Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

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ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
11715531 88697 21 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 5 2 4 1.9 C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL236013 88697 21 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 5 2 4 1.9 C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
28400380 89917 4 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 5 2 3 2.0 CCCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL237945 89917 4 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 5 2 3 2.0 CCCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11415838 136357 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 316 2 1 4 2.6 Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br 10.1021/jm070022x
CHEMBL373484 136357 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 316 2 1 4 2.6 Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br 10.1021/jm070022x
28400046 89810 3 None 32 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 4 2 3 1.8 CC(C)CNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL237737 89810 3 None 32 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 4 2 3 1.8 CC(C)CNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
10198518 73537 30 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 231 2 1 4 2.2 O=C(O)c1ccc2c(c1)nnn2C1CCCC1 10.1021/jm051099t
CHEMBL201724 73537 30 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 231 2 1 4 2.2 O=C(O)c1ccc2c(c1)nnn2C1CCCC1 10.1021/jm051099t
24955646 58034 0 None -186 4 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 310 5 1 4 2.9 CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1 10.1021/ml100251u
CHEMBL1672639 58034 0 None -186 4 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 310 5 1 4 2.9 CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1 10.1021/ml100251u
1591 131 63 None -33 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 168 4 2 2 1.5 CCCCc1cc(n[nH]1)C(=O)O 10.1016/j.bmcl.2007.07.101
6485181 131 63 None -33 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 168 4 2 2 1.5 CCCCc1cc(n[nH]1)C(=O)O 10.1016/j.bmcl.2007.07.101
CHEMBL428730 131 63 None -33 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 168 4 2 2 1.5 CCCCc1cc(n[nH]1)C(=O)O 10.1016/j.bmcl.2007.07.101
28400196 90252 19 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 266 7 1 4 2.9 CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL238376 90252 19 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 266 7 1 4 2.9 CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
44433532 152409 0 None -16 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 182 2 2 4 0.3 CCc1[nH]nc(-c2nnn[nH]2)c1F 10.1016/j.bmcl.2007.07.101
CHEMBL397055 152409 0 None -16 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 182 2 2 4 0.3 CCc1[nH]nc(-c2nnn[nH]2)c1F 10.1016/j.bmcl.2007.07.101
11219885 83462 0 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 286 2 1 3 2.5 CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL220001 83462 0 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 286 2 1 3 2.5 CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
15604642 75254 0 None -323 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 250 3 2 4 0.8 CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 10.1021/ml200243g
CHEMBL2036948 75254 0 None -323 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 250 3 2 4 0.8 CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 10.1021/ml200243g
43131474 151641 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 208 4 2 3 2.2 CC(C)C(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL396382 151641 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 208 4 2 3 2.2 CC(C)C(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11961288 196710 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 313 6 2 4 3.4 O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL564914 196710 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 313 6 2 4 3.4 O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1 10.1016/j.bmcl.2009.05.108
15604637 75260 0 None -70 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 262 4 2 4 0.9 O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1 10.1021/ml200243g
CHEMBL2036955 75260 0 None -70 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 262 4 2 4 0.9 O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1 10.1021/ml200243g
11380943 83459 1 None -20 2 Human 4.9 pEC50 = 4.9 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 296 2 1 3 2.2 CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL219980 83459 1 None -20 2 Human 4.9 pEC50 = 4.9 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 296 2 1 3 2.2 CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
45269912 195910 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 319 6 2 5 3.4 O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL559204 195910 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 319 6 2 5 3.4 O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1 10.1016/j.bmcl.2009.05.108
11687485 90049 4 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 254 6 2 5 1.7 COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL238164 90049 4 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 254 6 2 5 1.7 COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
11483496 126 0 None -14 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm800896z
1589 126 0 None -14 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm800896z
CHEMBL375493 126 0 None -14 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm800896z
11483496 126 0 None -14 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
1589 126 0 None -14 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
CHEMBL375493 126 0 None -14 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
28400406 89918 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 208 6 2 3 2.4 CCCCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL237946 89918 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 208 6 2 3 2.4 CCCCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11528819 145506 23 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 5 2 4 2.5 CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL391473 145506 23 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 5 2 4 2.5 CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
2829816 88747 54 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 6 2 4 2.5 CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL236219 88747 54 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 6 2 4 2.5 CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
17965902 89814 4 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 242 3 2 3 2.0 O=C(O)c1ccc(NC(=O)c2ccccc2)nc1 10.1016/j.bmcl.2007.09.058
CHEMBL237739 89814 4 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 242 3 2 3 2.0 O=C(O)c1ccc(NC(=O)c2ccccc2)nc1 10.1016/j.bmcl.2007.09.058
11379903 84271 0 None -6 2 Human 4.8 pEC50 = 4.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL221282 84271 0 None -6 2 Human 4.8 pEC50 = 4.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
43271548 90256 4 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 4 1 3 1.6 CCCN(C)c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL238387 90256 4 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 4 1 3 1.6 CCCN(C)c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11379903 84271 0 None -6 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL221282 84271 0 None -6 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
11379903 84271 0 None -6 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm800896z
CHEMBL221282 84271 0 None -6 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm800896z
11436345 143 0 None -1 2 Human 6.8 pEC50 = 6.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
1599 143 0 None -1 2 Human 6.8 pEC50 = 6.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
CHEMBL424938 143 0 None -1 2 Human 6.8 pEC50 = 6.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
11218626 84892 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1 10.1021/jm070022x
CHEMBL223623 84892 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1 10.1021/jm070022x
13153555 93863 27 None -42 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 182 5 2 2 1.8 CCCCCc1cc(C(=O)O)[nH]n1 10.1016/j.bmcl.2007.07.101
CHEMBL247921 93863 27 None -42 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 182 5 2 2 1.8 CCCCCc1cc(C(=O)O)[nH]n1 10.1016/j.bmcl.2007.07.101
15605571 75235 2 None -23 5 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 236 3 2 4 0.5 CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 10.1021/ml200243g
CHEMBL2036813 75235 2 None -23 5 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 236 3 2 4 0.5 CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 10.1021/ml200243g
11470798 137967 1 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL376419 137967 1 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
283475 89805 118 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 196 3 2 4 1.3 CNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL237731 89805 118 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 196 3 2 4 1.3 CNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
11528793 88702 4 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 236 4 2 4 2.3 O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
CHEMBL236028 88702 4 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 236 4 2 4 2.3 O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
10263467 140894 2 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 235 4 1 5 1.3 COCC(C)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL382096 140894 2 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 235 4 1 5 1.3 COCC(C)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
2776549 73391 82 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 177 1 1 4 0.7 Cn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL201513 73391 82 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 177 1 1 4 0.7 Cn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
3684804 90250 48 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 210 3 1 4 1.4 CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL238374 90250 48 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 210 3 1 4 1.4 CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
11322738 136766 1 None -13 2 Human 4.7 pEC50 = 4.7 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 252 2 1 3 2.1 CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL374111 136766 1 None -13 2 Human 4.7 pEC50 = 4.7 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 252 2 1 3 2.1 CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
3729086 145597 58 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 210 4 2 4 1.7 CCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL391547 145597 58 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 210 4 2 4 1.7 CCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
10465474 140457 27 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 203 2 1 4 1.5 O=C(O)c1ccc2c(c1)nnn2C1CC1 10.1021/jm051099t
CHEMBL380939 140457 27 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 203 2 1 4 1.5 O=C(O)c1ccc2c(c1)nnn2C1CC1 10.1021/jm051099t
11322761 141606 1 None -1 2 Human 4.6 pEC50 = 4.6 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL385103 141606 1 None -1 2 Human 4.6 pEC50 = 4.6 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O 10.1021/jm070022x
3824366 89508 57 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 258 4 2 4 3.0 O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
3953363 89508 57 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 258 4 2 4 3.0 O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
CHEMBL237296 89508 57 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 258 4 2 4 3.0 O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
45269046 196387 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 319 6 2 5 3.4 O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL562675 196387 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 319 6 2 5 3.4 O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1 10.1016/j.bmcl.2009.05.108
11708383 88519 36 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 224 4 2 4 2.1 CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL235144 88519 36 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 224 4 2 4 2.1 CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
10421571 74225 2 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 235 5 1 5 1.2 CCOCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL202351 74225 2 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 235 5 1 5 1.2 CCOCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
10398515 135291 33 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 219 1 1 4 1.9 CC(C)(C)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL372727 135291 33 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 219 1 1 4 1.9 CC(C)(C)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
28400056 152223 1 None 74 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 208 5 2 3 2.4 CCC(CC)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL396879 152223 1 None 74 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 208 5 2 3 2.4 CCC(CC)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11276453 84876 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1 10.1021/jm070022x
CHEMBL223566 84876 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1 10.1021/jm070022x
11492560 88518 5 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 252 7 2 4 2.9 CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL235141 88518 5 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 252 7 2 4 2.9 CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
10014206 73040 3 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 233 5 1 4 2.3 CCCCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL201048 73040 3 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 233 5 1 4 2.3 CCCCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
11715556 120 40 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 224 5 2 4 2.1 CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O 10.1016/j.bmcl.2007.09.058
5801 120 40 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 224 5 2 4 2.1 CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O 10.1016/j.bmcl.2007.09.058
CHEMBL236011 120 40 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 224 5 2 4 2.1 CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O 10.1016/j.bmcl.2007.09.058
44250176 1131 0 None 2951 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 319 6 2 5 3.4 OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1 10.1016/j.bmcl.2009.05.108
5800 1131 0 None 2951 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 319 6 2 5 3.4 OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1 10.1016/j.bmcl.2009.05.108
CHEMBL564300 1131 0 None 2951 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 319 6 2 5 3.4 OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1 10.1016/j.bmcl.2009.05.108
51346919 57843 6 None -100 4 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 296 5 1 4 2.5 O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1 10.1021/ml100251u
CHEMBL1671877 57843 6 None -100 4 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 296 5 1 4 2.5 O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1 10.1021/ml100251u
1595 259 49 None -4 2 Human 5.5 pEC50 = 5.5 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm070022x
51576 259 49 None -4 2 Human 5.5 pEC50 = 5.5 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm070022x
CHEMBL278488 259 49 None -4 2 Human 5.5 pEC50 = 5.5 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm070022x
10353934 133161 2 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 233 4 1 4 2.5 CCC(CC)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL370386 133161 2 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 233 4 1 4 2.5 CCC(CC)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
10422270 73372 2 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 251 5 1 5 1.9 CCSCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL201409 73372 2 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 251 5 1 5 1.9 CCSCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
4992776 90240 33 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 4 2 4 1.9 O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
CHEMBL238358 90240 33 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 4 2 4 1.9 O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
11565047 147218 25 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 250 4 2 4 2.6 O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
CHEMBL392830 147218 25 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 250 4 2 4 2.6 O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
2942936 149864 19 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 266 5 2 5 1.9 O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
CHEMBL394906 149864 19 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 266 5 2 5 1.9 O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
44434363 168971 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 286 4 2 4 2.5 O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
CHEMBL439028 168971 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 286 4 2 4 2.5 O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1 10.1016/j.bmcl.2007.09.058
10330955 169105 3 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 217 2 1 4 1.9 O=C(O)c1ccc2c(c1)nnn2C1CCC1 10.1021/jm051099t
CHEMBL440041 169105 3 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 217 2 1 4 1.9 O=C(O)c1ccc2c(c1)nnn2C1CCC1 10.1021/jm051099t
10398583 73969 13 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 221 4 1 5 0.8 COCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL202157 73969 13 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 221 4 1 5 0.8 COCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
28400038 88609 36 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 178 3 2 3 1.4 O=C(O)c1ccc(NC2CC2)nc1 10.1016/j.bmcl.2007.09.058
CHEMBL235615 88609 36 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 178 3 2 3 1.4 O=C(O)c1ccc(NC2CC2)nc1 10.1016/j.bmcl.2007.09.058
44433529 88536 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 176 2 2 4 0.5 c1c(-c2nnn[nH]2)n[nH]c1C1CC1 10.1016/j.bmcl.2007.07.101
CHEMBL235230 88536 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 176 2 2 4 0.5 c1c(-c2nnn[nH]2)n[nH]c1C1CC1 10.1016/j.bmcl.2007.07.101
2771812 89811 53 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 214 3 2 3 2.5 O=C(O)c1ccc(Nc2ccccc2)nc1 10.1016/j.bmcl.2007.09.058
CHEMBL237738 89811 53 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 214 3 2 3 2.5 O=C(O)c1ccc(Nc2ccccc2)nc1 10.1016/j.bmcl.2007.09.058
43187344 90254 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 210 5 2 4 1.2 COCC(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL238385 90254 1 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 210 5 2 4 1.2 COCC(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11817645 84906 1 None -12 2 Human 4.5 pEC50 = 4.5 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL223700 84906 1 None -12 2 Human 4.5 pEC50 = 4.5 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
10013684 74029 2 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 219 3 1 4 2.1 CCC(C)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL202206 74029 2 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 219 3 1 4 2.1 CCC(C)n1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
4712703 141222 44 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 204 2 1 3 2.3 CC(C)n1cnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL382863 141222 44 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 204 2 1 3 2.3 CC(C)n1cnc2cc(C(=O)O)ccc21 10.1021/jm051099t
44433529 88536 0 None 5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 176 2 2 4 0.5 c1c(-c2nnn[nH]2)n[nH]c1C1CC1 10.1016/j.bmcl.2007.07.101
CHEMBL235230 88536 0 None 5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 176 2 2 4 0.5 c1c(-c2nnn[nH]2)n[nH]c1C1CC1 10.1016/j.bmcl.2007.07.101
11322762 137602 1 None -5 2 Human 4.4 pEC50 = 4.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL375625 137602 1 None -5 2 Human 4.4 pEC50 = 4.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 254 2 1 3 1.7 CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O 10.1021/jm070022x
43085192 89431 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 252 5 2 4 2.7 CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL237077 89431 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 252 5 2 4 2.7 CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
11483496 126 0 None -14 2 Human 6.4 pEC50 = 6.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
1589 126 0 None -14 2 Human 6.4 pEC50 = 6.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
CHEMBL375493 126 0 None -14 2 Human 6.4 pEC50 = 6.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
11311474 165782 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL424750 165782 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
43187332 152220 2 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 4 2 3 2.0 CCC(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL396878 152220 2 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 194 4 2 3 2.0 CCC(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
1447952 89809 7 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 206 3 2 3 2.1 O=C(O)c1ccc(NC2CCCC2)nc1 10.1016/j.bmcl.2007.09.058
CHEMBL237735 89809 7 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 206 3 2 3 2.1 O=C(O)c1ccc(NC2CCCC2)nc1 10.1016/j.bmcl.2007.09.058
11744994 89806 26 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 166 3 2 3 1.2 CCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL237732 89806 26 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 166 3 2 3 1.2 CCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
1597 1965 80 None -1 2 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 205 2 1 4 1.7 OC(=O)c1ccc2c(c1)nnn2C(C)C 10.1021/jm051099t
2736690 1965 80 None -1 2 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 205 2 1 4 1.7 OC(=O)c1ccc2c(c1)nnn2C(C)C 10.1021/jm051099t
CHEMBL381638 1965 80 None -1 2 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 205 2 1 4 1.7 OC(=O)c1ccc2c(c1)nnn2C(C)C 10.1021/jm051099t
45268162 196239 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 235 6 2 3 1.7 O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL561720 196239 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 235 6 2 3 1.7 O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1 10.1016/j.bmcl.2009.05.108
28399894 149287 2 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 178 4 2 3 1.4 C=CCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2009.05.108
CHEMBL394468 149287 2 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 178 4 2 3 1.4 C=CCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2009.05.108
11324121 84666 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL222472 84666 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 302 2 1 4 2.3 CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
776421 89928 108 None -30 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 154 2 2 2 1.2 CC(C)c1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2007.07.101
CHEMBL238002 89928 108 None -30 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 154 2 2 2 1.2 CC(C)c1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2007.07.101
1595 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm800896z
51576 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm800896z
CHEMBL278488 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm800896z
1595 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm070022x
51576 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm070022x
CHEMBL278488 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm070022x
11183678 84772 1 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 224 2 1 4 1.5 CC1(c2ccsc2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL223140 84772 1 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 224 2 1 4 1.5 CC1(c2ccsc2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
1595 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1016/j.bmcl.2009.05.108
51576 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1016/j.bmcl.2009.05.108
CHEMBL278488 259 49 None -4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1016/j.bmcl.2009.05.108
11992587 195498 1 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 183 4 3 3 1.3 CCC(C)Nc1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2009.05.108
CHEMBL553415 195498 1 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 183 4 3 3 1.3 CCC(C)Nc1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2009.05.108
11148966 1122 4 None 4 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 232 3 1 3 1.9 CCC1(OC(=CC1=O)C(=O)O)c1ccccc1 10.1021/jm070022x
1598 1122 4 None 4 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 232 3 1 3 1.9 CCC1(OC(=CC1=O)C(=O)O)c1ccccc1 10.1021/jm070022x
CHEMBL436301 1122 4 None 4 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 232 3 1 3 1.9 CCC1(OC(=CC1=O)C(=O)O)c1ccccc1 10.1021/jm070022x
11380943 83459 1 None -20 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 296 2 1 3 2.2 CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL219980 83459 1 None -20 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 296 2 1 3 2.2 CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
11436345 143 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
1599 143 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
CHEMBL424938 143 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 10.1021/jm070022x
9971057 74303 4 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 283 4 1 5 2.2 COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1 10.1021/jm051099t
CHEMBL202427 74303 4 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 283 4 1 5 2.2 COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1 10.1021/jm051099t
28399946 89807 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 180 4 2 3 1.6 CCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL237733 89807 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 180 4 2 3 1.6 CCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11739420 84757 0 None -12 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 344 2 1 3 2.1 CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL223013 84757 0 None -12 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 344 2 1 3 2.1 CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
11413114 137619 0 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 208 2 1 3 1.4 CC1(C2=CCCC2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL375754 137619 0 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 208 2 1 3 1.4 CC1(C2=CCCC2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
43271417 90251 1 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 5 1 4 2.1 CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL238375 90251 1 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 5 1 4 2.1 CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
11992688 195739 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 335 8 2 3 3.4 O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL557298 195739 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 335 8 2 3 3.4 O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1 10.1016/j.bmcl.2009.05.108
11514348 153089 6 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 252 6 2 4 2.9 CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL397616 153089 6 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 252 6 2 4 2.9 CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
4738197 151305 39 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 240 6 2 5 1.4 COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL396073 151305 39 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 240 6 2 5 1.4 COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
653819 141261 50 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 245 2 1 4 2.6 O=C(O)c1ccc2c(c1)nnn2C1CCCCC1 10.1021/jm051099t
CHEMBL383099 141261 50 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 245 2 1 4 2.6 O=C(O)c1ccc2c(c1)nnn2C1CCCCC1 10.1021/jm051099t
59343664 75256 0 None -29 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 272 4 2 4 0.8 O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1 10.1021/ml200243g
CHEMBL2036951 75256 0 None -29 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 272 4 2 4 0.8 O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1 10.1021/ml200243g
43187366 90255 5 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 4 2 4 1.4 O=C(O)c1ccc(NCC2CCCO2)nc1 10.1016/j.bmcl.2007.09.058
CHEMBL238386 90255 5 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 4 2 4 1.4 O=C(O)c1ccc(NCC2CCCO2)nc1 10.1016/j.bmcl.2007.09.058
28400003 149289 37 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 180 3 2 3 1.6 CC(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL394469 149289 37 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 180 3 2 3 1.6 CC(C)Nc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
11184165 83454 0 None -5 2 Human 5.2 pEC50 = 5.2 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 246 3 1 3 2.0 CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1 10.1021/jm070022x
CHEMBL219950 83454 0 None -5 2 Human 5.2 pEC50 = 5.2 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 246 3 1 3 2.0 CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1 10.1021/jm070022x
2833647 149867 24 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 5 1 4 2.1 CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
CHEMBL394907 149867 24 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 238 5 1 4 2.1 CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.058
16775596 89611 3 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 6 1 3 2.4 CCCN(CCC)c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL237525 89611 3 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 222 6 1 3 2.4 CCCN(CCC)c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
59304608 75259 0 None -67 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 262 3 2 4 0.9 O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1 10.1021/ml200243g
CHEMBL2036954 75259 0 None -67 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 262 3 2 4 0.9 O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1 10.1021/ml200243g
11992588 195449 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 197 5 3 3 1.7 CCCC(C)Nc1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2009.05.108
CHEMBL552399 195449 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 197 5 3 3 1.7 CCCC(C)Nc1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2009.05.108
11379903 84271 0 None -6 2 Human 6.2 pEC50 = 6.2 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL221282 84271 0 None -6 2 Human 6.2 pEC50 = 6.2 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 258 2 1 4 2.2 CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
10331019 74413 31 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 219 4 1 4 1.9 CCCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL202586 74413 31 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 219 4 1 4 1.9 CCCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
28399894 149287 2 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 178 4 2 3 1.4 C=CCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL394468 149287 2 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 178 4 2 3 1.4 C=CCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
44434380 89610 21 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 192 3 2 3 1.7 O=C(O)c1ccc(NC2CCC2)nc1 10.1016/j.bmcl.2007.09.058
CHEMBL237524 89610 21 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 192 3 2 3 1.7 O=C(O)c1ccc(NC2CCC2)nc1 10.1016/j.bmcl.2007.09.058
44433528 147522 0 None 10 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 178 3 2 4 0.5 CCCc1cc(-c2nnn[nH]2)n[nH]1 10.1016/j.bmcl.2007.07.101
CHEMBL393064 147522 0 None 10 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 178 3 2 4 0.5 CCCc1cc(-c2nnn[nH]2)n[nH]1 10.1016/j.bmcl.2007.07.101
22271415 88524 57 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 152 2 2 3 0.8 CNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL235168 88524 57 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 152 2 2 3 0.8 CNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
10058774 74417 28 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 205 3 1 4 1.5 CCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL202614 74417 28 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 205 3 1 4 1.5 CCCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
44433530 147524 0 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 192 4 2 4 0.9 CCCCc1cc(-c2nnn[nH]2)n[nH]1 10.1016/j.bmcl.2007.07.101
CHEMBL393065 147524 0 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 192 4 2 4 0.9 CCCCc1cc(-c2nnn[nH]2)n[nH]1 10.1016/j.bmcl.2007.07.101
117629482 2823 140 None -26 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 123 1 1 2 0.8 OC(=O)c1cccnc1 10.1016/j.bmcl.2007.07.101
1588 2823 140 None -26 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 123 1 1 2 0.8 OC(=O)c1cccnc1 10.1016/j.bmcl.2007.07.101
1594 2823 140 None -26 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 123 1 1 2 0.8 OC(=O)c1cccnc1 10.1016/j.bmcl.2007.07.101
2835 2823 140 None -26 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 123 1 1 2 0.8 OC(=O)c1cccnc1 10.1016/j.bmcl.2007.07.101
938 2823 140 None -26 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 123 1 1 2 0.8 OC(=O)c1cccnc1 10.1016/j.bmcl.2007.07.101
CHEMBL573 2823 140 None -26 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 123 1 1 2 0.8 OC(=O)c1cccnc1 10.1016/j.bmcl.2007.07.101
DB00627 2823 140 None -26 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay
ChEMBL 123 1 1 2 0.8 OC(=O)c1cccnc1 10.1016/j.bmcl.2007.07.101
11992592 196031 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 211 6 2 3 1.7 CCCN(CCC)c1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2009.05.108
CHEMBL560254 196031 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 211 6 2 3 1.7 CCCN(CCC)c1cc(C(=O)O)n[nH]1 10.1016/j.bmcl.2009.05.108
11992591 196270 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 307 6 2 3 3.3 O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL561920 196270 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 307 6 2 3 3.3 O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1 10.1016/j.bmcl.2009.05.108
11992790 195192 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 343 6 2 3 3.6 O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL550563 195192 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 343 6 2 3 3.6 O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1 10.1016/j.bmcl.2009.05.108
2103992 169126 46 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 191 2 1 4 1.1 CCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
CHEMBL440217 169126 46 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 191 2 1 4 1.1 CCn1nnc2cc(C(=O)O)ccc21 10.1021/jm051099t
45269904 196732 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 287 6 2 5 2.5 O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1 10.1016/j.bmcl.2009.05.108
CHEMBL565055 196732 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay
ChEMBL 287 6 2 5 2.5 O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1 10.1016/j.bmcl.2009.05.108
11608532 73294 31 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 253 3 1 4 2.2 O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1 10.1021/jm051099t
CHEMBL201278 73294 31 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay
ChEMBL 253 3 1 4 2.2 O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1 10.1021/jm051099t
28400019 88566 9 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 196 5 2 4 0.8 COCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
CHEMBL235394 88566 9 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay
ChEMBL 196 5 2 4 0.8 COCCNc1ccc(C(=O)O)cn1 10.1016/j.bmcl.2007.09.058
56950369 3559 13 None -47 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 276 4 2 4 1.3 O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O 10.1021/ml200243g
8469 3559 13 None -47 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 276 4 2 4 1.3 O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O 10.1021/ml200243g
CHEMBL2036958 3559 13 None -47 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 276 4 2 4 1.3 O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O 10.1021/ml200243g
DB12433 3559 13 None -47 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human GPR109bAgonist activity at human GPR109b
ChEMBL 276 4 2 4 1.3 O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O 10.1021/ml200243g
11264843 137620 1 None -1 2 Human 5.0 pEC50 = 5 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 236 2 1 3 1.6 CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
CHEMBL375762 137620 1 None -1 2 Human 5.0 pEC50 = 5 Functional
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation
ChEMBL 236 2 1 3 1.6 CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O 10.1021/jm070022x
1595 259 49 None -4 2 Human 5.5 pIC50 = 5.5 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm800896z
51576 259 49 None -4 2 Human 5.5 pIC50 = 5.5 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm800896z
CHEMBL278488 259 49 None -4 2 Human 5.5 pIC50 = 5.5 Functional
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1021/jm800896z
117629482 2823 140 None -26 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 123 1 1 2 0.8 OC(=O)c1cccnc1 None
1588 2823 140 None -26 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 123 1 1 2 0.8 OC(=O)c1cccnc1 None
1594 2823 140 None -26 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 123 1 1 2 0.8 OC(=O)c1cccnc1 None
2835 2823 140 None -26 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 123 1 1 2 0.8 OC(=O)c1cccnc1 None
938 2823 140 None -26 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 123 1 1 2 0.8 OC(=O)c1cccnc1 None
CHEMBL573 2823 140 None -26 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 123 1 1 2 0.8 OC(=O)c1cccnc1 None
DB00627 2823 140 None -26 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 123 1 1 2 0.8 OC(=O)c1cccnc1 None
5798 1502 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N 19237584
6923517 1502 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N 19237584
9060 1502 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N 19237584
CHEMBL292303 1502 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N 19237584
DB03225 1502 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 204 3 3 2 1.1 OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N 19237584
5797 1475 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@@H](C(=O)O)Cc1ccccc1 19237584
6919011 1475 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@@H](C(=O)O)Cc1ccccc1 19237584
71567 1475 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@@H](C(=O)O)Cc1ccccc1 19237584
CHEMBL379630 1475 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@@H](C(=O)O)Cc1ccccc1 19237584
DB02556 1475 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 165 3 2 2 0.6 N[C@@H](C(=O)O)Cc1ccccc1 19237584
11367166 101 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 160 6 2 2 1.4 CCCCC[C@@H](CC(=O)O)O 19561068
2933 101 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 160 6 2 2 1.4 CCCCC[C@@H](CC(=O)O)O 19561068
117629482 2823 140 None -26 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 123 1 1 2 0.8 OC(=O)c1cccnc1 12522134
1588 2823 140 None -26 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 123 1 1 2 0.8 OC(=O)c1cccnc1 12522134
1594 2823 140 None -26 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 123 1 1 2 0.8 OC(=O)c1cccnc1 12522134
2835 2823 140 None -26 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 123 1 1 2 0.8 OC(=O)c1cccnc1 12522134
938 2823 140 None -26 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 123 1 1 2 0.8 OC(=O)c1cccnc1 12522134
CHEMBL573 2823 140 None -26 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 123 1 1 2 0.8 OC(=O)c1cccnc1 12522134
DB00627 2823 140 None -26 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 123 1 1 2 0.8 OC(=O)c1cccnc1 12522134
5796 67 77 None - 1 Human 5.4 pEC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 160 6 2 2 1.4 CCCCCCC(C(=O)O)O 19561068
94180 67 77 None - 1 Human 5.4 pEC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 160 6 2 2 1.4 CCCCCCC(C(=O)O)O 19561068
CHEMBL4447980 67 77 None - 1 Human 5.4 pEC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 160 6 2 2 1.4 CCCCCCC(C(=O)O)O 19561068
1152206 1440 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 208 4 3 4 0.3 OC(=O)[C@@H](CC(=O)c1ccccc1N)N 19237584
5799 1440 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 208 4 3 4 0.3 OC(=O)[C@@H](CC(=O)c1ccccc1N)N 19237584
6971244 1440 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 208 4 3 4 0.3 OC(=O)[C@@H](CC(=O)c1ccccc1N)N 19237584
CHEMBL1233899 1440 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 208 4 3 4 0.3 OC(=O)[C@@H](CC(=O)c1ccccc1N)N 19237584
1597 1965 80 None -1 2 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 205 2 1 4 1.7 OC(=O)c1ccc2c(c1)nnn2C(C)C 16480258
2736690 1965 80 None -1 2 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 205 2 1 4 1.7 OC(=O)c1ccc2c(c1)nnn2C(C)C 16480258
CHEMBL381638 1965 80 None -1 2 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 205 2 1 4 1.7 OC(=O)c1ccc2c(c1)nnn2C(C)C 16480258
12418 1476 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 166 3 2 2 0.7 C1=CC=C(C=C1)C[C@@H](C(=O)O)O 31120900
444718 1476 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 166 3 2 2 0.7 C1=CC=C(C=C1)C[C@@H](C(=O)O)O 31120900
DB02494 1476 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 166 3 2 2 0.7 C1=CC=C(C=C1)C[C@@H](C(=O)O)O 31120900
11715556 120 40 None - 1 Human 7.5 pEC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 224 5 2 4 2.1 CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O 17931863
5801 120 40 None - 1 Human 7.5 pEC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 224 5 2 4 2.1 CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O 17931863
CHEMBL236011 120 40 None - 1 Human 7.5 pEC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 224 5 2 4 2.1 CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O 17931863
44250176 1131 0 None 2951 2 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 6 2 5 3.4 OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1 19524438
5800 1131 0 None 2951 2 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 6 2 5 3.4 OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1 19524438
CHEMBL564300 1131 0 None 2951 2 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 319 6 2 5 3.4 OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1 19524438
1595 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 12522134
1595 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 15929991
1595 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 16389067
1595 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 17358052
51576 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 12522134
51576 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 15929991
51576 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 16389067
51576 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 17358052
CHEMBL278488 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 12522134
CHEMBL278488 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 15929991
CHEMBL278488 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 16389067
CHEMBL278488 259 49 None -4 2 Human 5.0 pEC50 None 5.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 17358052
11148966 1122 4 None 4 2 Human 5.3 pEC50 None 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 232 3 1 3 1.9 CCC1(OC(=CC1=O)C(=O)O)c1ccccc1 17358052
1598 1122 4 None 4 2 Human 5.3 pEC50 None 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 232 3 1 3 1.9 CCC1(OC(=CC1=O)C(=O)O)c1ccccc1 17358052
CHEMBL436301 1122 4 None 4 2 Human 5.3 pEC50 None 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 232 3 1 3 1.9 CCC1(OC(=CC1=O)C(=O)O)c1ccccc1 17358052
11436345 143 0 None -1 2 Human 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 17358052
1599 143 0 None -1 2 Human 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 17358052
CHEMBL424938 143 0 None -1 2 Human 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 238 2 1 4 1.8 Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O 17358052
53232 188625 95 None 1 10 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 None
CHEMBL503 188625 95 None 1 10 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 None


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

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 DOI
1595 259 49 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1016/j.bmc.2015.02.018
51576 259 49 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1016/j.bmc.2015.02.018
CHEMBL278488 259 49 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA
ChEMBL 218 2 1 3 1.5 OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1 10.1016/j.bmc.2015.02.018
135899171 16170 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B
ChEMBL 331 6 1 5 2.8 O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12 10.1016/j.bmcl.2010.07.108
CHEMBL1224070 16170 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B
ChEMBL 331 6 1 5 2.8 O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12 10.1016/j.bmcl.2010.07.108