PTH1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7VVJ

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.MOLCEL.2022.07.003

PUBLICATION DATE

Aug. 3, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

113 interactions (Click to see)

LIGANDS

PTHrP[1-36] - Agonist

PHYSIOLOGICAL LIGANDS

PTH, TIP39, PTHrP, PTHrP-(1-36)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 310 3x58 G.H5 H 377 G.H5.19
Hydrophobic ICL2 F 314 - G.H5 C 369 G.H5.11
Hydrophobic ICL3 A 394 - G.H4 L 336 G.H4.16
Hydrophobic TM5 L 385 5x61 G.H5 L 378 G.H5.20
Van-der-waals TM5 L 385 5x61 G.H5 L 378 G.H5.20
Hydrophobic TM5 K 388 5x64 G.H5 L 384 G.H5.26
Van-der-waals TM5 K 388 5x64 G.H5 L 384 G.H5.26
Hydrophobic ICL2 F 314 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 F 314 - G.H5 I 373 G.H5.15
Hydrophobic ICL3 A 394 - G.S6 P 351 G.S6.03
Van-der-waals ICL3 A 394 - G.S6 P 351 G.S6.03
Aromatic ICL2 F 314 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 314 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 314 - G.S1 H 41 G.S1.02
Van-der-waals TM3 Y 305 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM4 K 318 4x40 G.HN Q 35 G.HN.52
Polar TM4 K 319 4x41 G.HN Q 35 G.HN.52
Hydrophobic TM4 K 319 4x41 G.HN Q 35 G.HN.52
Van-der-waals TM4 K 319 4x41 G.HN Q 35 G.HN.52
Hydrophobic TM4 K 318 4x40 G.hns1 R 38 G.hns1.02
Polar TM3 L 309 3x57 G.H5 H 377 G.H5.19
Hydrophobic TM3 L 309 3x57 G.H5 H 377 G.H5.19
Van-der-waals TM3 L 309 3x57 G.H5 H 377 G.H5.19
Hydrophobic ICL2 A 313 - G.H5 R 370 G.H5.12
Van-der-waals ICL2 A 313 - G.H5 R 370 G.H5.12
Hydrophobic ICL2 F 314 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 F 314 - G.H5 F 366 G.H5.08
Hydrophobic TM3 L 306 3x54 G.H5 Y 381 G.H5.23
Van-der-waals TM3 L 306 3x54 G.H5 Y 381 G.H5.23
Hydrophobic TM5 I 381 5x57 G.H5 L 383 G.H5.25
Hydrophobic ICL2 F 314 - G.S3 V 217 G.S3.01
Hydrophobic TM4 E 317 4x39 G.H5 H 377 G.H5.19
Polar ICL3 N 393 - G.h4s6 S 339 G.h4s6.02
Van-der-waals ICL3 N 393 - G.h4s6 S 339 G.h4s6.02
Polar ICL3 R 396 - G.h4s6 T 340 G.h4s6.03
Hydrophobic ICL3 R 396 - G.h4s6 T 340 G.h4s6.03
Van-der-waals ICL3 R 396 - G.h4s6 T 340 G.h4s6.03
Hydrophobic ICL3 N 393 - G.h4s6 T 340 G.h4s6.03
Van-der-waals H8 N 463 8x47 G.H5 E 382 G.H5.24
Hydrophobic TM3 I 310 3x58 G.H5 L 378 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 378 G.H5.20
Hydrophobic TM3 L 306 3x54 G.H5 L 383 G.H5.25
Hydrophobic ICL3 N 393 - G.H4 L 336 G.H4.16
Hydrophobic TM3 L 309 3x57 G.H5 Y 381 G.H5.23
Hydrophobic ICL3 A 394 - G.H4 R 332 G.H4.12
Polar TM3 E 302 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 E 302 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 E 302 3x50 G.H5 Y 381 G.H5.23
Polar TM5 E 391 5x67 G.H5 R 375 G.H5.17
Van-der-waals TM5 E 391 5x67 G.H5 R 375 G.H5.17
Aromatic TM2 R 219 2x46 G.H5 Y 381 G.H5.23
Hydrophobic TM2 R 219 2x46 G.H5 Y 381 G.H5.23
Hydrophobic TM5 L 389 5x65 G.H5 L 384 G.H5.26
Hydrophobic ICL3 R 396 - G.H4 R 337 G.H4.17
Hydrophobic TM5 L 385 5x61 G.H5 L 384 G.H5.26
Van-der-waals TM5 L 385 5x61 G.H5 L 384 G.H5.26
Polar TM3 I 310 3x58 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 310 3x58 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 Q 374 G.H5.16
Polar TM5 K 388 5x64 G.H5 R 375 G.H5.17
Hydrophobic TM5 K 388 5x64 G.H5 R 375 G.H5.17
Van-der-waals TM5 K 388 5x64 G.H5 R 375 G.H5.17
Hydrophobic TM6 V 412 6x44 G.H5 L 383 G.H5.25
Polar TM2 R 219 2x46 G.H5 Q 380 G.H5.22
Hydrophobic TM2 R 219 2x46 G.H5 Q 380 G.H5.22
Hydrophobic ICL3 R 396 - G.H4 L 336 G.H4.16
Ionic TM5 K 388 5x64 G.H5 D 371 G.H5.13
Polar TM5 K 388 5x64 G.H5 D 371 G.H5.13
Hydrophobic TM5 K 388 5x64 G.H5 D 371 G.H5.13
Hydrophobic TM2 H 223 2x50 G.H5 Y 381 G.H5.23
Polar TM5 K 388 5x64 G.H5 Q 374 G.H5.16
Hydrophobic TM5 K 388 5x64 G.H5 Q 374 G.H5.16
Van-der-waals TM5 K 388 5x64 G.H5 Q 374 G.H5.16
Polar TM6 K 405 6x37 G.H5 E 382 G.H5.24
Polar H8 G 464 8x48 G.H5 E 382 G.H5.24
Van-der-waals H8 G 464 8x48 G.H5 E 382 G.H5.24
Polar ICL3 N 393 - G.S6 C 349 G.S6.01
Van-der-waals ICL3 N 393 - G.S6 C 349 G.S6.01
Hydrophobic TM7 Y 459 7x57 G.H5 Y 381 G.H5.23
Ionic ICL3 R 396 - G.H4 D 333 G.H4.13
Polar ICL3 R 396 - G.H4 D 333 G.H4.13
Van-der-waals ICL3 R 396 - G.H4 D 333 G.H4.13
Hydrophobic ICL2 F 314 - G.H5 R 370 G.H5.12
Van-der-waals ICL2 F 314 - G.H5 R 370 G.H5.12
Polar TM6 K 405 6x37 G.H5 L 384 G.H5.26
Hydrophobic TM6 K 405 6x37 G.H5 L 384 G.H5.26
Van-der-waals TM6 K 405 6x37 G.H5 L 384 G.H5.26
Polar TM6 S 409 6x41 G.H5 L 383 G.H5.25
Hydrophobic TM6 S 409 6x41 G.H5 L 383 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 383 G.H5.25
Polar TM6 K 405 6x37 G.H5 L 383 G.H5.25
Hydrophobic TM6 K 405 6x37 G.H5 L 383 G.H5.25
Hydrophobic ICL3 C 397 - G.h4s6 T 340 G.h4s6.03
Hydrophobic ICL2 A 313 - G.H5 F 366 G.H5.08
Hydrophobic TM5 L 385 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 L 385 5x61 G.H5 L 383 G.H5.25
Hydrophobic TM6 L 413 6x45 G.H5 L 383 G.H5.25
Van-der-waals TM6 L 413 6x45 G.H5 L 383 G.H5.25
Polar ICL3 T 392 - G.H5 R 375 G.H5.17