Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
| 11344 | 776 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | β-arrestin recruitment determined in a BRET assayβ-arrestin recruitment determined in a BRET assay |
Guide to Pharmacology | None | None | None | None | 31036565 | |||
| 574 | 774 | 0 | None | 69 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | None | |||
| 573 | 771 | 0 | None | -1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 11773063 | |||
| 5768 | 775 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 12899627 | |||
| 5770 | 914 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 17258808 | |||
| 574 | 774 | 0 | None | 69 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 11773063 | |||
| 574 | 774 | 0 | None | 69 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 12899627 | |||
| 573 | 771 | 0 | None | -1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 11773063 | |||
| 573 | 771 | 0 | None | -1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 12899627 | |||
| 5780 | 213 | 0 | None | - | 1 | Mouse | 6.0 | pIC50 | ~ | 6 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 14570896 | |||
Showing 1 to 10 of 10 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
| 155541442 | 173020 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 1119 | 29 | 17 | 13 | -0.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| CHEMBL4518532 | 173020 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 1119 | 29 | 17 | 13 | -0.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| 155555017 | 174311 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Binding | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| CHEMBL4550325 | 174311 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Binding | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| 155555017 | 174311 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assayDisplacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| CHEMBL4550325 | 174311 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assayDisplacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| 9384 | 2987 | 0 | None | - | 1 | Human | 3.7 | pKi | = | 3.7 | Binding | Binding assayBinding assay |
Guide to Pharmacology | None | None | None | None | 27108698 | ||||
| 9385 | 2989 | 0 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | Binding assayBinding assay |
Guide to Pharmacology | None | None | None | None | 27108698 | ||||
Showing 1 to 8 of 8 entries