Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Schipani E et al (1995)
pth1r_human 546 C-term E => K N/A N/A Schipani E et al (1995)
pth1r_human 2.50x50 223 TM2 H => W N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => E N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => R N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => L N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => A N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => Q N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => V N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => M N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => K N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => P N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => G N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => I N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => C N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => P N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => D N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => T N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => G N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => Q N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => E N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => Y N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => S N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => A N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => V N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => C N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => M N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => I N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => F N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => L N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => N N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => K N/A N/A Schipani E et al (1997)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => Y N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => F N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => W N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => S N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => D N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => H N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => N N/A N/A Schipani E et al (1997)
pth1r_human 6.46x46 414 TM6 M => L N/A N/A Bisello A et al (1998)
pth1r_human 6.57x57 425 TM6 M => L N/A N/A Bisello A et al (1998)
pth1r_human 132 N-term P => L N/A N/A Mannstadt M et al (1999)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Schipani E et al (1999)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A McEwen DG et al (1999)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Mannstadt M et al (1999)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Ferrari SL et al (2001)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Calvi LM et al (2001)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Gensure RC et al (2001)
pth1r_human 2.50x50 223 TM2 H => R N/A N/A Schipani E et al (1997)
pth1r_human 6.42x42 410 TM6 T => P N/A N/A Schipani E et al (1999)
pth1r_human 6.42x42 410 TM6 T => P N/A N/A McEwen DG et al (1999)
pth1r_human 6.42x42 410 TM6 T => P N/A N/A Mannstadt M et al (1999)
pth1r_human 6.42x42 410 TM6 T => P N/A N/A Ferrari SL et al (2001)
pth1r_human 6.42x42 410 TM6 T => P N/A N/A Gensure RC et al (2001)
pth1r_human 6.42x42 410 TM6 T => P N/A N/A Schipani E et al (1997)
pth1r_human 6.46x46 414 TM6 M => L N/A N/A Behar V et al (2000)
pth1r_human 6.46x46 414 TM6 M => L N/A N/A Bisello A et al (1998)
pth1r_human 6.46x46 414 TM6 M => V N/A N/A Gensure RC et al (2001)
pth1r_human 6.57x57 425 TM6 M => L N/A N/A Behar V et al (2000)
pth1r_human 6.57x57 425 TM6 M => L N/A N/A Gensure RC et al (2001)
pth1r_human 6.57x57 425 TM6 M => L N/A N/A Bisello A et al (1998)
pth1r_human 7.38x37 440 TM7 Q => R N/A N/A Clark JA et al (1998)
pth1r_human 7.39x38 441 TM7 M => L N/A N/A Gensure RC et al (2001)
pth1r_human 7.43x42 445 TM7 M => I N/A N/A Gensure RC et al (2001)
pth1r_human 7.56x56 458 TM7 I => R N/A N/A Schipani E et al (1999)
pth1r_human 7.56x56 458 TM7 I => R N/A N/A Mannstadt M et al (1999)
pth1r_human 7.56x56 458 TM7 I => R N/A N/A Gensure RC et al (2001)
pth1r_human 593 C-term M => A N/A N/A Sneddon WB et al (2003)
pth1r_human 593 C-term M => A N/A N/A Syme CA et al (2005)
pth1r_human 2.58x58 231 TM2 M => I 1.176↓ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.58x58 231 TM2 M => I 1.235↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.58x58 231 TM2 M => I 1.282↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.59x59 232 TM2 L => A 1.02↓ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.59x59 232 TM2 L => A 1.042↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.59x59 232 TM2 L => A 1.031↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.60x60 233 TM2 R => A N/A Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.60x60 233 TM2 R => A 6.667↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.60x60 233 TM2 R => A 1.087↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.61x61 234 TM2 A => V N/A Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.61x61 234 TM2 A => V 5.0↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.61x61 234 TM2 A => V 1.316↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.62x62 235 TM2 V => A 1.31↑ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.62x62 235 TM2 V => A 1.075↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.62x62 235 TM2 V => A 1.389↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.63x63 236 TM2 S => A 1.082↓ IC50 (Binding - Radioligand competition/displacement) [I125][M]PTH(1–20) A-V-A-E-I-Q-L-M-H-Q-Har-A-K-W-L-N-S-M-E-R-NH2 Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.63x63 236 TM2 S => A 1.064↑ IC50 (Binding - Radioligand competition/displacement) [I125][M]PTH(1–20) A-V-A-E-I-Q-L-M-H-Q-Har-A-K-W-L-N-S-M-R-R-NH2 Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.63x63 236 TM2 S => A 1.94↑ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.63x63 236 TM2 S => A 1.09↑ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.63x63 236 TM2 S => A 1.124↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.64x64 237 TM2 I => A 50.0↓ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.64x64 237 TM2 I => A 2.128↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.64x64 237 TM2 I => A 1.471↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.65x65 238 TM2 F => A 100.0↓ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.65x65 238 TM2 F => A 3.333↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.65x65 238 TM2 F => A 1.515↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.66x66 239 TM2 V => A 1.351↓ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.66x66 239 TM2 V => A 1.124↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.66x66 239 TM2 V => A 1.149↓ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 6.452↓ IC50 (Binding - Radioligand competition/displacement) [I125][M]PTH(1–20) A-V-A-E-I-Q-L-M-H-Q-Har-A-K-W-L-N-S-M-E-R-NH2 Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 4.405↓ IC50 (Binding - Radioligand competition/displacement) [I125][M]PTH(1–20) A-V-A-E-I-Q-L-M-H-Q-Har-A-K-W-L-N-S-M-R-R-NH2 Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 1.45↑ Single-point (Binding - Radioligand saturation) secretin Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 1.695↓ Single-point (Binding - Radioligand saturation) [I125][M3]PTH(1–21) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-L-A-S-V-R-R-Y Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 1.01↑ Single-point (Binding - Radioligand saturation) [I125]PTHrP[5-36] Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 4.444↑ IC50 (Binding - Radioligand competition/displacement) [M]PTH(1–14) A-V-A-E-I-Q-L-M-H-Q-Har-A-K-W-NH2 Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 5.917↓ IC50 (Binding - Radioligand competition/displacement) [M3]PTH(1–15) Aib-V-Aib-E-I-Q-L-Nle-H-Q-Har-A-K-W-Y*-NH2 Gensure RC et al (2003) Hollenstein K et al (2014)
pth1r_human 2.67x67 240 TM2 K => A 16.949↓ IC50 (Binding - Radioligand competition/displacement) [M3]PTH(1–19) Aib-V-Aib-E-I-Q-L-M-H-Q-Har-A-K-W-L-N-S-M-R-NH2 Gensure RC et al (2003) Hollenstein K et al (2014)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM2
2x43 2.50x50 H223
2x51 2.58x58 M231
2x52 2.59x59 L232
2x53 2.60x60 R233
2x54 2.61x61 A234
2x55 2.62x62 V235
2x56 2.63x63 S236
2x57 2.64x64 I237
2x58 2.65x65 F238
2x59 2.66x66 V239
2x60 2.67x67 K240
TM6
6x37 6.42x42 T410
6x41 6.46x46 M414
6x52 6.57x57 M425
TM7
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x38 7.43x42 M445
7x52 7.56x56 I458