GPER (gper1_human)

FAMILY

Class A (Rhodopsin) Steroid receptors Estrogen (G protein-coupled) receptors GPER

GENE

GPER1 (CEPR, CMKRL2, DRY12, GPER, GPR30)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-Br, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR, Membrane estrogen receptor, mER

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
V
T
S
Q
A
R
G
V
10
                   
G
L
E
M
Y
P
G
T
A
Q
20
                   
P
A
A
P
N
T
T
S
P
E
30
                   
L
N
L
S
H
P
L
L
G
T
40
                   
A
L
A
N
G
T
G
E
L
S
50
TM1              
E
H
Q
Q
Y
V
I
G
L
F
60
                   
L
S
C
L
Y
T
I
F
L
F
70
                   
P
I
G
F
V
G
N
I
L
I
80
                   
L
V
V
N
I
S
F
R
E
K
90
ICL1 TM2      
M
T
I
P
D
L
Y
F
I
N
100
                   
L
A
V
A
D
L
I
L
V
A
110
                   
D
S
L
I
E
V
F
N
L
H
120
ECL1   TM3    
E
R
Y
Y
D
I
A
V
L
C
130
                   
T
F
M
S
L
F
L
Q
V
N
140
                   
M
Y
S
S
V
F
F
L
T
W
150
                   
M
S
F
D
R
Y
I
A
L
A
160
  ICL2          
R
A
M
R
C
S
L
F
R
T
170
TM4              
K
H
H
A
R
L
S
C
G
L
180
                   
I
W
M
A
S
V
S
A
T
L
190
                   
V
P
F
T
A
V
H
L
Q
H
200
ECL2            
T
D
E
A
C
F
C
F
A
D
210
TM5              
V
R
E
V
Q
W
L
E
V
T
220
                   
L
G
F
I
V
P
F
A
I
I
230
                   
G
L
C
Y
S
L
I
V
R
V
240
            ICL3
L
V
R
A
H
R
H
R
G
L
250
      TM6        
R
P
R
R
Q
K
A
L
R
M
260
                   
I
L
A
V
V
L
V
F
F
V
270
                   
C
W
L
P
E
N
V
F
I
S
280
                   
V
H
L
L
Q
R
T
Q
P
G
290
ECL3 TM7      
A
A
P
C
K
Q
S
F
R
H
300
                   
A
H
P
L
T
G
H
I
V
N
310
                   
L
A
A
F
S
N
S
C
L
N
320
              H8  
P
L
I
Y
S
F
L
G
E
T
330
                   
F
R
D
K
L
R
L
Y
I
E
340
    C-term    
Q
K
T
N
L
P
A
L
N
R
350
                   
F
C
H
A
A
L
K
A
V
I
360
                   
P
D
S
T
E
Q
S
D
V
R
370
         
F
S
S
A
V

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R E K M ICL1ECL1 L H E R Y Y D ECL1ICL2 A M R C S L F R ICL2ECL2 T D E A C F C F A D ECL2ICL3 H R G L R P R ICL3ECL3 P G A A P C ECL3N-term M D V T S Q A R G V G L E M Y P G T A Q P A A P N T T S P E L N L S H P L L G T A L A N G T G E L S N-termC-term T N L P A L N R F C H A A L K A V I P D S T E Q S D V R F S S A V C-term E H Q Q Y V I G L F L S C L Y T I F L F P I G F V G N I L I L V V N I S F T I P D L Y F I N L A V A D L I L V A D S L I E V F N I A V L C T F M S L F L Q V N M Y S S V F F L T W M S F D R Y I A L A R T K H H A R L S C G L I W M A S V S A T L V P F T A V H L Q H V R E V Q W L E V T L G F I V P F A I I G L C Y S L I V R V L V R A H R R Q K A L R M I L A V V L V F F V C W L P E N V F I S V H L L Q R T Q K Q S F R H A H P L T G H I V N L A A F S N S C L N P L I Y S F L G E T L R L K F R D K Y I E Q
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

I N G V F G I P F L F I T Y L C S L F L 1 I N L A V A D L I L V A D S L I E V F N 2 W T L F F V S S Y M N V Q L F L S M F T 3 A R L S C G L I W M A S V S A T L V P F 4 Y C L G I I A F P V I F G L T V E L W Q V 5 L A V V L V F F V C W L P E N V F I S V 6 L P N L C S N S F A A L N V I H G T L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

17β-estradiol

STRUCTURE MODELS

gper1_human active,

gper1_human inactive

STRUCTURES

Found 5 structure(s) - view all details on the Structures page

PDBs: 8XOF, 8XOG, 8XOH, 8XOI, 8XOJ