Arrestin-C - LPA6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
LPA6 77.4
Arrestin-C 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 222 6x28 S6 F 71 N.S6.01
Hydrophobic TM3 A 117 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 117 3x53 S6 F 71 N.S6.01
Hydrophobic ICL1 V 48 12x50 s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 V 48 12x50 s5s6 D 62 N.s5s6.03
Hydrophobic TM6 R 219 6x25 S6 R 72 N.S6.02
Van-der-waals TM6 R 219 6x25 S6 R 72 N.S6.02
Ionic ICL2 R 128 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 128 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 128 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 128 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 I 118 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 A 117 3x53 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 A 117 3x53 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 K 125 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 K 125 34x54 S5 Y 59 N.S5.12
Polar ICL2 R 128 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 I 118 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 118 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 I 118 3x54 S6 F 71 N.S6.01
Hydrophobic TM2 N 50 2x37 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 N 50 2x37 s5s6 V 66 N.s5s6.07
Polar H8 W 307 8x59 s20c E 386 C.s20c.20
Hydrophobic H8 W 307 8x59 s20c E 386 C.s20c.20
Van-der-waals H8 W 307 8x59 s20c E 386 C.s20c.20
Polar ICL2 K 125 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 K 125 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 K 125 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 M 230 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 230 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 F 122 34x51 S5 F 57 N.S5.10
Polar TM6 R 219 6x25 S6 L 75 N.S6.05
Hydrophobic TM6 R 219 6x25 S6 L 75 N.S6.05
Hydrophobic ICL2 P 121 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 121 34x50 S6 F 71 N.S6.01
Polar TM6 R 219 6x25 S6 K 73 N.S6.03
Hydrophobic TM6 R 219 6x25 S6 K 73 N.S6.03
Van-der-waals TM6 R 219 6x25 S6 K 73 N.S6.03
Hydrophobic ICL2 F 122 34x51 S6 F 71 N.S6.01
Hydrophobic TM7 T 294 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 T 294 7x56 s5s6 V 66 N.s5s6.07
Ionic C-term R 311 - s20c E 386 C.s20c.20
Polar C-term R 311 - s20c E 386 C.s20c.20
Van-der-waals C-term R 311 - s20c E 386 C.s20c.20
Hydrophobic H8 M 304 8x56 s20c E 383 C.s20c.17
Van-der-waals H8 M 304 8x56 s20c E 383 C.s20c.17
Polar ICL2 K 125 34x54 S16 Y 246 C.S16.03
Hydrophobic H8 D 296 8x48 s5s6 G 68 N.s5s6.09
Van-der-waals H8 D 296 8x48 s5s6 G 68 N.s5s6.09
Hydrophobic TM2 N 50 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 50 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 V 48 12x50 s8s9 A 133 N.s8s9.07
Aromatic ICL2 F 122 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 F 122 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 F 122 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic TM2 T 52 2x39 s5s6 V 66 N.s5s6.07
Polar ICL2 K 125 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 K 125 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 K 125 34x54 s15s16 S 242 C.s15s16.04
Polar TM6 K 221 6x27 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 K 221 6x27 S6 R 72 N.S6.02
Polar TM6 S 220 6x26 S6 R 72 N.S6.02
Hydrophobic TM6 S 220 6x26 S6 R 72 N.S6.02
Van-der-waals TM6 S 220 6x26 S6 R 72 N.S6.02
Polar TM7 T 294 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 V 227 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 227 6x33 s5s6 L 69 N.s5s6.10
Polar TM2 N 50 2x37 s5s6 D 62 N.s5s6.03
Hydrophobic TM2 N 50 2x37 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 N 50 2x37 s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 R 128 34x57 s5s6 I 67 N.s5s6.08
Aromatic ICL2 F 122 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 F 122 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 F 122 34x51 S5 Y 59 N.S5.12
Polar H8 S 295 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 S 295 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 S 295 8x47 s5s6 V 66 N.s5s6.07
Polar TM6 R 219 6x25 S6 D 74 N.S6.04
Hydrophobic TM6 R 219 6x25 S6 D 74 N.S6.04
Van-der-waals TM6 R 219 6x25 S6 D 74 N.S6.04
Polar H8 D 296 8x48 s5s6 V 66 N.s5s6.07
Van-der-waals H8 D 296 8x48 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 E 51 2x38 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 K 226 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 F 122 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 F 122 34x51 s15s16 S 242 C.s15s16.04
Ionic ICL2 K 125 34x54 S16 D 244 C.S16.01
Polar ICL2 K 125 34x54 S16 D 244 C.S16.01
Hydrophobic ICL2 K 125 34x54 S16 D 244 C.S16.01
Van-der-waals ICL2 K 125 34x54 S16 D 244 C.S16.01
Polar H8 D 296 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 D 296 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 A 117 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 114 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 114 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 I 222 6x28 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 I 222 6x28 s5s6 L 69 N.s5s6.10