LPA6 receptor (lpar6_human)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA6 receptor

GENE

LPAR6 (P2RY5)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2Y purinoceptor 5, P2Y5, Purinergic receptor 5, RB intron encoded G-protein coupled receptor

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
V
S
V
N
S
S
H
C
F
10
                   
Y
N
D
S
F
K
Y
T
L
Y
20
                   
G
C
M
F
S
M
V
F
V
L
30
                   
G
L
I
S
N
C
V
A
I
Y
40
          ICL1  
I
F
I
C
V
L
K
V
R
N
50
TM2              
E
T
T
T
Y
M
I
N
L
A
60
                   
M
S
D
L
L
F
V
F
T
L
70
                   
P
F
R
I
F
Y
F
T
T
R
80
ECL1 TM3      
N
W
P
F
G
D
L
L
C
K
90
                   
I
S
V
M
L
F
Y
T
N
M
100
                   
Y
G
S
I
L
F
L
T
C
I
110
                   
S
V
D
R
F
L
A
I
V
Y
120
ICL2            
P
F
K
S
K
T
L
R
T
K
130
TM4              
R
N
A
K
I
V
C
T
G
V
140
                   
W
L
T
V
I
G
G
S
A
P
150
        ECL2    
A
V
F
V
Q
S
T
H
S
Q
160
                   
G
N
N
A
S
E
A
C
F
E
170
      TM5        
N
F
P
E
A
T
W
K
T
Y
180
                   
L
S
R
I
V
I
F
I
E
I
190
                   
V
G
F
F
I
P
L
I
L
N
200
                   
V
T
C
S
S
M
V
L
K
T
210
        ICL3 TM6
L
T
K
P
V
T
L
S
R
S
220
                 
K
I
N
K
T
K
V
L
K
M
230
                   
I
F
V
H
L
I
I
F
C
F
240
                   
C
F
V
P
Y
N
I
N
L
I
250
                   
L
Y
S
L
V
R
T
Q
T
F
260
ECL3 TM7      
V
N
C
S
V
V
A
A
V
R
270
                   
T
M
Y
P
I
T
L
C
I
A
280
                   
V
S
N
C
C
F
D
P
I
V
290
        H8        
Y
Y
F
T
S
D
T
I
Q
N
300
                   
S
I
K
M
K
N
W
S
V
R
310
C-term        
R
S
D
F
R
F
S
E
V
H
320
                   
G
A
E
N
F
I
Q
H
N
L
330
                   
Q
T
L
K
S
K
I
F
D
N
340
       
E
S
A
A

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 L K V R ICL1ECL1 R N W P F ECL1ICL2 P F K S K T L R ICL2ECL2 Q S T H S Q G N N A S E A C F E N F P ECL2ICL3 V T L ICL3ECL3 T F V ECL3N-term M V S V N-termC-term S V R R S D F R F S E V H G A E N F I Q H N L Q T L K S K I F D N E S A A C-term N S S H C F Y N D S F K Y T L Y G C M F S M V F V L G L I S N C V A I Y I F I C V N E T T T Y M I N L A M S D L L F V F T L P F R I F Y F T T G D L L C K I S V M L F Y T N M Y G S I L F L T C I S V D R F L A I V Y T K R N A K I V C T G V W L T V I G G S A P A V F V E A T W K T Y L S R I V I F I E I V G F F I P L I L N V T C S S M V L K T L T K P S R S K I N K T K V L K M I F V H L I I F C F C F V P Y N I N L I L Y S L V R T Q N C S V V A A V R T M Y P I T L C I A V S N C C F D P I V Y Y F T S D T I K M I Q N S K N W
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

C N S I L G L V F V M S F M C G Y L T Y 1 I N L A M S D L L F V F T L P F R I F Y 2 C T L F L I S G Y M N T Y F L M V S I K 3 A K I V C T G V W L T V I G G S A P A 4 S C T V N L I L P I F F G V I E I F I V I 5 F V H L I I F C F C F V P Y N I N L I L 6 I P D F C C N S V A I C L T I P Y M T 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

1-O-Oleoyl-D-glycerol 3-phosphoric acid, LPA, LYSOPHOSPHATIDIC ACID

STRUCTURE MODELS

lpar6_human active,

lpar6_human inactive

STRUCTURES

No structures available