	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	3035905	3804	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	CHEMBL260374	3804	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	25129877	169460	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(I)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL442865	169460	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(I)c3)nc(N)n2)CC1	10.1021/jm8005959
	44568847	187249	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	6	2.0	CN1CCN(c2cc(Sc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492652	187249	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	6	2.0	CN1CCN(c2cc(Sc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25101945	193106	0	None	1	2	Mouse	8.0	pEC50	=	8.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL522673	193106	0	None	1	2	Mouse	8.0	pEC50	=	8.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	25101945	193106	0	None	-1	2	Rat	8.0	pEC50	=	8.0	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL522673	193106	0	None	-1	2	Rat	8.0	pEC50	=	8.0	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	58227143	117127	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393541	117127	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	16061961	199679	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL593103	199679	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	112936251	137266	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
	CHEMBL3752085	137266	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
	58227163	176463	0	None	-8	3	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4518374	176463	0	None	-8	3	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596491	176463	0	None	-8	3	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	25131556	188871	7	None	-3	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL507063	188871	7	None	-3	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25128830	187713	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	234	1	0	4	1.5	CN1CCN(c2cc(C(C)(C)C)ncn2)CC1	10.1021/jm8005959
	CHEMBL495342	187713	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	234	1	0	4	1.5	CN1CCN(c2cc(C(C)(C)C)ncn2)CC1	10.1021/jm8005959
	127035835	137285	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	CHEMBL3752270	137285	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	11983344	5677	5	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	220	5	3	3	0.4	CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077862	5677	5	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	220	5	3	3	0.4	CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	25128829	187334	0	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	265	5	1	5	1.7	CN(C)CCCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL493100	187334	0	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	265	5	1	5	1.7	CN(C)CCCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	24745335	295	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	295	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	295	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	295	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	24745335	295	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	295	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	295	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	295	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	156013896	178240	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Inverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4635634	178240	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Inverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4650570	178240	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Inverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	44129134	199508	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	CHEMBL591969	199508	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	56835171	69740	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935574	69740	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	16082828	80260	0	None	-6	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	CHEMBL213886	80260	0	None	-6	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	71525678	89725	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376800	89725	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	71525679	89726	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376801	89726	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	1278	2150	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	1279	2150	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	4908365	2150	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	CHEMBL129198	2150	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	10446295	2132	34	None	11	2	Human	6.9	pIC50	=	6.9	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	1277	2132	34	None	11	2	Human	6.9	pIC50	=	6.9	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	CHEMBL185951	2132	34	None	11	2	Human	6.9	pIC50	=	6.9	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	155563181	175303	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	498	12	1	7	5.1	CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccc(OCCCCCN2CCCCC2)cc1	10.1021/acs.jmedchem.9b00937
	CHEMBL4573309	175303	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	498	12	1	7	5.1	CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccc(OCCCCCN2CCCCC2)cc1	10.1021/acs.jmedchem.9b00937
	25147771	174238	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	CHEMBL454890	174238	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	16082833	80347	0	None	-40	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
	CHEMBL214312	80347	0	None	-40	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
	90645145	112178	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	CHEMBL3290578	112178	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	1267	3804	49	None	-17	5	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.9b00937
	3035905	3804	49	None	-17	5	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.9b00937
	CHEMBL260374	3804	49	None	-17	5	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.9b00937
	1278	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1278	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	1279	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	4908365	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	CHEMBL129198	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	3201696	15769	4	None	-22	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human histamine H4 receptorAntagonist activity at human histamine H4 receptor	ChEMBL	348	5	0	6	2.1	CN1CCN(C(c2ccccc2)c2nnnn2Cc2ccccc2)CC1	10.1016/j.bmcl.2010.07.009
	CHEMBL1222728	15769	4	None	-22	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human histamine H4 receptorAntagonist activity at human histamine H4 receptor	ChEMBL	348	5	0	6	2.1	CN1CCN(C(c2ccccc2)c2nnnn2Cc2ccccc2)CC1	10.1016/j.bmcl.2010.07.009
	1278	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	2150	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	63868328	174251	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
	CHEMBL4549015	174251	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
	71548412	1909	20	None	14	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	9879	1909	20	None	14	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	CHEMBL4790724	1909	20	None	14	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	16656871	7976	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1090531	7976	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	16718567	8162	0	None	3311	2	Human	8.5	pIC50	=	8.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1091874	8162	0	None	3311	2	Human	8.5	pIC50	=	8.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	1278	2150	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	2150	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	2150	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	2150	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	155540438	172541	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
	CHEMBL4483783	172541	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
	44129130	199556	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	CHEMBL592379	199556	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	11682208	8274	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
	CHEMBL1092542	8274	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
	25112105	8163	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1091875	8163	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	24745335	295	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	295	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	295	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	295	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	1278	2150	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	1279	2150	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	4908365	2150	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	CHEMBL129198	2150	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	16656872	7912	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1090190	7912	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	122193095	123914	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
	CHEMBL3628042	123914	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
	49841846	69738	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935572	69738	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	49841719	69737	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935571	69737	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	1278	2150	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	2150	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	2150	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	2150	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	90645147	112176	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	CHEMBL3290576	112176	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	24745335	295	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	8985	295	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	CHEMBL1915540	295	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	DB15027	295	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	10446295	2132	34	None	11	2	Human	6.3	pIC50	=	6.3	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	1277	2132	34	None	11	2	Human	6.3	pIC50	=	6.3	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	CHEMBL185951	2132	34	None	11	2	Human	6.3	pIC50	=	6.3	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	122194625	124021	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
	CHEMBL3629828	124021	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
	1267	3804	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assayAntagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.09.061
	3035905	3804	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assayAntagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.09.061
	CHEMBL260374	3804	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assayAntagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.09.061
	1267	3804	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
	3035905	3804	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
	CHEMBL260374	3804	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
	25147772	173409	9	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	CHEMBL452847	173409	9	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	71548412	1909	20	None	-14	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	9879	1909	20	None	-14	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	CHEMBL4790724	1909	20	None	-14	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	11709443	8246	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
	CHEMBL1092332	8246	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
	71519674	89729	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376804	89729	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	16656874	8106	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1091569	8106	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	49841845	69739	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935573	69739	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	156013896	178240	0	None	-38	3	Mouse	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4635634	178240	0	None	-38	3	Mouse	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4650570	178240	0	None	-38	3	Mouse	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	1278	2150	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	1279	2150	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	4908365	2150	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	CHEMBL129198	2150	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	16082831	80346	0	None	-100	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	CHEMBL214311	80346	0	None	-100	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	71525681	89728	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376803	89728	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	1267	3804	49	None	-17	5	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	3035905	3804	49	None	-17	5	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	CHEMBL260374	3804	49	None	-17	5	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	58227148	117133	0	None	-	1	Human	10.1	pKd	=	10.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393547	117133	0	None	-	1	Human	10.1	pKd	=	10.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	59777258	110133	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
	CHEMBL3236561	110133	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
	24797604	110124	2	None	-	0	Human	9.9	pKd	=	9.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
	CHEMBL3236552	110124	2	None	-	0	Human	9.9	pKd	=	9.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
	24994542	110126	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236554	110126	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
	24798144	110125	2	None	-	1	Human	9.5	pKd	=	9.5	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	CHEMBL3236553	110125	2	None	-	1	Human	9.5	pKd	=	9.5	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	53257796	110147	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236575	110147	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
	54587790	61540	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770980	61540	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	24745337	61539	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770979	61539	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	59777338	110128	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
	CHEMBL3236556	110128	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
	44547268	117112	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393526	117112	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	58227340	117118	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393532	117118	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	58227200	117121	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393535	117121	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	54585781	61561	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1771000	61561	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	54583873	61529	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770969	61529	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	54587787	61531	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770971	61531	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	54581940	61552	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770992	61552	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	25130912	188739	0	None	-	1	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL505061	188739	0	None	-	1	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	23653543	68048	2	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	CHEMBL1914541	68048	2	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	24994636	110137	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
	CHEMBL3236565	110137	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
	42624149	110140	1	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236568	110140	1	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	59777262	110144	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236572	110144	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
	54584824	61537	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770977	61537	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	58227337	117139	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393553	117139	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	58227259	117142	0	None	-	1	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393556	117142	0	None	-	1	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	24798144	110125	2	None	-	1	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	CHEMBL3236553	110125	2	None	-	1	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	24826766	68101	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	CHEMBL1914750	68101	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	9944571	117017	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL338937	117017	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	24994634	2142	31	None	-	1	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	8984	2142	31	None	-	1	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	CHEMBL3236549	2142	31	None	-	1	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	53258370	110141	1	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236569	110141	1	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	24994635	110142	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236570	110142	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
	54582865	61519	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770959	61519	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
	54584825	61550	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770990	61550	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	11587279	125051	4	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL364400	125051	4	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
	46890627	6589	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083098	6589	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	66740470	109798	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
	CHEMBL3233048	109798	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
	11687917	14965	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
	CHEMBL120854	14965	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
	9966927	18875	5	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128252	18875	5	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
	54581938	61532	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770972	61532	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
	67087450	117136	0	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393550	117136	0	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	11594278	14690	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	CHEMBL120591	14690	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	9923162	18940	6	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128613	18940	6	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
	11120826	18918	1	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128505	18918	1	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
	46890677	7291	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086038	7291	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46890166	7316	0	None	-3	4	Mouse	4.8	pKd	=	4.8	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086105	7316	0	None	-3	4	Mouse	4.8	pKd	=	4.8	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	66740898	110134	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
	CHEMBL3236562	110134	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
	10468601	195591	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activityAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activity	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
	CHEMBL1202324	195591	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activityAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activity	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
	CHEMBL555434	195591	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activityAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activity	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
	53233904	61525	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770965	61525	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	10446295	2132	34	None	11	2	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	1277	2132	34	None	11	2	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	CHEMBL185951	2132	34	None	11	2	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	4242975	18842	9	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	CHEMBL128088	18842	9	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	9900313	19424	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129444	19424	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
	9839217	72519	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	CHEMBL199062	72519	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	11565330	97220	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
	CHEMBL268525	97220	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
	4906599	168662	11	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL436381	168662	11	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	24996854	110136	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
	CHEMBL3236564	110136	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
	42624150	110149	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236577	110149	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
	24797956	110130	3	None	-	1	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
	CHEMBL3236558	110130	3	None	-	1	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
	24992735	110155	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
	CHEMBL3236582	110155	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
	10244243	141313	3	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	CHEMBL383384	141313	3	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	46890592	6392	0	None	-	2	Human	7.6	pKd	=	7.6	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082296	6392	0	None	-	2	Human	7.6	pKd	=	7.6	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	44547127	115918	0	None	-	1	Human	8.5	pKd	=	8.5	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3354816	115918	0	None	-	1	Human	8.5	pKd	=	8.5	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	24992077	110143	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236571	110143	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	10934567	19258	1	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	CHEMBL129026	19258	1	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	11630326	72571	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	CHEMBL199231	72571	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	44547567	117119	2	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393533	117119	2	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	4060730	19379	56	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129199	19379	56	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
	53378711	110150	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236578	110150	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	24994634	2142	31	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	8984	2142	31	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	CHEMBL3236549	2142	31	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	54753437	68183	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	CHEMBL1915048	68183	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	42624149	110140	1	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236568	110140	1	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	46890590	7024	0	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084810	7024	0	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	11572877	67080	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	CHEMBL187285	67080	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	9992865	114427	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL333220	114427	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	11601630	132817	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL370135	132817	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
	46890546	6515	0	None	-	1	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082771	6515	0	None	-	1	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46890590	7024	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084810	7024	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	2063135	8378	9	None	-	1	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	CHEMBL1093180	8378	9	None	-	1	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	11066922	19423	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129436	19423	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
	24994634	2142	31	None	-	1	Rat	7.2	pKd	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	8984	2142	31	None	-	1	Rat	7.2	pKd	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	CHEMBL3236549	2142	31	None	-	1	Rat	7.2	pKd	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	10083188	140934	3	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL382276	140934	3	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
	46890019	7312	0	None	-	1	Human	7.2	pKd	=	7.2	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086085	7312	0	None	-	1	Human	7.2	pKd	=	7.2	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	1278	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	1279	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	4908365	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	CHEMBL129198	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	10967174	19442	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
	CHEMBL129540	19442	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
	42624148	110146	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236574	110146	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
	54583875	61555	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770995	61555	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	58227179	117134	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393548	117134	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	58227086	117143	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393557	117143	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	1278	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	1279	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	4908365	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	CHEMBL129198	2150	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	10967174	19442	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129540	19442	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
	10988959	118108	4	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL340740	118108	4	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
	10923241	19165	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128958	19165	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
	9878733	116844	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL338051	116844	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	11623296	117023	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL338972	117023	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
	16202258	68218	0	None	-	0	Human	10.5	pKi	=	10.5	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915536	68218	0	None	-	0	Human	10.5	pKi	=	10.5	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	24745506	68219	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915537	68219	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	24745335	295	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	295	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	295	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	295	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	44187557	195499	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at histamine H4 receptorAgonistic activity at histamine H4 receptor	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm1013488
	CHEMBL1202332	195499	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at histamine H4 receptorAgonistic activity at histamine H4 receptor	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm1013488
	CHEMBL553423	195499	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at histamine H4 receptorAgonistic activity at histamine H4 receptor	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm1013488
	135525668	68212	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915348	68212	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	136042270	69915	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938979	69915	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	24745507	68220	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915538	68220	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	57401167	69869	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938846	69869	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57400778	68210	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915346	68210	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	135525668	68212	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915348	68212	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57391926	69902	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938967	69902	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	136042269	69914	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938978	69914	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57402929	69867	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938844	69867	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57395538	68211	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915347	68211	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	136042267	69912	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938976	69912	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57400777	68209	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915345	68209	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	57400777	68209	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915345	68209	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	49841846	69738	0	None	-	1	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935572	69738	0	None	-	1	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	11688307	69903	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938968	69903	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	54754351	68217	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
	CHEMBL1915535	68217	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
	57400778	68210	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915346	68210	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	10446295	2132	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
	1277	2132	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
	CHEMBL185951	2132	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
	10446295	2132	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
	1277	2132	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
	CHEMBL185951	2132	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
	49841719	69737	0	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935571	69737	0	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	57391927	69904	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938969	69904	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	1278	2150	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	1279	2150	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	4908365	2150	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	CHEMBL129198	2150	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	49841845	69739	0	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935573	69739	0	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	57395538	68211	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915347	68211	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	136042265	69910	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938974	69910	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57395620	68216	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915534	68216	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
	57395620	68216	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
	CHEMBL1915534	68216	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
	1278	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1278	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	1279	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	4908365	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	CHEMBL129198	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	1278	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	1279	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	4908365	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	CHEMBL129198	2150	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	1267	3804	49	None	-17	5	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	3035905	3804	49	None	-17	5	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	CHEMBL260374	3804	49	None	-17	5	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	56835171	69740	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935574	69740	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	57390145	69906	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938970	69906	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
	136042268	69913	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938977	69913	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	136042266	69911	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	CHEMBL1938975	69911	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	54754351	68217	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915535	68217	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
	56950378	69868	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	CHEMBL1938845	69868	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	135	2532	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2532	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2532	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2532	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2532	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1225	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	5344	173473	101	None	60	6	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	None
	CHEMBL453	173473	101	None	60	6	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	None
	1272	831	0	None	-	1	Human	8.1	pIC50	None	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15265943

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		51354301	58892	0	None	-10	2	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
		CHEMBL1688969	58892	0	None	-10	2	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
		70692530	75691	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
		CHEMBL2047474	75691	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
		90667434	109489	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	2	3	1.9	CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220892	109489	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	2	3	1.9	CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1	10.1039/C3MD00245D
		44367568	45741	5	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@@H]2CCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL153051	45741	5	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@@H]2CCNC2)c[nH]1	10.1021/jm030905y
		9877454	205613	2	None	-4	2	Human	5.0	pEC50	=	5.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL81644	205613	2	None	-4	2	Human	5.0	pEC50	=	5.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		155512725	176241	0	None	-	2	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	176241	0	None	-	2	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	176241	0	None	-	2	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		1267	3804	49	None	-33	26	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm9000693
		3035905	3804	49	None	-33	26	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm9000693
		CHEMBL260374	3804	49	None	-33	26	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm9000693
		9793791	46018	3	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	137	2	2	2	0.5	NCC1CC1c1c[nH]cn1	10.1021/jm030905y
		CHEMBL153284	46018	3	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	137	2	2	2	0.5	NCC1CC1c1c[nH]cn1	10.1021/jm030905y
		155524115	176547	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	176547	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	176547	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		1204	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1247	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1375	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		774	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		DB05381	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1236	2067	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		1237	2067	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		156615	2067	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		CHEMBL268229	2067	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		46890592	6392	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082296	6392	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		46890166	7316	0	None	-4786	2	Mouse	7.9	pEC50	=	7.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086105	7316	0	None	-4786	2	Mouse	7.9	pEC50	=	7.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		1204	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1247	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1375	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		774	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		DB05381	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1204	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1247	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1375	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		774	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		DB05381	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1278	2150	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		1279	2150	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		4908365	2150	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		155524115	176547	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	176547	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	176547	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		11344458	205198	2	None	-14	2	Human	5.9	pEC50	=	5.9	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78497	205198	2	None	-14	2	Human	5.9	pEC50	=	5.9	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		1204	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1247	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1375	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		774	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		DB05381	1932	119	None	-3	24	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		24797956	110130	3	None	-	1	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human H4 receptorAgonist activity at human H4 receptor	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		CHEMBL3236558	110130	3	None	-	1	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human H4 receptorAgonist activity at human H4 receptor	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		58227373	176508	0	None	-	2	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	176508	0	None	-	2	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	176508	0	None	-	2	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		155552061	176478	0	None	38	2	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	176478	0	None	38	2	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	176478	0	None	38	2	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		46887115	8511	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)C[C@H](C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1094144	8511	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)C[C@H](C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		58227373	176508	0	None	1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	176508	0	None	1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	176508	0	None	1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		155517880	176667	0	None	-	2	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	176667	0	None	-	2	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	176667	0	None	-	2	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		25149335	184225	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9000693
		CHEMBL483406	184225	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9000693
		25149335	184225	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL483406	184225	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1039/C3MD00245D
		25149335	184225	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm800841w
		CHEMBL483406	184225	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm800841w
		45267230	196482	0	None	-1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL1202318	196482	0	None	-1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL563342	196482	0	None	-1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		42625223	179925	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	395	8	4	3	1.4	CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm9000693
		CHEMBL474617	179925	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	395	8	4	3	1.4	CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm9000693
		11240759	105213	5	None	-190	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL311473	105213	5	None	-190	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		9812843	205244	1	None	-4	2	Human	4.8	pEC50	=	4.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78838	205244	1	None	-4	2	Human	4.8	pEC50	=	4.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		11469514	104168	2	None	-64	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL309654	104168	2	None	-64	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		155524115	176547	0	None	-	3	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	176547	0	None	-	3	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	176547	0	None	-	3	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		127052293	140238	3	None	-	4	Mouse	6.8	pEC50	=	6.8	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	140238	3	None	-	4	Mouse	6.8	pEC50	=	6.8	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		155513612	176320	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		42626109	179768	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	324	6	4	2	1.5	N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL474447	179768	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	324	6	4	2	1.5	N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		155512725	176241	0	None	-	2	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	176241	0	None	-	2	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	176241	0	None	-	2	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		42625386	178353	0	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL465170	178353	0	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		46830167	8761	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096429	8761	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		11171320	45928	5	None	-	1	Human	5.7	pEC50	=	5.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	179	3	2	2	1.3	c1nc(CCC2CCCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL153207	45928	5	None	-	1	Human	5.7	pEC50	=	5.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	179	3	2	2	1.3	c1nc(CCC2CCCNC2)c[nH]1	10.1021/jm030905y
		170389	206981	35	None	1	3	Human	6.7	pEC50	=	6.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/jm030905y
		CHEMBL4634086	206981	35	None	1	3	Human	6.7	pEC50	=	6.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/jm030905y
		CHEMBL91353	206981	35	None	1	3	Human	6.7	pEC50	=	6.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/jm030905y
		46887041	8760	1	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096428	8760	1	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		155517880	176667	0	None	-	2	Mouse	6.6	pEC50	=	6.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	176667	0	None	-	2	Mouse	6.6	pEC50	=	6.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	176667	0	None	-	2	Mouse	6.6	pEC50	=	6.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		1204	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	1932	119	None	-15	24	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		127052293	140238	3	None	34	4	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	140238	3	None	34	4	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11301441	96154	10	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/acs.jmedchem.8b00435
		CHEMBL260549	96154	10	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/acs.jmedchem.8b00435
		1278	2150	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		1279	2150	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		4908365	2150	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		CHEMBL129198	2150	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		58227401	176451	0	None	-	2	Mouse	7.6	pEC50	=	7.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	176451	0	None	-	2	Mouse	7.6	pEC50	=	7.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	176451	0	None	-	2	Mouse	7.6	pEC50	=	7.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		42625222	179770	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	367	7	5	3	0.7	N/C(=N\C(=O)CNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL474449	179770	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	367	7	5	3	0.7	N/C(=N\C(=O)CNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		1267	3804	49	None	-21	26	Mouse	7.6	pEC50	=	7.6	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-21	26	Mouse	7.6	pEC50	=	7.6	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-21	26	Mouse	7.6	pEC50	=	7.6	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		90667228	109469	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220629	109469	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1ccccc1	10.1039/C3MD00245D
		58227401	176451	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	176451	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	176451	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		42625303	180766	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL475621	180766	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		42625304	179100	0	None	-	1	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL471724	179100	0	None	-	1	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		11286909	205284	2	None	-1	2	Human	5.5	pEC50	=	5.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL79126	205284	2	None	-1	2	Human	5.5	pEC50	=	5.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		9964223	205687	11	None	-36	2	Human	4.5	pEC50	=	4.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL82244	205687	11	None	-36	2	Human	4.5	pEC50	=	4.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		42626111	189694	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	381	8	5	3	1.1	N/C(=N\C(=O)CCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL515428	189694	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	381	8	5	3	1.1	N/C(=N\C(=O)CCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		1204	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	1932	119	None	-3	24	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		58227373	176508	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	176508	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	176508	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		155552061	176478	0	None	-	2	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	176478	0	None	-	2	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	176478	0	None	-	2	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		58227163	176463	0	None	-	2	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	176463	0	None	-	2	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	176463	0	None	-	2	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		127050776	140247	0	None	-	2	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805437	140247	0	None	-	2	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1204	1932	119	None	-12	24	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	1932	119	None	-12	24	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	1932	119	None	-12	24	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	1932	119	None	-12	24	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	1932	119	None	-12	24	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	1932	119	None	-12	24	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		45269820	195349	0	None	-1	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL1202326	195349	0	None	-1	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL551790	195349	0	None	-1	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		155512725	176241	0	None	154	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	176241	0	None	154	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	176241	0	None	154	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		16078981	44073	12	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	c1nc(CC2CCCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL151467	44073	12	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	c1nc(CC2CCCNC2)c[nH]1	10.1021/jm030905y
		155524115	176547	0	None	-2	3	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	176547	0	None	-2	3	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	176547	0	None	-2	3	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		46887043	8763	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096431	8763	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		42625384	169773	0	None	-	1	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL443896	169773	0	None	-	1	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		44367567	169201	3	None	-	1	Human	6.4	pEC50	=	6.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@H]2CCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL440730	169201	3	None	-	1	Human	6.4	pEC50	=	6.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@H]2CCNC2)c[nH]1	10.1021/jm030905y
		58227163	176463	0	None	40	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	176463	0	None	40	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	176463	0	None	40	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		156013896	178240	0	None	-22	4	Mouse	7.3	pEC50	=	7.3	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-22	4	Mouse	7.3	pEC50	=	7.3	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-22	4	Mouse	7.3	pEC50	=	7.3	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		127049855	140228	0	None	-1	4	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805220	140228	0	None	-1	4	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11957573	2010	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		1250	2010	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		3692	2010	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		CHEMBL19439	2010	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		155513612	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		127051301	140200	0	None	-	2	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	140200	0	None	-	2	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1204	1932	119	None	-3	24	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1247	1932	119	None	-3	24	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1375	1932	119	None	-3	24	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		774	1932	119	None	-3	24	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		CHEMBL90	1932	119	None	-3	24	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		DB05381	1932	119	None	-3	24	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		46235428	6604	0	None	-	1	Mouse	6.3	pEC50	=	6.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083162	6604	0	None	-	1	Mouse	6.3	pEC50	=	6.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		1251	2014	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		3035842	2014	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		CHEMBL18661	2014	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		1251	2014	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm030905y
		3035842	2014	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm030905y
		CHEMBL18661	2014	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm030905y
		11206058	104415	9	None	-10	2	Human	4.2	pEC50	=	4.2	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL310360	104415	9	None	-10	2	Human	4.2	pEC50	=	4.2	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		127049855	140228	0	None	-	4	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805220	140228	0	None	-	4	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		25149708	188436	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	319	7	4	4	2.2	CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)c1cccs1	10.1021/jm800841w
		CHEMBL502339	188436	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	319	7	4	4	2.2	CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)c1cccs1	10.1021/jm800841w
		58227401	176451	0	None	7	2	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	176451	0	None	7	2	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	176451	0	None	7	2	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		46887079	8509	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)CC(C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1094142	8509	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)CC(C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		127051301	140200	0	None	5	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	140200	0	None	5	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		25130914	187254	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
		CHEMBL492677	187254	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
		156015638	178272	0	None	-58	4	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	178272	0	None	-58	4	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	178272	0	None	-58	4	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		58227163	176463	0	None	-	2	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	176463	0	None	-	2	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	176463	0	None	-	2	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		25149613	179200	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	382	8	4	5	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1	10.1021/jm800841w
		CHEMBL472441	179200	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	382	8	4	5	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1	10.1021/jm800841w
		136773074	157365	0	None	-	1	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4077914	157365	0	None	-	1	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		42625221	189588	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	338	7	4	2	1.9	N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL514641	189588	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	338	7	4	2	1.9	N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		24798144	110125	2	None	-19	3	Mouse	8.1	pEC50	=	8.1	Binding	Partial agonist activity at mouse histamine H4 receptorPartial agonist activity at mouse histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		CHEMBL3236553	110125	2	None	-19	3	Mouse	8.1	pEC50	=	8.1	Binding	Partial agonist activity at mouse histamine H4 receptorPartial agonist activity at mouse histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		10374457	28895	2	None	-	2	Human	5.2	pEC50	=	5.2	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	123	1	2	2	0.2	N[C@H]1C[C@@H]1c1c[nH]cn1	10.1021/jm030905y
		CHEMBL13795	28895	2	None	-	2	Human	5.2	pEC50	=	5.2	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	123	1	2	2	0.2	N[C@H]1C[C@@H]1c1c[nH]cn1	10.1021/jm030905y
		11819221	45760	3	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(CC2CCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL153061	45760	3	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(CC2CCNC2)c[nH]1	10.1021/jm030905y
		1204	1932	119	None	-3	24	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		1247	1932	119	None	-3	24	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		1375	1932	119	None	-3	24	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		774	1932	119	None	-3	24	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		CHEMBL90	1932	119	None	-3	24	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		DB05381	1932	119	None	-3	24	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		90667229	109470	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	319	7	3	3	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1cccs1	10.1039/C3MD00245D
		CHEMBL3220630	109470	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	319	7	3	3	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1cccs1	10.1039/C3MD00245D
		11546127	95484	2	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL25725	95484	2	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		182527	110568	8	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	167	4	4	2	-0.2	N=C(N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL325327	110568	8	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	167	4	4	2	-0.2	N=C(N)NCCCc1c[nH]cn1	10.1021/jm9000693
		46887042	8762	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096430	8762	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		25149521	179052	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1021/jm800841w
		CHEMBL471413	179052	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1021/jm800841w
		155552061	176478	0	None	-	2	Mouse	6.1	pEC50	=	6.1	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	176478	0	None	-	2	Mouse	6.1	pEC50	=	6.1	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	176478	0	None	-	2	Mouse	6.1	pEC50	=	6.1	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		155517880	176667	0	None	16	2	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	176667	0	None	16	2	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	176667	0	None	16	2	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		1249	2009	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		13499360	2009	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		CHEMBL90019	2009	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		1249	2009	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm030905y
		13499360	2009	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm030905y
		CHEMBL90019	2009	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm030905y
		1204	1932	119	None	-3	24	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		1247	1932	119	None	-3	24	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		1375	1932	119	None	-3	24	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		774	1932	119	None	-3	24	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		CHEMBL90	1932	119	None	-3	24	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		DB05381	1932	119	None	-3	24	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		4024	2015	20	None	-301	2	Human	6.0	pEC50	=	6.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		9989505	2015	20	None	-301	2	Human	6.0	pEC50	=	6.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		CHEMBL82298	2015	20	None	-301	2	Human	6.0	pEC50	=	6.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		1204	1932	119	None	-15	24	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1247	1932	119	None	-15	24	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1375	1932	119	None	-15	24	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		774	1932	119	None	-15	24	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL90	1932	119	None	-15	24	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		DB05381	1932	119	None	-15	24	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		16718567	8162	0	None	-	1	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091874	8162	0	None	-	1	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		46885297	8415	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	318	1	1	6	2.5	CN1CCN(c2nc(O)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093438	8415	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	318	1	1	6	2.5	CN1CCN(c2nc(O)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		17747460	61329	12	None	-	4	Human	5.0	pIC50	=	5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
		CHEMBL1767164	61329	12	None	-	4	Human	5.0	pIC50	=	5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
		46884945	8245	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	330	1	0	5	3.6	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CC(C)N1C	10.1016/j.bmcl.2010.02.097
		CHEMBL1092331	8245	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	330	1	0	5	3.6	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CC(C)N1C	10.1016/j.bmcl.2010.02.097
		71547931	183111	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3c3ncnn23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4794724	183111	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3c3ncnn23)C1	10.1021/acs.jmedchem.7b01855
		11335478	160965	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL4115693	160965	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		1224	1432	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		11709443	8246	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		CHEMBL1092332	8246	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		71548405	182159	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	0	7	1.1	CN(C)C1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4782441	182159	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	0	7	1.1	CN(C)C1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		46884998	7977	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	1	1	5	2.6	NC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090532	7977	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	1	1	5	2.6	NC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		25112105	8163	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091875	8163	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		71547681	182945	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.7	Clc1cnc2nc(N3CCNCC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4792733	182945	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.7	Clc1cnc2nc(N3CCNCC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		46885128	7970	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.2	CNC1(C)CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090519	7970	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.2	CNC1(C)CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		46885129	7971	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	1	5	3.2	Clc1ccc2oc3c(N4CC5CCCNC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090520	7971	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	1	5	3.2	Clc1ccc2oc3c(N4CC5CCCNC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		46885241	8275	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	2	1	5	3.8	CN[C@@H]1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092543	8275	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	2	1	5	3.8	CN[C@@H]1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		156013896	178240	0	None	-7	4	Human	7.8	pIC50	=	7.8	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	7.8	pIC50	=	7.8	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	7.8	pIC50	=	7.8	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		16656869	8104	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.1	CNC1CCN(c2nc(C)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091559	8104	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.1	CNC1CCN(c2nc(C)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		124087	1389	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		11566111	8346	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1CC2CCC1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		CHEMBL1092933	8346	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1CC2CCC1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		71547932	182767	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3c3ncnn23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4790239	182767	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3c3ncnn23)CC1	10.1021/acs.jmedchem.7b01855
		13680692	183434	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	313	2	0	8	0.9	CN1CCN(c2nc3ccc([N+](=O)[O-])cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4798729	183434	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	313	2	0	8	0.9	CN1CCN(c2nc3ccc([N+](=O)[O-])cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		46885239	8194	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092064	8194	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2010.02.097
		71547762	182719	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.7	CN1CCN(c2nc3nc(Cl)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4789645	182719	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.7	CN1CCN(c2nc3nc(Cl)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		2063135	8378	9	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093180	8378	9	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		11695388	8244	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.2	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CCN1C	10.1016/j.bmcl.2010.02.097
		CHEMBL1092330	8244	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.2	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CCN1C	10.1016/j.bmcl.2010.02.097
		9904236	14076	22	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL1197564	14076	22	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46884997	7720	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	0	5	3.2	CN(C)C1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1088888	7720	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	0	5	3.2	CN(C)C1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		1530	2182	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		20889070	181872	6	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	302	1	0	6	1.7	CN1CCN(c2nc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778864	181872	6	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	302	1	0	6	1.7	CN1CCN(c2nc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		820836	102941	10	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	268	1	0	6	1.0	CN1CCN(c2nc3ccccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL306316	102941	10	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	268	1	0	6	1.0	CN1CCN(c2nc3ccccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		121237834	147359	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL3929465	147359	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46884996	7997	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	Clc1ccc2oc3c(N4CCN5CCCC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090655	7997	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	Clc1ccc2oc3c(N4CCN5CCCC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		71548223	181860	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	401	3	0	8	2.0	CN1CCN(c2nc3nc(OCC(F)(F)F)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778712	181860	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	401	3	0	8	2.0	CN1CCN(c2nc3nc(OCC(F)(F)F)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71547685	182990	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	294	1	0	8	0.3	CN1CCN(c2nc3ncc(C#N)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4793425	182990	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	294	1	0	8	0.3	CN1CCN(c2nc3ncc(C#N)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71548412	1909	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		9879	1909	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		CHEMBL4790724	1909	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		71547764	182353	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	328	1	0	8	0.9	CN1CCN(c2nc3nc(C#N)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4784683	182353	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	328	1	0	8	0.9	CN1CCN(c2nc3nc(C#N)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71548498	182240	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	348	1	0	8	0.6	CN1CCN(c2nc3ncc(Br)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4783487	182240	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	348	1	0	8	0.6	CN1CCN(c2nc3ncc(Br)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71548031	182908	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.4	CN1CCN(c2nc3ncc(C(F)(F)F)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4792352	182908	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.4	CN1CCN(c2nc3ncc(C(F)(F)F)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		16656871	7976	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090531	7976	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		1278	2150	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		1279	2150	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		4908365	2150	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		CHEMBL129198	2150	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		71548412	1909	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		9879	1909	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		CHEMBL4790724	1909	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		71548319	183238	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	CN1CCCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4796300	183238	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	CN1CCCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		46885178	7713	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	336	2	1	5	3.2	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1088859	7713	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	336	2	1	5	3.2	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2010.02.097
		71548224	182528	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	361	1	0	7	1.5	Cc1c(Br)cnc2nc(N3CCN(C)CC3)c3nncn3c12	10.1021/acs.jmedchem.7b01855
		CHEMBL4787243	182528	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	361	1	0	7	1.5	Cc1c(Br)cnc2nc(N3CCN(C)CC3)c3nncn3c12	10.1021/acs.jmedchem.7b01855
		71547599	182068	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3ncccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4781409	182068	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3ncccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71547680	182827	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3cccnc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4791152	182827	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3cccnc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		11709905	8371	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	342	2	0	5	3.7	CN1CCN(c2nc(C3CC3)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093138	8371	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	342	2	0	5	3.7	CN1CCN(c2nc(C3CC3)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		16656872	7912	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090190	7912	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		71548027	181850	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	395	1	0	7	1.0	CN1CCN(c2nc3ncc(I)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778591	181850	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	395	1	0	7	1.0	CN1CCN(c2nc3ncc(I)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		3934857	8103	29	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.1	Cc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091558	8103	29	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.1	Cc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		71547282	183073	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1C	10.1021/acs.jmedchem.7b01855
		CHEMBL4794336	183073	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1C	10.1021/acs.jmedchem.7b01855
		1278	2150	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		1279	2150	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		4908365	2150	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		CHEMBL129198	2150	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		89477685	183574	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	1	7	1.1	CN[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4800462	183574	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	1	7	1.1	CN[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		89477651	183448	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	315	1	0	7	1.2	CN1C[C@@H]2C[C@H]1CN2c1nc2ncc(Cl)cc2n2cnnc12	10.1021/acs.jmedchem.7b01855
		CHEMBL4798915	183448	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	315	1	0	7	1.2	CN1C[C@@H]2C[C@H]1CN2c1nc2ncc(Cl)cc2n2cnnc12	10.1021/acs.jmedchem.7b01855
		11638468	8347	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1C2CCC1CN(c1ncnc3c1oc1ccc(Cl)cc13)C2	10.1016/j.bmcl.2010.02.097
		CHEMBL1092934	8347	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1C2CCC1CN(c1ncnc3c1oc1ccc(Cl)cc13)C2	10.1016/j.bmcl.2010.02.097
		71547281	183287	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	2	0	7	1.5	CN(C)[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4796842	183287	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	2	0	7	1.5	CN(C)[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		1267	3804	49	None	-33	26	Human	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		89477709	182694	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	1	7	0.9	Clc1cnc2nc(N3C[C@@H]4C[C@H]3CN4)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4789385	182694	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	1	7	0.9	Clc1cnc2nc(N3C[C@@H]4C[C@H]3CN4)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71547597	183131	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	283	1	0	7	0.7	Cc1cnc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4795091	183131	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	283	1	0	7	0.7	Cc1cnc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71547848	183037	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	329	1	0	7	1.6	Clc1cnc2nc(N3CCN4CCCC4C3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4793974	183037	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	329	1	0	7	1.6	Clc1cnc2nc(N3CCN4CCCC4C3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71547765	182488	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	3	0	8	1.5	CCOc1nc2nc(N3CCN(C)CC3)c3nncn3c2cc1Cl	10.1021/acs.jmedchem.7b01855
		CHEMBL4786816	182488	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	3	0	8	1.5	CCOc1nc2nc(N3CCN(C)CC3)c3nncn3c2cc1Cl	10.1021/acs.jmedchem.7b01855
		71547682	182202	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	275	1	1	7	0.5	NC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4782945	182202	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	275	1	1	7	0.5	NC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		89477439	182076	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	290	2	1	8	0.1	CNC1CN(c2nc3ncc(Cl)cc3n3nnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4781484	182076	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	290	2	1	8	0.1	CNC1CN(c2nc3ncc(Cl)cc3n3nnnc23)C1	10.1021/acs.jmedchem.7b01855
		58475282	181652	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	282	1	0	6	1.3	Cc1ccc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4776004	181652	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	282	1	0	6	1.3	Cc1ccc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71548411	182579	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	304	1	0	8	0.5	CN1CCN(c2nc3ncc(Cl)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4787983	182579	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	304	1	0	8	0.5	CN1CCN(c2nc3ncc(Cl)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		53380276	182804	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	0	5	2.3	CN1CCN(c2cc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4790726	182804	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	0	5	2.3	CN1CCN(c2cc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		46885181	8337	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	293	2	1	6	2.0	CNC1CCN(c2ncnc3c2oc2ccc(C#N)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092880	8337	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	293	2	1	6	2.0	CNC1CCN(c2ncnc3c2oc2ccc(C#N)cc23)C1	10.1016/j.bmcl.2010.02.097
		89477539	182710	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.9	N[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4789543	182710	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.9	N[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		71515465	182144	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4782303	182144	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		71547683	181804	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	1	0	7	1.2	CN1CCN(c2nc3ncc(Br)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778068	181804	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	1	0	7	1.2	CN1CCN(c2nc3ncc(Br)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL5087167	215074	0	None	-	2	Mouse	5.2	pIC50	=	5.2	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL		None	None	None		Cn1cc2c(-c3c(-c4ccc(F)cn4)nn4c3COC(C)(C)C4)ccnc2n1	10.6019/CHEMBL5058645
		89477445	182050	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	1	7	1.1	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1	10.1021/acs.jmedchem.7b01855
		CHEMBL4781143	182050	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	1	7	1.1	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1	10.1021/acs.jmedchem.7b01855
		71547678	183340	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4797517	183340	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		24994634	2142	31	None	2	7	Mouse	8.1	pIC50	=	8.1	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		8984	2142	31	None	2	7	Mouse	8.1	pIC50	=	8.1	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		CHEMBL3236549	2142	31	None	2	7	Mouse	8.1	pIC50	=	8.1	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		11682208	8274	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092542	8274	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		46885177	8129	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	282	2	1	5	2.5	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091729	8129	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	282	2	1	5	2.5	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C)cc23)C1	10.1016/j.bmcl.2010.02.097
		1278	2150	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		1279	2150	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		4908365	2150	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		CHEMBL129198	2150	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		16656874	8106	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091569	8106	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		46885298	8416	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	332	2	0	6	2.8	COc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093439	8416	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	332	2	0	6	2.8	COc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		16656870	7721	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CNC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1088889	7721	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CNC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		1278	2150	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		1279	2150	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		4908365	2150	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		CHEMBL129198	2150	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		71525681	89728	0	None	2	6	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	89728	0	None	2	6	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		11846300	80266	3	None	-2	4	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	80266	3	None	-2	4	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		156013896	178240	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		135398737	958	93	None	-57	89	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	958	93	None	-57	89	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	958	93	None	-57	89	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	958	93	None	-57	89	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	958	93	None	-57	89	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		24994634	2142	31	None	-2	7	Human	7.9	pKd	=	7.9	Binding	Cell based cAMP Assays (pA2)Cell based cAMP Assays (pA2)	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		8984	2142	31	None	-2	7	Human	7.9	pKd	=	7.9	Binding	Cell based cAMP Assays (pA2)Cell based cAMP Assays (pA2)	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		CHEMBL3236549	2142	31	None	-2	7	Human	7.9	pKd	=	7.9	Binding	Cell based cAMP Assays (pA2)Cell based cAMP Assays (pA2)	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		11846300	80266	3	None	-2	4	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	80266	3	None	-2	4	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		71519674	89729	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	89729	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		1204	1932	119	None	-12	24	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	1932	119	None	-12	24	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	1932	119	None	-12	24	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	1932	119	None	-12	24	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	1932	119	None	-12	24	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	1932	119	None	-12	24	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		135398737	958	93	None	-57	89	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	958	93	None	-57	89	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	958	93	None	-57	89	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	958	93	None	-57	89	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	958	93	None	-57	89	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		155513612	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156015638	178272	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	178272	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	178272	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1247	1932	119	None	-3	24	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1375	1932	119	None	-3	24	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		774	1932	119	None	-3	24	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		CHEMBL90	1932	119	None	-3	24	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		DB05381	1932	119	None	-3	24	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		119570	3159	96	None	-301	40	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		2233	3159	96	None	-301	40	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		953	3159	96	None	-301	40	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		CHEMBL301265	3159	96	None	-301	40	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		DB00413	3159	96	None	-301	40	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		168268716	192762	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5170276	192762	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221176	192762	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168268680	192766	0	None	-2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5172675	192766	0	None	-2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221210	192766	0	None	-2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		168268827	192779	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5179906	192779	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221314	192779	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		168268853	192785	0	None	-83	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5180504	192785	0	None	-83	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221353	192785	0	None	-83	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		168273471	192801	0	None	-50	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173079	192801	0	None	-50	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221433	192801	0	None	-50	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168273549	192803	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174342	192803	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221438	192803	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		168273640	192805	0	None	-12	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176229	192805	0	None	-12	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221444	192805	0	None	-12	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168273745	192808	0	None	-11	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5178472	192808	0	None	-11	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221451	192808	0	None	-11	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		168274129	192809	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176780	192809	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221468	192809	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168275750	192826	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5175558	192826	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221581	192826	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		168276867	192835	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174278	192835	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221653	192835	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		168277996	192846	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173373	192846	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221736	192846	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		168278471	192848	0	None	-17	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183205	192848	0	None	-17	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221757	192848	0	None	-17	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		168278543	192851	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184846	192851	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221764	192851	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168280339	192865	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5188592	192865	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221885	192865	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168281536	192881	0	None	2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5189006	192881	0	None	2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221966	192881	0	None	2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		168281746	192882	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184911	192882	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221974	192882	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		168283097	192893	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5186770	192893	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222043	192893	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		168283321	192895	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183015	192895	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222057	192895	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		168283536	192900	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5187758	192900	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222074	192900	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		168284289	192906	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5194860	192906	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222123	192906	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168284480	192910	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5197548	192910	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222137	192910	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		168286141	192924	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5192993	192924	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222231	192924	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		168286426	192926	0	None	-109	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5198795	192926	0	None	-109	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222241	192926	0	None	-109	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168290235	192968	0	None	-1071	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-1071	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-1071	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168290815	192973	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200771	192973	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222529	192973	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168291233	192979	0	None	5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200106	192979	0	None	5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222556	192979	0	None	5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		168292954	192997	0	None	-112	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5202592	192997	0	None	-112	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222660	192997	0	None	-112	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		168294161	193006	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204739	193006	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222742	193006	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		168294445	193010	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208113	193010	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222768	193010	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		168294166	193014	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209081	193014	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222775	193014	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		168294449	193018	0	None	-181	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204599	193018	0	None	-181	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222793	193018	0	None	-181	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		168294767	193019	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294770	193020	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208327	193020	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222806	193020	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		168294776	193026	0	None	7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209479	193026	0	None	7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222831	193026	0	None	7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		168295528	193031	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294178	193035	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5205197	193035	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222887	193035	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168295541	193040	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208845	193040	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222926	193040	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168295543	193041	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209021	193041	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222929	193041	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		168295803	193045	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207206	193045	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222937	193045	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168294182	193048	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208722	193048	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222960	193048	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		156013896	178240	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156015638	178272	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	178272	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	178272	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		155513612	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	178240	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		135398737	958	93	None	-57	89	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	958	93	None	-57	89	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	958	93	None	-57	89	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	958	93	None	-57	89	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	958	93	None	-57	89	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		71525679	89726	0	None	6	6	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	89726	0	None	6	6	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		155513612	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		11846300	80266	3	None	-2	4	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	80266	3	None	-2	4	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		24745335	295	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	295	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	295	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	295	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		1278	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		1279	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		4908365	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		1223	953	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		2790	953	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		CHEMBL14690	953	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		1223	953	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		2790	953	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		CHEMBL14690	953	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		156013896	178240	0	None	-22	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-22	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-22	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		155513612	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	178240	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		56835171	69740	0	None	1	9	Human	7.4	pKd	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL1935574	69740	0	None	1	9	Human	7.4	pKd	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		155513612	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	178240	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-15	24	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	1932	119	None	-15	24	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	1932	119	None	-15	24	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	1932	119	None	-15	24	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	1932	119	None	-15	24	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	1932	119	None	-15	24	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		156013896	178240	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	1932	119	None	-3	24	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	1932	119	None	-3	24	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	1932	119	None	-3	24	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	1932	119	None	-3	24	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	1932	119	None	-3	24	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		156013896	178240	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		155513612	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156013896	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156013896	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		135398737	958	93	None	-57	89	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	958	93	None	-57	89	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	958	93	None	-57	89	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	958	93	None	-57	89	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	958	93	None	-57	89	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		11846300	80266	3	None	-2	4	Human	7.1	pKd	=	7.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	80266	3	None	-2	4	Human	7.1	pKd	=	7.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		156015638	178272	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	178272	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	178272	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156015638	178272	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	178272	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	178272	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		71525678	89725	0	None	5	6	Human	8.1	pKd	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	89725	0	None	5	6	Human	8.1	pKd	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		156013896	178240	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		54587788	61535	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	4	3	5	1.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770975	61535	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	4	3	5	1.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		23653543	68048	2	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914541	68048	2	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		54587787	61531	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770971	61531	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		46235428	6604	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083162	6604	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		54586763	61528	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	3	2	5	1.9	CN1CCN(c2cc(N)nc(NCC(C)(C)C)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770968	61528	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	3	2	5	1.9	CN1CCN(c2cc(N)nc(NCC(C)(C)C)c2)CC1	10.1016/j.bmcl.2011.03.017
		24826169	68040	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914462	68040	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		16718567	8162	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1091874	8162	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24737950	68131	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	361	2	2	6	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914781	68131	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	361	2	2	6	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		58227148	117133	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393547	117133	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		57399746	68106	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914755	68106	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		54580885	61533	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	4	3	5	1.8	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770973	61533	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	4	3	5	1.8	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		24826766	68101	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914750	68101	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		59777338	110128	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236556	110128	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		1204	1932	119	None	-3	24	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		1247	1932	119	None	-3	24	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		1375	1932	119	None	-3	24	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		774	1932	119	None	-3	24	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		CHEMBL90	1932	119	None	-3	24	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		DB05381	1932	119	None	-3	24	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		1223	953	41	None	-60	11	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	953	41	None	-60	11	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	953	41	None	-60	11	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		54581940	61552	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770992	61552	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		24797598	61562	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1771001	61562	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		11224088	136457	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1021/jm800876b
		CHEMBL373579	136457	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1021/jm800876b
		24798144	110125	2	None	19	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3236553	110125	2	None	19	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		58227342	117120	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393534	117120	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		11224088	136457	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		CHEMBL373579	136457	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		24825998	68111	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914760	68111	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)CC1	10.1016/j.bmcl.2011.08.014
		57396301	68133	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	2.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914783	68133	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	2.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2011.08.014
		127050310	140835	0	None	-	1	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	347	3	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(C(C)(F)F)cc23)C1	10.1039/C6MD00108D
		CHEMBL3819260	140835	0	None	-	1	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	347	3	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(C(C)(F)F)cc23)C1	10.1039/C6MD00108D
		46222048	8984	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1016/j.bmc.2010.04.052
		CHEMBL1098230	8984	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1016/j.bmc.2010.04.052
		24994542	110126	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236554	110126	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		24948752	68047	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.4	Nc1nc(N2CCCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914540	68047	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.4	Nc1nc(N2CCCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		24825727	68049	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914542	68049	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		46222048	8984	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Inhibition of human recombinant histamine H4 receptor expressed in CHO cellsInhibition of human recombinant histamine H4 receptor expressed in CHO cells	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1021/jm901890s
		CHEMBL1098230	8984	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Inhibition of human recombinant histamine H4 receptor expressed in CHO cellsInhibition of human recombinant histamine H4 receptor expressed in CHO cells	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1021/jm901890s
		155524115	176547	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	176547	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	176547	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		24798144	110125	2	None	19	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		CHEMBL3236553	110125	2	None	19	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		155524115	176547	0	None	1	3	Mouse	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	176547	0	None	1	3	Mouse	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	176547	0	None	1	3	Mouse	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		24797604	110124	2	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
		CHEMBL3236552	110124	2	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
		44231618	5890	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1079516	5890	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		25128824	193178	0	None	3	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		CHEMBL523225	193178	0	None	3	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		24992077	110143	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236571	110143	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		44231618	5890	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1079516	5890	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		44129130	199556	0	None	2	2	Rat	8.8	pKi	=	8.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592379	199556	0	None	2	2	Rat	8.8	pKi	=	8.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		1223	953	41	None	-60	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	953	41	None	-60	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	953	41	None	-60	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		44187557	195499	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202332	195499	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL553423	195499	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1204	1932	119	None	-3	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		1247	1932	119	None	-3	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		1375	1932	119	None	-3	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		774	1932	119	None	-3	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		CHEMBL90	1932	119	None	-3	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		DB05381	1932	119	None	-3	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		11957573	2010	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		1250	2010	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		3692	2010	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		CHEMBL19439	2010	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		16202258	68218	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915536	68218	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		66740859	110151	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	327	3	2	5	2.3	CN[C@@H]1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236579	110151	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	327	3	2	5	2.3	CN[C@@H]1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)C1	10.1021/jm401727m
		24798232	110132	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	1.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCCN[C@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236560	110132	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	1.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCCN[C@H]3C2)n1	10.1021/jm401727m
		44231735	7785	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089390	7785	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		25129527	187414	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL493720	187414	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		135525668	68212	0	None	263	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915348	68212	0	None	263	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		25217643	112170	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysis	ChEMBL	289	2	0	5	1.9	CN1CCN(c2ncnc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290570	112170	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysis	ChEMBL	289	2	0	5	1.9	CN1CCN(c2ncnc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		1249	2009	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		13499360	2009	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90019	2009	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10176414	4063	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1246	4063	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL281576	4063	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10060212	204534	0	None	5	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL72769	204534	0	None	5	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		71681807	89646	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	8	3	8	1.6	CC(C)CCc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375668	89646	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	8	3	8	1.6	CC(C)CCc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		71681804	89671	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1ccnc(N)n1)c1cc(-c2ccccc2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375770	89671	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1ccnc(N)n1)c1cc(-c2ccccc2)nc(N)n1	10.1021/jm301886t
		1223	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		1223	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		1249	2009	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm0504353
		13499360	2009	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm0504353
		CHEMBL90019	2009	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm0504353
		53233802	61547	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770987	61547	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		70692529	75683	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	303	2	1	2	2.7	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047466	75683	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	303	2	1	2	2.7	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		46228994	199429	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	466	6	1	7	2.7	CC1CCCCN1S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591249	199429	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	466	6	1	7	2.7	CC1CCCCN1S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		1223	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2009.04.007
		2790	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2009.04.007
		CHEMBL14690	953	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2009.04.007
		45268092	196014	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	352	6	3	3	3.6	N=C(NCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1743881	196014	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	352	6	3	3	3.6	N=C(NCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560111	196014	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	352	6	3	3	3.6	N=C(NCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		45268093	196015	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	400	6	3	3	3.4	N=C(NCc1ccc(I)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202321	196015	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	400	6	3	3	3.4	N=C(NCc1ccc(I)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560112	196015	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	400	6	3	3	3.4	N=C(NCc1ccc(I)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		45267230	196482	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202318	196482	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL563342	196482	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		24737954	68129	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(F)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914778	68129	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(F)c23)C1	10.1016/j.bmcl.2011.08.014
		24826522	68136	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914786	68136	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		24826168	68139	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914789	68139	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24745335	295	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	295	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	295	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	295	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		71525680	89731	0	None	97	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	284	3	2	6	1.3	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376806	89731	0	None	97	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	284	3	2	6	1.3	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		71525678	89725	0	None	5	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	89725	0	None	5	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25101945	193106	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL522673	193106	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		136192886	56480	0	None	-1	4	Mouse	7.0	pKi	=	7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632411	56480	0	None	-1	4	Mouse	7.0	pKi	=	7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		44129134	199508	0	None	-22	2	Rat	7.0	pKi	=	7	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591969	199508	0	None	-22	2	Rat	7.0	pKi	=	7	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		11694543	75799	4	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	6	2	2	1.3	CCNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL204843	75799	4	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	6	2	2	1.3	CCNCCCCc1c[nH]cn1	10.1021/jm0504353
		11521414	141297	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	2	2	2.7	c1nc(CCCCNC2CCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL383324	141297	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	2	2	2.7	c1nc(CCCCNC2CCCCC2)c[nH]1	10.1021/jm0504353
		9812843	205244	1	None	-4	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1016/j.bmcl.2011.06.123
		CHEMBL78838	205244	1	None	-4	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1016/j.bmcl.2011.06.123
		53233904	61525	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770965	61525	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		39732699	75680	2	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	1	2	2	1.4	O=C(c1cc2cccc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047463	75680	2	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	1	2	2	1.4	O=C(c1cc2cccc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		70696623	75688	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	2	2	2	2.0	CNC1CN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047471	75688	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	2	2	2	2.0	CNC1CN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		51354298	58887	2	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	233	4	1	4	1.9	CC(C)(C)c1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		CHEMBL1688944	58887	2	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	233	4	1	4	1.9	CC(C)(C)c1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		45267237	196202	0	None	-7	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	7	3	3	3.2	Cc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202320	196202	0	None	-7	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	7	3	3	3.2	Cc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL561451	196202	0	None	-7	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	7	3	3	3.2	Cc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		53378933	110145	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	269	3	2	5	1.2	Nc1nc(Cc2ccccc2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236573	110145	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	269	3	2	5	1.2	Nc1nc(Cc2ccccc2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		11087453	75644	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL2047270	75644	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1039/C2MD20212C
		44395335	67062	0	None	25	2	Human	6.0	pKi	=	6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	266	4	2	3	1.5	CN(C)CCNC(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL187210	67062	0	None	25	2	Human	6.0	pKi	=	6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	266	4	2	3	1.5	CN(C)CCNC(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		10978141	5150	1	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL105803	5150	1	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		71681477	89658	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	398	7	4	8	3.3	Nc1nc(NCCNc2cc(-c3ccccc3)nc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		CHEMBL2375758	89658	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	398	7	4	8	3.3	Nc1nc(NCCNc2cc(-c3ccccc3)nc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		71681802	89669	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1cc(NCCNc2ccnc(N)n2)ncn1	10.1021/jm301886t
		CHEMBL2375769	89669	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1cc(NCCNc2ccnc(N)n2)ncn1	10.1021/jm301886t
		206876	18945	7	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL128637	18945	7	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		66572107	75639	1	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047265	75639	1	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		66572115	75659	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047442	75659	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		11469514	104168	2	None	-64	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL309654	104168	2	None	-64	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		46890591	7025	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	436	6	1	4	4.8	Cc1cc(OCCCN2CC3CCCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084811	7025	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	436	6	1	4	4.8	Cc1cc(OCCCN2CC3CCCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		44275807	98970	0	None	-9120	10	Human	5.0	pKi	=	5	Binding	Binding affinity towards human histaminergic (H4) receptorBinding affinity towards human histaminergic (H4) receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		CHEMBL27979	98970	0	None	-9120	10	Human	5.0	pKi	=	5	Binding	Binding affinity towards human histaminergic (H4) receptorBinding affinity towards human histaminergic (H4) receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		4242418	117432	12	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	2	1	2	1.9	CN1CCN(Cc2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL339826	117432	12	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	2	1	2	1.9	CN1CCN(Cc2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		71681978	89653	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	310	5	3	5	1.7	CN(CCNc1ccnc(N)n1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm301886t
		CHEMBL2375753	89653	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	310	5	3	5	1.7	CN(CCNc1ccnc(N)n1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm301886t
		58227158	117135	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1cc(N2CCN(C)CC2)cnn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393549	117135	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1cc(N2CCN(C)CC2)cnn1	10.1016/j.bmcl.2014.12.027
		57391926	69902	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938967	69902	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		11846300	80266	3	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL213912	80266	3	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2015.12.035
		24854583	96122	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	304	2	0	4	3.0	CN1CCN(c2nc3ccccc3nc2-c2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260372	96122	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	304	2	0	4	3.0	CN1CCN(c2nc3ccccc3nc2-c2ccccc2)CC1	10.1021/jm7014217
		16082860	138611	0	None	-7	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL377572	138611	0	None	-7	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		57391032	68100	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@H]3C[C@@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914749	68100	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@H]3C[C@@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25179297	173831	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL453877	173831	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		24759518	179309	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL473302	179309	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178342	186786	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489070	186786	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25179297	173831	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL453877	173831	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25178342	186786	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489070	186786	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		71518535	86487	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	1	5	2.6	CN1CCN(c2nc(N(C)C)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314763	86487	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	1	5	2.6	CN1CCN(c2nc(N(C)C)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		10978141	5150	1	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL105803	5150	1	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		57393730	67884	0	None	-2754	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910386	67884	0	None	-2754	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
		24826681	68119	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914768	68119	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		127049855	140228	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805220	140228	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		57391869	63120	0	None	-19	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774589	63120	0	None	-19	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789349	63120	0	None	-19	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		90645163	112190	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1cc(C)cc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290590	112190	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1cc(C)cc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		10656971	16421	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL123137	16421	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2011.07.114
		121238070	166487	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4278404	166487	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		25178555	174239	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454891	174239	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178555	174239	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL454891	174239	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		155540201	172908	0	None	-67	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	513	16	2	4	5.5	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1	10.1039/C8MD00527C
		CHEMBL4516173	172908	0	None	-67	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	513	16	2	4	5.5	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1	10.1039/C8MD00527C
		1278	2150	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	2150	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	2150	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	2150	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		832283	12398	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL118572	12398	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		832283	12398	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL118572	12398	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		10269628	138716	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	355	1	0	4	4.6	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL377985	138716	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	355	1	0	4	4.6	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		54582866	61548	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(N)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770988	61548	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(N)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2011.03.017
		25133970	187588	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL494679	187588	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		49841962	69728	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3c(-c4ccoc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935562	69728	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3c(-c4ccoc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		44547568	117116	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393530	117116	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		13731320	158650	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	2	2	2	4.0	O=C(Nc1cccc2ccccc12)N1CCC(c2c[nH]cn2)CC1	10.1016/j.ejmech.2016.09.074
		CHEMBL4092578	158650	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	2	2	2	4.0	O=C(Nc1cccc2ccccc12)N1CCC(c2c[nH]cn2)CC1	10.1016/j.ejmech.2016.09.074
		127035837	137417	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	403	4	1	5	3.7	CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753334	137417	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	403	4	1	5	3.7	CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		21842421	112171	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	270	2	1	6	0.9	CN1CCN(c2nc(N)nc(-c3ccccc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290571	112171	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	270	2	1	6	0.9	CN1CCN(c2nc(N)nc(-c3ccccc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		10688021	156111	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	332	8	1	3	4.3	O=C(/C=C/c1ccccc1)c1ccc(OCCCc2c[nH]cn2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4063170	156111	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	332	8	1	3	4.3	O=C(/C=C/c1ccccc1)c1ccc(OCCCc2c[nH]cn2)cc1	10.1016/j.ejmech.2016.09.074
		9944571	117017	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL338937	117017	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9944571	117017	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL338937	117017	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		23650961	3846	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		9276	3846	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		CHEMBL3301609	3846	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		DB12522	3846	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		24803710	150329	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	400	6	2	5	4.1	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(F)c(F)ccc2[nH]1	nan
		CHEMBL3953011	150329	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	400	6	2	5	4.1	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(F)c(F)ccc2[nH]1	nan
		25101945	193106	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL522673	193106	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		118720437	115913	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	275	3	2	5	1.0	CN[C@@H]1CCN(c2cc(CC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354811	115913	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	275	3	2	5	1.0	CN[C@@H]1CCN(c2cc(CC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		24737952	68134	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(OC)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914784	68134	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(OC)cc23)C1	10.1016/j.bmcl.2011.08.014
		9944571	117017	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338937	117017	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		24996854	110136	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
		CHEMBL3236564	110136	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
		71603142	89721	0	None	54	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	3	2	5	1.2	CCc1ccc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376796	89721	0	None	54	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	3	2	5	1.2	CCc1ccc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		44129282	199199	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)cc(Cl)c3n2)CC1	10.1021/jm901379s
		CHEMBL589746	199199	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)cc(Cl)c3n2)CC1	10.1021/jm901379s
		71603139	89718	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	2	2	5	1.5	Nc1nc(N2CCNCC2)c2ccc(C3CC3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376793	89718	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	2	2	5	1.5	Nc1nc(N2CCNCC2)c2ccc(C3CC3)cc2n1	10.1016/j.bmcl.2013.02.091
		45257132	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		8983	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		CHEMBL595180	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		155513612	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		44450493	96534	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	1	1	4	1.3	CN1CCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		CHEMBL262859	96534	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	1	1	4	1.3	CN1CCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		1278	2150	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		126963283	160963	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL4115677	160963	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		1224	1432	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		1241	2037	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		1242	2037	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		3614	2037	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		CHEMBL507	2037	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		49841609	69722	15	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3c(Br)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935556	69722	15	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3c(Br)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		51354871	58905	0	None	-22	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	290	6	0	4	3.3	c1c(CC2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		CHEMBL1688982	58905	0	None	-22	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	290	6	0	4	3.3	c1c(CC2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		164618508	185932	0	None	-363	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	6	4	4	2.7	Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4869194	185932	0	None	-363	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	6	4	4	2.7	Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		164620678	186019	0	None	-177	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.7	CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4870510	186019	0	None	-177	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.7	CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		58227159	176385	0	None	47	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	1	5	1.7	CN1CCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4534254	176385	0	None	47	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	1	5	1.7	CN1CCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595907	176385	0	None	47	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	1	5	1.7	CN1CCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		122193099	123918	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	374	3	1	6	2.1	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Br)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628046	123918	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	374	3	1	6	2.1	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Br)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		51354008	58882	0	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	253	5	1	4	1.8	c1ccc(Cc2cn(CCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688939	58882	0	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	253	5	1	4	1.8	c1ccc(Cc2cn(CCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		51354586	58902	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	2.9	CC(c1cn(CCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		CHEMBL1688978	58902	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	2.9	CC(c1cn(CCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		16082824	77948	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL209598	77948	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		54585778	61549	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(N)nc(NCCO)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770989	61549	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(N)nc(NCCO)n2)CC1	10.1016/j.bmcl.2011.03.017
		58227165	117122	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393536	117122	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		24853664	96341	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL261517	96341	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		10773349	8091	1	None	-11	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL109130	8091	1	None	-11	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		10715857	75016	1	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	398	8	1	3	3.5	O=C(CCCc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		CHEMBL20338	75016	1	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	398	8	1	3	3.5	O=C(CCCc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		16082820	80118	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL213250	80118	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		10776393	5496	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	239	7	2	3	2.1	CC[C@H](C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1076267	5496	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	239	7	2	3	2.1	CC[C@H](C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL156912	5496	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	239	7	2	3	2.1	CC[C@H](C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		118725542	117123	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393537	117123	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		1278	2150	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1279	2150	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		4908365	2150	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL129198	2150	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		90645161	112188	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3cc(F)cc(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290588	112188	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3cc(F)cc(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		1278	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1279	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		4908365	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		45257132	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		8983	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		CHEMBL595180	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		24994634	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1016/j.bmcl.2014.12.027
		24994634	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1016/j.bmcl.2014.12.027
		8984	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1016/j.bmcl.2014.12.027
		CHEMBL3236549	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		24994635	110142	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236570	110142	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
		24826442	68107	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1ccc2oc3c(N4CCN(C)CC4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914756	68107	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1ccc2oc3c(N4CCN(C)CC4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		1278	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1278	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1279	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1279	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		4908365	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		4908365	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1204	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		1247	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		1375	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		774	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		DB05381	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		1278	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		1279	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		4908365	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		1204	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		1204	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		1247	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		1247	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		1375	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		1375	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		774	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		774	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		DB05381	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		DB05381	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		155513612	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		1226	2019	20	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm0341047
		41376	2019	20	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm0341047
		CHEMBL12608	2019	20	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm0341047
		24745335	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		71603135	89714	0	None	26	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	2	2	5	2.3	Nc1nc(N2CCNCC2)c2ccc(C3CCCC3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376789	89714	0	None	26	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	2	2	5	2.3	Nc1nc(N2CCNCC2)c2ccc(C3CCCC3)cc2n1	10.1016/j.bmcl.2013.02.091
		71525589	89732	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	286	3	2	6	1.5	CN[C@@H]1CCN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376807	89732	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	286	3	2	6	1.5	CN[C@@H]1CCN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		24745335	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	295	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		24994634	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Binding assayBinding assay	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		8984	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Binding assayBinding assay	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		CHEMBL3236549	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Binding assayBinding assay	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		24994634	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		3035746	188180	9	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL1237146	188180	9	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL498770	188180	9	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1204	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		155513612	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	176320	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1249	2009	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		13499360	2009	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90019	2009	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1253	2058	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		132937	2058	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL19010	2058	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10023327	169016	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	169016	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		10023327	169016	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	169016	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		10023327	169016	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	169016	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		1253	2058	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1021/jm201042n
		132937	2058	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1021/jm201042n
		CHEMBL19010	2058	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1021/jm201042n
		1204	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		1247	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		1375	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		774	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		DB05381	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		11065080	19434	2	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL129488	19434	2	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		66573460	75668	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.2	Cc1cc(Cl)cc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047451	75668	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.2	Cc1cc(Cl)cc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		21638785	188658	5	None	-4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL503605	188658	5	None	-4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		44129132	199534	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	6	1	7	1.3	CN1CCN(c2nc(NCCS(=O)(=O)N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592188	199534	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	6	1	7	1.3	CN1CCN(c2nc(NCCS(=O)(=O)N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10176414	4063	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		1246	4063	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL281576	4063	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		45267233	194907	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	304	7	3	4	2.8	COc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202319	194907	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	304	7	3	4	2.8	COc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL541171	194907	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	304	7	3	4	2.8	COc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		1278	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1249	2009	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		13499360	2009	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL90019	2009	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		25128823	192717	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		CHEMBL521995	192717	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		127050431	140315	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806206	140315	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11451949	68045	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	384	6	1	4	3.9	CN1CCN(CCCOc2ccc(-c3nc4cc(Cl)ccc4[nH]3)cc2)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914533	68045	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	384	6	1	4	3.9	CN1CCN(CCCOc2ccc(-c3nc4cc(Cl)ccc4[nH]3)cc2)CC1	10.1016/j.bmcl.2011.08.014
		46228126	202612	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.4	CN1CCN(c2cc(NCc3ccc(C(F)(F)F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL612131	202612	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.4	CN1CCN(c2cc(NCc3ccc(C(F)(F)F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		60150166	174724	0	None	-323	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	524	17	2	6	4.7	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1	10.1039/C8MD00527C
		CHEMBL4560123	174724	0	None	-323	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	524	17	2	6	4.7	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1	10.1039/C8MD00527C
		168295543	193041	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209021	193041	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222929	193041	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		164610648	184838	0	None	-120	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4852212	184838	0	None	-120	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		10820930	5799	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL107877	5799	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		24826443	68121	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914770	68121	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		10800875	6280	0	None	-75	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1081718	6280	0	None	-75	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL345828	6280	0	None	-75	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		24745335	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		24745335	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	295	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		1223	953	41	None	-363	11	Mouse	6.9	pKi	=	6.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-363	11	Mouse	6.9	pKi	=	6.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-363	11	Mouse	6.9	pKi	=	6.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		10800875	6280	0	None	-75	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1081718	6280	0	None	-75	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL345828	6280	0	None	-75	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		11206058	104415	9	None	-10	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL310360	104415	9	None	-10	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		1267	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
		3035905	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
		CHEMBL260374	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
		3062060	10381	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	221	4	6	3	-1.0	N=C(N)NCc1cccc(CNC(=N)N)n1	10.1021/jm7014777
		CHEMBL1162346	10381	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	221	4	6	3	-1.0	N=C(N)NCc1cccc(CNC(=N)N)n1	10.1021/jm7014777
		11511026	16036	0	None	-208	4	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3ccc4ccccc4n3)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		CHEMBL1223683	16036	0	None	-208	4	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3ccc4ccccc4n3)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		1267	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		3035905	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		CHEMBL260374	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		10106063	109271	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting method	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
		CHEMBL321860	109271	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting method	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
		24826000	68143	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	2	2	6	3.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914793	68143	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	2	2	6	3.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)C1	10.1016/j.bmcl.2011.08.014
		1267	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		3035905	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		CHEMBL260374	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		1278	2150	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		10106063	109271	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL321860	109271	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		9974306	204474	0	None	-15	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL72372	204474	0	None	-15	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
		56849569	71612	0	None	-77	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	381	7	2	4	4.4	N#Cc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923033	71612	0	None	-77	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	381	7	2	4	4.4	N#Cc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963332	71612	0	None	-77	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	381	7	2	4	4.4	N#Cc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11499453	76211	0	None	-79	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	2	2	2.4	CC(C)CNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205834	76211	0	None	-79	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	2	2	2.4	CC(C)CNCCCCCc1c[nH]cn1	10.1021/jm0504353
		11672850	76673	3	None	-10	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.1	CC(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL206451	76673	3	None	-10	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.1	CC(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		1267	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.04.007
		3035905	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.04.007
		CHEMBL260374	3804	49	None	-33	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.04.007
		10106063	109271	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL321860	109271	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		5310982	93612	4	None	-1348	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
		CHEMBL24665	93612	4	None	-1348	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
		71681975	89650	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	296	5	4	5	1.4	Nc1nccc(NCCNC(=O)c2cc3ccccc3[nH]2)n1	10.1021/jm301886t
		CHEMBL2375750	89650	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	296	5	4	5	1.4	Nc1nccc(NCCNC(=O)c2cc3ccccc3[nH]2)n1	10.1021/jm301886t
		71681642	89665	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nc(NCCNc2ccnc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		CHEMBL2375765	89665	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nc(NCCNc2ccnc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		11286909	205284	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL79126	205284	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		10678661	5362	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106931	5362	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		11043445	56479	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632410	56479	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		168294449	193018	0	None	-181	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204599	193018	0	None	-181	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222793	193018	0	None	-181	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		66572111	75645	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047271	75645	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		118720435	115912	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	225	3	2	5	0.3	CN[C@@H]1CCN(c2cc(CF)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354809	115912	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	225	3	2	5	0.3	CN[C@@H]1CCN(c2cc(CF)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		90645151	112172	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290572	112172	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2014.06.032
		16082833	80347	0	None	-23	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL214312	80347	0	None	-23	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		54584826	61553	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770993	61553	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		57395538	68211	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915347	68211	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		57395538	68211	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915347	68211	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		25178343	172591	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL448962	172591	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178343	172591	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL448962	172591	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		57403269	68117	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	1	6	2.5	CN1CCN(c2nc(N)nc3c4cc(Cl)ccc4[s+]([O-])c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914766	68117	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	1	6	2.5	CN1CCN(c2nc(N)nc3c4cc(Cl)ccc4[s+]([O-])c23)CC1	10.1016/j.bmcl.2011.08.014
		24854705	96111	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	3	0	6	2.6	CN1CCN(c2nc3ccccc3nc2Oc2cccnc2)CC1	10.1021/jm7014217
		CHEMBL260274	96111	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	3	0	6	2.6	CN1CCN(c2nc3ccccc3nc2Oc2cccnc2)CC1	10.1021/jm7014217
		164619208	185662	0	None	-446	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F	10.1016/j.ejmech.2021.113190
		CHEMBL4864852	185662	0	None	-446	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F	10.1016/j.ejmech.2021.113190
		10678661	5362	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106931	5362	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		57402929	69867	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938844	69867	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		1278	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		1279	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		4908365	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		57392827	68123	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914772	68123	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		58227163	176463	0	None	40	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	176463	0	None	40	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	176463	0	None	40	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		1204	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		1247	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		1375	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		774	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		DB05381	1932	119	None	-3	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		16082856	81113	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL215628	81113	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		46929647	16758	0	None	-91	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		CHEMBL1243394	16758	0	None	-91	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		11858011	159003	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	9	0	3	4.6	O=C(c1ccccc1)c1ccc(OCCCCCN2CCCC2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4096444	159003	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	9	0	3	4.6	O=C(c1ccccc1)c1ccc(OCCCCCN2CCCC2)cc1	10.1016/j.ejmech.2016.09.074
		16352	117185	13	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL339414	117185	13	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
		11240759	105213	5	None	-190	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL311473	105213	5	None	-190	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		24853662	96075	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	3	0	5	3.1	CN1CCN(c2nc3ccccc3nc2OC2CCCCC2)CC1	10.1021/jm7014217
		CHEMBL260043	96075	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	3	0	5	3.1	CN1CCN(c2nc3ccccc3nc2OC2CCCCC2)CC1	10.1021/jm7014217
		54584378	63159	0	None	-50	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774595	63159	0	None	-50	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789782	63159	0	None	-50	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		164626153	186378	0	None	-6456	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4875600	186378	0	None	-6456	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
		54583874	61546	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N)nc(N3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770986	61546	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N)nc(N3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		54584378	63159	0	None	-50	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774595	63159	0	None	-50	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789782	63159	0	None	-50	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		46890122	7373	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	421	9	2	5	4.3	Cc1cc(OCCCNCCc2cn(C)cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086344	7373	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	421	9	2	5	4.3	Cc1cc(OCCCNCCc2cn(C)cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		155568016	176038	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	4	1	6	1.1	CCC(CC)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4590367	176038	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	4	1	6	1.1	CCC(CC)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		58227319	117126	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393540	117126	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		56849571	71613	0	None	-117	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	401	8	2	5	4.5	O=[N+]([O-])c1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923034	71613	0	None	-117	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	401	8	2	5	4.5	O=[N+]([O-])c1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963347	71613	0	None	-117	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	401	8	2	5	4.5	O=[N+]([O-])c1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		25179126	173413	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm800876b
		CHEMBL452849	173413	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm800876b
		25179126	173413	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm901379s
		CHEMBL452849	173413	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm901379s
		164609729	185098	0	None	-2187	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856059	185098	0	None	-2187	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		164622886	185942	0	None	-131	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4869389	185942	0	None	-131	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		164626509	186335	0	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	358	3	4	4	3.2	N/C(=N\C(=O)NC1CCCCC1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4874969	186335	0	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	358	3	4	4	3.2	N/C(=N\C(=O)NC1CCCCC1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		11043445	56479	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL1632410	56479	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		1204	1932	119	None	-12	24	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	1932	119	None	-12	24	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	1932	119	None	-12	24	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	1932	119	None	-12	24	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	1932	119	None	-12	24	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	1932	119	None	-12	24	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		11609325	14530	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.3	CN1CCN(C(=O)c2nc3c(Cl)cc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL120221	14530	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.3	CN1CCN(C(=O)c2nc3c(Cl)cc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		24825796	68095	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	NC[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914744	68095	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	NC[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		46228100	200016	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	315	4	1	6	2.1	CN1CCN(c2cc(SCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595413	200016	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	315	4	1	6	2.1	CN1CCN(c2cc(SCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		44628631	68124	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3c(Cl)cc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914773	68124	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3c(Cl)cc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		71525679	89726	0	None	-9	6	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	89726	0	None	-9	6	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		4060730	19379	56	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL129199	19379	56	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		24853594	96137	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	4	0	5	3.3	Cc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL260470	96137	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	4	0	5	3.3	Cc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		44414495	80019	0	None	-34	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	5	0	2	6.3	CC1CC(C)CN(Cc2ccc(-c3ccc(CN4CC(C)CC(C)C4)cc3)cc2)C1	10.1016/j.bmc.2008.10.029
		CHEMBL212869	80019	0	None	-34	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	5	0	2	6.3	CC1CC(C)CN(Cc2ccc(-c3ccc(CN4CC(C)CC(C)C4)cc3)cc2)C1	10.1016/j.bmc.2008.10.029
		127026017	137358	0	None	-12	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752972	137358	0	None	-12	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1	10.1016/j.bmcl.2015.12.035
		164614907	184584	0	None	-436	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848697	184584	0	None	-436	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1	10.1016/j.ejmech.2021.113190
		57390263	68187	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	330	1	2	7	1.8	Nc1nc(N2CC3CCNC3C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915052	68187	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	330	1	2	7	1.8	Nc1nc(N2CC3CCNC3C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		9900313	19424	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL129444	19424	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9900313	19424	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129444	19424	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0341047
		1278	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		1279	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		4908365	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		CHEMBL129198	2150	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		46890592	6392	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082296	6392	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		9900313	19424	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129444	19424	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
		156013896	178240	0	None	-7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	178240	0	None	-7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	178240	0	None	-7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		25129523	187287	45	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL492884	187287	45	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		1249	2009	16	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		13499360	2009	16	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		CHEMBL90019	2009	16	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		1204	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1247	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1375	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		774	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		CHEMBL90	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		DB05381	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		137655927	158888	0	None	17	2	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	403	7	2	3	5.2	O=C(NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		CHEMBL4095224	158888	0	None	17	2	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	403	7	2	3	5.2	O=C(NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		71603141	89720	0	None	14	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	5	1.2	CCc1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376795	89720	0	None	14	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	5	1.2	CCc1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		54585779	61551	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770991	61551	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		25179303	189346	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCCC3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL512568	189346	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCCC3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		51354304	58896	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCn2cc(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688972	58896	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCn2cc(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		71519016	86469	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314501	86469	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		71518859	86495	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	294	2	3	5	1.6	Nc1nc(N2CCNCC2)c2cc(-c3ccccc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314772	86495	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	294	2	3	5	1.6	Nc1nc(N2CCNCC2)c2cc(-c3ccccc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		156014317	178277	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	575	10	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/C=C/c3ccc(N(C)C)cc3)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634728	178277	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	575	10	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/C=C/c3ccc(N(C)C)cc3)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650854	178277	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	575	10	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/C=C/c3ccc(N(C)C)cc3)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		11724853	97020	0	None	-19	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	340	0	0	4	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C)c3ccccc32)CC1	10.1021/jm051008s
		CHEMBL266723	97020	0	None	-19	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	340	0	0	4	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C)c3ccccc32)CC1	10.1021/jm051008s
		57398985	67883	0	None	-1122	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910385	67883	0	None	-1122	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		118725539	117109	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	2	0	4	1.8	CN1CCN(c2ccnc(N3CCCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393523	117109	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	2	0	4	1.8	CN1CCN(c2ccnc(N3CCCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		16082822	79980	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@@H]2C[C@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL212705	79980	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@@H]2C[C@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		46228160	199859	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	308	3	0	6	1.6	CN1CCN(c2ncnc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594468	199859	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	308	3	0	6	1.6	CN1CCN(c2ncnc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		2306318	87008	12	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1039/C5MD00022J
		CHEMBL232421	87008	12	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1039/C5MD00022J
		127036980	137346	0	None	-16	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752885	137346	0	None	-16	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		57391033	68120	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	287	1	2	6	1.5	Nc1nc(N2CCNCC2)c2oc3cccc(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914769	68120	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	287	1	2	6	1.5	Nc1nc(N2CCNCC2)c2oc3cccc(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		1236	2067	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		1237	2067	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		156615	2067	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		CHEMBL268229	2067	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		24797248	199866	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594490	199866	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		9951970	5500	1	None	-81	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1076300	5500	1	None	-81	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL154797	5500	1	None	-81	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		121238066	166692	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	2	8	-1.0	CN1CCN(c2nc(N)nc(CN3C(=O)NC(C)(C)C3=O)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4282283	166692	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	2	8	-1.0	CN1CCN(c2nc(N)nc(CN3C(=O)NC(C)(C)C3=O)n2)CC1	10.1016/j.ejmech.2017.09.035
		10860228	116835	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL338001	116835	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0341047
		10860228	116835	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338001	116835	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0502081
		3840250	136617	16	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	5	2.4	Cc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		CHEMBL3739776	136617	16	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	5	2.4	Cc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		56851447	71625	0	None	-144	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	424	7	2	3	5.9	Clc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1923026	71625	0	None	-144	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	424	7	2	3	5.9	Clc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1963433	71625	0	None	-144	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	424	7	2	3	5.9	Clc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		90645157	112184	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1Cl	10.1016/j.ejmech.2014.06.032
		CHEMBL3290584	112184	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1Cl	10.1016/j.ejmech.2014.06.032
		2971762	193227	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL523617	193227	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		44450401	156131	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	3	2	4	2.0	O=c1[nH]c2ccc(Cl)cc2nc1NCN1CCCC1	10.1021/jm7014217
		CHEMBL406345	156131	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	3	2	4	2.0	O=c1[nH]c2ccc(Cl)cc2nc1NCN1CCCC1	10.1021/jm7014217
		2971762	193227	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL523617	193227	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		164622190	185616	0	None	-93	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4864067	185616	0	None	-93	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCCc1ccccc1	10.1016/j.ejmech.2021.113190
		54586762	61527	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	4	2	5	2.0	CN1CCN(c2cc(N)nc(NCc3ccccc3)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770967	61527	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	4	2	5	2.0	CN1CCN(c2cc(N)nc(NCc3ccccc3)c2)CC1	10.1016/j.bmcl.2011.03.017
		136066109	200434	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	289	6	2	2	3.7	Cc1[nH]cnc1[C@@H]1C[C@H]1CCNCc1ccc(Cl)cc1	10.1016/j.bmc.2009.12.046
		46231557	200434	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	289	6	2	2	3.7	Cc1[nH]cnc1[C@@H]1C[C@H]1CCNCc1ccc(Cl)cc1	10.1016/j.bmc.2009.12.046
		CHEMBL598291	200434	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	289	6	2	2	3.7	Cc1[nH]cnc1[C@@H]1C[C@H]1CCNCc1ccc(Cl)cc1	10.1016/j.bmc.2009.12.046
		5477514	10380	1	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	408	4	4	5	2.6	C/N=C(\N)N/N=C(/C)c1ccc2sc3ccc(/C(C)=N\N/C(N)=N/C)cc3c2c1	10.1021/jm7014777
		CHEMBL1162345	10380	1	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	408	4	4	5	2.6	C/N=C(\N)N/N=C(/C)c1ccc2sc3ccc(/C(C)=N\N/C(N)=N/C)cc3c2c1	10.1021/jm7014777
		24826083	68147	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914797	68147	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		10988959	118108	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL340740	118108	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		4906599	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL436381	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		10988959	118108	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL340740	118108	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0341047
		4906599	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL436381	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0341047
		57391819	69736	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935570	69736	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)c1	10.1016/j.bmcl.2011.10.104
		53233801	61545	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770985	61545	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		10988959	118108	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL340740	118108	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		4906599	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL436381	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		71519674	89729	0	None	-1	5	Mouse	7.8	pKi	=	7.8	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	89729	0	None	-1	5	Mouse	7.8	pKi	=	7.8	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		56835171	69740	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL1935574	69740	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		71603138	89717	0	None	32	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	2	5	1.9	CNC1CN(c2nc(N)nc3cc(C(C)(C)C)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376792	89717	0	None	32	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	2	5	1.9	CNC1CN(c2nc(N)nc3cc(C(C)(C)C)ccc23)C1	10.1016/j.bmcl.2013.02.091
		25128822	187481	0	None	-10	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		CHEMBL494093	187481	0	None	-10	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		44129214	199201	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	538	7	2	7	3.7	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Br)c(Cl)cc3n2)CC1	10.1021/jm901379s
		CHEMBL589782	199201	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	538	7	2	7	3.7	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Br)c(Cl)cc3n2)CC1	10.1021/jm901379s
		136192874	56483	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632414	56483	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		25147772	173409	9	None	1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452847	173409	9	None	1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		136192874	56483	0	None	-1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632414	56483	0	None	-1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1204	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		1247	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		1375	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		774	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		CHEMBL90	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		DB05381	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		1223	953	41	None	-60	11	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	953	41	None	-60	11	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	953	41	None	-60	11	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		1204	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		1247	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		1375	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		774	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		CHEMBL90	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		DB05381	1932	119	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		1278	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		1279	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		4908365	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		CHEMBL129198	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		10967174	19442	3	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL129540	19442	3	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70681963	75687	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	2	1	2	2.9	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047470	75687	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	2	1	2	2.9	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		4906599	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL436381	168662	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1278	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		1279	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		4908365	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		CHEMBL129198	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		3035746	188180	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL1237146	188180	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL498770	188180	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		45269820	195349	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202326	195349	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL551790	195349	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1278	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		1279	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		4908365	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		CHEMBL129198	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		155491015	176495	4	None	-15	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4441731	176495	4	None	-15	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4596734	176495	4	None	-15	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		25129525	187583	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1039/C2MD20212C
		CHEMBL494648	187583	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1039/C2MD20212C
		46228125	199988	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595215	199988	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46890020	7368	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	8	3	4	4.5	Cc1cc(OCCCNCC2CCCCN2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086327	7368	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	8	3	4	4.5	Cc1cc(OCCCNCC2CCCCN2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		42641407	199386	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(Cl)cc(Cl)cc3n2)CC1	10.1021/jm901379s
		CHEMBL591013	199386	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(Cl)cc(Cl)cc3n2)CC1	10.1021/jm901379s
		127036981	137450	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753621	137450	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		135570464	179097	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	1	5	1.7	CN1CCN(c2nc(O)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL471712	179097	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	1	5	1.7	CN1CCN(c2nc(O)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		51354297	58886	0	None	-5	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	289	6	1	6	0.4	CN1CCN(Cc2cn(CCCc3c[nH]cn3)nn2)CC1	10.1021/jm1013488
		CHEMBL1688943	58886	0	None	-5	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	289	6	1	6	0.4	CN1CCN(Cc2cn(CCCc3c[nH]cn3)nn2)CC1	10.1021/jm1013488
		46890074	6603	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	403	8	1	3	6.2	Cc1cc(OCCCCCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083160	6603	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	403	8	1	3	6.2	Cc1cc(OCCCCCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		10107667	63165	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774599	63165	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789800	63165	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		25178755	176874	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCC[C@H]3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL461537	176874	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCC[C@H]3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		24759518	179309	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL473302	179309	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		1267	3804	49	None	-33	26	Human	6.8	pKi	=	6.8	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.8	pKi	=	6.8	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.8	pKi	=	6.8	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		118720439	115919	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	246	2	2	4	2.2	Nc1nc(C2CCCC2)cc(C2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354817	115919	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	246	2	2	4	2.2	Nc1nc(C2CCCC2)cc(C2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		24853527	167427	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	4	0	6	3.2	CN1CCN(c2nc3ccccc3nc2Oc2cccc(N(C)C)c2)CC1	10.1021/jm7014217
		CHEMBL429691	167427	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	4	0	6	3.2	CN1CCN(c2nc3ccccc3nc2Oc2cccc(N(C)C)c2)CC1	10.1021/jm7014217
		10107667	63165	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774599	63165	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789800	63165	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		10760516	63172	0	None	-9	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774598	63172	0	None	-9	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789829	63172	0	None	-9	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		127050431	140315	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806206	140315	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		10760516	63172	0	None	-9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774598	63172	0	None	-9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789829	63172	0	None	-9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		57391034	68144	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914794	68144	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		57396299	68109	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	1	1	6	2.0	CN1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914758	68109	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	1	1	6	2.0	CN1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		57396300	68126	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	305	1	2	6	1.6	Nc1nc(N2CCNCC2)c2oc3ccc(F)c(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914775	68126	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	305	1	2	6	1.6	Nc1nc(N2CCNCC2)c2oc3ccc(F)c(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		46228161	199900	14	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	233	1	2	6	-0.3	CN1CCN(c2nc(N)nc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594694	199900	14	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	233	1	2	6	-0.3	CN1CCN(c2nc(N)nc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		1223	953	41	None	-363	11	Mouse	6.8	pKi	=	6.8	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-363	11	Mouse	6.8	pKi	=	6.8	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-363	11	Mouse	6.8	pKi	=	6.8	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		10023327	169016	0	None	-144	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	169016	0	None	-144	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11615601	75020	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	1	2	3.0	c1nc(CCCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL203390	75020	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	1	2	3.0	c1nc(CCCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		11600849	140544	0	None	-31	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL381074	140544	0	None	-31	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		66572108	75640	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3c(O)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047266	75640	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3c(O)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		9965450	75646	3	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3ccc(Cl)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047272	75646	3	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3ccc(Cl)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		45268970	196183	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	318	8	3	4	2.9	COc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202325	196183	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	318	8	3	4	2.9	COc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL561369	196183	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	318	8	3	4	2.9	COc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		45267238	196230	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	345	7	4	2	3.5	N=C(NC=C(c1ccccc1)c1ccccc1)NCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL561651	196230	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	345	7	4	2	3.5	N=C(NC=C(c1ccccc1)c1ccccc1)NCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1204	1932	119	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		127050019	140765	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	233	2	2	5	0.3	CN[C@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1039/C6MD00108D
		CHEMBL3818355	140765	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	233	2	2	5	0.3	CN[C@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1039/C6MD00108D
		1194	45	3	None	-1318	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
		23786499	45	3	None	-1318	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
		CHEMBL26116	45	3	None	-1318	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
		127035835	137285	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752270	137285	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		70690368	75678	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	1	1	2	2.3	Cc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047461	75678	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	1	1	2	2.3	Cc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		24854707	96295	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	338	3	0	5	3.3	CN1CCN(c2nc3ccccc3nc2Oc2ccc(F)cc2)CC1	10.1021/jm7014217
		CHEMBL261222	96295	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	338	3	0	5	3.3	CN1CCN(c2nc3ccccc3nc2Oc2ccc(F)cc2)CC1	10.1021/jm7014217
		57390224	67877	0	None	-776	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910379	67877	0	None	-776	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		4905344	35336	9	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2cc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL1437043	35336	9	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2cc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1016/j.ejmech.2012.06.016
		70690367	75676	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	3	2.0	COc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047459	75676	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	3	2.0	COc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		59777309	110154	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.3	CN[C@@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1021/jm401727m
		CHEMBL3236581	110154	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.3	CN[C@@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1021/jm401727m
		57400777	68209	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915345	68209	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		56835171	69740	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	69740	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		3035746	188180	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL1237146	188180	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL498770	188180	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		53378928	115914	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	289	4	2	5	1.4	CN[C@@H]1CCN(c2cc(CCC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354812	115914	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	289	4	2	5	1.4	CN[C@@H]1CCN(c2cc(CCC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		44547564	117117	2	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	2.2	CN1CCN(c2ccnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393531	117117	2	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	2.2	CN1CCN(c2ccnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		57400777	68209	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915345	68209	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		57400738	68184	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.5	Nc1nc(N2CC[C@@H](N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915049	68184	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.5	Nc1nc(N2CC[C@@H](N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		56851445	71641	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	8	2	3	3.8	CCCCN/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923025	71641	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	8	2	3	3.8	CCCCN/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963551	71641	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	8	2	3	3.8	CCCCN/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		71603194	89722	0	None	35	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	3	2	5	1.6	CCc1ccc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376797	89722	0	None	35	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	3	2	5	1.6	CCc1ccc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		45257133	199904	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594721	199904	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		155540438	172541	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL4483783	172541	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		57394625	68317	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	325	7	2	6	1.7	COc1ccccc1Cn1ccc(NCCc2cnc[nH]2)nc1=O	10.1016/j.bmcl.2011.07.114
		CHEMBL1916493	68317	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	325	7	2	6	1.7	COc1ccccc1Cn1ccc(NCCc2cnc[nH]2)nc1=O	10.1016/j.bmcl.2011.07.114
		124087	1389	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		54587791	61543	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770983	61543	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		10515050	6249	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCCC(C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1081541	6249	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCCC(C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL350478	6249	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCCC(C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		73355143	91870	0	None	-22	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	323	8	2	4	2.8	O=C(NCCOc1ccccc1Cl)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL2413362	91870	0	None	-22	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	323	8	2	4	2.8	O=C(NCCOc1ccccc1Cl)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		56678756	65629	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4	ChEMBL	391	5	1	4	4.2	CCC(=O)N[C@@H]1CC[C@H](C(=O)N(C)c2ccc(-c3nc4ccccc4o3)cc2)C1	10.6019/CHEMBL5212743
		CHEMBL1834199	65629	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4	ChEMBL	391	5	1	4	4.2	CCC(=O)N[C@@H]1CC[C@H](C(=O)N(C)c2ccc(-c3nc4ccccc4o3)cc2)C1	10.6019/CHEMBL5212743
		137634349	156015	0	None	-741	2	Human	4.8	pKi	=	4.8	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	6	0	3	4.7	CC(=O)c1ccc(OCc2ccc(CN3CCCC(C)C3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4062122	156015	0	None	-741	2	Human	4.8	pKi	=	4.8	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	6	0	3	4.7	CC(=O)c1ccc(OCc2ccc(CN3CCCC(C)C3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		164626370	186473	0	None	-14	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	6	4	4	1.8	CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		CHEMBL4876799	186473	0	None	-14	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	6	4	4	1.8	CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		155568977	176152	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	281	6	3	3	2.6	c1ccc2[nH]c(CNCC[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		CHEMBL4592695	176152	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	281	6	3	3	2.6	c1ccc2[nH]c(CNCC[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		24854706	95978	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)c(Cl)c2)CC1	10.1021/jm7014217
		CHEMBL259536	95978	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)c(Cl)c2)CC1	10.1021/jm7014217
		1278	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		1279	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		4908365	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		CHEMBL129198	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		46929554	16754	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	349	5	1	3	4.7	FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		CHEMBL1243367	16754	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	349	5	1	3	4.7	FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		4060730	19379	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129199	19379	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		49841608	69731	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935565	69731	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		1278	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		1279	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		4908365	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		CHEMBL129198	2150	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		4060730	19379	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129199	19379	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
		45379805	199428	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	7	1.9	CN1CCN(c2nc(NCCS(=O)(=O)N3CCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591248	199428	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	7	1.9	CN1CCN(c2nc(NCCS(=O)(=O)N3CCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		164585473	184562	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to H4 receptor (unknown origin)Binding affinity to H4 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4848380	184562	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to H4 receptor (unknown origin)Binding affinity to H4 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		71519177	86484	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314760	86484	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		112936262	137276	1	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752195	137276	1	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		1403136	180509	9	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL475331	180509	9	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm901379s
		164611143	184716	0	None	-75	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	414	6	4	4	2.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F	10.1016/j.ejmech.2021.113190
		CHEMBL4850448	184716	0	None	-75	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	414	6	4	4	2.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F	10.1016/j.ejmech.2021.113190
		137646744	157820	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	391	10	1	5	3.0	O=C(CCNC(=O)C(Cc1ccccc1)Cn1ccnc1)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4083336	157820	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	391	10	1	5	3.0	O=C(CCNC(=O)C(Cc1ccccc1)Cn1ccnc1)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		56835171	69740	0	None	-10	9	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from rat H4RDisplacement of [3H]histamine from rat H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	69740	0	None	-10	9	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from rat H4RDisplacement of [3H]histamine from rat H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		90645149	112174	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1cccc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290574	112174	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1cccc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		46890021	7369	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.8	Cc1cc(OCCCNCC2CCCCN2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086328	7369	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.8	Cc1cc(OCCCNCC2CCCCN2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		118725541	117114	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	1	4	2.0	CCCCNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393528	117114	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	1	4	2.0	CCCCNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		16082858	80092	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL213133	80092	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		45379809	199389	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	420	5	1	8	2.1	CN1CCN(c2nc(NCCN3C(=O)CSC3=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591027	199389	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	420	5	1	8	2.1	CN1CCN(c2nc(NCCN3C(=O)CSC3=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		135398737	958	93	None	-57	89	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	958	93	None	-57	89	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	958	93	None	-57	89	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	958	93	None	-57	89	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	958	93	None	-57	89	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		10575070	67881	0	None	-79	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	439	7	1	3	4.7	O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910383	67881	0	None	-79	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	439	7	1	3	4.7	O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2011.09.001
		164622330	185862	0	None	-724	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4867962	185862	0	None	-724	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		1267	3804	49	None	-33	26	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		3035905	3804	49	None	-33	26	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		CHEMBL260374	3804	49	None	-33	26	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		122193098	123917	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628045	123917	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		90645162	112189	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	324	2	1	6	1.3	CN1CCN(c2nc(N)nc(-c3cc(F)c(F)c(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290589	112189	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	324	2	1	6	1.3	CN1CCN(c2nc(N)nc(-c3cc(F)c(F)c(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		24745507	68220	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915538	68220	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		45257133	199904	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594721	199904	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		24826165	68114	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914763	68114	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		1278	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		1279	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		4908365	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		CHEMBL129198	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		3032915	15495	24	None	-1	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1021/jm0341047
		CHEMBL12160	15495	24	None	-1	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1021/jm0341047
		127052294	140302	0	None	5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806079	140302	0	None	5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		57394550	68116	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	2	1	7	2.2	COc1ccc2c(c1)sc1c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.08.014
		CHEMBL1914765	68116	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	2	1	7	2.2	COc1ccc2c(c1)sc1c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.08.014
		51354009	58883	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cc2cn(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688940	58883	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cc2cn(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		156011119	177122	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	841	18	4	6	8.7	Cc1cc(OCCCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6ccc[nH]6)n5[B-]4(F)F)C=C3)cc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4633688	177122	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	841	18	4	6	8.7	Cc1cc(OCCCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6ccc[nH]6)n5[B-]4(F)F)C=C3)cc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		51354296	58885	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	274	6	1	5	1.6	c1nc(CCCn2cc(CN3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688942	58885	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	274	6	1	5	1.6	c1nc(CCCn2cc(CN3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		1236	2067	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		1237	2067	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		156615	2067	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		CHEMBL268229	2067	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		756701	199817	33	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	218	1	1	5	0.1	CN1CCN(c2ncnc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594152	199817	33	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	218	1	1	5	0.1	CN1CCN(c2ncnc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		63868328	174251	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4549015	174251	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		58227381	176616	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.3	CC(C)(C)CNc1nccc(N2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4513989	176616	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.3	CC(C)(C)CNc1nccc(N2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597817	176616	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.3	CC(C)(C)CNc1nccc(N2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		25128822	187481	0	None	-10	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL494093	187481	0	None	-10	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		25179124	174233	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm800876b
		CHEMBL454883	174233	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm800876b
		25179122	193273	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL523941	193273	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25179124	174233	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm901379s
		CHEMBL454883	174233	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm901379s
		25179122	193273	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL523941	193273	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		1265	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		6422124	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		CHEMBL14638	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		24994634	2142	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	2142	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	2142	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		24994634	2142	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat recombinant histamine H4 receptorDisplacement of [3H]histamine from rat recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	2142	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat recombinant histamine H4 receptorDisplacement of [3H]histamine from rat recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	2142	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat recombinant histamine H4 receptorDisplacement of [3H]histamine from rat recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL4520788	213975	10	None	-89	25	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HRH4Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HRH4	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		54581937	61523	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	3	1	5	1.3	CC(C)N(C)c1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770963	61523	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	3	1	5	1.3	CC(C)N(C)c1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		137646939	157738	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	335	5	3	4	3.6	CC(C)(CN=C(c1ccccc1O)c1ccccc1O)c1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		CHEMBL4082297	157738	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	335	5	3	4	3.6	CC(C)(CN=C(c1ccccc1O)c1ccccc1O)c1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		9878733	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL338051	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9878733	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL338051	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		49841610	69732	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3cc(-c4ccccc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935566	69732	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3cc(-c4ccccc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		44547127	115918	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		44547127	115918	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3354816	115918	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354816	115918	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		24739219	68053	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	289	1	2	6	1.8	Nc1nc(N2CC(N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914546	68053	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	289	1	2	6	1.8	Nc1nc(N2CC(N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		24826265	68112	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.3	CN1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914761	68112	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.3	CN1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		9992865	114427	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL333220	114427	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		9878733	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338051	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		2063135	8378	9	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093180	8378	9	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		44129213	199383	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)c(Cl)cc3n2)CC1	10.1021/jm901379s
		CHEMBL590995	199383	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)c(Cl)cc3n2)CC1	10.1021/jm901379s
		71525681	89728	0	None	-2	6	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	89728	0	None	-2	6	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		136141537	56481	3	None	2	3	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632412	56481	3	None	2	3	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		136030655	56482	0	None	-2	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632413	56482	0	None	-2	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1278	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		1279	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		4908365	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		CHEMBL129198	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		1251	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		3035842	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		CHEMBL18661	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		1251	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		3035842	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		CHEMBL18661	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		1251	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm201042n
		3035842	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm201042n
		CHEMBL18661	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm201042n
		11673377	139262	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	263	7	2	2	3.2	Clc1ccc(CNCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		CHEMBL379027	139262	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	263	7	2	2	3.2	Clc1ccc(CNCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		25129523	187287	45	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL492884	187287	45	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		66572114	75650	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047276	75650	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70690369	75690	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	1	2	2	2.0	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047473	75690	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	1	2	2	2.0	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		9878733	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL338051	116844	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1204	1932	119	None	-3	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		1247	1932	119	None	-3	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		1375	1932	119	None	-3	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		774	1932	119	None	-3	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		CHEMBL90	1932	119	None	-3	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		DB05381	1932	119	None	-3	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		1278	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		1279	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		4908365	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		CHEMBL129198	2150	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		11846298	139281	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
		CHEMBL379102	139281	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
		155538989	176329	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	3	5	2.1	CC(C)(C)CNc1nccc(NC2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4513421	176329	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	3	5	2.1	CC(C)(C)CNc1nccc(NC2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595438	176329	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	3	5	2.1	CC(C)(C)CNc1nccc(NC2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		164608815	184454	0	None	-47	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4846638	184454	0	None	-47	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
		164611342	185088	0	None	-416	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856005	185088	0	None	-416	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
		155513612	176320	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156015838	178246	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	373	7	1	2	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4640263	178246	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	373	7	1	2	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650622	178246	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	373	7	1	2	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		127036982	137467	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	525	6	1	6	5.9	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753784	137467	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	525	6	1	6	5.9	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1	10.1016/j.bmcl.2015.12.035
		57393769	68170	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	281	1	2	6	1.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915030	68170	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	281	1	2	6	1.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		11688307	69903	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938968	69903	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		136141537	56481	3	None	-10	3	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632412	56481	3	None	-10	3	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		44395364	66899	0	None	15	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	276	2	1	2	3.3	CN1CCC(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL186456	66899	0	None	15	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	276	2	1	2	3.3	CN1CCC(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		10037650	5209	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106158	5209	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		135398737	958	93	None	-57	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		38	958	93	None	-57	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		722	958	93	None	-57	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		CHEMBL42	958	93	None	-57	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		DB00363	958	93	None	-57	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		11572015	75030	0	None	-50	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	9	2	2	2.5	CCCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL203441	75030	0	None	-50	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	9	2	2	2.5	CCCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		11600780	76049	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	2	2	1.7	CC(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205732	76049	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	2	2	1.7	CC(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		1408942	65123	4	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL1824046	65123	4	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.06.123
		4060730	19379	56	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL129199	19379	56	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		25129527	187414	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL493720	187414	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		66573462	75670	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	2	2	2	2.2	CNC1CN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047453	75670	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	2	2	2	2.2	CNC1CN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		767246	96017	5	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	242	1	0	4	1.7	Cc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL259745	96017	5	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	242	1	0	4	1.7	Cc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		155550732	176629	0	None	-794	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4540849	176629	0	None	-794	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4597895	176629	0	None	-794	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		11313837	2500	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		1254	2500	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		CHEMBL175782	2500	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		11313837	2500	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		1254	2500	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		CHEMBL175782	2500	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		71681480	89661	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	307	6	3	7	2.0	Nc1nc(NCCNc2ccncn2)cc(-c2ccccc2)n1	10.1021/jm301886t
		CHEMBL2375761	89661	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	307	6	3	7	2.0	Nc1nc(NCCNc2ccncn2)cc(-c2ccccc2)n1	10.1021/jm301886t
		57392460	69866	0	None	14	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL1938843	69866	0	None	14	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572104	75636	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ccncc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047262	75636	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ccncc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572112	75648	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3ccc([N+](=O)[O-])cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047274	75648	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3ccc([N+](=O)[O-])cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		44395361	66940	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	293	1	2	3	2.0	CN1CCN(C(=O)Nc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL186640	66940	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	293	1	2	3	2.0	CN1CCN(C(=O)Nc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		10879463	5290	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106570	5290	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		10945113	109629	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL322256	109629	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		127035836	137518	0	None	-5	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	4	1	5	3.9	Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3754176	137518	0	None	-5	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	4	1	5	3.9	Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		164618283	184544	0	None	-537	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	5	2.4	COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848026	184544	0	None	-537	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	5	2.4	COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		53233805	61524	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770964	61524	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		54585781	61561	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1771000	61561	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		118720442	115921	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	3	5	1.4	Nc1cc(N2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354820	115921	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	3	5	1.4	Nc1cc(N2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		44547268	117112	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393526	117112	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		58227255	117125	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393539	117125	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		58227252	117130	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393544	117130	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		25112105	8163	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1091875	8163	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24737949	68132	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914782	68132	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		24825996	68138	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914788	68138	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		59777341	110148	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	275	3	2	5	1.9	CN[C@@H]1CCN(c2cc(C3CCCCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236576	110148	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	275	3	2	5	1.9	CN[C@@H]1CCN(c2cc(C3CCCCC3)nc(N)n2)C1	10.1021/jm401727m
		1278	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		1279	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		4908365	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		CHEMBL129198	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		24745335	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		24745335	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	295	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		53257796	110147	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236575	110147	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
		24738269	68050	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.1	Nc1nc(N2CC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914543	68050	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.1	Nc1nc(N2CC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		1223	953	41	None	-60	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	953	41	None	-60	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	953	41	None	-60	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		44231735	7785	0	None	-1	4	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089390	7785	0	None	-1	4	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		44462956	5599	0	None	2	2	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL1077276	5599	0	None	2	2	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		1278	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1278	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1279	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1279	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		4908365	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		4908365	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		CHEMBL129198	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		CHEMBL129198	2150	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		137657169	159587	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	8	1	4	4.1	O=[N+]([O-])c1cccc(C(OCCCc2c[nH]cn2)c2ccccc2)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4102970	159587	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	8	1	4	4.1	O=[N+]([O-])c1cccc(C(OCCCc2c[nH]cn2)c2ccccc2)c1	10.1016/j.ejmech.2016.09.074
		59777258	110133	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236561	110133	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
		25130914	187254	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL492677	187254	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		46890547	6516	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082772	6516	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
		10446295	2132	34	None	269	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm401727m
		1277	2132	34	None	269	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm401727m
		CHEMBL185951	2132	34	None	269	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm401727m
		68081305	110122	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	1	1	2	1.3	CN1CCN(C(=O)c2cc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		CHEMBL3236550	110122	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	1	1	2	1.3	CN1CCN(C(=O)c2cc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		24798144	110125	2	None	-19	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		CHEMBL3236553	110125	2	None	-19	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		24738103	68130	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(OC)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914780	68130	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(OC)c23)C1	10.1016/j.bmcl.2011.08.014
		24745335	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		24745335	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	295	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		16362	3125	71	None	-562	30	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		2172	3125	71	None	-562	30	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		90	3125	71	None	-562	30	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		CHEMBL1423	3125	71	None	-562	30	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		DB01100	3125	71	None	-562	30	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		9904236	14076	22	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL1197564	14076	22	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46890589	7022	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	7	1	4	4.8	Cc1cc(OCCCN2CCCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084809	7022	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	7	1	4	4.8	Cc1cc(OCCCN2CCCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		57396382	68319	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	9	2	7	3.8	COCc1ccc(CN2CC[C@H](Nc3cc(NCCC(C)(C)C)ncn3)C2)o1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916495	68319	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	9	2	7	3.8	COCc1ccc(CN2CC[C@H](Nc3cc(NCCC(C)(C)C)ncn3)C2)o1	10.1016/j.bmcl.2011.07.114
		57391122	68320	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	7	3	6	3.9	CC(C)(C)CCNc1cc(N[C@H]2CCN(Cc3cccc(F)c3O)C2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916496	68320	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	7	3	6	3.9	CC(C)(C)CCNc1cc(N[C@H]2CCN(Cc3cccc(F)c3O)C2)ncn1	10.1016/j.bmcl.2011.07.114
		57394628	68325	1	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	4	2	5	1.7	CC(C)(C)CCNc1cc(N2CCNCC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916500	68325	1	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	4	2	5	1.7	CC(C)(C)CCNc1cc(N2CCNCC2)ncn1	10.1016/j.bmcl.2011.07.114
		57397738	69864	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	245	1	0	5	0.1	CN1CCN(C(=O)c2cn3ccncc3n2)CC1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938841	69864	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	245	1	0	5	0.1	CN1CCN(C(=O)c2cn3ccncc3n2)CC1	10.1016/j.bmcl.2011.11.098
		10399535	118441	3	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	2	2	1.6	CC1CN(C(=O)c2cc3ccccc3[nH]2)CCN1	10.1021/jm0341047
		CHEMBL341087	118441	3	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	2	2	1.6	CC1CN(C(=O)c2cc3ccccc3[nH]2)CCN1	10.1021/jm0341047
		90645147	112176	0	None	13	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290576	112176	0	None	13	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		155567108	176636	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	223	5	3	5	1.3	CC(C)(C)CNc1nccc(NCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4586599	176636	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	223	5	3	5	1.3	CC(C)(C)CNc1nccc(NCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597946	176636	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	223	5	3	5	1.3	CC(C)(C)CNc1nccc(NCCN)n1	10.1021/acs.jmedchem.9b01342
		155536509	176472	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	274	6	3	5	2.3	CC(C)(C)CNc1nccc(NCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4473753	176472	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	274	6	3	5	2.3	CC(C)(C)CNc1nccc(NCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596582	176472	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	274	6	3	5	2.3	CC(C)(C)CNc1nccc(NCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		4687476	96311	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL261320	96311	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		9928073	203649	0	None	-67	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL67284	203649	0	None	-67	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm051008s
		90654501	110309	0	None	-21877	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	314	6	0	5	3.1	Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		CHEMBL3238444	110309	0	None	-21877	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	314	6	0	5	3.1	Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		4687476	96311	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1021/jm7014217
		CHEMBL261320	96311	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1021/jm7014217
		10879463	5290	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106570	5290	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		46228132	202145	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		CHEMBL609161	202145	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		46228071	200178	18	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL596562	200178	18	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		51354870	58904	0	None	-26	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	305	6	0	5	2.0	CN1CCN(CCCn2cc(CC3CCCCC3)nn2)CC1	10.1021/jm1013488
		CHEMBL1688981	58904	0	None	-26	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	305	6	0	5	2.0	CN1CCN(CCCn2cc(CC3CCCCC3)nn2)CC1	10.1021/jm1013488
		57391928	69909	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4ccc(Cl)nc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938973	69909	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4ccc(Cl)nc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		23650960	149129	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(F)ccc2[nH]1	nan
		CHEMBL3943309	149129	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(F)ccc2[nH]1	nan
		42624149	110140	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3236568	110140	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1016/j.bmcl.2014.10.013
		25218146	117107	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	2	0	4	2.6	CN1CCN(c2ccnc(-c3ccsc3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393521	117107	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	2	0	4	2.6	CN1CCN(c2ccnc(-c3ccsc3)c2)CC1	10.1016/j.bmcl.2014.12.027
		42624149	110140	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236568	110140	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		53258370	110141	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236569	110141	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		57394548	68098	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@@H]3CCCN[C@@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914747	68098	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@@H]3CCCN[C@@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		57396298	68103	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	1	1	6	1.8	CN1CCN(c2nc(N)nc3c2oc2cccc(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914752	68103	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	1	1	6	1.8	CN1CCN(c2nc(N)nc3c2oc2cccc(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		44628629	68118	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	269	1	2	6	1.4	Nc1nc(N2CCNCC2)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914767	68118	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	269	1	2	6	1.4	Nc1nc(N2CCNCC2)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		11630326	72571	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		CHEMBL199231	72571	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		51354582	58898	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.3	CC(c1cn(CCCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		CHEMBL1688974	58898	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.3	CC(c1cn(CCCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		71603195	89723	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	3	2	5	1.9	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376798	89723	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	3	2	5	1.9	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		1251	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		3035842	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		CHEMBL18661	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		1530	2182	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		57399107	68214	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1021/acs.jmedchem.5b00516
		CHEMBL1915532	68214	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1021/acs.jmedchem.5b00516
		57399107	68214	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915532	68214	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.125
		57399107	68214	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915532	68214	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.114
		57395619	68215	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915533	68215	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		57395619	68215	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915533	68215	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		168268680	192766	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5172675	192766	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221210	192766	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		1403136	180509	9	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL475331	180509	9	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm800876b
		1204	1932	119	None	-15	24	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-15	24	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-15	24	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-15	24	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-15	24	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-15	24	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		164610824	185110	0	None	-14	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	452	8	4	4	3.6	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856200	185110	0	None	-14	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	452	8	4	4	3.6	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		10945113	109629	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL322256	109629	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		21896704	159526	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	429	9	1	7	2.7	CC(=O)SCC(Cc1ccc2c(c1)OCO2)C(=O)NCC(=O)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4102243	159526	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	429	9	1	7	2.7	CC(=O)SCC(Cc1ccc2c(c1)OCO2)C(=O)NCC(=O)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		46912441	10902	0	None	-117	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	309	3	1	2	3.9	FC(F)(F)c1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		CHEMBL1172754	10902	0	None	-117	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	309	3	1	2	3.9	FC(F)(F)c1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		118725538	117108	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	3	1	4	2.6	CN[C@@H]1CCN(c2ccnc(-c3ccsc3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393522	117108	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	3	1	4	2.6	CN[C@@H]1CCN(c2ccnc(-c3ccsc3)c2)C1	10.1016/j.bmcl.2014.12.027
		1204	1932	119	None	-3	24	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		155567030	176417	0	None	-645	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4586133	176417	0	None	-645	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4596108	176417	0	None	-645	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		24854708	155723	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL405416	155723	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		51354587	58903	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	0	5	2.7	c1cn(CCCn2cc(CC3CCCCC3)nn2)cn1	10.1021/jm1013488
		CHEMBL1688979	58903	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	0	5	2.7	c1cn(CCCn2cc(CC3CCCCC3)nn2)cn1	10.1021/jm1013488
		10702196	108568	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL320279	108568	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		136016345	10384	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	377	5	4	6	2.1	CCOC(=O)c1ccc(NC2=CC(=O)/C(=N\NC(=N)N)c3ccccc32)cc1	10.1021/jm7014777
		CHEMBL1162352	10384	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	377	5	4	6	2.1	CCOC(=O)c1ccc(NC2=CC(=O)/C(=N\NC(=N)N)c3ccccc32)cc1	10.1021/jm7014777
		127052293	140238	3	None	34	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	140238	3	None	34	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1251	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmc.2010.04.052
		3035842	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmc.2010.04.052
		CHEMBL18661	2014	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmc.2010.04.052
		11258459	84229	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		CHEMBL220933	84229	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		46228082	202379	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	340	5	2	6	2.5	CC(C)c1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		CHEMBL610626	202379	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	340	5	2	6	2.5	CC(C)c1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		49841721	69724	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		CHEMBL1935558	69724	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		25178551	174231	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454882	174231	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm800876b
		25178551	174231	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL454882	174231	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm901379s
		45379807	199509	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	6	3.5	CN1CCN(c2nc(NCCC(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591970	199509	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	6	3.5	CN1CCN(c2nc(NCCC(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10037650	5209	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106158	5209	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		122194624	124020	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccccc1/C=C/c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629827	124020	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccccc1/C=C/c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2015.08.014
		57400700	67878	0	None	-3090	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910380	67878	0	None	-3090	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		164610421	185260	0	None	-7	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	332	5	4	4	2.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4858567	185260	0	None	-7	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	332	5	4	4	2.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113190
		46890120	6537	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	416	6	1	4	5.2	Cc1cc(OCCCN2Cc3cccnc3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082851	6537	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	416	6	1	4	5.2	Cc1cc(OCCCN2Cc3cccnc3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		56851604	71629	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	8	2	3	5.1	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923028	71629	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	8	2	3	5.1	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963460	71629	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	8	2	3	5.1	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		24853663	96031	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	272	3	0	5	1.8	CCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL259839	96031	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	272	3	0	5	1.8	CCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		24278976	96251	61	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2nc3ccccc3nc2Cl)CC1	10.1021/jm7014217
		CHEMBL261010	96251	61	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2nc3ccccc3nc2Cl)CC1	10.1021/jm7014217
		24854704	96134	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		CHEMBL260456	96134	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		10923241	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128958	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		10923241	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128958	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0341047
		56835171	69740	0	None	-1	9	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from mouse H4RDisplacement of [3H]histamine from mouse H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	69740	0	None	-1	9	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from mouse H4RDisplacement of [3H]histamine from mouse H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		11687917	14965	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
		CHEMBL120854	14965	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
		10923241	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128958	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
		45257131	199908	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		CHEMBL594731	199908	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		57403350	68322	0	None	35	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	3	1	5	1.7	CN1CCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916498	68322	0	None	35	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	3	1	5	1.7	CN1CCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		24804058	144097	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	424	7	2	5	5.1	Cc1c(F)ccc2[nH]c(-c3cnc(NCCCC4CCN(C)CC4)nc3C(C)C)nc12	nan
		CHEMBL3903520	144097	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	424	7	2	5	5.1	Cc1c(F)ccc2[nH]c(-c3cnc(NCCCC4CCN(C)CC4)nc3C(C)C)nc12	nan
		126963284	144774	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL3909134	144774	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46890675	7242	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	1	4	4.4	Cc1cc(OCCCN2CC3CCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1085803	7242	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	1	4	4.4	Cc1cc(OCCCN2CC3CCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		49841722	69725	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3c(-c4ccc(C#N)cc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935559	69725	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3c(-c4ccc(C#N)cc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		168276867	192835	0	None	-4	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174278	192835	0	None	-4	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221653	192835	0	None	-4	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		24853598	96223	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	350	4	0	6	3.2	COc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL260851	96223	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	350	4	0	6	3.2	COc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		24853596	96298	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	354	3	0	5	3.8	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		CHEMBL261225	96298	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	354	3	0	5	3.8	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		164610289	185133	0	None	-38	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	7	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856602	185133	0	None	-38	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	7	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		57399827	68326	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916501	68326	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		90645155	112182	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290582	112182	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		90645155	112182	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL3290582	112182	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		46228114	200176	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL596551	200176	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		25178131	186938	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	381	5	1	5	3.7	CN1CCN(c2nc(NCCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL490072	186938	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	381	5	1	5	3.7	CN1CCN(c2nc(NCCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		90645152	112179	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	396	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(I)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290579	112179	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	396	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(I)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		49818718	69730	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935564	69730	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		54582867	61559	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770999	61559	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		25147771	174238	0	None	1	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454890	174238	0	None	1	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		11440060	207031	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	368	8	1	2	5.4	c1ccc(C(OCCCc2c[nH]cn2)(c2ccccc2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL91576	207031	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	368	8	1	2	5.4	c1ccc(C(OCCCc2c[nH]cn2)(c2ccccc2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		127051301	140200	0	None	5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	140200	0	None	5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		58227216	117140	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393554	117140	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		550981	69031	12	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	280	5	2	3	2.9	OC(CNC1CC1)Cn1c2ccccc2c2ccccc21	10.1021/jm2011589
		CHEMBL1923533	69031	12	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	280	5	2	3	2.9	OC(CNC1CC1)Cn1c2ccccc2c2ccccc21	10.1021/jm2011589
		24804056	150652	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	420	8	2	5	5.1	CCCc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(C)ccc2[nH]1	nan
		CHEMBL3955597	150652	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	420	8	2	5	5.1	CCCc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(C)ccc2[nH]1	nan
		71461658	79057	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	4	0.5	CN1CCN(C(=O)c2nc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL2113162	79057	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	4	0.5	CN1CCN(C(=O)c2nc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		4024	2015	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		9989505	2015	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		CHEMBL82298	2015	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		122193101	123920	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.4	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C(F)(F)F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628048	123920	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.4	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C(F)(F)F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		155546701	173655	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	2	1	6	0.8	CN1CCN(c2nc(N)nc(CC(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL4534504	173655	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	2	1	6	0.8	CN1CCN(c2nc(N)nc(CC(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		24798596	199867	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594491	199867	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		21193534	11265	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	292	7	1	2	4.1	c1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL1179089	11265	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	292	7	1	2	4.1	c1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL59679	11265	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	292	7	1	2	4.1	c1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		54587789	61536	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(NCCO)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770976	61536	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(NCCO)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		45257131	199908	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		CHEMBL594731	199908	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		90655027	110127	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236555	110127	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		66740898	110134	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
		CHEMBL3236562	110134	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
		24826082	68141	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914791	68141	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		11587279	125051	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL364400	125051	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
		1226	2019	20	None	2	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
		41376	2019	20	None	2	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
		CHEMBL12608	2019	20	None	2	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
		10105117	104195	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL309819	104195	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		10466840	204481	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CC/N=C(\S)NCCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL72424	204481	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CC/N=C(\S)NCCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		1204	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1247	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1375	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		774	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		CHEMBL90	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		DB05381	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		71681476	89656	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	316	8	4	8	1.5	CC(C)CCc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375756	89656	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	316	8	4	8	1.5	CC(C)CCc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		4060730	19379	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm301886t
		CHEMBL129199	19379	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm301886t
		10923241	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL128958	19165	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		4060730	19379	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL129199	19379	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		22660616	75647	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3ccc(O)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047273	75647	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3ccc(O)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		71525588	89730	0	None	33	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.1	CNC1CN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376805	89730	0	None	33	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.1	CNC1CN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		11846300	80266	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm7014217
		CHEMBL213912	80266	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm7014217
		45271470	195050	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	6	3	3	3.1	Cc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202329	195050	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	6	3	3	3.1	Cc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL549481	195050	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	6	3	3	3.1	Cc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		45270644	195472	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	257	6	4	2	1.7	N=C(NCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmc.2009.04.007
		CHEMBL552694	195472	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	257	6	4	2	1.7	N=C(NCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmc.2009.04.007
		45271464	195503	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	6	3	3	2.9	N=C(NCc1ccc(F)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202328	195503	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	6	3	3	2.9	N=C(NCc1ccc(F)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL553455	195503	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	6	3	3	2.9	N=C(NCc1ccc(F)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		10468601	195591	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202324	195591	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL555434	195591	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		45268095	196040	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	378	9	3	3	4.8	N=C(NCCC(c1ccccc1)c1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202323	196040	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	378	9	3	3	4.8	N=C(NCCC(c1ccccc1)c1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560313	196040	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	378	9	3	3	4.8	N=C(NCCC(c1ccccc1)c1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1204	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1247	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1375	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		774	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		CHEMBL90	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		DB05381	1932	119	None	-3	24	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1274	4064	16	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1039/C2MD20212C
		3063228	4064	16	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1039/C2MD20212C
		CHEMBL1196470	4064	16	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1039/C2MD20212C
		10988959	118108	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL340740	118108	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1039/C2MD20212C
		21638785	188658	5	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		CHEMBL503605	188658	5	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		127052294	140302	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806079	140302	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11751419	137881	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		CHEMBL376268	137881	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		11751419	137881	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2006.08.117
		CHEMBL376268	137881	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2006.08.117
		57402512	68167	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915022	68167	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		46228092	199948	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	299	4	1	6	1.4	CN1CCN(c2cc(OCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594973	199948	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	299	4	1	6	1.4	CN1CCN(c2cc(OCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		4024	2015	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		9989505	2015	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL82298	2015	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		1252	2017	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		9793868	2017	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL417096	2017	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1236	2067	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		1237	2067	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		156615	2067	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		CHEMBL268229	2067	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		1252	2017	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/jm0504353
		9793868	2017	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/jm0504353
		CHEMBL417096	2017	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/jm0504353
		81371	12770	11	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	178	3	4	4	0.2	N=C(N)SCCSC(=N)N	10.1021/jm060880d
		CHEMBL1187946	12770	11	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	178	3	4	4	0.2	N=C(N)SCCSC(=N)N	10.1021/jm060880d
		CHEMBL534494	12770	11	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	178	3	4	4	0.2	N=C(N)SCCSC(=N)N	10.1021/jm060880d
		52128564	75633	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	0	3	2.5	CN1CCN(C(=O)c2cc3cc(Cl)ccc3o2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047259	75633	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	0	3	2.5	CN1CCN(C(=O)c2cc3cc(Cl)ccc3o2)CC1	10.1016/j.ejmech.2012.06.016
		70684084	75669	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	2	2	2.6	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047452	75669	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	2	2	2.6	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		70692528	75675	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047458	75675	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70686224	75689	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	2	2.4	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047472	75689	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	2	2.4	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		51355156	58910	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	3.1	c1nc(CCCc2cn(C3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688989	58910	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	3.1	c1nc(CCCc2cn(C3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		9990475	56477	0	None	3	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	205	2	2	3	-0.5	Cc1nc(N)[se]c1CCN	10.1016/j.bmcl.2010.10.041
		CHEMBL1632408	56477	0	None	3	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	205	2	2	3	-0.5	Cc1nc(N)[se]c1CCN	10.1016/j.bmcl.2010.10.041
		CHEMBL2448450	56477	0	None	3	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	205	2	2	3	-0.5	Cc1nc(N)[se]c1CCN	10.1016/j.bmcl.2010.10.041
		10583206	109360	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL321920	109360	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		71681640	89663	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nc(Cl)cc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375763	89663	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nc(Cl)cc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		12438303	75632	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	260	1	0	3	2.3	CN1CCN(C(=O)c2cc3ccccc3s2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047258	75632	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	260	1	0	3	2.3	CN1CCN(C(=O)c2cc3ccccc3s2)CC1	10.1016/j.ejmech.2012.06.016
		22660598	75657	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047440	75657	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		24854636	156317	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	296	1	0	4	2.4	CN1CCN(c2nc3ccccc3nc2C(F)(F)F)CC1	10.1021/jm7014217
		CHEMBL406558	156317	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	296	1	0	4	2.4	CN1CCN(c2nc3ccccc3nc2C(F)(F)F)CC1	10.1021/jm7014217
		10583206	109360	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL321920	109360	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		44395263	66703	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	292	2	2	3	1.7	CN1CCN(NC(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL185546	66703	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	292	2	2	3	1.7	CN1CCN(NC(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		44395336	66790	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	280	4	1	3	1.9	CN(C)CCN(C)C(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL185948	66790	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	280	4	1	3	1.9	CN(C)CCN(C)C(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		44395290	125517	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	279	4	1	2	2.5	CN(C)CCN(C)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL364629	125517	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	279	4	1	2	2.5	CN(C)CCN(C)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		15984057	140121	0	None	-35481	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	348	5	0	2	5.3	c1cc(-c2ccc(CN3CCCCC3)cc2)ccc1CN1CCCCC1	10.1016/j.bmc.2008.10.029
		CHEMBL380101	140121	0	None	-35481	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	348	5	0	2	5.3	c1cc(-c2ccc(CN3CCCCC3)cc2)ccc1CN1CCCCC1	10.1016/j.bmc.2008.10.029
		71519348	86490	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	3	2	6	1.5	Nc1nc(N2CCNCC2)c2ccn(Cc3ccccc3)c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314766	86490	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	3	2	6	1.5	Nc1nc(N2CCNCC2)c2ccn(Cc3ccccc3)c2n1	10.1016/j.bmcl.2012.10.139
		122193106	123924	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	335	3	2	6	1.9	CN1CCN(c2nc(N)nc(/C=C/c3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628052	123924	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	335	3	2	6	1.9	CN1CCN(c2nc(N)nc(/C=C/c3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		122193095	123914	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628042	123914	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		54585776	61521	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(N)nc(NCCO)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770961	61521	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(N)nc(NCCO)n2)C1	10.1016/j.bmcl.2011.03.017
		24994630	110131	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	2	5	1.6	Nc1nc(C2CCCC2)cc(N2CCC[C@@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236559	110131	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	2	5	1.6	Nc1nc(C2CCCC2)cc(N2CCC[C@@H](N)C2)n1	10.1021/jm401727m
		25178933	186937	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL490071	186937	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178933	186937	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL490071	186937	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		122193103	123922	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	341	4	1	8	1.3	CN1CCN(c2nc(N)nc(/C=C/c3cccc([N+](=O)[O-])c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628050	123922	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	341	4	1	8	1.3	CN1CCN(c2nc(N)nc(/C=C/c3cccc([N+](=O)[O-])c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		10446295	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.10.104
		1277	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL185951	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.10.104
		10446295	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.03.017
		1277	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.03.017
		CHEMBL185951	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.03.017
		46890627	6589	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083098	6589	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		11340020	84263	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		CHEMBL221210	84263	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		136042265	69910	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938974	69910	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		11340020	84263	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL221210	84263	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		11189343	141977	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	420	6	1	4	4.9	Cc1cc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)ccc1OCCCN1CCN(C)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL387342	141977	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	420	6	1	4	4.9	Cc1cc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)ccc1OCCCN1CCN(C)CC1	10.1016/j.bmcl.2006.08.117
		57394549	68099	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914748	68099	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		10446295	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
		1277	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
		CHEMBL185951	2132	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
		24759624	96132	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	0	5	2.0	COc1nc2cc(Cl)ccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL260444	96132	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	0	5	2.0	COc1nc2cc(Cl)ccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		25147771	174238	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454890	174238	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		44129211	200975	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	383	5	1	7	1.5	CN1CCN(c2nc(NCCS(C)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL601946	200975	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	383	5	1	7	1.5	CN1CCN(c2nc(NCCS(C)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		11821243	18852	8	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	2	1	2	1.9	CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128134	18852	8	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	2	1	2	1.9	CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		155549319	176324	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	5	2	5	2.0	CCC(=O)N[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4538671	176324	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	5	2	5	2.0	CCC(=O)N[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595399	176324	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	5	2	5	2.0	CCC(=O)N[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		164620704	186083	0	None	-17	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	8	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4871482	186083	0	None	-17	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	8	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1	10.1016/j.ejmech.2021.113190
		127026016	137489	0	None	-13	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753967	137489	0	None	-13	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		71518861	86497	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	5	2.1	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314774	86497	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	5	2.1	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		122193102	123921	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	321	3	1	7	1.2	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628049	123921	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	321	3	1	7	1.2	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		63868018	175376	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	208	1	1	6	-0.5	Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4574940	175376	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	208	1	1	6	-0.5	Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		71518536	86494	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	3	5	0.3	Cc1cc2c(N3CCNCC3)nc(N)nc2[nH]1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314771	86494	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	3	5	0.3	Cc1cc2c(N3CCNCC3)nc(N)nc2[nH]1	10.1016/j.bmcl.2012.10.139
		57391927	69904	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938969	69904	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		3991311	136861	9	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	296	2	0	5	2.7	CCc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		CHEMBL3741986	136861	9	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	296	2	0	5	2.7	CCc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		25178556	189085	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL509961	189085	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		44563707	202598	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccc(Cl)cc3nc2OCc2ccccc2)CC1	10.1021/jm800876b
		CHEMBL612059	202598	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccc(Cl)cc3nc2OCc2ccccc2)CC1	10.1021/jm800876b
		24853595	160171	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2cccc(Cl)c2)CC1	10.1021/jm7014217
		CHEMBL410925	160171	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2cccc(Cl)c2)CC1	10.1021/jm7014217
		155535098	176386	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	3	3	5	1.3	CC(C)(C)CNc1nccc(N2CCCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4471442	176386	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	3	3	5	1.3	CC(C)(C)CNc1nccc(N2CCCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595908	176386	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	3	3	5	1.3	CC(C)(C)CNc1nccc(N2CCCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		10782821	96222	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	332	4	0	4	3.4	CCN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260850	96222	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	332	4	0	4	3.4	CCN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		164616851	184950	0	None	-446	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4853772	184950	0	None	-446	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		10591811	159353	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	9	1	2	4.7	c1ccc(-c2ccc(CCCOCCCc3c[nH]cn3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4100315	159353	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	9	1	2	4.7	c1ccc(-c2ccc(CCCOCCCc3c[nH]cn3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		1267	3804	49	None	-33	26	Human	7.6	pKi	=	7.6	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0341047
		3035905	3804	49	None	-33	26	Human	7.6	pKi	=	7.6	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0341047
		CHEMBL260374	3804	49	None	-33	26	Human	7.6	pKi	=	7.6	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0341047
		24804219	148563	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	378	6	2	5	4.2	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cccc2[nH]1	nan
		CHEMBL3938862	148563	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	378	6	2	5	4.2	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cccc2[nH]1	nan
		11565330	97220	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
		CHEMBL268525	97220	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
		1267	3804	49	None	-33	26	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2010.02.097
		3035905	3804	49	None	-33	26	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2010.02.097
		CHEMBL260374	3804	49	None	-33	26	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2010.02.097
		71525681	89728	0	None	-3	6	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	89728	0	None	-3	6	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		11846634	78009	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		CHEMBL209758	78009	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		57395496	68173	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915034	68173	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		51354302	58894	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688970	58894	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		25130235	187587	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		25130235	187587	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL494678	187587	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	187587	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		57390225	67882	0	None	-3235	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910384	67882	0	None	-3235	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		55251397	173264	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	2	1	6	0.3	CC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4525008	173264	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	2	1	6	0.3	CC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		53233803	61522	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770962	61522	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		11293460	84843	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	434	6	1	4	5.1	CN1CCN(CCCOc2ccc(-c3nc4c(ccc5ccccc54)[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL223490	84843	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	434	6	1	4	5.1	CN1CCN(CCCOc2ccc(-c3nc4c(ccc5ccccc54)[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		42624148	110146	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236574	110146	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
		11846300	80266	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm800876b
		CHEMBL213912	80266	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm800876b
		11846300	80266	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	80266	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		217674	179281	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL473098	179281	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		217674	179281	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL473098	179281	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		156009715	178320	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	601	8	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/c3cc4c5c(c3)CCCN5CCC4)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634631	178320	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	601	8	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/c3cc4c5c(c3)CCCN5CCC4)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4651103	178320	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	601	8	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/c3cc4c5c(c3)CCCN5CCC4)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		45257134	199943	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
		CHEMBL594949	199943	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
		155539562	172843	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	304	4	1	6	1.7	CN1CCN(c2nc(N)nc(CCC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL4514667	172843	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	304	4	1	6	1.7	CN1CCN(c2nc(N)nc(CCC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		10083188	140934	3	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL382276	140934	3	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		9927983	79852	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	341	1	0	4	4.2	CCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL1795042	79852	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	341	1	0	4	4.2	CCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL212212	79852	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	341	1	0	4	4.2	CCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		49841612	69734	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3cc(-c4ccc(C#N)cc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935568	69734	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3cc(-c4ccc(C#N)cc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		54587786	61530	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770970	61530	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		24825897	68110	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	1	1	6	2.2	CN1CCN(c2nc(N)nc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914759	68110	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	1	1	6	2.2	CN1CCN(c2nc(N)nc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		71519674	89729	0	None	-3	5	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	89729	0	None	-3	5	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		56851610	71627	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	5	2	3	3.8	CC(C)(C)N/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923031	71627	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	5	2	3	3.8	CC(C)(C)N/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963448	71627	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	5	2	3	3.8	CC(C)(C)N/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		127049856	140245	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805431	140245	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		10680721	5981	0	None	-23	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	225	6	2	3	1.9	CC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1080089	5981	0	None	-23	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	225	6	2	3	1.9	CC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL158085	5981	0	None	-23	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	225	6	2	3	1.9	CC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		753256	179350	12	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL473662	179350	12	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46228133	200054	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595639	200054	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		29136870	69021	7	None	-46	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		CHEMBL1923522	69021	7	None	-46	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		71519176	86483	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	2	5	2.5	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314759	86483	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	2	5	2.5	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		155545717	173469	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	238	3	2	2	2.6	c1ccc2[nH]c(C[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		CHEMBL4529871	173469	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	238	3	2	2	2.6	c1ccc2[nH]c(C[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		156015791	178244	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	442	8	1	3	4.6	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCN1CCc2nc[nH]c2C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4646286	178244	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	442	8	1	3	4.6	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCN1CCc2nc[nH]c2C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650609	178244	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	442	8	1	3	4.6	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCN1CCc2nc[nH]c2C1	10.1021/acs.jmedchem.0c00160
		24854638	155195	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL402470	155195	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCc2ccccc2)CC1	10.1021/jm7014217
		24854702	96057	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2cccnc2)CC1	10.1021/jm7014217
		CHEMBL259955	96057	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2cccnc2)CC1	10.1021/jm7014217
		24853592	156157	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	376	7	0	5	3.8	CN1CCN(c2nc3ccccc3nc2OCCCCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL406380	156157	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	376	7	0	5	3.8	CN1CCN(c2nc3ccccc3nc2OCCCCc2ccccc2)CC1	10.1021/jm7014217
		122193104	123888	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3627724	123888	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		137632569	156272	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	418	7	1	2	4.8	Ic1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4065099	156272	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	418	7	1	2	4.8	Ic1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		53233804	61526	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770966	61526	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		54583873	61529	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770969	61529	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		54584824	61537	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770977	61537	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		54585780	61558	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770998	61558	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		58227326	117128	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393542	117128	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
		9839217	72519	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		CHEMBL199062	72519	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		54583873	61529	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL1770969	61529	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		54585781	61561	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		CHEMBL1771000	61561	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		71551636	89673	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	263	4	1	5	1.4	CC(C)CCc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375772	89673	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	263	4	1	5	1.4	CC(C)CCc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		25129527	187414	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm301886t
		CHEMBL493720	187414	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm301886t
		46881855	7746	0	None	15	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089040	7746	0	None	15	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		10967174	19442	3	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129540	19442	3	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		46890166	7316	0	None	4786	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086105	7316	0	None	4786	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		1278	2150	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	2150	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	2150	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	2150	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		71603136	89715	0	None	46	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	3	2	5	2.3	CNC1CN(c2nc(N)nc3cc(C4CCCC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376790	89715	0	None	46	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	3	2	5	2.3	CNC1CN(c2nc(N)nc3cc(C4CCCC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		25109291	191386	10	None	-79	8	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		CHEMBL519240	191386	10	None	-79	8	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		127050309	140849	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	283	2	2	6	1.8	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1039/C6MD00108D
		CHEMBL3819470	140849	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	283	2	2	6	1.8	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1039/C6MD00108D
		53476465	68054	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	2	2	6	2.0	NCC1CN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914547	68054	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	2	2	6	2.0	NCC1CN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24737947	68127	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	283	2	2	6	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914776	68127	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	283	2	2	6	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1016/j.bmcl.2011.08.014
		25071004	192718	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL521996	192718	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		25071004	192718	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL521996	192718	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		11957573	2010	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		1250	2010	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		3692	2010	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL19439	2010	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		24826358	68096	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	1	2	6	2.4	Nc1nc(N2CC3CCNC3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914745	68096	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	1	2	6	2.4	Nc1nc(N2CC3CCNC3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25101945	193106	0	None	3	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL522673	193106	0	None	3	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		58227401	176451	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	176451	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	176451	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		25068753	188438	19	None	1	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL502347	188438	19	None	1	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		1278	2150	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	2150	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	2150	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	2150	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1267	3804	49	None	-33	26	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
		3035905	3804	49	None	-33	26	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
		CHEMBL260374	3804	49	None	-33	26	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
		21638785	188658	5	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		CHEMBL503605	188658	5	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		24994636	110137	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
		CHEMBL3236565	110137	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
		24826441	68105	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1cccc2oc3c(N4CCN(C)CC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		CHEMBL1914754	68105	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1cccc2oc3c(N4CCN(C)CC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		10244243	141313	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		CHEMBL383384	141313	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		73353369	89713	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	6	0.4	CN1CCN(c2nc(N)nc3cccnc23)CC1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376788	89713	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	6	0.4	CN1CCN(c2nc(N)nc3cccnc23)CC1	10.1016/j.bmcl.2013.02.091
		11846636	77952	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		CHEMBL209628	77952	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		155513612	176320	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	176320	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	176320	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	176320	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		206876	18945	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		CHEMBL128637	18945	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		206876	18945	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL128637	18945	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		11249610	157967	0	None	-6309	2	Human	4.5	pKi	=	4.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	354	9	2	5	3.6	Nc1ccc(NCCc2ccc(OCCCN3CCCCC3)cc2)nc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4084820	157967	0	None	-6309	2	Human	4.5	pKi	=	4.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	354	9	2	5	3.6	Nc1ccc(NCCc2ccc(OCCCN3CCCCC3)cc2)nc1	10.1016/j.ejmech.2016.09.074
		137634777	155976	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	453	8	3	6	1.0	CCOC(=O)CN1Cc2ccccc2C[C@@H](NC(=O)C(Cc2ccccc2)C(=O)NO)C1=O	10.1016/j.ejmech.2016.09.074
		CHEMBL4061504	155976	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	453	8	3	6	1.0	CCOC(=O)CN1Cc2ccccc2C[C@@H](NC(=O)C(Cc2ccccc2)C(=O)NO)C1=O	10.1016/j.ejmech.2016.09.074
		164611474	185452	0	None	-478	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	6	4	5	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1	10.1016/j.ejmech.2021.113190
		CHEMBL4861704	185452	0	None	-478	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	6	4	5	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1	10.1016/j.ejmech.2021.113190
		164619427	186069	0	None	-7	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	5	4	4	3.1	N/C(=N\C(=O)NCCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4871221	186069	0	None	-7	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	5	4	4	3.1	N/C(=N\C(=O)NCCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		164627774	186565	0	None	-58	6	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	344	3	4	4	1.4	N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		CHEMBL4878215	186565	0	None	-58	6	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	344	3	4	4	1.4	N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		24994634	2142	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	2142	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	2142	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		24994634	2142	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from guinea pig recombinant histamine H4 receptorDisplacement of [3H]histamine from guinea pig recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	2142	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from guinea pig recombinant histamine H4 receptorDisplacement of [3H]histamine from guinea pig recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	2142	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from guinea pig recombinant histamine H4 receptorDisplacement of [3H]histamine from guinea pig recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		155552341	176384	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	4	3	5	1.7	CC(C)(C)CNc1nccc(NC2CCNC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543928	176384	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	4	3	5	1.7	CC(C)(C)CNc1nccc(NC2CCNC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595906	176384	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	4	3	5	1.7	CC(C)(C)CNc1nccc(NC2CCNC2)n1	10.1021/acs.jmedchem.9b01342
		44129283	201027	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3ccc(Cl)c(Cl)c3n2)CC1	10.1021/jm901379s
		CHEMBL602330	201027	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3ccc(Cl)c(Cl)c3n2)CC1	10.1021/jm901379s
		11846299	139220	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
		CHEMBL378788	139220	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
		10934567	19258	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		CHEMBL129026	19258	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		10934567	19258	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		CHEMBL129026	19258	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		25128833	188402	38	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL501882	188402	38	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1016/j.bmcl.2011.10.104
		24826354	68140	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914790	68140	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		10934567	19258	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL129026	19258	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		16006947	139057	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL378619	139057	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		136030655	56482	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632413	56482	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		9923162	18940	6	None	199	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL128613	18940	6	None	199	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		170389	206981	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634086	206981	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL91353	206981	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1274	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
		3063228	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
		CHEMBL1196470	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
		170389	206981	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL4634086	206981	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL91353	206981	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		71681808	89648	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	3	8	3.1	CC(C)CNc1nccc(NCCN(C)c2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375748	89648	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	3	8	3.1	CC(C)CNc1nccc(NCCN(C)c2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		1274	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm201042n
		3063228	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm201042n
		CHEMBL1196470	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm201042n
		56851608	71630	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	334	6	2	3	4.3	c1nc(CCCS/C(=N\C2CCCC2)NC2CCCCC2)c[nH]1	10.1021/jm201042n
		CHEMBL1923030	71630	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	334	6	2	3	4.3	c1nc(CCCS/C(=N\C2CCCC2)NC2CCCCC2)c[nH]1	10.1021/jm201042n
		CHEMBL1963461	71630	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	334	6	2	3	4.3	c1nc(CCCS/C(=N\C2CCCC2)NC2CCCCC2)c[nH]1	10.1021/jm201042n
		1274	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
		3063228	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
		CHEMBL1196470	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
		1278	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		1279	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		4908365	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		CHEMBL129198	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		66572105	75637	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047263	75637	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572106	75638	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3c(Cl)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047264	75638	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3c(Cl)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573463	75671	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	2	3.1	Cc1cc(Cl)cc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047454	75671	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	2	3.1	Cc1cc(Cl)cc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		70696622	75686	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047469	75686	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10988959	118108	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL340740	118108	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10087533	196010	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	322	7	3	3	3.5	N=C(NCCc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202322	196010	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	322	7	3	3	3.5	N=C(NCCc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560068	196010	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	322	7	3	3	3.5	N=C(NCCc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		46929648	16759	0	None	-6	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		CHEMBL1243395	16759	0	None	-6	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		137650793	157442	0	None	-1096	2	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	484	7	1	4	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc(Br)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4078910	157442	0	None	-1096	2	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	484	7	1	4	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc(Br)c1	10.1016/j.ejmech.2016.09.074
		46912442	10904	0	None	-575	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	271	4	1	3	2.9	COc1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		CHEMBL1172775	10904	0	None	-575	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	271	4	1	3	2.9	COc1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		57392460	69866	0	None	14	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938843	69866	0	None	14	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.bmcl.2011.11.098
		136192886	56480	0	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632411	56480	0	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1248	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		3077	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		90045	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		CHEMBL12344	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		1239	2033	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1240	2033	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		912	2033	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL268490	2033	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		71681976	89651	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	5	4	5	2.0	Nc1nccc(NCCNC(=O)c2cc3cc(Cl)ccc3[nH]2)n1	10.1021/jm301886t
		CHEMBL2375751	89651	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	5	4	5	2.0	Nc1nccc(NCCNC(=O)c2cc3cc(Cl)ccc3[nH]2)n1	10.1021/jm301886t
		10023327	169016	0	None	-144	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	169016	0	None	-144	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11622672	75019	2	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	1	2	2.6	c1nc(CCCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL203389	75019	2	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	1	2	2.6	c1nc(CCCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		11679919	75541	0	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL204413	75541	0	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		11701199	75572	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	1	2	2.1	CCN(CC)CCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL204615	75572	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	1	2	2.1	CCN(CC)CCCCc1c[nH]cn1	10.1021/jm0504353
		1248	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		3077	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		90045	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		CHEMBL12344	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		4060730	19379	56	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL129199	19379	56	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		10377814	75642	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3c(N)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047268	75642	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3c(N)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1248	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		3077	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		90045	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		CHEMBL12344	1424	28	None	-15	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		4563101	66758	11	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	265	4	2	2	2.1	CN(C)CCNC(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL185842	66758	11	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	265	4	2	2	2.1	CN(C)CCNC(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		71681977	89652	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	344	5	3	5	2.4	CN(CCNc1ccnc(N)n1)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1021/jm301886t
		CHEMBL2375752	89652	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	344	5	3	5	2.4	CN(CCNc1ccnc(N)n1)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1021/jm301886t
		71681479	89660	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	393	9	5	9	2.7	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375760	89660	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	393	9	5	9	2.7	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		3063453	12772	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	189	5	5	3	-0.1	N=C(N)NCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL1187950	12772	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	189	5	5	3	-0.1	N=C(N)NCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL534498	12772	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	189	5	5	3	-0.1	N=C(N)NCCCCSC(=N)N	10.1021/jm060880d
		112936341	137474	1	None	-12	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753849	137474	1	None	-12	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		164628701	186467	0	None	-186	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	5	4	4	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4876743	186467	0	None	-186	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	5	4	4	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1	10.1016/j.ejmech.2021.113190
		57402928	69865	0	None	9	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	0	4	1.4	CN1CCN(C(=O)c2cn3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938842	69865	0	None	9	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	0	4	1.4	CN1CCN(C(=O)c2cn3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.11.098
		121238071	167240	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	271	2	1	7	0.3	CN1CCN(c2nc(N)nc(-c3ccncc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4292486	167240	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	271	2	1	7	0.3	CN1CCN(c2nc(N)nc(-c3ccncc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		11120826	18918	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128505	18918	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		11120826	18918	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128505	18918	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0341047
		49841720	69723	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3c(-c4ccccc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935557	69723	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3c(-c4ccccc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		44275465	99221	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL281590	99221	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		46890545	7385	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086460	7385	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		11120826	18918	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128505	18918	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
		57399829	68330	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	235	7	2	5	1.3	CN(C)CCNc1cc(NCC2CC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916505	68330	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	235	7	2	5	1.3	CN(C)CCNc1cc(NCC2CC2)ncn1	10.1016/j.bmcl.2011.07.114
		44126357	115915	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(N)nc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354813	115915	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(N)nc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		57393772	68177	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Br)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915041	68177	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Br)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		24854637	96319	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc3ccccc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL261363	96319	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc3ccccc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		11738520	139266	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1O2	10.1021/jm051008s
		CHEMBL1794919	139266	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1O2	10.1021/jm051008s
		CHEMBL379044	139266	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1O2	10.1021/jm051008s
		60150162	173866	0	None	-524	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	479	16	2	4	4.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		CHEMBL4539444	173866	0	None	-524	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	479	16	2	4	4.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		164624107	185722	0	None	-70	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4865765	185722	0	None	-70	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
		164608941	184383	0	None	-75	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4845733	184383	0	None	-75	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		57392890	68316	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	370	7	1	5	2.5	COc1cccc(C(O)(COc2ccccc2C)CN2CCN(C)CC2)c1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916492	68316	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	370	7	1	5	2.5	COc1cccc(C(O)(COc2ccccc2C)CN2CCN(C)CC2)c1	10.1016/j.bmcl.2011.07.114
		21029584	188866	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncnc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL506969	188866	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncnc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		1267	3804	49	None	-33	26	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014777
		3035905	3804	49	None	-33	26	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014777
		CHEMBL260374	3804	49	None	-33	26	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014777
		90655029	110135	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.4	Nc1nc(C2CCCC2)cc(N2C[C@@H]3CNC[C@@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236563	110135	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.4	Nc1nc(C2CCCC2)cc(N2C[C@@H]3CNC[C@@H]3C2)n1	10.1021/jm401727m
		71518862	86498	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	342	2	2	5	2.6	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314775	86498	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	342	2	2	5	2.6	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		44547567	117119	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393533	117119	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		24826163	68166	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915020	68166	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		57393773	68179	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	1	7	1.8	CN1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915044	68179	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	1	7	1.8	CN1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		11572877	67080	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL187285	67080	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		44129210	199485	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	7	2	7	1.4	CNS(=O)(=O)CCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591711	199485	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	7	2	7	1.4	CNS(=O)(=O)CCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		156015638	178272	0	None	-58	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	178272	0	None	-58	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	178272	0	None	-58	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		25179127	189079	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL509852	189079	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25179127	189079	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL509852	189079	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		71518863	86499	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	338	3	2	6	2.0	COc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314776	86499	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	338	3	2	6	2.0	COc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		8070960	155692	10	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	258	2	0	5	1.4	COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL405044	155692	10	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	258	2	0	5	1.4	COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		25130576	187626	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		25130576	187626	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		CHEMBL494890	187626	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		CHEMBL494890	187626	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		86277887	123811	26	None	-	1	Human	5.5	pKi	=	5.5	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL	802	18	0	11	7.4	COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@H](c2cc(OC)c(OC)c(OC)c2)C2CCCCC2)c2cccc(OCCN3CCOCC3)c2)cc1OC	10.6019/CHEMBL5058648
		CHEMBL3623630	123811	26	None	-	1	Human	5.5	pKi	=	5.5	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL	802	18	0	11	7.4	COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@H](c2cc(OC)c(OC)c(OC)c2)C2CCCCC2)c2cccc(OCCN3CCOCC3)c2)cc1OC	10.6019/CHEMBL5058648
		168294445	193010	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208113	193010	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222768	193010	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		25130235	187587	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		25130235	187587	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL494678	187587	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	187587	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		46228076	202100	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	354	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(C(C)(C)C)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL608864	202100	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	354	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(C(C)(C)C)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46228158	202158	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL609289	202158	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		57402514	68175	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Br)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915039	68175	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Br)cc3c2n1	10.1016/j.bmcl.2011.08.014
		164619039	186148	0	None	-17	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	4	4	4	3.0	N/C(=N\C(=O)NCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4872277	186148	0	None	-17	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	4	4	4	3.0	N/C(=N\C(=O)NCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		57392889	68315	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	379	4	1	5	2.2	CN1CCN(c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916491	68315	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	379	4	1	5	2.2	CN1CCN(c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		25130235	187587	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL494678	187587	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		57393774	68180	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.4	Nc1nc(N2CCNCC2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915045	68180	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.4	Nc1nc(N2CCNCC2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		10083188	140934	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL382276	140934	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
		1278	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		1279	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		4908365	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		CHEMBL129198	2150	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		71603137	89716	0	None	23	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	1	2	5	1.9	CC(C)(C)c1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376791	89716	0	None	23	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	1	2	5	1.9	CC(C)(C)c1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25179125	189024	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL509142	189024	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25179125	189024	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL509142	189024	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		127051047	140311	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806162	140311	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		7015108	199906	8	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	3	0	7	1.7	CN1CCN(c2ncnc3c2nnn3Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594729	199906	8	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	3	0	7	1.7	CN1CCN(c2ncnc3c2nnn3Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2009.08.059
		46228070	199725	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	271	4	0	5	1.1	CN1CCN(Cc2cn(Cc3ccccc3)nn2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593448	199725	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	271	4	0	5	1.1	CN1CCN(Cc2cn(Cc3ccccc3)nn2)CC1	10.1016/j.bmc.2009.08.059
		122193100	123919	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	314	3	1	6	1.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc(F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628047	123919	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	314	3	1	6	1.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc(F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		155513612	176320	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		127050018	140768	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	221	2	2	5	0.5	CN[C@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1039/C6MD00108D
		CHEMBL3818402	140768	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	221	2	2	5	0.5	CN[C@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1039/C6MD00108D
		24994950	110153	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.5	CN[C@@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1021/jm401727m
		CHEMBL3236580	110153	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.5	CN[C@@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1021/jm401727m
		54583875	61555	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770995	61555	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		90655028	110129	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236557	110129	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@H](N)C2)n1	10.1021/jm401727m
		59777262	110144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236572	110144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
		155512725	176241	0	None	154	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	176241	0	None	154	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	176241	0	None	154	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		46929553	16753	0	None	-5	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2cccnc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		CHEMBL1243366	16753	0	None	-5	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2cccnc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		71519011	86464	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	376	2	2	5	3.3	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)c(Cl)c4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314496	86464	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	376	2	2	5	3.3	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)c(Cl)c4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		24826598	68169	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	2	7	1.9	COc1ccc2oc3c(N4CCC[C@H](N)C4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915027	68169	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	2	7	1.9	COc1ccc2oc3c(N4CCC[C@H](N)C4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		25178939	186850	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm800876b
		CHEMBL489464	186850	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm800876b
		24853529	96123	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	336	3	0	5	3.5	CN1CCN(c2nc3ccccc3nc2Sc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260388	96123	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	336	3	0	5	3.5	CN1CCN(c2nc3ccccc3nc2Sc2ccccc2)CC1	10.1021/jm7014217
		25178939	186850	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm901379s
		CHEMBL489464	186850	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm901379s
		164611757	184903	0	None	-50	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4853107	184903	0	None	-50	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		112936357	137359	1	None	-18	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752978	137359	1	None	-18	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		71519346	86488	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	2	6	-0.0	Cn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		CHEMBL2314764	86488	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	2	6	-0.0	Cn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		58227144	117141	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2cnnc(NC3CC4CCC3C4)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393555	117141	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2cnnc(NC3CC4CCC3C4)c2)CC1	10.1016/j.bmcl.2014.12.027
		57399018	68182	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	332	1	1	7	2.1	CN1CCCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915047	68182	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	332	1	1	7	2.1	CN1CCCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		16082831	80346	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL214311	80346	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		25178554	173427	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm800876b
		CHEMBL452870	173427	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm800876b
		25178554	173427	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm901379s
		CHEMBL452870	173427	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm901379s
		164610892	185198	0	None	-52	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4857560	185198	0	None	-52	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
		71518864	86500	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	Cc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314777	86500	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	Cc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		122194626	124022	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629829	124022	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2015.08.014
		57399019	68186	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	2	2	7	1.4	NCC1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915051	68186	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	2	2	7	1.4	NCC1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		90645146	112177	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	288	2	1	6	1.0	CN1CCN(c2nc(N)nc(-c3ccc(F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290577	112177	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	288	2	1	6	1.0	CN1CCN(c2nc(N)nc(-c3ccc(F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		54584374	63124	0	None	-6	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774590	63124	0	None	-6	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789360	63124	0	None	-6	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		122193105	123923	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628051	123923	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		921599	19455	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0341047
		CHEMBL129660	19455	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0341047
		921599	19455	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0502081
		CHEMBL129660	19455	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0502081
		4060730	19379	56	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL129199	19379	56	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.02.097
		25178553	173426	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm800876b
		CHEMBL452869	173426	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm800876b
		25178553	173426	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm901379s
		CHEMBL452869	173426	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm901379s
		11846465	141932	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
		CHEMBL387054	141932	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
		56851606	71600	0	None	-11	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	432	8	2	3	5.7	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1923029	71600	0	None	-11	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	432	8	2	3	5.7	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1963244	71600	0	None	-11	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	432	8	2	3	5.7	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		51354877	58909	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCc2cn(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688988	58909	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCc2cn(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		137658819	159310	0	None	-7585	2	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	467	9	1	5	3.9	COc1cc2c(cc1OC)C(C)=C(C(=O)NCCCCN1CCN(c3ccccc3F)CC1)C2	10.1016/j.ejmech.2016.09.074
		CHEMBL4099779	159310	0	None	-7585	2	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	467	9	1	5	3.9	COc1cc2c(cc1OC)C(C)=C(C(=O)NCCCCN1CCN(c3ccccc3F)CC1)C2	10.1016/j.ejmech.2016.09.074
		54584374	63124	0	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774590	63124	0	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789360	63124	0	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		58227207	117137	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393551	117137	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		51354872	60199	0	None	-323	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	291	6	0	5	2.1	c1c(CN2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		CHEMBL1688983	60199	0	None	-323	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	291	6	0	5	2.1	c1c(CN2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		CHEMBL1739923	60199	0	None	-323	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	291	6	0	5	2.1	c1c(CN2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		68081433	110123	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	248	1	1	3	0.7	CN1CCN(C(=O)c2nc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		CHEMBL3236551	110123	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	248	1	1	3	0.7	CN1CCN(C(=O)c2nc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		57399747	68137	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	2	2	6	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914787	68137	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	2	2	6	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)C1	10.1016/j.bmcl.2011.08.014
		25129169	187181	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		CHEMBL492231	187181	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		25129169	187181	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL492231	187181	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		3032915	15495	24	None	-1	6	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL12160	15495	24	None	-1	6	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		71681806	89645	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	331	8	4	9	1.0	CC(C)CNc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375667	89645	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	331	8	4	9	1.0	CC(C)CNc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		71681639	89662	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	321	6	3	7	2.3	Cc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375762	89662	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	321	6	3	7	2.3	Cc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		11492393	4060	6	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	7	2	2	3.0	C(CCc1cnc[nH]1)CCNC1CCCCC1	10.1021/jm0504353
		1263	4060	6	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	7	2	2	3.0	C(CCc1cnc[nH]1)CCNC1CCCCC1	10.1021/jm0504353
		CHEMBL206346	4060	6	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	7	2	2	3.0	C(CCc1cnc[nH]1)CCNC1CCCCC1	10.1021/jm0504353
		11557610	74447	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	7	2	2	2.7	c1nc(CCCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL202744	74447	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	7	2	2	2.7	c1nc(CCCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		11615406	139492	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	2	2	2.3	c1nc(CCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL379447	139492	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	2	2	2.3	c1nc(CCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		66572116	75660	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	2	2	1.5	Cc1cccc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047443	75660	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	2	2	1.5	Cc1cccc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		70681961	75672	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.6	CN1CCCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047455	75672	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.6	CN1CCCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70696621	75679	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	2	2.2	O=C(c1cc2cccc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047462	75679	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	2	2.2	O=C(c1cc2cccc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		70692531	75692	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.0	Cc1ccc(F)c2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047475	75692	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.0	Cc1ccc(F)c2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		24759623	96349	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm800876b
		CHEMBL261551	96349	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm800876b
		25129169	187181	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		CHEMBL492231	187181	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		24759623	96349	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL261551	96349	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		10429016	196160	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	366	7	3	3	3.6	N=C(NCCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL561250	196160	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	366	7	3	3	3.6	N=C(NCCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1223	953	41	None	-60	11	Human	7.4	pKi	=	7.4	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-60	11	Human	7.4	pKi	=	7.4	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-60	11	Human	7.4	pKi	=	7.4	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		71519012	86465	0	None	218	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.8	Nc1nc(N2CCNCC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314497	86465	0	None	218	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.8	Nc1nc(N2CCNCC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		10934158	108577	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL320331	108577	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		71681478	89659	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	4	8	3.2	CC(C)CCc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375759	89659	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	4	8	3.2	CC(C)CCc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		11629829	76022	0	None	-19	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	5	1	2	2.2	c1nc(CCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL205583	76022	0	None	-19	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	5	1	2	2.2	c1nc(CCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		25831	13008	28	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	144	3	6	2	-2.0	N=C(N)NCCNC(=N)N	10.1021/jm060880d
		CHEMBL1189742	13008	28	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	144	3	6	2	-2.0	N=C(N)NCCNC(=N)N	10.1021/jm060880d
		CHEMBL539343	13008	28	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	144	3	6	2	-2.0	N=C(N)NCCNC(=N)N	10.1021/jm060880d
		1278	2150	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		1279	2150	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		4908365	2150	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		CHEMBL129198	2150	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		66573456	75662	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	2	2	2	1.5	CNC1CN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047445	75662	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	2	2	2	1.5	CNC1CN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		43398194	75673	25	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	CN1CCCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047456	75673	25	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	CN1CCCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70694582	75677	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047460	75677	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70686223	75682	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	2	2	2	1.4	CNC1CN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047465	75682	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	2	2	2	1.4	CNC1CN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		70692530	75691	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047474	75691	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1238	2082	13	None	-19	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		6603865	2082	13	None	-19	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		CHEMBL11919	2082	13	None	-19	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		44417445	12802	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	217	7	5	3	0.7	N=C(N)NCCCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL1188154	12802	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	217	7	5	3	0.7	N=C(N)NCCCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL535387	12802	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	217	7	5	3	0.7	N=C(N)NCCCCCCSC(=N)N	10.1021/jm060880d
		66572102	75634	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ncccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047260	75634	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ncccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		24854634	156156	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	400	4	0	4	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2CCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL406379	156156	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	400	4	0	4	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2CCc2ccccc2)CC1	10.1021/jm7014217
		24853528	167082	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	329	6	0	6	1.7	CN(C)CCCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL428964	167082	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	329	6	0	6	1.7	CN(C)CCCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		137659490	159196	0	None	11	2	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	420	7	1	2	6.1	Brc1ccc(C(OCCCc2c[nH]cn2)c2ccc3ccccc3c2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4098585	159196	0	None	11	2	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	420	7	1	2	6.1	Brc1ccc(C(OCCCc2c[nH]cn2)c2ccc3ccccc3c2)cc1	10.1016/j.ejmech.2016.09.074
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		24803709	145930	1	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cc(F)cc2[nH]1	nan
		CHEMBL3917992	145930	1	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cc(F)cc2[nH]1	nan
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		49841846	69738	0	None	18	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935572	69738	0	None	18	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		44129130	199556	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL592379	199556	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.10.104
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		24745337	61539	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770979	61539	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		58227340	117118	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393532	117118	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	2150	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	2150	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	2150	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		44129133	199385	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	398	6	2	7	1.0	CNS(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591011	199385	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	398	6	2	7	1.0	CNS(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		1223	953	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2011.03.046
		2790	953	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2011.03.046
		CHEMBL14690	953	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2011.03.046
		1223	953	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmcl.2009.10.005
		2790	953	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmcl.2009.10.005
		CHEMBL14690	953	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmcl.2009.10.005
		25129169	187181	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL492231	187181	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		44129134	199508	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591969	199508	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25129169	187181	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		CHEMBL492231	187181	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		1278	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		1279	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		4908365	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		24745506	68219	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915537	68219	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		136042266	69911	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		CHEMBL1938975	69911	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		136042268	69913	0	None	186	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938977	69913	0	None	186	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		25068753	188438	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL502347	188438	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		1278	2150	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		1279	2150	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		4908365	2150	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		CHEMBL129198	2150	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		25068753	188438	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL502347	188438	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		2063135	8378	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1093180	8378	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		24826437	68097	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@H]3CCCN[C@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914746	68097	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@H]3CCCN[C@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25128823	192717	0	None	2	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		CHEMBL521995	192717	0	None	2	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		1204	1932	119	None	-3	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	1932	119	None	-3	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	1932	119	None	-3	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	1932	119	None	-3	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	1932	119	None	-3	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	1932	119	None	-3	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1278	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		1279	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		4908365	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		CHEMBL129198	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		44129130	199556	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592379	199556	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		54581941	61557	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	288	2	2	6	0.8	Nc1nc(N2CCCC2)cc(N2CC3CCCNC3C2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770997	61557	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	288	2	2	6	0.8	Nc1nc(N2CCCC2)cc(N2CC3CCCNC3C2)n1	10.1016/j.bmcl.2011.03.017
		24826680	68128	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914777	68128	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		11601630	132817	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL370135	132817	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		137640214	156967	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	394	6	1	2	5.5	O=C(NCCCCN1Cc2cccc3cccc(c23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4072893	156967	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	394	6	1	2	5.5	O=C(NCCCCN1Cc2cccc3cccc(c23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2016.09.074
		71519013	86466	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	3	2	5	2.5	CCN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314498	86466	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	3	2	5	2.5	CCN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		168284289	192906	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5194860	192906	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222123	192906	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		3076002	179282	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL473099	179282	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		3076002	179282	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL473099	179282	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		90645150	112173	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290573	112173	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		25130576	187626	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		25130576	187626	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		CHEMBL494890	187626	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		CHEMBL494890	187626	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		10018335	72012	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL197477	72012	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		57393771	68174	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	311	2	2	7	1.5	COc1ccc2oc3c(N4C[C@@H]5C[C@H]4CN5)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915035	68174	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	311	2	2	7	1.5	COc1ccc2oc3c(N4C[C@@H]5C[C@H]4CN5)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		10545988	63147	0	None	-93	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774593	63147	0	None	-93	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789558	63147	0	None	-93	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		46228071	200178	18	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL596562	200178	18	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmc.2009.08.059
		1204	1932	119	None	-15	24	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	1932	119	None	-15	24	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	1932	119	None	-15	24	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	1932	119	None	-15	24	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	1932	119	None	-15	24	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	1932	119	None	-15	24	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		46890590	7024	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084810	7024	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		57400735	68168	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	2	6	2.9	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915026	68168	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	2	6	2.9	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		56851441	71599	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	7	2	3	4.2	c1ccc(CN/C(=N/C2CCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923023	71599	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	7	2	3	4.2	c1ccc(CN/C(=N/C2CCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963243	71599	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	7	2	3	4.2	c1ccc(CN/C(=N/C2CCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		25147772	173409	9	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL452847	173409	9	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2015.12.035
		16061961	199679	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593103	199679	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		10381810	205174	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL7828	205174	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		137647794	157981	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	464	8	1	6	4.2	COc1ccc2c(c1)c(CC(=O)NCCCn1ccnc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4085023	157981	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	464	8	1	6	4.2	COc1ccc2c(c1)c(CC(=O)NCCCn1ccnc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		10545988	63147	0	None	-93	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774593	63147	0	None	-93	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789558	63147	0	None	-93	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		122193096	123915	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628043	123915	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		90645154	112181	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	1.9	CN1CCN(c2nc(N)nc(-c3ccc(C(F)(F)F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290581	112181	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	1.9	CN1CCN(c2nc(N)nc(-c3ccc(C(F)(F)F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		10777275	5895	1	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079553	5895	1	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL156005	5895	1	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		1267	3804	49	None	-33	26	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2013.06.075
		3035905	3804	49	None	-33	26	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2013.06.075
		CHEMBL260374	3804	49	None	-33	26	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2013.06.075
		127036978	137281	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752225	137281	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		164612037	185377	0	None	-81283	20	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4860528	185377	0	None	-81283	20	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		1224	1432	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		3100	1432	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		8980	1432	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		916	1432	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		CHEMBL657	1432	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		DB01075	1432	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		9883231	113386	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.0	CN1CCN(C(=O)c2nc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL331773	113386	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.0	CN1CCN(C(=O)c2nc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		1267	3804	49	None	-33	26	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.03.046
		3035905	3804	49	None	-33	26	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.03.046
		CHEMBL260374	3804	49	None	-33	26	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.03.046
		1267	3804	49	None	-33	26	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2009.10.005
		3035905	3804	49	None	-33	26	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2009.10.005
		CHEMBL260374	3804	49	None	-33	26	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2009.10.005
		24992735	110155	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
		CHEMBL3236582	110155	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
		24826081	68113	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914762	68113	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		90645153	112180	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290580	112180	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2014.06.032
		25178344	186886	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489664	186886	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10934158	108577	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL320331	108577	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		24853593	96058	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccncc2)CC1	10.1021/jm7014217
		CHEMBL259956	96058	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccncc2)CC1	10.1021/jm7014217
		54586765	61542	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(NCCO)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770982	61542	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(NCCO)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		44275465	99221	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2013.02.091
		CHEMBL281590	99221	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2013.02.091
		24826080	68115	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	1	1	6	3.2	CN1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914764	68115	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	1	1	6	3.2	CN1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		71519349	86491	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	6	1.8	Cn1c(-c2ccc(F)cc2)cc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		CHEMBL2314767	86491	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	6	1.8	Cn1c(-c2ccc(F)cc2)cc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		57393770	68171	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915031	68171	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		155534519	176483	0	None	-47	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	288	7	3	5	2.7	CC(C)(C)CNc1nccc(NCCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4470527	176483	0	None	-47	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	288	7	3	5	2.7	CC(C)(C)CNc1nccc(NCCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596640	176483	0	None	-47	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	288	7	3	5	2.7	CC(C)(C)CNc1nccc(NCCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		51354873	58906	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688984	58906	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		51354874	58907	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	335	6	1	4	3.5	Clc1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1Cl	10.1021/jm1013488
		CHEMBL1688985	58907	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	335	6	1	4	3.5	Clc1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1Cl	10.1021/jm1013488
		168292954	192997	0	None	-112	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5202592	192997	0	None	-112	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222660	192997	0	None	-112	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		11779175	63166	0	None	-5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774600	63166	0	None	-5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789801	63166	0	None	-5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		164612760	184718	0	None	-38	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4850490	184718	0	None	-38	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		11779175	63166	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774600	63166	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789801	63166	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		58227085	117131	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393545	117131	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		1267	3804	49	None	-33	26	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1039/C8MD00527C
		3035905	3804	49	None	-33	26	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1039/C8MD00527C
		CHEMBL260374	3804	49	None	-33	26	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1039/C8MD00527C
		11846464	78460	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
		CHEMBL211170	78460	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
		118720433	115910	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	206	3	1	4	0.8	CCc1cc(N2CC[C@@H](NC)C2)ncn1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354807	115910	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	206	3	1	4	0.8	CCc1cc(N2CC[C@@H](NC)C2)ncn1	10.1016/j.bmcl.2014.10.013
		51354581	58897	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	275	10	1	4	3.1	CCCCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		CHEMBL1688973	58897	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	275	10	1	4	3.1	CCCCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		9877454	205613	2	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL81644	205613	2	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		1613	2348	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		205	2348	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		3964	2348	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		CHEMBL831	2348	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		DB00408	2348	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		164609493	184436	0	None	-2630	6	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
		CHEMBL4846380	184436	0	None	-2630	6	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
		71518698	86493	2	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	218	1	3	5	-0.1	Nc1nc(N2CCNCC2)c2cc[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314770	86493	2	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	218	1	3	5	-0.1	Nc1nc(N2CCNCC2)c2cc[nH]c2n1	10.1016/j.bmcl.2012.10.139
		4242975	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		CHEMBL128088	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		4242975	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		CHEMBL128088	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		16061961	199679	0	None	7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593103	199679	0	None	7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		11258458	83453	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		CHEMBL219930	83453	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		57398183	68052	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	347	4	3	7	1.8	Nc1nc(N2CC[C@@H](NCCO)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914545	68052	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	347	4	3	7	1.8	Nc1nc(N2CC[C@@H](NCCO)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		4242975	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL128088	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		118720438	115916	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	220	3	1	4	1.4	CN[C@@H]1CCN(c2ccnc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354814	115916	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	220	3	1	4	1.4	CN[C@@H]1CCN(c2ccnc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		24854640	96059	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccccn2)CC1	10.1021/jm7014217
		CHEMBL259957	96059	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccccn2)CC1	10.1021/jm7014217
		135589846	141820	3	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	356	2	2	5	3.1	OCCN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL386333	141820	3	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	356	2	2	5	3.1	OCCN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1021/jm051008s
		24826439	68122	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	2	2	7	1.4	COc1cccc2oc3c(N4CCNCC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		CHEMBL1914771	68122	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	2	2	7	1.4	COc1cccc2oc3c(N4CCNCC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		10446295	2132	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
		1277	2132	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
		CHEMBL185951	2132	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
		10446295	2132	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
		1277	2132	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL185951	2132	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
		10023327	169016	0	None	-144	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	169016	0	None	-144	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		1267	3804	49	None	-33	26	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		3035905	3804	49	None	-33	26	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		CHEMBL260374	3804	49	None	-33	26	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		155556721	174554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	248	2	1	6	0.6	CC(C)=Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4556243	174554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	248	2	1	6	0.6	CC(C)=Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		24854639	96135	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	5	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260458	96135	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	5	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCCc2ccccc2)CC1	10.1021/jm7014217
		11344458	205198	2	None	-14	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78497	205198	2	None	-14	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		51354588	60171	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	6	0	5	2.1	c1c(CC2CCCCC2)nnn1CCCN1CCOCC1	10.1021/jm1013488
		CHEMBL1688980	60171	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	6	0	5	2.1	c1c(CC2CCCCC2)nnn1CCCN1CCOCC1	10.1021/jm1013488
		CHEMBL1739759	60171	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	6	0	5	2.1	c1c(CC2CCCCC2)nnn1CCCN1CCOCC1	10.1021/jm1013488
		16106	118146	34	None	-20	12	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL340801	118146	34	None	-20	12	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	10.1021/jm051008s
		46881855	7746	0	None	-15	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089040	7746	0	None	-15	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		71519014	86467	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	2	5	2.9	CC(C)N1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314499	86467	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	2	5	2.9	CC(C)N1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		122193094	123913	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628041	123913	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		155513612	176320	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	176320	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	176320	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	176320	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		45379808	201219	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	362	5	2	6	1.6	CC(=O)NCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL603621	201219	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	362	5	2	6	1.6	CC(=O)NCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		168286426	192926	0	None	-109	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5198795	192926	0	None	-109	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222241	192926	0	None	-109	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		164620139	185788	0	None	-56	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	436	8	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4866734	185788	0	None	-56	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	436	8	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		136042267	69912	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938976	69912	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		11623296	117023	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338972	117023	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
		11066922	19423	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL129436	19423	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		11066922	19423	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129436	19423	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0341047
		49841845	69739	0	None	19	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935573	69739	0	None	19	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		25068753	188438	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.10.104
		CHEMBL502347	188438	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.10.104
		1223	953	41	None	-60	11	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm7014777
		2790	953	41	None	-60	11	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm7014777
		CHEMBL14690	953	41	None	-60	11	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm7014777
		1278	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		1278	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		1279	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		1279	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		4908365	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		4908365	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		CHEMBL129198	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		CHEMBL129198	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		58227086	117143	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393557	117143	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		1278	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		1279	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		4908365	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		CHEMBL129198	2150	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		2063135	8378	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1021/jm401727m
		CHEMBL1093180	8378	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1021/jm401727m
		23650959	110121	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	410	7	1	4	5.3	Cc1cnc(OCCCCC2CCN(C)CC2)cc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/jm401727m
		CHEMBL3236548	110121	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	410	7	1	4	5.3	Cc1cnc(OCCCCC2CCN(C)CC2)cc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/jm401727m
		11066922	19423	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129436	19423	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
		155524115	176547	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	176547	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	176547	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		70696620	75667	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	1	2	3	1.8	CN1CCN(C(=O)c2cc3cc(Cl)cc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047450	75667	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	1	2	3	1.8	CN1CCN(C(=O)c2cc3cc(Cl)cc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		25129523	187287	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL492884	187287	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		76311195	106051	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	284	2	2	6	1.1	CN1CCN(c2cc(-c3ccc(N)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL3133130	106051	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	284	2	2	6	1.1	CN1CCN(c2cc(-c3ccc(N)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		25129523	187287	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL492884	187287	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		25128824	193178	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		CHEMBL523225	193178	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		155524115	176547	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	176547	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	176547	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		25128824	193178	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		CHEMBL523225	193178	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		25071004	192718	0	None	-1	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL521996	192718	0	None	-1	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		11705395	16052	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		CHEMBL1223749	16052	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		24826162	68142	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914792	68142	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		71519674	89729	0	None	1	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	89729	0	None	1	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		46890072	6910	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084355	6910	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		24994634	2142	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	2142	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	2142	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		24994634	2142	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	2142	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	2142	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		44129056	199600	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	474	7	1	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592663	199600	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	474	7	1	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25128822	187481	0	None	10	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		CHEMBL494093	187481	0	None	10	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		11554490	16053	0	None	-5	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.3	FC(F)(F)c1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL1223750	16053	0	None	-5	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.3	FC(F)(F)c1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1	10.1016/j.ejmech.2016.09.074
		24797956	110130	3	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		CHEMBL3236558	110130	3	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		24825514	186855	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	256	4	1	2	3.6	CC(C)(C)CC(=O)c1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		CHEMBL489493	186855	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	256	4	1	2	3.6	CC(C)(C)CC(=O)c1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		24825515	187317	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	238	2	1	1	3.4	CC(C)(C)C#Cc1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		CHEMBL493014	187317	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	238	2	1	1	3.4	CC(C)(C)C#Cc1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		11301441	96154	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm800876b
		CHEMBL260549	96154	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm800876b
		11301441	96154	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm7014217
		CHEMBL260549	96154	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm7014217
		24825791	68055	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914548	68055	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25109291	191386	10	None	-501	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		CHEMBL519240	191386	10	None	-501	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		45379922	199563	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	552	7	2	7	2.8	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(I)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592434	199563	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	552	7	2	7	2.8	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(I)ccc3n2)CC1	10.1021/jm901379s
		54585777	61534	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	5	3	5	2.1	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770974	61534	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	5	3	5	2.1	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)c2)C1	10.1016/j.bmcl.2011.03.017
		118720441	115920	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	3	4	2.5	Nc1cc(C2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354819	115920	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	3	4	2.5	Nc1cc(C2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		24826518	68104	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2cccc(C(F)(F)F)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914753	68104	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2cccc(C(F)(F)F)c23)CC1	10.1016/j.bmcl.2011.08.014
		1278	2150	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		1279	2150	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		4908365	2150	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		CHEMBL129198	2150	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		136192886	56480	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632411	56480	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		136141537	56481	3	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632412	56481	3	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		71525678	89725	0	None	-5	6	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	89725	0	None	-5	6	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		1267	3804	49	None	-14	26	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		3035905	3804	49	None	-14	26	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		CHEMBL260374	3804	49	None	-14	26	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		1223	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1269	121	41	None	213	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
		37463	121	41	None	213	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL275443	121	41	None	213	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
		1255	3195	19	None	-12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
		6421522	3195	19	None	-12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
		CHEMBL19173	3195	19	None	-12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
		10017000	204485	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
		CHEMBL72431	204485	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
		1223	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	953	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		71681644	89667	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	412	9	4	8	3.8	CC(C)CNc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375767	89667	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	412	9	4	8	3.8	CC(C)CNc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		71681805	89672	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	426	9	3	8	3.8	CC(C)CNc1nccc(NCCN(C)c2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375771	89672	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	426	9	3	8	3.8	CC(C)CNc1nccc(NCCN(C)c2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		11506928	74442	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	2	2	3.0	c1nc(CCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL202728	74442	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	2	2	3.0	c1nc(CCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		11600779	76048	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205731	76048	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		11536119	138707	0	None	-15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	249	7	2	2	3.4	c1nc(CCCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL377954	138707	0	None	-15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	249	7	2	2	3.4	c1nc(CCCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		4242975	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL128088	18842	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		45379921	199203	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	426	6	1	7	3.6	CN1CCN(c2nc(NCCc3ccc([N+](=O)[O-])cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL589800	199203	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	426	6	1	7	3.6	CN1CCN(c2nc(NCCc3ccc([N+](=O)[O-])cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		9972181	195217	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	8	3	3	3.2	N=C(NCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202331	195217	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	8	3	3	3.2	N=C(NCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL550757	195217	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	8	3	3	3.2	N=C(NCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		10063835	63123	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774601	63123	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789356	63123	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		46890200	7160	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	442	9	1	4	5.4	CN(C)CCN(C)CCCOc1ccc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)cc1Cl	10.1016/j.bmcl.2010.04.017
		CHEMBL1085403	7160	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	442	9	1	4	5.4	CN(C)CCN(C)CCCOc1ccc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)cc1Cl	10.1016/j.bmcl.2010.04.017
		1267	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-15	24	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-15	24	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-15	24	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-15	24	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-15	24	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-15	24	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1267	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		71681803	89616	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)ncn1	10.1021/jm301886t
		CHEMBL2375363	89616	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)ncn1	10.1021/jm301886t
		11672774	4061	11	None	-31	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	1	2	1.7	CN(CCCCCc1[nH]cnc1)C	10.1021/jm0504353
		1245	4061	11	None	-31	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	1	2	1.7	CN(CCCCCc1[nH]cnc1)C	10.1021/jm0504353
		CHEMBL206548	4061	11	None	-31	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	1	2	1.7	CN(CCCCCc1[nH]cnc1)C	10.1021/jm0504353
		11564628	75531	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	193	5	1	2	1.8	c1nc(CCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL204360	75531	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	193	5	1	2	1.8	c1nc(CCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		11629931	76311	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	5	1	2	2.6	c1nc(CCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL205868	76311	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	5	1	2	2.6	c1nc(CCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		70686222	75681	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	2	2	2	1.7	CN[C@@H]1CCN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047464	75681	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	2	2	2	1.7	CN[C@@H]1CCN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		135398737	958	93	None	-57	89	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		38	958	93	None	-57	89	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		722	958	93	None	-57	89	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		CHEMBL42	958	93	None	-57	89	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		DB00363	958	93	None	-57	89	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		44395314	123686	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	2	2	2	3.2	CN1CCC(C(O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL362163	123686	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	2	2	2	3.2	CN1CCC(C(O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		126688	404	33	None	1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
		4025	404	33	None	1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
		CHEMBL293762	404	33	None	1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
		66572110	75643	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047269	75643	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		70684085	75674	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	325	1	1	2	3.0	CN1CCCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047457	75674	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	325	1	1	2	3.0	CN1CCCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10063835	63123	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774601	63123	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789356	63123	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		206876	18945	7	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1039/C2MD20212C
		CHEMBL128637	18945	7	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1039/C2MD20212C
		57395620	68216	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915534	68216	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
		57395620	68216	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915534	68216	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		90645160	112187	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3c(F)cccc3F)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290587	112187	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3c(F)cccc3F)n2)CC1	10.1016/j.ejmech.2014.06.032
		57390145	69906	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938970	69906	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
		49865668	16051	0	None	-51	4	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	390	8	1	5	4.3	COc1ccccc1N1CCN(CCCCNc2nccc3ccccc23)CC1	10.1016/j.ejmech.2016.09.074
		CHEMBL1223748	16051	0	None	-51	4	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	390	8	1	5	4.3	COc1ccccc1N1CCN(CCCCNc2nccc3ccccc23)CC1	10.1016/j.ejmech.2016.09.074
		54586764	61538	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N(C)C(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770978	61538	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N(C)C(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		44546966	117111	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	4	1	4	1.9	CC(C)CNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393525	117111	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	4	1	4	1.9	CC(C)CNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		9964223	205687	11	None	-36	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL82244	205687	11	None	-36	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		90645148	112175	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290575	112175	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		56950378	69868	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		CHEMBL1938845	69868	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		25071940	187354	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		CHEMBL493281	187354	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		90645145	112178	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL3290578	112178	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		66741667	110138	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236566	110138	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		122194623	124019	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	296	3	1	6	1.4	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629826	124019	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	296	3	1	6	1.4	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		90645145	112178	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290578	112178	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		10083861	15507	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)nc2c1	10.1021/jm0502081
		CHEMBL121679	15507	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)nc2c1	10.1021/jm0502081
		121238067	167111	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4290148	167111	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		57394636	68046	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	284	1	0	5	2.6	CN1CCN(c2ncnc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914534	68046	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	284	1	0	5	2.6	CN1CCN(c2ncnc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		71525587	89727	0	None	177	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	255	2	2	7	-0.1	CNC1CN(c2nc(N)nc3cc(C#N)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376802	89727	0	None	177	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	255	2	2	7	-0.1	CNC1CN(c2nc(N)nc3cc(C#N)cnc23)C1	10.1016/j.bmcl.2013.02.091
		753256	179350	12	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL473662	179350	12	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmcl.2012.10.139
		46228143	200083	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595880	200083	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		24745335	295	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	295	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	295	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	295	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		24745335	295	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	295	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	295	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	295	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		51354583	58899	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.1	c1nc(CCCn2cc(CC3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688975	58899	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.1	c1nc(CCCn2cc(CC3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		71518860	86496	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	2	2	5	2.0	CN1CCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314773	86496	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	2	2	5	2.0	CN1CCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		46228113	202073	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	328	5	2	7	1.4	COc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		CHEMBL608717	202073	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	328	5	2	7	1.4	COc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		164611807	184984	0	None	-162	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4854278	184984	0	None	-162	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		49841718	69735	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)cc1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935569	69735	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)cc1	10.1016/j.bmcl.2011.10.104
		58227143	117127	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393541	117127	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		67087450	117136	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393550	117136	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		46890071	6909	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.7	Cc1cc(OCCCNCC2CCCN(C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084354	6909	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.7	Cc1cc(OCCCNCC2CCCN(C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		66740470	109798	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		CHEMBL3233048	109798	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		2306318	87008	12	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL232421	87008	12	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		121238068	157210	0	None	-281	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	1	6	2.0	CN1CCN(c2nc(N)nc(Cc3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4076046	157210	0	None	-281	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	1	6	2.0	CN1CCN(c2nc(N)nc(Cc3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2017.09.035
		25178341	186809	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489271	186809	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178341	186809	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489271	186809	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25178556	189085	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL509961	189085	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		23649429	96297	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	2	0	5	2.7	COc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL261224	96297	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	2	0	5	2.7	COc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		44478385	5776	6	None	9	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
		CHEMBL1078642	5776	6	None	9	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
		25178344	186886	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489664	186886	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		24853597	96296	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1cccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)c1	10.1021/jm7014217
		CHEMBL261223	96296	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1cccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)c1	10.1021/jm7014217
		8070044	155952	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	300	4	0	5	2.4	CC(C)COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL406123	155952	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	300	4	0	5	2.4	CC(C)COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		16061844	61541	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(NCc3ccccc3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770981	61541	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(NCc3ccccc3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		57403351	68323	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2cc(NCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916499	68323	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2cc(NCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		156011443	178341	0	None	-50	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	387	8	1	2	4.7	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4636487	178341	0	None	-50	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	387	8	1	2	4.7	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4651225	178341	0	None	-50	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	387	8	1	2	4.7	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		25178339	186783	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489061	186783	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		51354585	58901	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	245	5	1	4	2.0	c1nc(CCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688977	58901	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	245	5	1	4	2.0	c1nc(CCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		51354876	60200	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1739924	60200	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL3216267	60200	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		12741697	96160	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		CHEMBL260565	96160	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		25178339	186783	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489061	186783	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		919019	136732	7	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2[nH]c3c(N4CCN(C)CC4)ncnc3c2c1	10.1039/C5MD00022J
		CHEMBL3740837	136732	7	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2[nH]c3c(N4CCN(C)CC4)ncnc3c2c1	10.1039/C5MD00022J
		929854	199085	8	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	289	4	2	4	2.7	CN(C)CCNc1ncnc2c1[nH]c1ccc(Cl)cc12	10.1039/C5MD00022J
		CHEMBL588176	199085	8	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	289	4	2	4	2.7	CN(C)CCNc1ncnc2c1[nH]c1ccc(Cl)cc12	10.1039/C5MD00022J
		168278543	192851	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184846	192851	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221764	192851	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168295803	193045	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207206	193045	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222937	193045	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		57402471	67876	0	None	-549	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910378	67876	0	None	-549	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		164614645	185132	0	None	-57	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		CHEMBL4856572	185132	0	None	-57	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		57394627	68321	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	5	2	5	2.4	CN1CC[C@H](Nc2cc(NCCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916497	68321	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	5	2	5	2.4	CN1CC[C@H](Nc2cc(NCCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		71519179	86486	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	3	4	5	2.1	Nc1nc(N[C@H]2CCNC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314762	86486	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	3	4	5	2.1	Nc1nc(N[C@H]2CCNC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		1204	1932	119	None	1	24	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	1932	119	None	1	24	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	1932	119	None	1	24	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	1932	119	None	1	24	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	1932	119	None	1	24	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	1932	119	None	1	24	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1278	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1279	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		4908365	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL129198	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1278	2150	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1279	2150	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		4908365	2150	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL129198	2150	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		44538833	69719	26	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@H]2CCCC[C@H]2O1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935450	69719	26	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@H]2CCCC[C@H]2O1	10.1016/j.bmcl.2011.10.104
		49841719	69737	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935571	69737	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		11846300	80266	3	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL213912	80266	3	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2011.10.104
		11301441	96154	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL260549	96154	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1016/j.bmcl.2011.10.104
		54582865	61519	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770959	61519	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		54584825	61550	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770990	61550	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		25130912	188739	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL505061	188739	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		54584825	61550	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL1770990	61550	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		58227157	115917	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354815	115917	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		58227200	117121	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393535	117121	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		58227337	117139	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393553	117139	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		24745335	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		24745335	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	295	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		11957573	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1250	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		3692	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL19439	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		44595856	89657	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375757	89657	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		1278	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		1279	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		4908365	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		CHEMBL129198	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		11957573	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		1250	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		3692	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		CHEMBL19439	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		25129523	187287	45	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL492884	187287	45	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.06.123
		1278	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		1279	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		4908365	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		CHEMBL129198	2150	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		11066922	19423	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL129436	19423	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573458	75664	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047447	75664	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573459	75665	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047448	75665	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		9860842	75666	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)cc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047449	75666	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)cc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		11957573	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		1250	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		3692	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL19439	2010	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		71525681	89728	0	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	89728	0	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		136042270	69915	0	None	426	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938979	69915	0	None	426	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		1204	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		1247	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		1375	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		774	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL90	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		DB05381	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		25178552	173411	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452848	173411	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178552	173411	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL452848	173411	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		90645158	112185	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(Cl)cc1-c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290585	112185	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(Cl)cc1-c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2014.06.032
		57399828	68327	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	345	5	1	5	3.8	CC(C)(C)CCNc1cc(N2CCN(C3CCCCC3)CC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916502	68327	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	345	5	1	5	3.8	CC(C)(C)CCNc1cc(N2CCN(C3CCCCC3)CC2)ncn1	10.1016/j.bmcl.2011.07.114
		805994	174355	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL455133	174355	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm800876b
		805994	174355	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL455133	174355	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm901379s
		168286141	192924	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5192993	192924	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222231	192924	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		46890167	7258	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN1CCC(N(C)CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		CHEMBL1085872	7258	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN1CCC(N(C)CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		9966927	18875	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128252	18875	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9966927	18875	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128252	18875	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0341047
		9966927	18875	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128252	18875	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
		12686479	161795	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1021/jm7014217
		CHEMBL414183	161795	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1021/jm7014217
		1265	942	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmc.2011.03.046
		6422124	942	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmc.2011.03.046
		CHEMBL14638	942	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmc.2011.03.046
		1265	942	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmcl.2009.10.005
		6422124	942	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmcl.2009.10.005
		CHEMBL14638	942	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmcl.2009.10.005
		57390262	68185	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	290	1	2	7	1.2	Nc1nc(N2CC(N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915050	68185	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	290	1	2	7	1.2	Nc1nc(N2CC(N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		155552102	176563	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	3	3	5	1.0	CC(C)(C)CNc1nccc(N2CCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4576393	176563	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	3	3	5	1.0	CC(C)(C)CNc1nccc(N2CCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597352	176563	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	3	3	5	1.0	CC(C)(C)CNc1nccc(N2CCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		25178936	186782	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489060	186782	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178936	186782	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489060	186782	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		137646103	157906	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	393	8	3	3	3.7	O=C(O)C(Cc1cccc2ccccc12)NC(=O)[C@@H](CS)Cc1ccccc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4084275	157906	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	393	8	3	3	3.7	O=C(O)C(Cc1cccc2ccccc12)NC(=O)[C@@H](CS)Cc1ccccc1	10.1016/j.ejmech.2016.09.074
		42624149	110140	1	None	-3	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236568	110140	1	None	-3	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		58227127	117129	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393543	117129	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
		1204	1932	119	None	-12	24	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	1932	119	None	-12	24	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	1932	119	None	-12	24	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	1932	119	None	-12	24	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	1932	119	None	-12	24	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	1932	119	None	-12	24	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		44395308	66828	0	None	39	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	369	1	1	2	2.2	CN1CCN(C(=O)c2cc3cc(I)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL186108	66828	0	None	39	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	369	1	1	2	2.2	CN1CCN(C(=O)c2cc3cc(I)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		155552061	176478	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	176478	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	176478	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		1204	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		10017821	103786	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
		CHEMBL308913	103786	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
		1204	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	1932	119	None	-3	24	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		10023327	169016	0	None	-144	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	169016	0	None	-144	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11499454	74420	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	6	2	2	2.5	CC(C)(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL202638	74420	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	6	2	2	2.5	CC(C)(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		10446240	74998	1	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	277	8	2	2	3.6	Clc1ccc(CNCCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		CHEMBL203263	74998	1	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	277	8	2	2	3.6	Clc1ccc(CNCCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		11622495	76577	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL206303	76577	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		1267	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.ejmech.2014.03.014
		3035905	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.ejmech.2014.03.014
		CHEMBL260374	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.ejmech.2014.03.014
		12686479	161795	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL414183	161795	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1016/j.bmcl.2011.06.123
		25129523	187287	45	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL492884	187287	45	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		25129527	187414	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL493720	187414	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		70681962	75684	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.3	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047467	75684	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.3	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCNCC1	10.1016/j.ejmech.2012.06.016
		70688339	75685	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047468	75685	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1267	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
		3035905	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
		CHEMBL260374	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
		1267	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014217
		1267	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm901379s
		3035905	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014217
		3035905	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm901379s
		CHEMBL260374	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014217
		CHEMBL260374	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm901379s
		24854635	96342	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	310	1	0	4	3.0	Cc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL261519	96342	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	310	1	0	4	3.0	Cc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		10085528	195194	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	7	3	3	2.8	N=C(NCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202330	195194	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	7	3	3	2.8	N=C(NCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL550570	195194	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	7	3	3	2.8	N=C(NCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		10041484	195250	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	316	9	3	3	3.6	N=C(NCCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL551047	195250	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	316	9	3	3	3.6	N=C(NCCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1267	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1252	2017	21	None	-100	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		9793868	2017	21	None	-100	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL417096	2017	21	None	-100	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		71681641	89664	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	350	8	4	8	2.2	CC(C)CCc1cc(NCCNc2cc(Cl)nc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375764	89664	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	350	8	4	8	2.2	CC(C)CCc1cc(NCCNc2cc(Cl)nc(N)n2)nc(N)n1	10.1021/jm301886t
		11492189	76006	0	None	-10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	1	2	2.5	CCN(CC)CCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205511	76006	0	None	-10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	1	2	2.5	CCN(CC)CCCCCc1c[nH]cn1	10.1021/jm0504353
		14712103	61885	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	201	5	2	2	1.7	c1ccc(CNCCc2c[nH]cn2)cc1	10.1016/j.bmcl.2011.06.123
		CHEMBL17740	61885	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	201	5	2	2	1.7	c1ccc(CNCCc2c[nH]cn2)cc1	10.1016/j.bmcl.2011.06.123
		12741697	96160	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL260565	96160	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.06.123
		9793921	65128	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	164	2	1	1	2.5	c1nc(CC2CCCCC2)c[nH]1	10.1016/j.bmcl.2011.06.123
		CHEMBL1824228	65128	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	164	2	1	1	2.5	c1nc(CC2CCCCC2)c[nH]1	10.1016/j.bmcl.2011.06.123
		24764570	75661	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	2	1.9	CN[C@@H]1CCN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047444	75661	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	2	1.9	CN[C@@H]1CCN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		25178938	186759	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm901379s
		CHEMBL488885	186759	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm901379s
		933006	136573	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2c(c1)[nH]c1c(N3CCN(C)CC3)ncnc12	10.1039/C5MD00022J
		CHEMBL3739430	136573	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2c(c1)[nH]c1c(N3CCN(C)CC3)ncnc12	10.1039/C5MD00022J
		10419556	5358	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106913	5358	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		168273549	192803	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174342	192803	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221438	192803	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		66572103	75635	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cnccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047261	75635	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cnccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		164627020	186408	0	None	-144	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	422	7	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4876025	186408	0	None	-144	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	422	7	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		10515993	5961	1	None	-27	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079918	5961	1	None	-27	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL154944	5961	1	None	-27	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		54587792	61554	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.2	Nc1nc(N2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770994	61554	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.2	Nc1nc(N2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1016/j.bmcl.2011.03.017
		90645156	112183	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	313	3	1	7	0.9	CN1CCN(c2nc(N)nc(-c3ccc(N(C)C)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290583	112183	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	313	3	1	7	0.9	CN1CCN(c2nc(N)nc(-c3ccc(N(C)C)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		763018	136734	10	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	6	1.3	Cc1nnc2c(N3CCN(C)CC3)nc3ccccc3n12	10.1039/C5MD00022J
		CHEMBL3740846	136734	10	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	6	1.3	Cc1nnc2c(N3CCN(C)CC3)nc3ccccc3n12	10.1039/C5MD00022J
		44414498	79996	0	None	-173	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	7	0	2	6.9	CN(Cc1ccc(-c2ccc(CN(C)C3CCCCC3)cc2)cc1)C1CCCCC1	10.1016/j.bmc.2008.10.029
		CHEMBL212775	79996	0	None	-173	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	7	0	2	6.9	CN(Cc1ccc(-c2ccc(CN(C)C3CCCCC3)cc2)cc1)C1CCCCC1	10.1016/j.bmc.2008.10.029
		44414433	139529	0	None	-8	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	352	13	2	2	5.9	CCCCCNCc1ccc(-c2ccc(CNCCCCC)cc2)cc1	10.1016/j.bmc.2008.10.029
		CHEMBL379545	139529	0	None	-8	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	352	13	2	2	5.9	CCCCCNCc1ccc(-c2ccc(CNCCCCC)cc2)cc1	10.1016/j.bmc.2008.10.029
		10419556	5358	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106913	5358	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		164623155	185575	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	352	3	4	4	3.4	N/C(=N\C(=O)Nc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4863393	185575	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	352	3	4	4	3.4	N/C(=N\C(=O)Nc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		57395260	69729	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2nc(N)nc(N3CCN(C)CC3)c2c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935563	69729	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2nc(N)nc(N3CCN(C)CC3)c2c1	10.1016/j.bmcl.2011.10.104
		11408069	84264	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		CHEMBL221211	84264	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		11408069	84264	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL221211	84264	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		24825995	68145	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914795	68145	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		1267	3804	49	None	-21	26	Mouse	7.2	pKi	=	7.2	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-21	26	Mouse	7.2	pKi	=	7.2	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-21	26	Mouse	7.2	pKi	=	7.2	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		762810	199907	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	262	2	0	5	2.0	CCc1cc2c(N3CCN(C)CC3)ncnc2s1	10.1016/j.bmc.2009.08.059
		CHEMBL594730	199907	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	262	2	0	5	2.0	CCc1cc2c(N3CCN(C)CC3)ncnc2s1	10.1016/j.bmc.2009.08.059
		51354299	58888	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	247	8	1	4	2.4	CCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		CHEMBL1688945	58888	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	247	8	1	4	2.4	CCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		136773074	157365	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4077914	157365	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		57400473	69727	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935561	69727	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)c1	10.1016/j.bmcl.2011.10.104
		57397301	67880	0	None	-891	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910382	67880	0	None	-891	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		127026018	137492	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753985	137492	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		73346048	91867	0	None	-15	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	7	2	3	3.0	O=C(NCCc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL2413359	91867	0	None	-15	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	7	2	3	3.0	O=C(NCCc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		164617783	184590	0	None	-104	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848815	184590	0	None	-104	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		71519499	86492	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	1	6	2.1	CN1CCN(c2nc(N)nc3c2cc(-c2ccc(F)cc2)n3C)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314768	86492	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	1	6	2.1	CN1CCN(c2nc(N)nc3c2cc(-c2ccc(F)cc2)n3C)CC1	10.1016/j.bmcl.2012.10.139
		54583872	61520	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770960	61520	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)n2)C1	10.1016/j.bmcl.2011.03.017
		1278	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		1279	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		4908365	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		CHEMBL129198	2150	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		58227388	117124	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393538	117124	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		155517880	176667	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	176667	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	176667	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		155517880	176667	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	176667	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	176667	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		46890626	6588	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@@H]3CCCN[C@@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083097	6588	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@@H]3CCCN[C@@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		25178938	186759	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm800876b
		CHEMBL488885	186759	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm800876b
		9812843	205244	1	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78838	205244	1	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		647957	29077	13	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	2	0	6	0.4	Cc1cc(N2CCN(C)CC2)nc(N2CCOCC2)n1	10.1039/C5MD00022J
		CHEMBL1381010	29077	13	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	2	0	6	0.4	Cc1cc(N2CCN(C)CC2)nc(N2CCOCC2)n1	10.1039/C5MD00022J
		747187	136638	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	249	4	1	3	2.8	Cc1cc2nc(SCCN(C)C)[nH]c2cc1C	10.1039/C5MD00022J
		CHEMBL3739949	136638	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	249	4	1	3	2.8	Cc1cc2nc(SCCN(C)C)[nH]c2cc1C	10.1039/C5MD00022J
		168268716	192762	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5170276	192762	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221176	192762	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168268853	192785	0	None	-83	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5180504	192785	0	None	-83	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221353	192785	0	None	-83	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		5013	100237	32	None	-16	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2ccc3ccccc3n2)CC1	10.1021/jm7014217
		CHEMBL288591	100237	32	None	-16	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2ccc3ccccc3n2)CC1	10.1021/jm7014217
		10243990	5894	0	None	-79	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCCC(C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079552	5894	0	None	-79	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCCC(C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL155830	5894	0	None	-79	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCCC(C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		11065080	19434	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1007/s00044-004-0106-7
		CHEMBL129488	19434	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1007/s00044-004-0106-7
		11065080	19434	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0341047
		CHEMBL129488	19434	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0341047
		117724523	117115	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393529	117115	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		11594278	14690	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		CHEMBL120591	14690	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		11065080	19434	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		CHEMBL129488	19434	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		44462956	5599	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL1077276	5599	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		71603140	89719	0	None	97	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	3	2	5	1.5	CNC1CN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376794	89719	0	None	97	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	3	2	5	1.5	CNC1CN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		25147772	173409	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452847	173409	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25147772	173409	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL452847	173409	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		44129131	199454	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	440	8	1	7	2.1	CCN(CC)S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591500	199454	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	440	8	1	7	2.1	CCN(CC)S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		25071319	189062	14	None	9	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL509540	189062	14	None	9	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		16082828	80260	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL213886	80260	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		57398091	68108	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	3.0	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914757	68108	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	3.0	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		57401517	68125	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)c(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914774	68125	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)c(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		3035746	188180	9	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL1237146	188180	9	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL498770	188180	9	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/jm7014777
		136030655	56482	0	None	2	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632413	56482	0	None	2	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		136192874	56483	0	None	1	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632414	56483	0	None	1	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1204	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		1247	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		1375	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		774	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		1204	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		53321919	56478	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632409	56478	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		10060213	102911	1	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL306077	102911	1	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		155491015	176495	4	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4441731	176495	4	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4596734	176495	4	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		44609412	89674	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	322	6	4	8	1.6	Nc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375773	89674	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	322	6	4	8	1.6	Nc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		25129523	187287	45	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm301886t
		CHEMBL492884	187287	45	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm301886t
		51354584	58900	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	6	1	4	2.4	c1nc(CCCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688976	58900	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	6	1	4	2.4	c1nc(CCCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		76314798	106052	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	314	3	1	7	1.4	CN1CCN(c2cc(-c3ccc([N+](=O)[O-])cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL3133131	106052	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	314	3	1	7	1.4	CN1CCN(c2cc(-c3ccc([N+](=O)[O-])cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		136042269	69914	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938978	69914	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		71525678	89725	0	None	-7	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	89725	0	None	-7	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25178937	186784	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL489062	186784	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25071319	189062	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL509540	189062	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		44129209	202029	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	586	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccc(I)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL608373	202029	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	586	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccc(I)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		11013044	18910	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	333	4	1	2	3.2	O=C(c1cc2ccccc2[nH]1)N1CCN(CCc2ccccc2)CC1	10.1021/jm0341047
		CHEMBL128470	18910	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	333	4	1	2	3.2	O=C(c1cc2ccccc2[nH]1)N1CCN(CCc2ccccc2)CC1	10.1021/jm0341047
		122194625	124021	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629828	124021	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
		52952957	63163	0	None	-29	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774594	63163	0	None	-29	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789799	63163	0	None	-29	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		24854703	166887	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	364	5	0	6	3.0	COc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL428606	166887	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	364	5	0	6	3.0	COc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL4748908	214035	1	None	-8	12	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		156013005	177499	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	899	20	2	7	10.6	Cc1cc(OCCCNC(=O)CCCCCN2/C(=C\C=C\C=C\C3=[N+](CCCCS(=O)(=O)[O-])c4ccccc4C3(C)C)C(C)(C)c3ccccc32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4639472	177499	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	899	20	2	7	10.6	Cc1cc(OCCCNC(=O)CCCCCN2/C(=C\C=C\C=C\C3=[N+](CCCCS(=O)(=O)[O-])c4ccccc4C3(C)C)C(C)(C)c3ccccc32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		168268827	192779	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5179906	192779	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221314	192779	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		52952957	63163	0	None	-29	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774594	63163	0	None	-29	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789799	63163	0	None	-29	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		25071319	189062	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL509540	189062	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		46228101	199798	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594022	199798	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL4748908	214035	1	None	-8	12	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		46228083	199741	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	374	5	2	6	3.1	CN1CCN(c2cc(NCc3ccc(-c4ccccc4)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593551	199741	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	374	5	2	6	3.1	CN1CCN(c2cc(NCc3ccc(-c4ccccc4)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46890549	6585	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083085	6585	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		112936352	137494	1	None	-17	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3754008	137494	1	None	-17	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		155563489	175329	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.7	CCC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4573929	175329	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.7	CCC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		71518865	86462	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	333	2	2	6	1.8	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(C#N)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314494	86462	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	333	2	2	6	1.8	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(C#N)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		57401167	69869	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938846	69869	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		24826679	68102	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914751	68102	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		168294161	193006	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204739	193006	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222742	193006	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		168294770	193020	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208327	193020	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222806	193020	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		44450438	96121	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc3ccccc3nc2NCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260371	96121	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc3ccccc3nc2NCc2ccccc2)CC1	10.1021/jm7014217
		71528209	86972	0	None	-1148	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		CHEMBL2323582	86972	0	None	-1148	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		121238069	159126	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting methodDisplacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.04.033
		CHEMBL4097856	159126	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting methodDisplacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.04.033
		24826268	68051	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	3	2	6	2.8	CCN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914544	68051	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	3	2	6	2.8	CCN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		56851443	71628	0	None	-7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	356	7	2	3	4.6	c1ccc(CN/C(=N/C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923024	71628	0	None	-7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	356	7	2	3	4.6	c1ccc(CN/C(=N/C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963459	71628	0	None	-7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	356	7	2	3	4.6	c1ccc(CN/C(=N/C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		121238069	159126	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4097856	159126	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		25178132	186939	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL490073	186939	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25178132	186939	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL490073	186939	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		168283321	192895	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183015	192895	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222057	192895	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		24759622	169679	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL443764	169679	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm800876b
		24759622	169679	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm7014217
		24759622	169679	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL443764	169679	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm7014217
		CHEMBL443764	169679	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm901379s
		164622259	185730	0	None	-7244	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	336	6	4	5	1.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1	10.1016/j.ejmech.2021.113190
		CHEMBL4865965	185730	0	None	-7244	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	336	6	4	5	1.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1	10.1016/j.ejmech.2021.113190
		24826167	68146	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914796	68146	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		54581938	61532	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770972	61532	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		46890019	7312	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086085	7312	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		24994945	110139	1	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CN[C@@H]1CCN(c2cc(C)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236567	110139	1	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CN[C@@H]1CCN(c2cc(C)nc(N)n2)C1	10.1021/jm401727m
		1223	953	41	None	-60	11	Human	7.1	pKi	=	7.1	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	953	41	None	-60	11	Human	7.1	pKi	=	7.1	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	953	41	None	-60	11	Human	7.1	pKi	=	7.1	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		51354301	58892	0	None	-10	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688969	58892	0	None	-10	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		164609017	184425	0	None	-13	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4846201	184425	0	None	-13	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
		168294166	193014	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209081	193014	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222775	193014	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		168294178	193035	0	None	-5	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5205197	193035	0	None	-5	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222887	193035	0	None	-5	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		127026019	137460	0	None	-6	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	378	2	0	6	1.7	CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753705	137460	0	None	-6	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	378	2	0	6	1.7	CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		11546127	95484	2	None	-	1	Human	5.1	pKi	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL25725	95484	2	None	-	1	Human	5.1	pKi	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		10715823	5930	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	281	10	2	3	3.3	CCCCC(CC)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079747	5930	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	281	10	2	3	3.3	CCCCC(CC)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		1267	3804	49	None	-33	26	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
		3035905	3804	49	None	-33	26	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
		CHEMBL260374	3804	49	None	-33	26	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
		25071319	189062	14	None	-9	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.06.123
		CHEMBL509540	189062	14	None	-9	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.06.123
		25109291	191386	10	None	-501	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1016/j.bmcl.2011.06.123
		CHEMBL519240	191386	10	None	-501	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1016/j.bmcl.2011.06.123
		1204	1932	119	None	-15	24	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	1932	119	None	-15	24	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	1932	119	None	-15	24	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	1932	119	None	-15	24	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	1932	119	None	-15	24	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	1932	119	None	-15	24	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10446295	2132	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2004.08.035
		1277	2132	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2004.08.035
		CHEMBL185951	2132	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2004.08.035
		1267	3804	49	None	-21	26	Mouse	7.1	pKi	=	7.1	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	3804	49	None	-21	26	Mouse	7.1	pKi	=	7.1	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	3804	49	None	-21	26	Mouse	7.1	pKi	=	7.1	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		937120	175101	8	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	244	1	0	3	1.8	CN1CCN(C(=O)c2cc3ccccc3o2)CC1	10.1016/j.bmc.2020.115924
		CHEMBL4568949	175101	8	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	244	1	0	3	1.8	CN1CCN(C(=O)c2cc3ccccc3o2)CC1	10.1016/j.bmc.2020.115924
		71681974	89649	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1cc(-c2ccccc2)nc(N)n1)c1ccnc(N)n1	10.1021/jm301886t
		CHEMBL2375749	89649	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1cc(-c2ccccc2)nc(N)n1)c1ccnc(N)n1	10.1021/jm301886t
		71681475	89655	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	317	8	5	9	1.0	CC(C)CNc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375755	89655	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	317	8	5	9	1.0	CC(C)CNc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		71681643	89666	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375766	89666	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		71681645	89668	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375768	89668	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		11679993	76017	0	None	-25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.0	CC(C)CNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205559	76017	0	None	-25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.0	CC(C)CNCCCCc1c[nH]cn1	10.1021/jm0504353
		11087453	75644	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047270	75644	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572113	75649	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3ccc(N)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047275	75649	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3ccc(N)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573457	75663	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	2	1	2	2.4	Cc1cccc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047446	75663	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	2	1	2	2.4	Cc1cccc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		70688340	75693	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3c(F)ccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047476	75693	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3c(F)ccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		51354875	58908	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688986	58908	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		25178937	186784	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL489062	186784	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		11846635	78680	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
		CHEMBL211242	78680	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
		4060730	19379	56	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL129199	19379	56	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		90645159	112186	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	2.2	CN1CCN(c2nc(N)nc(-c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290586	112186	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	2.2	CN1CCN(c2nc(N)nc(-c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		162671115	182947	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	266	2	0	3	1.9	CN1CCN(CC2Cc3cc(Cl)ccc3O2)CC1	10.1016/j.bmc.2020.115924
		CHEMBL4792753	182947	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	266	2	0	3	1.9	CN1CCN(CC2Cc3cc(Cl)ccc3O2)CC1	10.1016/j.bmc.2020.115924
		10197870	5301	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106612	5301	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		91613	17987	34	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL12620	17987	34	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
		71681474	89654	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	246	5	4	8	-0.0	Nc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375754	89654	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	246	5	4	8	-0.0	Nc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		11637064	74954	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	1	2	2.2	c1nc(CCCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL203228	74954	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	1	2	2.2	c1nc(CCCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		11708125	76519	3	None	-251	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	5	1	2	1.3	CN(C)CCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL206000	76519	3	None	-251	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	5	1	2	1.3	CN(C)CCCCc1c[nH]cn1	10.1021/jm0504353
		11499376	138503	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	5	2	2	2.1	CC(C)(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL377491	138503	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	5	2	2	2.1	CC(C)(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		56672434	65124	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	1	2	3.3	CN1CCC(=Cc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL1824048	65124	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	1	2	3.3	CN1CCC(=Cc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2011.06.123
		66572109	75641	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3c([N+](=O)[O-])cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047267	75641	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3c([N+](=O)[O-])cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10957150	75658	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cccc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047441	75658	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cccc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		3939214	126645	6	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	262	1	1	1	3.4	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCCC1	10.1016/j.bmcl.2004.08.035
		CHEMBL365257	126645	6	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	262	1	1	1	3.4	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCCC1	10.1016/j.bmcl.2004.08.035
		11086114	7394	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL108649	7394	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		2247	505	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		249	505	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		2603	505	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		CHEMBL296419	505	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		DB00637	505	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		44417471	12771	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	175	4	5	3	-0.5	N=C(N)NCCCSC(=N)N	10.1021/jm060880d
		CHEMBL1187948	12771	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	175	4	5	3	-0.5	N=C(N)NCCCSC(=N)N	10.1021/jm060880d
		CHEMBL534496	12771	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	175	4	5	3	-0.5	N=C(N)NCCCSC(=N)N	10.1021/jm060880d
		164614841	185274	0	None	-223	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	7	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		CHEMBL4858849	185274	0	None	-223	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	7	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		9923162	18940	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128613	18940	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		10967174	19442	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL129540	19442	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		1204	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		9923162	18940	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128613	18940	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0341047
		10967174	19442	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129540	19442	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		1278	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		54580746	61391	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.1	Nc1nc(N2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770160	61391	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.1	Nc1nc(N2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2011.03.017
		1278	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		1279	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		4908365	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		CHEMBL129198	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		58227157	115917	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3354815	115917	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		58227179	117134	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393548	117134	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		58227259	117142	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393556	117142	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		1278	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1279	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		4908365	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL129198	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		42624150	110149	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236577	110149	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
		24827129	68135	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2c(Cl)cc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914785	68135	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2c(Cl)cc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		9923162	18940	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128613	18940	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
		10967174	19442	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129540	19442	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
		44129212	199453	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.3	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(C(F)(F)F)cccc3n2)CC1	10.1021/jm901379s
		CHEMBL591496	199453	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.3	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(C(F)(F)F)cccc3n2)CC1	10.1021/jm901379s
		24825522	187643	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	283	3	1	3	3.3	CC1CC(C)(C)N=C(c2cccc(Cc3c[nH]cn3)c2)O1	10.1021/jm7014149
		CHEMBL494982	187643	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	283	3	1	3	3.3	CC1CC(C)(C)N=C(c2cccc(Cc3c[nH]cn3)c2)O1	10.1021/jm7014149
		51354300	58889	0	None	15	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688946	58889	0	None	15	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		58227373	176508	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	176508	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	176508	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		168294182	193048	0	None	-5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208722	193048	0	None	-5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222960	193048	0	None	-5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		46890546	6515	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082771	6515	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		46228069	200150	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	3	1	7	1.2	CN1CCN(c2nc(N)nc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL596348	200150	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	3	1	7	1.2	CN1CCN(c2nc(N)nc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		63868172	176056	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	222	2	1	6	-0.2	CCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4590628	176056	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	222	2	1	6	-0.2	CCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		164614549	184943	0	None	-575	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4853668	184943	0	None	-575	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		164621681	185580	0	None	-64	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	444	7	4	5	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4863523	185580	0	None	-64	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	444	7	4	5	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1	10.1016/j.ejmech.2021.113190
		164627241	186429	0	None	-269	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	6	4	4	3.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4876267	186429	0	None	-269	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	6	4	4	3.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1	10.1016/j.ejmech.2021.113190
		11086114	7394	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL108649	7394	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		71519347	86489	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	274	4	2	6	1.2	CCCCn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		CHEMBL2314765	86489	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	274	4	2	6	1.2	CCCCn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		54754351	68217	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915535	68217	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		54754351	68217	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915535	68217	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		58227242	117138	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2cnnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393552	117138	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2cnnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		121238067	167111	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2017.09.035
		CHEMBL4290148	167111	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2017.09.035
		57400778	68210	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915346	68210	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		54584827	61556	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770996	61556	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		57400778	68210	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915346	68210	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		57400589	69908	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)cnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938972	69908	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)cnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		90645164	112191	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1C	10.1016/j.ejmech.2014.06.032
		CHEMBL3290591	112191	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1C	10.1016/j.ejmech.2014.06.032
		57399016	68176	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915040	68176	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		46890548	6584	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083084	6584	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		46929551	16744	0	None	-52	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2ccccn2)c2c[nH]cn2)cc1	10.1021/jm100643t
		CHEMBL1243335	16744	0	None	-52	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2ccccn2)c2c[nH]cn2)cc1	10.1021/jm100643t
		5159263	10383	11	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	259	4	3	4	0.8	Cc1cc(C)nc(N/C(N)=N/CCc2c[nH]cn2)n1	10.1021/jm7014777
		CHEMBL1162351	10383	11	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	259	4	3	4	0.8	Cc1cc(C)nc(N/C(N)=N/CCc2c[nH]cn2)n1	10.1021/jm7014777
		71525679	89726	0	None	-6	6	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	89726	0	None	-6	6	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25178130	189745	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL515870	189745	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		25178130	189745	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL515870	189745	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		164622153	185568	0	None	-181	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	6	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4863347	185568	0	None	-181	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	6	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1	10.1016/j.ejmech.2021.113190
		54581939	61544	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770984	61544	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		122193095	123914	0	None	-3	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assayDisplacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628042	123914	0	None	-3	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assayDisplacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		58227260	117132	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393546	117132	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
		57398176	68328	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	273	2	0	5	1.4	CN1CCN(c2cc(N3[C@@H]4CCC[C@@H]3C4)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916503	68328	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	273	2	0	5	1.4	CN1CCN(c2cc(N3[C@@H]4CCC[C@@H]3C4)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		127050776	140247	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805437	140247	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		164627189	186321	0	None	-831	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	298	6	4	4	1.0	CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4874758	186321	0	None	-831	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	298	6	4	4	1.0	CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		71519015	86468	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	246	1	2	5	0.7	CN1CCCN(c2nc(N)nc3[nH]ccc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314500	86468	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	246	1	2	5	0.7	CN1CCCN(c2nc(N)nc3[nH]ccc23)CC1	10.1016/j.bmcl.2012.10.139
		57400737	68178	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Cl)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915042	68178	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Cl)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		57395494	68172	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915032	68172	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		57395499	68181	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	2	7	1.8	C[C@H]1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CCN1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915046	68181	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	2	7	1.8	C[C@H]1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CCN1	10.1016/j.bmcl.2011.08.014
		46890677	7291	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086038	7291	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		56851612	71601	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	9	2	3	5.3	CCCCN/C(=N/Cc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923032	71601	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	9	2	3	5.3	CCCCN/C(=N/Cc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963245	71601	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	9	2	3	5.3	CCCCN/C(=N/Cc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm201042n
		56851602	71603	0	None	-18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	364	9	2	3	4.7	CCCCN/C(=N/Cc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923027	71603	0	None	-18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	364	9	2	3	4.7	CCCCN/C(=N/Cc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963260	71603	0	None	-18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	364	9	2	3	4.7	CCCCN/C(=N/Cc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1021/jm201042n
		25178345	173446	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccco3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452925	173446	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccco3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		51354303	58895	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.7	c1nc(CCCn2cc(C3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688971	58895	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.7	c1nc(CCCn2cc(C3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		25147771	174238	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL454890	174238	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10656971	16421	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1021/jm7014217
		CHEMBL123137	16421	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1021/jm7014217
		25179123	189100	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL510181	189100	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		10197870	5301	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106612	5301	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		168273471	192801	0	None	-50	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173079	192801	0	None	-50	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221433	192801	0	None	-50	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		57402472	67879	0	None	-1819	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910381	67879	0	None	-1819	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		44576985	10382	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	212	4	7	4	-1.3	CC(/C=C(\C)NNC(=N)N)=N/NC(=N)N	10.1021/jm7014777
		CHEMBL1162347	10382	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	212	4	7	4	-1.3	CC(/C=C(\C)NNC(=N)N)=N/NC(=N)N	10.1021/jm7014777
		71519010	86463	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	386	2	2	5	2.7	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Br)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314495	86463	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	386	2	2	5	2.7	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Br)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		1204	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		1247	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		1375	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		774	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		54587790	61540	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770980	61540	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		54753437	68183	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL1915048	68183	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2014.12.027
		11750684	83460	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		CHEMBL219982	83460	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		54753437	68183	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1021/jm401727m
		CHEMBL1915048	68183	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1021/jm401727m
		24825794	68056	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914549	68056	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		71525679	89726	0	None	6	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	89726	0	None	6	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25071940	187354	0	None	5	2	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		CHEMBL493281	187354	0	None	5	2	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		71525586	89724	0	None	22	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	2	1	6	0.9	CCc1cnc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376799	89724	0	None	22	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	2	1	6	0.9	CCc1cnc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		44129135	199430	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	454	6	1	8	1.1	CN1CCN(c2nc(NCCS(=O)(=O)N3CCOCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591250	199430	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	454	6	1	8	1.1	CN1CCN(c2nc(NCCS(=O)(=O)N3CCOCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		53378711	110150	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236578	110150	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		54753437	68183	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915048	68183	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		135525668	68212	0	None	263	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915348	68212	0	None	263	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		49841611	69733	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935567	69733	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		1248	1424	28	None	-15	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		3077	1424	28	None	-15	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		90045	1424	28	None	-15	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		CHEMBL12344	1424	28	None	-15	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		11615753	72938	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3sccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL200546	72938	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3sccc3[nH]2)CC1	10.1021/jm0502081
		10444761	123838	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3ccsc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL362495	123838	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3ccsc3[nH]2)CC1	10.1021/jm0502081
		16082826	80313	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@H]2C[C@@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL214156	80313	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@H]2C[C@@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		122193097	123916	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628044	123916	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		57390344	68221	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	248	5	3	6	0.3	CNC1CN(c2cc(N)nc(NCC3CC3)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915539	68221	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	248	5	3	6	0.3	CNC1CN(c2cc(N)nc(NCC3CC3)n2)C1	10.1016/j.bmcl.2011.07.125
		49841607	69721	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		CHEMBL1935555	69721	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		12686451	204049	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2cnc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		CHEMBL1743969	204049	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2cnc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		CHEMBL6992	204049	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2cnc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		51354010	58884	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	281	7	1	4	2.6	c1ccc(Cc2cn(CCCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688941	58884	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	281	7	1	4	2.6	c1ccc(Cc2cn(CCCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		127036979	137488	0	None	1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753962	137488	0	None	1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		118720434	115911	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	241	3	2	5	0.6	CN[C@@H]1CCN(c2cc(CCl)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354808	115911	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	241	3	2	5	0.6	CN[C@@H]1CCN(c2cc(CCl)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		11212855	84230	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL220934	84230	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		57401602	68329	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	242	1	0	4	1.3	Cc1ccc(C#N)c(N2CC3CN(C)CC3C2)n1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916504	68329	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	242	1	0	4	1.3	Cc1ccc(C#N)c(N2CC3CN(C)CC3C2)n1	10.1016/j.bmcl.2011.07.114
		156010537	178309	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	430	11	2	3	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCNCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634235	178309	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	430	11	2	3	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCNCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4651053	178309	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	430	11	2	3	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCNCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		90654503	110312	0	None	-123	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	483	9	1	4	4.9	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		CHEMBL3238447	110312	0	None	-123	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	483	9	1	4	4.9	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		57394626	68318	0	None	14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916494	68318	0	None	14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		49841723	69726	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)cc1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935560	69726	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)cc1	10.1016/j.bmcl.2011.10.104
		112936251	137266	1	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752085	137266	1	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		25178340	186785	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm800876b
		CHEMBL489069	186785	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm800876b
		25179123	189100	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL510181	189100	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25178340	186785	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm901379s
		CHEMBL489069	186785	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm901379s
		164618690	186156	0	None	-13	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	3.4	CCCCCCNC(=O)/N=C(\N)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4872375	186156	0	None	-13	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	3.4	CCCCCCNC(=O)/N=C(\N)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		44547126	117113	1	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393527	117113	1	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		118725540	117110	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	1.9	CN[C@@H]1CCN(c2ccnc(N3CCCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393524	117110	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	1.9	CN[C@@H]1CCN(c2ccnc(N3CCCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		46890676	7243	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	1	4	4.0	Cc1cc(OCCCN2CC3CN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1085804	7243	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	1	4	4.0	Cc1cc(OCCCN2CC3CN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		57393651	69907	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3cc4cccnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938971	69907	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3cc4cccnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		24853666	156118	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	1	1	4	1.7	CN1CCCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		CHEMBL406327	156118	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	1	1	4	1.7	CN1CCCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		112936267	137295	1	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752383	137295	1	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		127051301	140200	0	None	5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	140200	0	None	5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		25130914	187254	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL492677	187254	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		71519178	86485	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314761	86485	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		127052293	140238	3	None	34	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	140238	3	None	34	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1530	2182	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		124087	1389	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		7157	1389	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		814	1389	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		CHEMBL1172	1389	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		DB00967	1389	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		71548412	1909	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		9879	1909	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		CHEMBL4790724	1909	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		71548412	1909	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		9879	1909	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		CHEMBL4790724	1909	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		1278	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1279	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		4908365	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		CHEMBL129198	2150	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1204	1932	119	None	-12	24	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	1932	119	None	-12	24	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	1932	119	None	-12	24	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	1932	119	None	-12	24	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	1932	119	None	-12	24	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	1932	119	None	-12	24	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1236	2067	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1237	2067	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		156615	2067	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		CHEMBL268229	2067	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1204	1932	119	None	-15	24	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	1932	119	None	-15	24	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	1932	119	None	-15	24	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	1932	119	None	-15	24	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	1932	119	None	-15	24	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	1932	119	None	-15	24	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1241	2037	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1242	2037	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		3614	2037	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		CHEMBL507	2037	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1204	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		1204	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1204	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		1204	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1204	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1204	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1247	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		1247	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1247	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		1247	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1247	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1375	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		1375	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1375	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		1375	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1375	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		774	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		774	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		774	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		774	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		774	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		DB05381	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		DB05381	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		DB05381	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		DB05381	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		DB05381	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	1932	119	None	-3	24	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		None	216141	0	3H-Histamine	4	6	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		1204	1932	119	3H-Histamine	1	24	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	1	24	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	1	24	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	1	24	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	1	24	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	1	24	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		None	216141	0	3H-Histamine	4	6	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		179	400	115	3H-Histamine	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-Histamine	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-Histamine	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-Histamine	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-Histamine	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		242	470	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		1231	937	116	3H-Histamine	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		1231	937	116	3H-PYRILAMINE	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		2756	937	116	3H-Histamine	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		2756	937	116	3H-PYRILAMINE	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		645	937	116	3H-Histamine	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		645	937	116	3H-PYRILAMINE	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		CHEMBL30	937	116	3H-Histamine	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		CHEMBL30	937	116	3H-PYRILAMINE	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		DB00501	937	116	3H-Histamine	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		DB00501	937	116	3H-PYRILAMINE	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		277	1301	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1248	1424	28	3H-PYRILAMINE	-15	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		3077	1424	28	3H-PYRILAMINE	-15	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		90045	1424	28	3H-PYRILAMINE	-15	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		CHEMBL12344	1424	28	3H-PYRILAMINE	-15	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		1224	1432	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1212	1662	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1353	1911	93	3H-Histamine	-6918	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-Histamine	-6918	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-Histamine	-6918	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-Histamine	-6918	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-Histamine	-6918	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	2914	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		119570	3159	96	3H-Histamine	-301	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-Histamine	-301	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-Histamine	-301	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-Histamine	-301	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-Histamine	-301	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2337	3256	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1234	3291	68	3H-Histamine	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		3001055	3291	68	3H-Histamine	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		CHEMBL512	3291	68	3H-Histamine	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		DB00863	3291	68	3H-Histamine	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		2389	3331	118	3H-Histamine	-26915	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-Histamine	-26915	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-Histamine	-26915	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-Histamine	-26915	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-Histamine	-26915	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		6917970	3691	61	3H-Histamine	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	3691	61	3H-Histamine	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	3691	61	3H-Histamine	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		213	3853	55	3H-Histamine	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-Histamine	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-Histamine	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-Histamine	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-Histamine	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		185	4006	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		2865	4143	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		10297	27112	30	3H-Histamine	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	27112	30	3H-Histamine	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	46800	99	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	46800	99	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	46800	99	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		10624	70300	19	3H-Histamine	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-Histamine	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-Histamine	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		21830793	91835	10	3H-8-OH-DPAT	-66069	45	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	91835	10	3H-8-OH-DPAT	-66069	45	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		46780481	107531	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		446220	133521	14	3H-Histamine	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	133521	14	3H-Histamine	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		4495	196535	92	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	196535	92	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	200551	115	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	200551	115	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	200551	115	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	202274	22	3H-Histamine	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-Histamine	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-Histamine	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4054	205501	72	3H-Histamine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	205501	72	3H-Histamine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	205501	72	3H-Histamine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		11954259	215979	0	3H-Histamine	-33113	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		None	215993	0	3H-Histamine	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		104911	216019	0	3H-Histamine	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	216141	0	3H-PYRILAMINE	-7585	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		25137849	216179	0	3H-Histamine	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-Histamine	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	216311	0	3H-Histamine	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	216312	0	3H-Histamine	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	216313	0	3H-Histamine	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	216314	0	3H-Histamine	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	216315	0	3H-Histamine	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	216316	0	3H-Histamine	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	216317	0	3H-Histamine	-1	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	216325	0	3H-Histamine	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	216326	0	3H-Histamine	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		135269	216389	0	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	216390	0	3H-Histamine	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		123619	216393	0	3H-Histamine	-1412	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	216394	0	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	216395	0	3H-Histamine	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	216489	0	3H-Histamine	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		135409468	2035	69	3H-Histamine	-363	39	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-Histamine	-363	39	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-Histamine	-363	39	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		1204	1932	119	3H-Histamine	1	24	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	1	24	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	1	24	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	1	24	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	1	24	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	1	24	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1225	1471	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		1226	2019	20	3H-Histamine	2	6	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		41376	2019	20	3H-Histamine	2	6	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		CHEMBL12608	2019	20	3H-Histamine	2	6	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		1223	953	41	3H-JNJ 7777120	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	3H-JNJ 7777120	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	3H-JNJ 7777120	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1251	2014	39	3H-JNJ 7777120	-100	5	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	2014	39	3H-JNJ 7777120	-100	5	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	2014	39	3H-JNJ 7777120	-100	5	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		1253	2058	7	3H-N-alpha-methylhistamine	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	None
		132937	2058	7	3H-N-alpha-methylhistamine	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	None
		CHEMBL19010	2058	7	3H-N-alpha-methylhistamine	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	None
		None	216254	0	3H-Histamine	-13	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		None	216254	0	3H-N-alpha-methylhistamine	-13	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		1223	953	41	3H-Histamine	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	3H-Histamine	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	3H-Histamine	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1267	3804	49	3H-Histamine	-33	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1267	3804	49	3H-N-alpha-methylhistamine	-33	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-Histamine	-33	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-N-alpha-methylhistamine	-33	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-Histamine	-33	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-N-alpha-methylhistamine	-33	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1547484	940	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	940	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	940	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	940	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	940	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		45037031	216156	0	3H-Histamine	-70	4	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	285	2	2	2	1.5	C[C@H](CC1=CN=CN1)N.Br.Br	None
		1223	953	41	125I-iodophenpropit	-60	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	125I-iodophenpropit	-60	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	125I-iodophenpropit	-60	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1204	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-N-alpha-methylhistamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-N-alpha-methylhistamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-N-alpha-methylhistamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-N-alpha-methylhistamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-N-alpha-methylhistamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-N-alpha-methylhistamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		2286	3183	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		1204	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	-3	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		3032915	15495	24	3H-Histamine	-1	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		CHEMBL12160	15495	24	3H-Histamine	-1	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		1204	1932	119	3H-JNJ 7777120	-3	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-JNJ 7777120	-3	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-JNJ 7777120	-3	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-JNJ 7777120	-3	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-JNJ 7777120	-3	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-JNJ 7777120	-3	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1251	2014	39	125I-iodophenpropit	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		1251	2014	39	3H-Histamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		1251	2014	39	3H-N-alpha-methylhistamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	2014	39	125I-iodophenpropit	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	2014	39	3H-Histamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	2014	39	3H-N-alpha-methylhistamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	2014	39	125I-iodophenpropit	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	2014	39	3H-Histamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	2014	39	3H-N-alpha-methylhistamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		None	216254	0	125I-iodophenpropit	-13	19	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		None	216254	0	3H-JNJ 7777120	-13	19	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		103	4153	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	958	93	3H-Histamine	-57	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-Histamine	-57	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-Histamine	-57	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-Histamine	-57	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-Histamine	-57	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1204	1932	119	3H-Histamine	-3	24	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	-3	24	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	-3	24	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	-3	24	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	-3	24	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	-3	24	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		11957573	2010	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		1250	2010	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		3692	2010	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		CHEMBL19439	2010	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		277	1301	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1241	2037	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		1242	2037	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		3614	2037	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		CHEMBL507	2037	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		None	216141	0	3H-Histamine	-7585	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		100	3805	58	3H-Histamine	-56	55	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-Histamine	-56	55	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-Histamine	-56	55	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-Histamine	-56	55	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-Histamine	-56	55	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1204	1932	119	125I-iodophenpropit	-3	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	125I-iodophenpropit	-3	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	125I-iodophenpropit	-3	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	125I-iodophenpropit	-3	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	125I-iodophenpropit	-3	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	125I-iodophenpropit	-3	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1226	2019	20	3H-N-alpha-methylhistamine	2	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		41376	2019	20	3H-N-alpha-methylhistamine	2	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		CHEMBL12608	2019	20	3H-N-alpha-methylhistamine	2	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		45037031	216156	0	3H-N-alpha-methylhistamine	-70	4	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	285	2	2	2	1.5	C[C@H](CC1=CN=CN1)N.Br.Br	None
		1267	3804	49	3H-Histamine	-33	26	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-Histamine	-33	26	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-Histamine	-33	26	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1210	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		135398737	958	93	125I-iodophenpropit	-57	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	125I-iodophenpropit	-57	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	125I-iodophenpropit	-57	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	125I-iodophenpropit	-57	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	125I-iodophenpropit	-57	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1239	2033	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		1240	2033	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		912	2033	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		CHEMBL268490	2033	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		180	401	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1204	1932	119	3H-PYRILAMINE	-3	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-PYRILAMINE	-3	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-PYRILAMINE	-3	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-PYRILAMINE	-3	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-PYRILAMINE	-3	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-PYRILAMINE	-3	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		None	216141	0	3H-Histamine	-7585	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		1248	1424	28	3H-Histamine	-15	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		3077	1424	28	3H-Histamine	-15	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		90045	1424	28	3H-Histamine	-15	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		CHEMBL12344	1424	28	3H-Histamine	-15	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		11957573	2010	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		1250	2010	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		3692	2010	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		CHEMBL19439	2010	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		921599	19455	51	3H-Histamine	234	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	None
		CHEMBL129660	19455	51	3H-Histamine	234	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	None
		1204	1932	119	3H-Histamine	-3	24	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	-3	24	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	-3	24	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	-3	24	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	-3	24	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	-3	24	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1267	3804	49	125I-iodophenpropit	-33	26	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	125I-iodophenpropit	-33	26	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	125I-iodophenpropit	-33	26	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3032915	15495	24	3H-Histamine	-1	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		3032915	15495	24	3H-N-alpha-methylhistamine	-1	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		CHEMBL12160	15495	24	3H-Histamine	-1	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		CHEMBL12160	15495	24	3H-N-alpha-methylhistamine	-1	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		135398737	958	93	3H-JNJ 7777120	-57	89	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-JNJ 7777120	-57	89	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-JNJ 7777120	-57	89	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-JNJ 7777120	-57	89	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-JNJ 7777120	-57	89	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		45073439	216157	0	3H-N-alpha-methylhistamine	-75	4	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	285	2	2	2	1.5	C[C@@H](CC1=CN=CN1)N.Br.Br	None
		1224	1432	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		2782	32000	67	3H-PYRILAMINE	-	1	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL1407943	32000	67	3H-PYRILAMINE	-	1	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL3216363	32000	67	3H-PYRILAMINE	-	1	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		1223	953	41	3H-Histamine	-60	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	3H-Histamine	-60	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	3H-Histamine	-60	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		4761	13441	42	3H-PYRILAMINE	-	1	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1193	13441	42	3H-PYRILAMINE	-	1	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1580221	13441	42	3H-PYRILAMINE	-	1	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		1267	3804	49	3H-Histamine	-33	26	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-Histamine	-33	26	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-Histamine	-33	26	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1267	3804	49	3H-Histamine	-33	26	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-Histamine	-33	26	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-Histamine	-33	26	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		115237	55585	119	None	-891	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	None	-891	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		2247	505	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		5625	199668	72	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	None
		CHEMBL593	199668	72	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	None
		1613	2348	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		16106	118146	34	None	-20	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
		CHEMBL340801	118146	34	None	-20	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
		4761	13441	42	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1193	13441	42	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1580221	13441	42	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		135398737	958	93	None	-54	89	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-54	89	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-54	89	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-54	89	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-54	89	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	3805	58	None	-56	55	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-56	55	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-56	55	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-56	55	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-56	55	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		16362	3125	71	None	-562	30	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	None	-562	30	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	None	-562	30	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	None	-562	30	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	None	-562	30	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		135398737	958	93	None	-44	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-44	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-44	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-44	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-44	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		103	4153	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	919	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	919	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1613	2348	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398737	958	93	3H-Histamine	-57	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-Histamine	-57	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-Histamine	-57	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-Histamine	-57	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-Histamine	-57	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11957573	2010	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		1250	2010	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		3692	2010	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		CHEMBL19439	2010	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		2782	32000	67	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL1407943	32000	67	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL3216363	32000	67	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		1210	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2286	3183	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2726	919	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1204	1932	119	None	-15	24	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	None	-15	24	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	None	-15	24	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	None	-15	24	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	None	-15	24	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	None	-15	24	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	None	-12	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	None	-12	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	None	-12	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	None	-12	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	None	-12	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	None	-12	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1223	953	41	3H-Histamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1223	953	41	3H-N-alpha-methylhistamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	3H-Histamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	3H-N-alpha-methylhistamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	3H-Histamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	3H-N-alpha-methylhistamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		135	2532	43	3H-PYRILAMINE	-389	58	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-PYRILAMINE	-389	58	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-PYRILAMINE	-389	58	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-PYRILAMINE	-389	58	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-PYRILAMINE	-389	58	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1267	3804	49	3H-JNJ 7777120	-33	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1267	3804	49	3H-JNJ-5207852	-33	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-JNJ 7777120	-33	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-JNJ-5207852	-33	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-JNJ 7777120	-33	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-JNJ-5207852	-33	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1204	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-Histamine	-3	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	-3	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	-3	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	-3	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	-3	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	-3	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		180	401	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		277	1301	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1204	1932	119	None	1	24	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	None	1	24	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	None	1	24	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	None	1	24	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	None	1	24	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	None	1	24	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		135398737	958	93	None	-57	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-57	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-57	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-57	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-57	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-Histamine	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-Histamine	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-Histamine	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-Histamine	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-Histamine	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-PYRILAMINE	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	-57	89	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		115237	55585	119	3H-Histamine	-891	54	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-Histamine	-891	54	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		1251	2014	39	3H-Histamine	-100	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	2014	39	3H-Histamine	-100	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	2014	39	3H-Histamine	-100	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		23650961	3846	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		9276	3846	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		CHEMBL3301609	3846	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		DB12522	3846	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		1265	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	12606603
		1265	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	15294456
		1265	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		6422124	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	12606603
		6422124	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	15294456
		6422124	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		CHEMBL14638	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	12606603
		CHEMBL14638	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	15294456
		CHEMBL14638	942	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		1267	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179434
		1267	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179436
		1267	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11181941
		1267	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		1267	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	12606603
		1267	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	15294456
		3035905	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179434
		3035905	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179436
		3035905	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11181941
		3035905	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		3035905	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	12606603
		3035905	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	15294456
		CHEMBL260374	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179434
		CHEMBL260374	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179436
		CHEMBL260374	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11181941
		CHEMBL260374	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		CHEMBL260374	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	12606603
		CHEMBL260374	3804	49	None	-33	26	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	15294456
		10446295	2132	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	15454206
		1277	2132	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	15454206
		CHEMBL185951	2132	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	15454206
		1223	953	41	None	-338	11	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		2790	953	41	None	-338	11	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		CHEMBL14690	953	41	None	-338	11	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		1274	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	17154494
		3063228	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	17154494
		CHEMBL1196470	4064	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	17154494
		1269	121	41	None	213	3	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	15947036
		1269	121	41	None	213	3	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	16432504
		37463	121	41	None	213	3	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	15947036
		37463	121	41	None	213	3	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	16432504
		CHEMBL275443	121	41	None	213	3	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	15947036
		CHEMBL275443	121	41	None	213	3	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	16432504
		1223	953	41	None	-363	11	Mouse	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		2790	953	41	None	-363	11	Mouse	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		CHEMBL14690	953	41	None	-363	11	Mouse	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		1223	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11179434
		1223	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11181941
		1223	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		1223	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		1223	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	15947036
		2790	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11179434
		2790	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11181941
		2790	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		2790	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		2790	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	15947036
		CHEMBL14690	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11179434
		CHEMBL14690	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11181941
		CHEMBL14690	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		CHEMBL14690	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		CHEMBL14690	953	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	15947036
		24994634	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	24495018
		24994634	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		8984	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	24495018
		8984	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		CHEMBL3236549	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	24495018
		CHEMBL3236549	2142	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		45257132	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		8983	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		CHEMBL595180	3682	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		1278	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1278	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		1278	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		1279	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1279	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		1279	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		4908365	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		4908365	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		4908365	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		CHEMBL129198	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		CHEMBL129198	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		CHEMBL129198	2150	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		117072554	2023	0	None	81	4	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	5	2	6	2.3	CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1	26084539
		8982	2023	0	None	81	4	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	5	2	6	2.3	CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1	26084539
		24745335	295	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		8985	295	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		CHEMBL1915540	295	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		DB15027	295	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		5048	3133	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		8924	3133	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		9948102	3133	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		CHEMBL462605	3133	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		DB11642	3133	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		441082	1163	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		8981	1163	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		CHEMBL191703	1163	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		11697697	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		7346	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		CHEMBL476323	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		DB11910	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		1547484	940	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	940	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	940	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	940	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	940	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		10058807	2018	2	None	-1	2	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	4	3	3	-0.0	CN=C(NC#N)NCCCc1cnc[nH]1	11179436
		1276	2018	2	None	-1	2	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	4	3	3	-0.0	CN=C(NC#N)NCCCc1cnc[nH]1	11179436
		CHEMBL2261340	2018	2	None	-1	2	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	4	3	3	-0.0	CN=C(NC#N)NCCCc1cnc[nH]1	11179436
		135398737	958	93	None	-54	89	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		38	958	93	None	-54	89	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		722	958	93	None	-54	89	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		CHEMBL42	958	93	None	-54	89	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		DB00363	958	93	None	-54	89	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		1238	2082	13	None	-19	3	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	11181941
		6603865	2082	13	None	-19	3	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	11181941
		CHEMBL11919	2082	13	None	-19	3	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	11181941
		1248	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		1248	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		1248	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		1248	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		3077	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		3077	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		3077	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		3077	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		90045	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		90045	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		90045	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		90045	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		CHEMBL12344	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		CHEMBL12344	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		CHEMBL12344	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		CHEMBL12344	1424	28	None	-15	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		135398737	958	93	None	-44	89	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		38	958	93	None	-44	89	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		722	958	93	None	-44	89	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		CHEMBL42	958	93	None	-44	89	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		DB00363	958	93	None	-44	89	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		11313837	2500	8	None	-1995	2	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	15771452
		1254	2500	8	None	-1995	2	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	15771452
		CHEMBL175782	2500	8	None	-1995	2	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	15771452
		124846	1946	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	10	3	3	4.1	CC(NCCc1cnc[nH]1)CCCCC(=O)Nc1ccc(cc1)C(F)(F)F	11179436
		1273	1946	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	10	3	3	4.1	CC(NCCc1cnc[nH]1)CCCCC(=O)Nc1ccc(cc1)C(F)(F)F	11179436
		CHEMBL67601	1946	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	10	3	3	4.1	CC(NCCc1cnc[nH]1)CCCCC(=O)Nc1ccc(cc1)C(F)(F)F	11179436
		12656	2040	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	2	0.5	CN(CCc1[nH]cnc1)C	16432504
		1270	2040	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	2	0.5	CN(CCc1[nH]cnc1)C	16432504
		CHEMBL12704	2040	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	2	0.5	CN(CCc1[nH]cnc1)C	16432504
		1194	45	3	None	-1318	4	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	15947036
		23786499	45	3	None	-1318	4	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	15947036
		CHEMBL26116	45	3	None	-1318	4	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	15947036
		1229	743	0	None	-19	6	Rat	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		5311293	743	0	None	-19	6	Rat	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		1229	743	0	None	-15	6	Mouse	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		5311293	743	0	None	-15	6	Mouse	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		1236	2067	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1237	2067	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		156615	2067	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		CHEMBL268229	2067	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1241	2037	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1242	2037	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		3614	2037	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		CHEMBL507	2037	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1268	82	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	15947036
		1268	82	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	16432504
		92613	82	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	15947036
		92613	82	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	16432504
		1236	2067	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1237	2067	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		156615	2067	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		CHEMBL268229	2067	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		135398737	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		135398737	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		135398737	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		135398737	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		38	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		38	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		38	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		38	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		722	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		722	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		722	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		722	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		CHEMBL42	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		CHEMBL42	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		CHEMBL42	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		CHEMBL42	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		DB00363	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		DB00363	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		DB00363	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		DB00363	958	93	None	-57	89	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		1241	2037	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1242	2037	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		3614	2037	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		CHEMBL507	2037	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1236	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1236	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		1236	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		1236	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1237	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1237	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		1237	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		1237	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		156615	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		156615	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		156615	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		156615	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		CHEMBL268229	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		CHEMBL268229	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		CHEMBL268229	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		CHEMBL268229	2067	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1271	2036	0	None	-	1	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	3	0.4	NCCc1ncn(c1)CC	16432504
		44292270	2036	0	None	-	1	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	3	0.4	NCCc1ncn(c1)CC	16432504
		CHEMBL46296	2036	0	None	-	1	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	3	0.4	NCCc1ncn(c1)CC	16432504
		1239	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		1239	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		1240	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		1240	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		912	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		912	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		CHEMBL268490	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		CHEMBL268490	2033	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		1229	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179434
		1229	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179436
		1229	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11181941
		1229	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		1229	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	15947036
		5311293	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179434
		5311293	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179436
		5311293	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11181941
		5311293	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		5311293	743	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	15947036
		1204	1932	119	None	-12	24	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	1932	119	None	-12	24	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	1932	119	None	-12	24	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	1932	119	None	-12	24	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	1932	119	None	-12	24	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	1932	119	None	-12	24	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1204	1932	119	None	-15	24	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	1932	119	None	-15	24	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	1932	119	None	-15	24	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	1932	119	None	-15	24	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	1932	119	None	-15	24	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	1932	119	None	-15	24	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1241	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1241	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1241	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		1242	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1242	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1242	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		3614	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		3614	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		3614	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		CHEMBL507	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		CHEMBL507	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		CHEMBL507	2037	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		1267	3804	49	None	-21	26	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		1267	3804	49	None	-14	26	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		3035905	3804	49	None	-21	26	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		3035905	3804	49	None	-14	26	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		CHEMBL260374	3804	49	None	-21	26	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		CHEMBL260374	3804	49	None	-14	26	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		1266	2057	0	None	-23	3	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	9	3	4	2.8	N[C@H](SCCCc1cnc[nH]1)NCCc1ccc(cc1)I	11179436
		3960	2057	0	None	-23	3	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	9	3	4	2.8	N[C@H](SCCCc1cnc[nH]1)NCCc1ccc(cc1)I	11179436
		5311186	2057	0	None	-23	3	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	9	3	4	2.8	N[C@H](SCCCc1cnc[nH]1)NCCc1ccc(cc1)I	11179436
		1226	2019	20	None	2	6	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	11179434
		1226	2019	20	None	2	6	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	15947036
		41376	2019	20	None	2	6	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	11179434
		41376	2019	20	None	2	6	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	15947036
		CHEMBL12608	2019	20	None	2	6	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	11179434
		CHEMBL12608	2019	20	None	2	6	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	15947036
		1251	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179434
		1251	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179436
		1251	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	14640553
		3035842	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179434
		3035842	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179436
		3035842	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	14640553
		CHEMBL18661	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179434
		CHEMBL18661	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179436
		CHEMBL18661	2014	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	14640553
		1204	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1204	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		1204	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1204	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1204	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		1204	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		1204	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1247	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1247	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		1247	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1247	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		1247	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		1247	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1375	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1375	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		1375	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1375	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		1375	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		1375	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		774	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		774	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		774	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		774	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		774	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		774	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		CHEMBL90	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		DB05381	1932	119	None	-3	24	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		11957573	2010	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		11957573	2010	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		1250	2010	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		1250	2010	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		3692	2010	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		3692	2010	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		CHEMBL19439	2010	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		CHEMBL19439	2010	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		11957573	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		11957573	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		11957573	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		11957573	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		1250	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		1250	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		1250	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		1250	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		3692	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		3692	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		3692	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		3692	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		CHEMBL19439	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		CHEMBL19439	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		CHEMBL19439	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		CHEMBL19439	2010	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071

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