Beta-arrestin-2 - FPR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FPR1 84.7
Beta-arrestin-2 82.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 T 58 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 T 58 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 T 58 2x37 s5s6 E 67 N.s5s6.03
Polar ICL2 P 130 34x50 S16 Y 250 C.S16.03
Hydrophobic ICL3 L 233 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 L 233 - s15s16 F 245 C.s15s16.03
Polar TM5 Q 231 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Q 231 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 231 5x68 s15s16 F 245 C.s15s16.03
Polar ICL3 K 235 - S6 R 77 N.S6.02
Hydrophobic ICL3 K 235 - S6 R 77 N.S6.02
Van-der-waals ICL3 K 235 - S6 R 77 N.S6.02
Polar ICL2 Q 134 34x54 s8s9 D 136 N.s8s9.06
Polar H8 Q 306 8x48 s5s6 D 70 N.s5s6.06
Polar ICL2 V 131 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 V 131 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 131 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 I 228 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 228 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM4 T 138 4x38 s17s18 R 286 C.s17s18.11
Hydrophobic TM6 L 243 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 243 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic H8 G 305 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 P 130 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 130 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 R 123 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 127 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 127 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 Y 64 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 T 58 2x37 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 T 58 2x37 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 K 235 - S6 F 76 N.S6.01
Van-der-waals ICL3 K 235 - S6 F 76 N.S6.01
Polar ICL2 Q 134 34x54 s8s9 Q 131 N.s8s9.01
Van-der-waals ICL2 Q 134 34x54 s8s9 Q 131 N.s8s9.01
Hydrophobic ICL2 V 131 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 V 131 34x51 S16 A 248 C.S16.01
Hydrophobic TM1 M 55 1x61 s5s6 E 67 N.s5s6.03
Van-der-waals TM1 M 55 1x61 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 T 58 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 58 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 130 34x50 S16 A 248 C.S16.01
Polar TM6 P 239 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 P 239 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 P 239 6x33 s5s6 L 72 N.s5s6.08
Polar TM2 T 61 2x40 s5s6 E 67 N.s5s6.03
Polar ICL2 Q 134 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 134 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 134 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 V 242 6x36 s5s6 L 72 N.s5s6.08
Polar H8 R 311 8x53 s20c Y 404 C.s20c.14
Hydrophobic H8 R 311 8x53 s20c Y 404 C.s20c.14
Van-der-waals H8 R 311 8x53 s20c Y 404 C.s20c.14
Hydrophobic ICL2 V 131 34x51 S16 Q 249 C.S16.02
Hydrophobic TM7 Y 301 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 301 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals ICL2 P 130 34x50 S5 Y 64 N.S5.12
Polar TM3 C 126 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 C 126 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 C 126 3x53 s5s6 D 68 N.s5s6.04
Ionic ICL2 R 137 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 137 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 137 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 Q 134 34x54 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 Q 134 34x54 s17s18 G 287 C.s17s18.12
Polar TM4 V 139 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 V 139 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 V 139 4x39 s8s9 E 135 N.s8s9.05
Polar H8 D 307 8x49 s5s6 D 70 N.s5s6.06
Polar ICL2 T 133 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 T 133 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 133 34x53 s5s6 R 66 N.s5s6.02
Polar TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Polar ICL2 R 137 34x57 s17s18 R 286 C.s17s18.11
Hydrophobic TM3 R 123 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Q 134 34x54 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 Q 134 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 I 224 5x61 s5s6 L 74 N.s5s6.10
Polar TM5 K 227 5x64 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 P 239 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 P 239 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 Q 134 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 Q 134 34x54 S16 Y 250 C.S16.03
Hydrophobic TM6 P 239 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 P 239 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 127 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL1 T 56 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 T 56 - s8s9 T 137 N.s8s9.07