Mutant Browser

Download
Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
cxcr1_human 3.47x47 132 TM3 S => A 1.337↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2015) Lazzeri I et al (2024)
cxcr1_human 6.34x34 241 TM6 M => V 3.627↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2015) Lazzeri I et al (2024)
cxcr1_human 6.44x44 251 TM6 F => A 5.409↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2015) Lazzeri I et al (2024)
cxcr1_human 6.44x44 251 TM6 F => H 1.142↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2015) Lazzeri I et al (2024)
cxcr1_human 6.44x44 251 TM6 F => Y 1.596↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2015) Lazzeri I et al (2024)
cxcr1_human 3.43x43 128 TM3 L => A 9.103↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2012) Lazzeri I et al (2024)
cxcr1_human 3.43x43 128 TM3 L => Q 3.607↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2012) Lazzeri I et al (2024)
cxcr1_human 3.43x43 128 TM3 L => R 7.099↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2012) Lazzeri I et al (2024)
cxcr1_human 6.40x40 247 TM6 V => A 8.855↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2012) Lazzeri I et al (2024)
cxcr1_human 6.40x40 247 TM6 V => N 1.551↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2012) Lazzeri I et al (2024)
cxcr1_human 6.40x40 247 TM6 V => Y 7.027↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Han X et al (2012) Lazzeri I et al (2024)
cxcr1_human 5.35x36 199 TM5 R => H 1.048↓ IC50 (Binding - Radioligand competition/displacement) CXCL8 Suetomi K et al (2002) Lazzeri I et al (2024)
cxcr1_human 5.39x40 203 TM5 R => H 1.01↑ IC50 (Binding - Radioligand competition/displacement) CXCL8 Suetomi K et al (2002) Lazzeri I et al (2024)
cxcr1_human 6.58x58 265 TM6 D => H 1.316↑ IC50 (Binding - Radioligand competition/displacement) CXCL8 Suetomi K et al (2002) Lazzeri I et al (2024)
cxcr1_human 5.35x36 199 TM5 R => H 2.37↓ EC50 (Calcium mobilization assay) CXCL8 Suetomi K et al (2002) Lazzeri I et al (2024)
cxcr1_human 5.39x40 203 TM5 R => H 1.209↓ EC50 (Calcium mobilization assay) CXCL8 Suetomi K et al (2002) Lazzeri I et al (2024)
cxcr1_human 6.58x58 265 TM6 D => H 1.07↓ EC50 (Calcium mobilization assay) CXCL8 Suetomi K et al (2002) Lazzeri I et al (2024)
cxcr1_human 6 N-term D => A 1.09↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 11 N-term D => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 11 N-term D => E 1.238↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 11 N-term D => K 2.994↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 2.50x50 85 TM2 D => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 3.32x32 117 TM3 K => A 1.34↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 3.33x33 118 TM3 E => A 4.219↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 45.52x52 189 ECL2 E => A 1.495↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 5.30x31 194 TM5 D => A 1.289↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 6.58x58 265 TM6 D => A 2.577↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 275 ECL3 E => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 7.26x25 278 TM7 E => A 3.717↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 7.27x26 279 TM7 R => A 1.289↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 7.28x27 280 TM7 R => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 7.36x35 288 TM7 D => A 1.103↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 7.39x38 291 TM7 E => A 1.238↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Hebert CA et al (1993) Lazzeri I et al (2024)
cxcr1_human 12 N-term F => A 1.59↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 34 N-term T => A 1.645↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 1.29x29 36 TM1 T => A 1.053↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 45.51x51 188 ECL2 Y => A >8.264↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 18 N-term T => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 19 N-term G => A 1.667↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 20 N-term M => A 1.149↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 21 N-term P => A 8.333↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 22 N-term P => A 3.333↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 27 N-term Y => A 25.0↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 30 N-term C => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 23.49x49 102 ECL1 G => A 2.778↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 23.50x50 103 ECL1 W => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 23.51x51 104 ECL1 I => A 1.389↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 23.52x52 105 ECL1 F => A 3.333↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 3.21x21 106 TM3 G => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 3.22x22 107 TM3 T => A 4.167↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 3.25x25 110 TM3 C => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 178 ECL2 Y => A 25.0↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 179 ECL2 H => A 1.259↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 180 ECL2 P => A 2.041↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 45.50x50 187 ECL2 C => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 190 ECL2 V => A 1.695↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 191 ECL2 L => A 11.111↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 192 ECL2 G => A 10.0↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 5.35x36 199 TM5 R => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 5.36x37 200 TM5 M => A 50.0↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 5.37x38 201 TM5 V => A 2.273↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 5.38x39 202 TM5 L => A 2.128↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 5.39x40 203 TM5 R => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 6.58x58 265 TM6 D => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 6.59x59 266 TM6 T => A 2.857↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 6.60x60 267 TM6 L => A 1.724↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 6.61x61 268 TM6 M => A 50.0↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 6.62x62 269 TM6 R => A 14.286↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 6.63x63 270 TM6 T => A 5.556↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 6.64x64 271 TM6 Q => A 1.12↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 272 ECL3 V => A 1.515↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 273 ECL3 I => A 33.333↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 274 ECL3 Q => A 1.631↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 275 ECL3 E => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 7.25x24 277 TM7 C => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 7.28x27 280 TM7 R => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Leong SR et al (1994) Lazzeri I et al (2024)
cxcr1_human 3.51x51 136 TM3 Y => A 1.325↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 3.52x52 137 TM3 L => A 1.325↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 3.53x53 138 TM3 A => A 1.332↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 3.54x54 139 TM3 I => A 1.019↓ Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 3.55x55 140 TM3 V => A 1.02↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 6.32x32 239 TM6 R => A Abolished Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 6.34x34 241 TM6 M => A 1.678↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 6.35x35 242 TM6 R => A 2.603↑ Kd (Binding - Radioligand competition/displacement) CXCL8 Damaj BB et al (1996) Lazzeri I et al (2024)
cxcr1_human 6 N-term D => A N/A N/A Hebert CA et al (1993)
cxcr1_human 11 N-term D => K N/A N/A Hebert CA et al (1993)
cxcr1_human 11 N-term D => A N/A N/A Hebert CA et al (1993)
cxcr1_human 11 N-term D => E N/A N/A Hebert CA et al (1993)
cxcr1_human 12 N-term F => A N/A N/A Leong SR et al (1994)
cxcr1_human 18 N-term T => A N/A N/A Leong SR et al (1994)
cxcr1_human 19 N-term G => A N/A N/A Leong SR et al (1994)
cxcr1_human 20 N-term M => A N/A N/A Leong SR et al (1994)
cxcr1_human 21 N-term P => A N/A N/A Leong SR et al (1994)
cxcr1_human 22 N-term P => A N/A N/A Leong SR et al (1994)
cxcr1_human 27 N-term Y => A N/A N/A Leong SR et al (1994)
cxcr1_human 30 N-term C => A N/A N/A Leong SR et al (1994)
cxcr1_human 34 N-term T => A N/A N/A Leong SR et al (1994)
cxcr1_human 1.29x29 36 TM1 T => A N/A N/A Leong SR et al (1994)
cxcr1_human 2.50x50 85 TM2 D => A N/A N/A Hebert CA et al (1993)
cxcr1_human 23.49x49 102 ECL1 G => A N/A N/A Leong SR et al (1994)
cxcr1_human 23.50x50 103 ECL1 W => A N/A N/A Leong SR et al (1994)
cxcr1_human 23.51x51 104 ECL1 I => A N/A N/A Leong SR et al (1994)
cxcr1_human 23.52x52 105 ECL1 F => A N/A N/A Leong SR et al (1994)
cxcr1_human 3.21x21 106 TM3 G => A N/A N/A Leong SR et al (1994)
cxcr1_human 3.22x22 107 TM3 T => A N/A N/A Leong SR et al (1994)
cxcr1_human 3.25x25 110 TM3 C => A N/A N/A Leong SR et al (1994)
cxcr1_human 3.26x26 111 TM3 K => A N/A N/A Leong SR et al (1994)
cxcr1_human 3.32x32 117 TM3 K => A N/A N/A Hebert CA et al (1993)
cxcr1_human 3.33x33 118 TM3 E => A N/A N/A Hebert CA et al (1993)
cxcr1_human 178 ECL2 Y => A N/A N/A Leong SR et al (1994)
cxcr1_human 179 ECL2 H => A N/A N/A Leong SR et al (1994)
cxcr1_human 180 ECL2 P => A N/A N/A Leong SR et al (1994)
cxcr1_human 45.50x50 187 ECL2 C => A N/A N/A Leong SR et al (1994)
cxcr1_human 45.51x51 188 ECL2 Y => A N/A N/A Leong SR et al (1994)
cxcr1_human 45.52x52 189 ECL2 E => A N/A N/A Hebert CA et al (1993)
cxcr1_human 190 ECL2 V => A N/A N/A Leong SR et al (1994)
cxcr1_human 191 ECL2 L => A N/A N/A Leong SR et al (1994)
cxcr1_human 192 ECL2 G => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.30x31 194 TM5 D => A N/A N/A Hebert CA et al (1993)
cxcr1_human 5.35x36 199 TM5 R => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.36x37 200 TM5 M => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.37x38 201 TM5 V => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.38x39 202 TM5 L => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.39x40 203 TM5 R => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.58x58 265 TM6 D => A N/A N/A Hebert CA et al (1993)
cxcr1_human 6.58x58 265 TM6 D => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.59x59 266 TM6 T => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.60x60 267 TM6 L => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.61x61 268 TM6 M => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.62x62 269 TM6 R => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.63x63 270 TM6 T => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.64x64 271 TM6 Q => A N/A N/A Leong SR et al (1994)
cxcr1_human 272 ECL3 V => A N/A N/A Leong SR et al (1994)
cxcr1_human 273 ECL3 I => A N/A N/A Leong SR et al (1994)
cxcr1_human 274 ECL3 Q => A N/A N/A Leong SR et al (1994)
cxcr1_human 275 ECL3 E => A N/A N/A Hebert CA et al (1993)
cxcr1_human 275 ECL3 E => A N/A N/A Leong SR et al (1994)
cxcr1_human 7.25x24 277 TM7 C => A N/A N/A Leong SR et al (1994)
cxcr1_human 7.26x25 278 TM7 E => A N/A N/A Hebert CA et al (1993)
cxcr1_human 7.27x26 279 TM7 R => A N/A N/A Hebert CA et al (1993)
cxcr1_human 7.28x27 280 TM7 R => A N/A N/A Hebert CA et al (1993)
cxcr1_human 7.28x27 280 TM7 R => A N/A N/A Leong SR et al (1994)
cxcr1_human 7.35x34 287 TM7 L => A N/A N/A Leong SR et al (1994)
cxcr1_human 7.36x35 288 TM7 D => A N/A N/A Hebert CA et al (1993)
cxcr1_human 7.38x37 290 TM7 T => A N/A N/A Leong SR et al (1994)
cxcr1_human 7.39x38 291 TM7 E => A N/A N/A Hebert CA et al (1993)
cxcr1_human 3.49x49 134 TM3 D => A N/A N/A Damaj BB et al (1996)
cxcr1_human 3.50x50 135 TM3 R => A N/A N/A Damaj BB et al (1996)
cxcr1_human 3.51x51 136 TM3 Y => A N/A N/A Damaj BB et al (1996)
cxcr1_human 3.52x52 137 TM3 L => A N/A N/A Damaj BB et al (1996)
cxcr1_human 3.54x54 139 TM3 I => A N/A N/A Damaj BB et al (1996)
cxcr1_human 3.55x55 140 TM3 V => A N/A N/A Damaj BB et al (1996)
cxcr1_human 6.32x32 239 TM6 R => A N/A N/A Damaj BB et al (1996)
cxcr1_human 6.34x34 241 TM6 M => A N/A N/A Damaj BB et al (1996)
cxcr1_human 6.35x35 242 TM6 R => A N/A N/A Damaj BB et al (1996)
cxcr1_human 3.49x49 134 TM3 D => V N/A N/A Burger M et al (1999)
cxcr1_human 30 N-term C => A N/A N/A Leong SR et al (1994)
cxcr1_human 2.64x64 99 TM2 K => A N/A N/A Allegretti M et al (2005)
cxcr1_human 3.25x25 110 TM3 C => A N/A N/A Leong SR et al (1994)
cxcr1_human 45.50x50 187 ECL2 C => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.35x36 199 TM5 R => A N/A N/A Suetomi K et al (2002)
cxcr1_human 5.35x36 199 TM5 R => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.35x36 199 TM5 R => H N/A N/A Suetomi K et al (2002)
cxcr1_human 5.39x40 203 TM5 R => A N/A N/A Suetomi K et al (2002)
cxcr1_human 5.39x40 203 TM5 R => A N/A N/A Leong SR et al (1994)
cxcr1_human 5.39x40 203 TM5 R => H N/A N/A Suetomi K et al (2002)
cxcr1_human 5.43x44 207 TM5 H => Q N/A N/A Suetomi K et al (2002)
cxcr1_human 6.58x58 265 TM6 D => A N/A N/A Suetomi K et al (2002)
cxcr1_human 6.58x58 265 TM6 D => A N/A N/A Leong SR et al (1994)
cxcr1_human 6.58x58 265 TM6 D => H N/A N/A Suetomi K et al (2002)
cxcr1_human 7.25x24 277 TM7 C => A N/A N/A Leong SR et al (1994)
cxcr1_human 7.39x38 291 TM7 E => A N/A N/A Allegretti M et al (2005)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R H ICL2ECL2 Q A Y H P N N S S P V C Y E V L G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M S N I T D P Q M W D F D D L N F T G M P P A D E D Y S P C M L E T E N-termC-term G L V S K E F L A R H R V T S Y T S S S V N V S S N L C-term T L N K Y V V I I A Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F V C L G C W G L S M N L S L P F F L F R D T A K W R M V L R I L P H T F G F I V P L F V M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q S C E R R N N I G R A L D A T E I L G F L H S C L N P I I Y A F I G Q N F L K H F R H G I L A M
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N G L L S L L F V L A Y A I I V V Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F V C L G C W G L S M N L S L P F 4 Y C F L M V F L P V I F G F T H P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 I P N L C S H L F G L I E T A D L A R 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR1
TM1
1x29 1.29x29 T36
TM2
2x50 2.50x50 D85
2x64 2.64x64 K99
TM3
3x21 3.21x21 G106
3x22 3.22x22 T107
3x25 3.25x25 C110
3x26 3.26x26 K111
3x32 3.32x32 K117
3x33 3.33x33 E118
3x43 3.43x43 L128
3x47 3.47x47 S132
3x49 3.49x49 D134
3x50 3.50x50 R135
3x51 3.51x51 Y136
3x52 3.52x52 L137
3x53 3.53x53 A138
3x54 3.54x54 I139
3x55 3.55x55 V140
TM5
5x31 5.30x31 D194
5x36 5.35x36 R199
5x37 5.36x37 M200
5x38 5.37x38 V201
5x39 5.38x39 L202
5x40 5.39x40 R203
5x44 5.43x44 H207
TM6
6x32 6.32x32 R239
6x34 6.34x34 M241
6x35 6.35x35 R242
6x40 6.40x40 V247
6x44 6.44x44 F251
6x58 6.58x58 D265
6x59 6.59x59 T266
6x60 6.60x60 L267
6x61 6.61x61 M268
6x62 6.62x62 R269
6x63 6.63x63 T270
6x64 6.64x64 Q271
TM7
7x24 7.25x24 C277
7x25 7.26x25 E278
7x26 7.27x26 R279
7x27 7.28x27 R280
7x34 7.35x34 L287
7x35 7.36x35 D288
7x37 7.38x37 T290
7x38 7.39x38 E291