Beta-arrestin-2 - GPER complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPER 68.2
Beta-arrestin-2 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 251 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 251 - S6 R 77 N.S6.02
Polar ICL2 S 166 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 S 166 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 S 166 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL3 R 253 - s5s6 S 75 N.s5s6.11
Hydrophobic TM2 P 94 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 P 94 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 R 169 34x57 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 169 34x57 s8s9 T 137 N.s8s9.07
Polar TM2 T 92 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 92 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 92 2x37 s5s6 D 68 N.s5s6.04
Ionic ICL3 R 251 - S9 E 146 N.S9.06
Polar ICL3 R 251 - S9 E 146 N.S9.06
Van-der-waals ICL3 R 251 - S9 E 146 N.S9.06
Hydrophobic ICL3 R 253 - s5s6 G 73 N.s5s6.09
Van-der-waals ICL3 R 253 - s5s6 G 73 N.s5s6.09
Hydrophobic TM6 A 257 6x33 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 A 257 6x33 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 K 90 12x50 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 90 12x50 s20c Y 404 C.s20c.14
Polar C-term Q 366 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term Q 366 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term Q 366 - s9s10 R 162 N.s9s10.13
Polar ICL2 R 164 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic TM6 A 257 6x33 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 A 257 6x33 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 A 162 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 A 162 34x50 s15s16 F 245 C.s15s16.03
Polar ICL2 M 163 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 M 163 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 M 163 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 L 250 - S6 R 77 N.S6.02
Van-der-waals ICL3 L 250 - S6 R 77 N.S6.02
Polar ICL3 R 253 - s20c L 408 C.s20c.18
Van-der-waals ICL3 R 253 - s20c L 408 C.s20c.18
Polar ICL2 A 162 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 A 162 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 A 162 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 M 163 34x51 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 M 163 34x51 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 M 163 34x51 s15s16 F 245 C.s15s16.03
Polar TM4 K 171 4x39 s8s9 P 134 N.s8s9.04
Hydrophobic TM7 Y 324 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 A 158 3x53 S6 F 76 N.S6.01
Hydrophobic ICL2 R 169 34x57 s5s6 L 69 N.s5s6.05
Ionic ICL3 R 251 - S6 D 79 N.S6.04
Hydrophobic TM3 A 158 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 A 257 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 257 6x33 s5s6 L 72 N.s5s6.08
Polar TM3 R 155 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 155 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 155 3x50 s5s6 L 72 N.s5s6.08
Polar H8 D 333 8x52 s20c Q 407 C.s20c.17
Hydrophobic H8 D 333 8x52 s20c Q 407 C.s20c.17
Van-der-waals H8 D 333 8x52 s20c Q 407 C.s20c.17
Aromatic TM6 R 254 6x30 S6 F 76 N.S6.01
Hydrophobic TM6 R 254 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 R 254 6x30 S6 F 76 N.S6.01
Hydrophobic TM3 L 159 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 159 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 M 163 34x51 s15s16 C 243 C.s15s16.01
Hydrophobic TM6 I 261 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 261 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 S 166 34x54 S16 A 248 C.S16.01
Van-der-waals ICL2 S 166 34x54 S16 A 248 C.S16.01
Hydrophobic TM4 T 170 4x38 s8s9 T 137 N.s8s9.07
Van-der-waals TM4 T 170 4x38 s8s9 T 137 N.s8s9.07
Hydrophobic H8 T 330 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 T 330 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals ICL3 G 249 - S6 D 79 N.S6.04
Hydrophobic TM2 P 94 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 P 94 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 L 159 3x54 S6 F 76 N.S6.01
Polar ICL2 M 163 34x51 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 M 163 34x51 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 M 163 34x51 s15s16 T 247 C.s15s16.05
Polar TM6 R 254 6x30 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 254 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 254 6x30 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 254 6x30 s5s6 L 74 N.s5s6.10
Aromatic TM6 R 254 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 R 254 6x30 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 A 257 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 A 257 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 M 260 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 M 260 6x36 s5s6 V 71 N.s5s6.07
Ionic ICL1 K 90 12x50 s20c D 402 C.s20c.12
Polar ICL1 K 90 12x50 s20c D 402 C.s20c.12
Hydrophobic ICL1 K 90 12x50 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 90 12x50 s20c D 402 C.s20c.12
Hydrophobic ICL2 M 163 34x51 s15s16 L 244 C.s15s16.02
Hydrophobic H8 T 330 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 T 330 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 A 162 34x50 S6 F 76 N.S6.01
Polar ICL3 R 253 - s20c Q 407 C.s20c.17
Van-der-waals ICL3 R 253 - s20c Q 407 C.s20c.17
Hydrophobic TM2 F 98 2x43 s5s6 V 71 N.s5s6.07