Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ghrhr_human 1.39x39 129 TM1 V => L N/A N/A DeAlmeida VI et al (1998)
ghrhr_human 1.39x39 129 TM1 V => L N/A N/A DeAlmeida VI et al (1998)
ghrhr_human 60 N-term D => G N/A N/A Kajkowski EM et al (1997)
ghrhr_human 60 N-term D => G N/A N/A Alba M et al (2005)
ghrhr_human 72 N-term E => X N/A N/A Baumann G et al (1999)
ghrhr_human 72 N-term E => X N/A N/A Wajnrajch MP et al (2003)
ghrhr_human 72 N-term E => X N/A N/A Kamijo T et al (2004)
ghrhr_human 72 N-term E => X N/A N/A Desai MP et al (2005)
ghrhr_human 113 N-term P => L N/A N/A Lee EJ et al (2001)
ghrhr_human 1.31x31 121 TM1 E => D N/A N/A Lee EJ et al (2001)
ghrhr_human 1.47x47 137 TM1 H => L N/A N/A Alba M et al (2005)
ghrhr_human 1.47x47 137 TM1 H => Y N/A N/A Lee EJ et al (2001)
ghrhr_human 1.54x54 144 TM1 L => H N/A N/A Salvatori R et al (2002)
ghrhr_human 1.54x54 144 TM1 L => H N/A N/A Alba M et al (2005)
ghrhr_human 2.61x61 176 TM2 A => V N/A N/A Carakushansky M et al (2003)
ghrhr_human 2.61x61 176 TM2 A => V N/A N/A Alba M et al (2005)
ghrhr_human 2.68x68 183 TM2 D => N N/A N/A Lee EJ et al (2001)
ghrhr_human 3.49x49 222 TM3 A => E N/A N/A Alba M et al (2005)
ghrhr_human 3.52x52 225 TM3 V => I N/A N/A Lee EJ et al (2001)
ghrhr_human 4.42x43 242 TM4 F => C N/A N/A Alba M et al (2005)
ghrhr_human 4.50x50 250 TM4 W => X N/A N/A Lee EJ et al (2001)
ghrhr_human 4.54x54 254 TM4 V => M N/A N/A Lee EJ et al (2001)
ghrhr_human 4.62x62 262 TM4 S => N N/A N/A Lee EJ et al (2001)
ghrhr_human 5.48x48 294 TM5 G => R N/A N/A Lee EJ et al (2001)
ghrhr_human 6.40x40 329 TM6 K => E N/A N/A Alba M et al (2005)
ghrhr_human 410 C-term T => P N/A N/A Lee EJ et al (2001)
ghrhr_human 423 C-term C => Y N/A N/A Lee EJ et al (2001)
ghrhr_human 2.50x50 165 TM2 H => R 8.5↓ Single-point (Functional - cAMP accumulation) GHRH Schipani E et al (1997) Lazzeri I et al (2024)
ghrhr_human 57 N-term A => T 1.07↑ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 57 N-term A => T 1.4↑ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 113 N-term P => L 2.0↓ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 113 N-term P => L 1.667↓ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 1.31x31 121 TM1 E => D 1.111↓ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 1.31x31 121 TM1 E => D 1.111↓ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 1.47x47 137 TM1 H => Y 1.0 Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 1.47x47 137 TM1 H => Y 1.0 Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 2.68x68 183 TM2 D => N 2.0↓ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 2.68x68 183 TM2 D => N 1.667↓ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 3.52x52 225 TM3 V => I 1.429↓ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 3.52x52 225 TM3 V => I 1.429↓ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 4.50x50 250 TM4 W => X 2.273↓ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 4.50x50 250 TM4 W => X 2.273↓ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 4.54x54 254 TM4 V => M 1.0 Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 4.54x54 254 TM4 V => M 1.6↑ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 4.62x62 262 TM4 S => N 2.0↓ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 4.62x62 262 TM4 S => N 1.667↓ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 5.48x48 294 TM5 G => R Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 5.48x48 294 TM5 G => R Abolished effect Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 423 C-term C => Y 1.429↓ Single-point (Functional - cAMP accumulation) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 423 C-term C => Y 1.25↓ Single-point (Binding - Radioligand competition/displacement) GHRH Lee EJ et al (2001) Lazzeri I et al (2024)
ghrhr_human 2.61x61 176 TM2 A => V Abolished effect Single-point (Functional - cAMP accumulation) GHRH Carakushansky M et al (2003) Lazzeri I et al (2024)
ghrhr_human 60 N-term D => G Abolished effect Single-point (Functional - cAMP accumulation) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 60 N-term D => G Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 1.47x47 137 TM1 H => L Abolished effect Single-point (Functional - cAMP accumulation) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 1.47x47 137 TM1 H => L Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 1.54x54 144 TM1 L => H Abolished effect Single-point (Functional - cAMP accumulation) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 1.54x54 144 TM1 L => H Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 2.61x61 176 TM2 A => V Abolished effect Single-point (Functional - cAMP accumulation) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 2.61x61 176 TM2 A => V Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 3.49x49 222 TM3 A => E Abolished effect Single-point (Functional - cAMP accumulation) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 3.49x49 222 TM3 A => E Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 4.42x43 242 TM4 F => C Abolished effect Single-point (Functional - cAMP accumulation) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 4.42x43 242 TM4 F => C Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 6.40x40 329 TM6 K => E Abolished effect Single-point (Functional - cAMP accumulation) GHRH Alba M et al (2005) Lazzeri I et al (2024)
ghrhr_human 6.40x40 329 TM6 K => E Abolished effect Single-point (Binding - Radioligand competition/displacement) GHRH Alba M et al (2005) Lazzeri I et al (2024)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R R L H ICL1ECL1 H S D D T D H C S F S ECL1ICL2 T S P S S ICL2ECL2 D I A C W D L D D T S P Y ECL2ICL3 E P A Q G S L ICL3ECL3 P D N A ECL3N-term M D R R M W G A H V F C V L S P L P T V L G H M H P E C D F I T Q L R E D E S A C L Q A A E E M P N T T L G C P A T W D G L L C W P T A G S G E W V T L P C P D F F S H F S S E S G A V K R D C T I T G W S E P F P P Y P V A C P V P N-termC-term A K W T T P S R S A A K V L T S M C C-term L E L L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L H T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E I S R H D P A W R V R T E K W H G E L L P T R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
F L A V I S I S H G V T Y I I K V T S F 1 T Q L F T T F I L K A G A V F L K D A A 2 A L L W S F N T M T A F H S A A V S V K 3 A F W W L V L G A W G L P V L F T G T W V 4 F L G F N V G V S L V I P G K I I W W 5 L F L I P L F G I H Y I I F N F L 6 I A V I F G Q F S G L G L E L P L R I 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
GHRH receptor
TM1
1x27 1.31x31 E121
1x35 1.39x39 V129
1x43 1.47x47 H137
1x50 1.54x54 L144
TM2
2x43 2.50x50 H165
2x54 2.61x61 A176
2x61 2.68x68 D183
TM3
3x45 3.49x49 A222
3x48 3.52x52 V225
TM4
4x43 4.42x43 F242
4x50 4.50x50 W250
4x54 4.54x54 V254
4x62 4.62x62 S262
TM5
5x52 5.48x48 G294
TM6
6x35 6.40x40 K329