ArrestinDb

Ligand source activities (1 row/activity)

Potency
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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1499	2091	47	None	-63	38	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	3779	2091	47	None	-63	38	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	536	2091	47	None	-63	38	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	CHEMBL434	2091	47	None	-63	38	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	DB01064	2091	47	None	-63	38	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	1499	2091	47	None	-63	38	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	3779	2091	47	None	-63	38	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	536	2091	47	None	-63	38	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	CHEMBL434	2091	47	None	-63	38	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	DB01064	2091	47	None	-63	38	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	2270	3171	69	None	-446	3	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	19092995
	4811	3171	69	None	-446	3	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	19092995
	4913	3171	69	None	-446	3	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	19092995
	CHEMBL640	3171	69	None	-446	3	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	19092995
	DB01035	3171	69	None	-446	3	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	19092995
	2200	3131	46	None	-239883	10	Human	2.7	pEC50	=	2.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	19092995
	328	3131	46	None	-239883	10	Human	2.7	pEC50	=	2.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	19092995
	4848	3131	46	None	-239883	10	Human	2.7	pEC50	=	2.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	19092995
	CHEMBL9967	3131	46	None	-239883	10	Human	2.7	pEC50	=	2.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	19092995
	DB00670	3131	46	None	-239883	10	Human	2.7	pEC50	=	2.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	19092995
	10918	2909	118	None	-45708	3	Human	3.7	pEC50	=	3.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	2	1	6	1.5	CN1CCN(CC1)c1c(F)cc2c3c1OCC(n3cc(c2=O)C(=O)O)C	19092995
	1981	2909	118	None	-45708	3	Human	3.7	pEC50	=	3.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	2	1	6	1.5	CN1CCN(CC1)c1c(F)cc2c3c1OCC(n3cc(c2=O)C(=O)O)C	19092995
	4583	2909	118	None	-45708	3	Human	3.7	pEC50	=	3.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	2	1	6	1.5	CN1CCN(CC1)c1c(F)cc2c3c1OCC(n3cc(c2=O)C(=O)O)C	19092995
	CHEMBL4	2909	118	None	-45708	3	Human	3.7	pEC50	=	3.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	2	1	6	1.5	CN1CCN(CC1)c1c(F)cc2c3c1OCC(n3cc(c2=O)C(=O)O)C	19092995
	DB01165	2909	118	None	-45708	3	Human	3.7	pEC50	=	3.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	2	1	6	1.5	CN1CCN(CC1)c1c(F)cc2c3c1OCC(n3cc(c2=O)C(=O)O)C	19092995

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)