Ligand source activities (1 row/activity)



Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
102331684 115253 0 None - 1 Mouse 4.1 pEC50 = 4.1 Functional
Agonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assayAgonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assay
ChEMBL 186 4 5 3 -1.3 N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O 10.1039/C1MD00186H
CHEMBL3347673 115253 0 None - 1 Mouse 4.1 pEC50 = 4.1 Functional
Agonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assayAgonist activity at mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D after 30 mins by inositol phosphate turnover assay
ChEMBL 186 4 5 3 -1.3 N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O 10.1039/C1MD00186H
8693156 124108 1 None - 1 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633655 124108 1 None - 1 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
8693156 124108 1 None - 1 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633655 124108 1 None - 1 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
9044803 124105 11 None 1 2 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 391 6 1 4 2.8 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633650 124105 11 None 1 2 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 391 6 1 4 2.8 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
9044803 124105 11 None 1 2 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 391 6 1 4 2.8 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633650 124105 11 None 1 2 Mouse 4.7 pIC50 = 4.7 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 391 6 1 4 2.8 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
122195442 124106 0 None - 1 Mouse 4.4 pIC50 = 4.4 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633651 124106 0 None - 1 Mouse 4.4 pIC50 = 4.4 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
122195442 124106 0 None - 1 Mouse 4.4 pIC50 = 4.4 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633651 124106 0 None - 1 Mouse 4.4 pIC50 = 4.4 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 409 6 1 4 2.9 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 10.1021/acs.jmedchem.5b01254
122195453 124110 0 None 2 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 431 5 1 4 3.6 O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
CHEMBL3633663 124110 0 None 2 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 431 5 1 4 3.6 O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
122195453 124110 0 None 2 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 431 5 1 4 3.6 O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
CHEMBL3633663 124110 0 None 2 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 431 5 1 4 3.6 O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
17521846 124111 4 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 375 6 1 3 3.6 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633664 124111 4 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 375 6 1 3 3.6 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 10.1021/acs.jmedchem.5b01254
17521846 124111 4 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 375 6 1 3 3.6 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 10.1021/acs.jmedchem.5b01254
CHEMBL3633664 124111 4 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 375 6 1 3 3.6 CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 10.1021/acs.jmedchem.5b01254
122195454 124112 0 None 8 2 Mouse 5.2 pIC50 = 5.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 377 7 1 4 3.3 CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
CHEMBL3633665 124112 0 None 8 2 Mouse 5.2 pIC50 = 5.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 377 7 1 4 3.3 CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
122195454 124112 0 None 8 2 Mouse 5.2 pIC50 = 5.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 377 7 1 4 3.3 CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
CHEMBL3633665 124112 0 None 8 2 Mouse 5.2 pIC50 = 5.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 377 7 1 4 3.3 CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 10.1021/acs.jmedchem.5b01254
122195445 124107 0 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 10.1021/acs.jmedchem.5b01254
CHEMBL3633654 124107 0 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 10.1021/acs.jmedchem.5b01254
122195445 124107 0 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 10.1021/acs.jmedchem.5b01254
CHEMBL3633654 124107 0 None - 1 Mouse 4.2 pIC50 = 4.2 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 10.1021/acs.jmedchem.5b01254
122195446 124109 0 None 1 5 Mouse 5.0 pIC50 = 5.0 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 10.1021/acs.jmedchem.5b01254
CHEMBL3633656 124109 0 None 1 5 Mouse 5.0 pIC50 = 5.0 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 10.1021/acs.jmedchem.5b01254
122195446 124109 0 None 1 5 Mouse 5.0 pIC50 = 5.0 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 10.1021/acs.jmedchem.5b01254
CHEMBL3633656 124109 0 None 1 5 Mouse 5.0 pIC50 = 5.0 Functional
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assayAntagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulation after 1 hr by FRET assay
ChEMBL 421 7 1 5 2.8 COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 10.1021/acs.jmedchem.5b01254
3401 2346 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN None
6262 2346 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN None
725 2346 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN None
88747248 2346 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN None
CHEMBL446143 2346 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN None
DB00129 2346 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN None
1549 2279 111 None -1 3 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N None
28782 2279 111 None -1 3 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N None
6322 2279 111 None -1 3 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N None
721 2279 111 None -1 3 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N None
CHEMBL1485 2279 111 None -1 3 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N None
DB00125 2279 111 None -1 3 Human 8.4 pEC50 = 8.4 Functional
NoneNone
Drug Central 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N None
1311 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
4633 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
4634 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
5961 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
6992086 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
723 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
CHEMBL930 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
DB00130 2316 0 None - 1 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 4 3 3 -1.3 NC(=O)CC[C@@H](C(=O)O)N 15576628
4127 2360 117 None -1348 2 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 105 2 3 3 -1.6 OC[C@@H](C(=O)O)N 15576628
5951 2360 117 None -1348 2 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 105 2 3 3 -1.6 OC[C@@H](C(=O)O)N 15576628
6857581 2360 117 None -1348 2 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 105 2 3 3 -1.6 OC[C@@H](C(=O)O)N 15576628
726 2360 117 None -1348 2 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 105 2 3 3 -1.6 OC[C@@H](C(=O)O)N 15576628
CHEMBL11298 2360 117 None -1348 2 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 105 2 3 3 -1.6 OC[C@@H](C(=O)O)N 15576628
DB00133 2360 117 None -1348 2 Human 3.2 pEC50 None 3.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 105 2 3 3 -1.6 OC[C@@H](C(=O)O)N 15576628
1319 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
4084 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
4635 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
5257127 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
727 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
750 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
CHEMBL773 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
DB00145 1826 130 None -12302 2 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 75 1 2 2 -1.0 NCC(=O)O 15576628
3103 2291 0 None - 1 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 175 5 4 3 -1.2 NC(=O)NCCC[C@@H](C(=O)O)N 15576628
6992098 2291 0 None - 1 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 175 5 4 3 -1.2 NC(=O)NCCC[C@@H](C(=O)O)N 15576628
722 2291 0 None - 1 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 175 5 4 3 -1.2 NC(=O)NCCC[C@@H](C(=O)O)N 15576628
9750 2291 0 None - 1 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 175 5 4 3 -1.2 NC(=O)NCCC[C@@H](C(=O)O)N 15576628
CHEMBL444814 2291 0 None - 1 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 175 5 4 3 -1.2 NC(=O)NCCC[C@@H](C(=O)O)N 15576628
DB00155 2291 0 None - 1 Human 3.6 pEC50 None 3.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 175 5 4 3 -1.2 NC(=O)NCCC[C@@H](C(=O)O)N 15576628
4255 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
4542 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
4543 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
5950 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
720 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
7311724 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
CHEMBL279597 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
DB00160 2270 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 89 1 2 2 -0.6 C[C@@H](C(=O)O)N 15576628
122198194 2337 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 5 3 3 -0.5 NCCCC[C@@H](C(=O)O)N 15576628
1622 2337 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 5 3 3 -0.5 NCCCC[C@@H](C(=O)O)N 15576628
5962 2337 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 5 3 3 -0.5 NCCCC[C@@H](C(=O)O)N 15576628
71774817 2337 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 5 3 3 -0.5 NCCCC[C@@H](C(=O)O)N 15576628
724 2337 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 5 3 3 -0.5 NCCCC[C@@H](C(=O)O)N 15576628
CHEMBL8085 2337 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 5 3 3 -0.5 NCCCC[C@@H](C(=O)O)N 15576628
DB00123 2337 0 None - 1 Human 3.8 pEC50 None 3.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 146 5 3 3 -0.5 NCCCC[C@@H](C(=O)O)N 15576628
3401 2346 0 None - 1 Human 4.0 pEC50 None 4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN 15576628
6262 2346 0 None - 1 Human 4.0 pEC50 None 4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN 15576628
725 2346 0 None - 1 Human 4.0 pEC50 None 4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN 15576628
88747248 2346 0 None - 1 Human 4.0 pEC50 None 4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN 15576628
CHEMBL446143 2346 0 None - 1 Human 4.0 pEC50 None 4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN 15576628
DB00129 2346 0 None - 1 Human 4.0 pEC50 None 4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 132 4 3 3 -0.9 N[C@H](C(=O)O)CCCN 15576628
1549 2279 111 None -1 3 Human 4.4 pEC50 None 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N 15576628
28782 2279 111 None -1 3 Human 4.4 pEC50 None 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N 15576628
6322 2279 111 None -1 3 Human 4.4 pEC50 None 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N 15576628
721 2279 111 None -1 3 Human 4.4 pEC50 None 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N 15576628
CHEMBL1485 2279 111 None -1 3 Human 4.4 pEC50 None 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N 15576628
DB00125 2279 111 None -1 3 Human 4.4 pEC50 None 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 174 5 4 3 -1.5 OC(=O)[C@H](CCCN=C(N)N)N 15576628
719 784 5 None -27 3 Mouse 5.0 pIC50 ~ 5 Functional
This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).
Guide to Pharmacology 300 4 2 1 5.2 C[C@H](c1cccc2c1cccc2)NCc1cc2c([nH]1)cccc2 19836834
9882793 784 5 None -27 3 Mouse 5.0 pIC50 ~ 5 Functional
This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).
Guide to Pharmacology 300 4 2 1 5.2 C[C@H](c1cccc2c1cccc2)NCc1cc2c([nH]1)cccc2 19836834
CHEMBL1801356 784 5 None -27 3 Mouse 5.0 pIC50 ~ 5 Functional
This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).
Guide to Pharmacology 300 4 2 1 5.2 C[C@H](c1cccc2c1cccc2)NCc1cc2c([nH]1)cccc2 19836834
6918446 2879 56 None -616 6 Mouse 5.0 pIC50 ~ 5 Functional
This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).
Guide to Pharmacology 408 8 2 4 4.7 N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O 19836834
716 2879 56 None -616 6 Mouse 5.0 pIC50 ~ 5 Functional
This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).
Guide to Pharmacology 408 8 2 4 4.7 N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O 19836834
CHEMBL180672 2879 56 None -616 6 Mouse 5.0 pIC50 ~ 5 Functional
This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).
Guide to Pharmacology 408 8 2 4 4.7 N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O 19836834
DB05695 2879 56 None -616 6 Mouse 5.0 pIC50 ~ 5 Functional
This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference).
Guide to Pharmacology 408 8 2 4 4.7 N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O 19836834


Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
102331684 115253 0 None - 1 Mouse 4.1 pKi = 4.1 Binding
Binding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66DBinding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D
ChEMBL 186 4 5 3 -1.3 N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O 10.1039/C1MD00186H
CHEMBL3347673 115253 0 None - 1 Mouse 4.1 pKi = 4.1 Binding
Binding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66DBinding affinity to mouse GPRC6A expressed in human tsA201 cells coexpressing GalphaqG66D
ChEMBL 186 4 5 3 -1.3 N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O 10.1039/C1MD00186H