NMU2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7W55

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-022-29683-W

PUBLICATION DATE

April 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

94 interactions (Click to see)

LIGANDS

Neuromedin U-25 (human) - Agonist pubchem

PHYSIOLOGICAL LIGANDS

neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 S 331 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 S 331 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 N 359 G.H5.24
Hydrophobic ICL2 F 152 34x51 G.S1 L 34 G.S1.02
Van-der-waals ICL2 F 152 34x51 G.S1 L 34 G.S1.02
Polar TM3 A 147 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 P 151 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 151 34x50 G.H5 I 350 G.H5.15
Polar ICL2 P 151 34x50 G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 151 34x50 G.H5 N 354 G.H5.19
Hydrophobic TM3 E 143 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 E 143 3x49 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 K 155 34x54 G.H5 I 350 G.H5.15
Van-der-waals ICL2 K 155 34x54 G.H5 I 350 G.H5.15
Polar ICL3 E 253 - G.H4 Y 306 G.H4.09
Hydrophobic ICL3 E 253 - G.H4 Y 306 G.H4.09
Van-der-waals ICL3 E 253 - G.H4 Y 306 G.H4.09
Polar TM2 T 78 2x37 G.H5 E 357 G.H5.22
Hydrophobic TM2 T 78 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 78 2x37 G.H5 E 357 G.H5.22
Hydrophobic TM3 I 148 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 I 148 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 N 359 G.H5.24
Hydrophobic ICL2 F 152 34x51 G.H5 I 350 G.H5.15
Van-der-waals ICL2 F 152 34x51 G.H5 I 350 G.H5.15
Hydrophobic TM5 M 239 5x61 G.H5 L 360 G.H5.25
Van-der-waals TM5 M 239 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM6 C 262 6x29 G.H5 V 361 G.H5.26
Ionic H8 R 333 8x49 G.H5 E 357 G.H5.22
Polar H8 R 333 8x49 G.H5 E 357 G.H5.22
Hydrophobic H8 R 333 8x49 G.H5 E 357 G.H5.22
Van-der-waals H8 R 333 8x49 G.H5 E 357 G.H5.22
Polar ICL2 S 158 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 S 158 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 I 148 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM6 V 266 6x33 G.H5 V 361 G.H5.26
Van-der-waals TM6 V 266 6x33 G.H5 V 361 G.H5.26
Hydrophobic TM5 L 243 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM5 L 243 5x65 G.H5 L 355 G.H5.20
Polar ICL2 K 155 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 T 80 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 Y 358 G.H5.23
Hydrophobic H8 S 331 8x47 G.H5 V 361 G.H5.26
Van-der-waals H8 S 331 8x47 G.H5 V 361 G.H5.26
Hydrophobic ICL2 K 155 34x54 G.S1 L 34 G.S1.02
Aromatic ICL2 F 152 34x51 G.H5 F 343 G.H5.08
Hydrophobic ICL2 F 152 34x51 G.H5 F 343 G.H5.08
Van-der-waals ICL2 F 152 34x51 G.H5 F 343 G.H5.08
Hydrophobic ICL2 L 156 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 156 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 C 262 6x29 G.H5 L 355 G.H5.20
Van-der-waals TM6 C 262 6x29 G.H5 L 355 G.H5.20
Hydrophobic TM6 I 258 6x25 G.h4s6 I 325 G.h4s6.20
Hydrophobic TM6 I 258 6x25 G.S6 Y 327 G.S6.02
Hydrophobic ICL2 F 152 34x51 G.H5 K 347 G.H5.12
Van-der-waals ICL2 F 152 34x51 G.H5 K 347 G.H5.12
Ionic ICL3 E 253 - G.H4 R 309 G.H4.12
Polar ICL3 E 253 - G.H4 R 309 G.H4.12
Hydrophobic ICL3 E 253 - G.H4 R 309 G.H4.12
Van-der-waals ICL3 E 253 - G.H4 R 309 G.H4.12
Van-der-waals TM7 Y 327 7x53 G.H5 N 359 G.H5.24
Hydrophobic TM3 A 147 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM5 L 243 5x65 G.H5 L 351 G.H5.16
Van-der-waals TM5 L 243 5x65 G.H5 L 351 G.H5.16
Hydrophobic TM6 L 270 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 270 6x37 G.H5 L 360 G.H5.25
Hydrophobic H8 R 333 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 R 333 8x49 G.H5 R 356 G.H5.21
Polar TM6 C 262 6x29 G.H5 Q 352 G.H5.17
Van-der-waals TM6 C 262 6x29 G.H5 Q 352 G.H5.17
Hydrophobic ICL2 P 151 34x50 G.H5 K 347 G.H5.12
Van-der-waals ICL2 P 151 34x50 G.H5 K 347 G.H5.12
Polar TM3 R 144 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM2 L 84 2x43 G.H5 N 359 G.H5.24
Van-der-waals TM2 L 84 2x43 G.H5 N 359 G.H5.24
Hydrophobic ICL2 F 152 34x51 G.S3 V 194 G.S3.01
Polar H8 R 332 8x48 G.H5 V 361 G.H5.26
Hydrophobic H8 R 332 8x48 G.H5 V 361 G.H5.26
Van-der-waals H8 R 332 8x48 G.H5 V 361 G.H5.26
Polar ICL2 L 156 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 156 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 V 266 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 P 151 34x50 G.H5 L 351 G.H5.16
Hydrophobic TM4 T 159 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 159 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 I 148 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 355 G.H5.20
Polar TM6 Q 259 6x26 G.H5 Q 352 G.H5.17
Hydrophobic ICL2 F 152 34x51 G.H5 C 346 G.H5.11
Van-der-waals ICL2 F 152 34x51 G.H5 C 346 G.H5.11