Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
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Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
145985766 | 165694 | 0 | None | -1862 | 3 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1 | 10.1016/j.bmcl.2018.07.042 | |
CHEMBL4245355 | 165694 | 0 | None | -1862 | 3 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1 | 10.1016/j.bmcl.2018.07.042 | |
134817249 | 165827 | 16 | None | -20892 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1 | 10.1016/j.bmcl.2018.07.042 | |
CHEMBL4248604 | 165827 | 16 | None | -20892 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1 | 10.1016/j.bmcl.2018.07.042 | |
8652 | 845 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 16904643 | |||
810 | 834 | 0 | None | -2 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 16904643 | |||
810 | 834 | 0 | None | -2 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9153236 | |||
810 | 834 | 0 | None | -2 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9507024 | |||
811 | 843 | 0 | None | 12 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9507024 |
Showing 1 to 9 of 9 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
183790 | 3742 | 11 | None | - | 2 | Human | 8.9 | pIC50 | = | 8.9 | Binding | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/acs.jmedchem.9b01701 | ||
783 | 3742 | 11 | None | - | 2 | Human | 8.9 | pIC50 | = | 8.9 | Binding | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/acs.jmedchem.9b01701 | ||
CHEMBL1178786 | 3742 | 11 | None | - | 2 | Human | 8.9 | pIC50 | = | 8.9 | Binding | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/acs.jmedchem.9b01701 | ||
11285792 | 879 | 34 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
801 | 879 | 34 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
CHEMBL2110727 | 879 | 34 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
DB11758 | 879 | 34 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
810 | 834 | 0 | None | 39 | 3 | Human | 10.0 | pKd | = | 10 | Binding | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 10512740 | ||||
8652 | 845 | 0 | None | - | 1 | Human | 9.9 | pKd | = | 9.9 | Binding | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 10512740 |
Showing 1 to 9 of 9 entries