Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
|
GPCRdb(A)
|
MC5
Human |
MC5
Mouse |
MC5
Rat |
|
|---|---|---|---|---|
| TM1 | ||||
| 1x35 | A39 | A39 | A39 | |
| 1x36 | V40 | V40 | V40 | |
| 1x37 | E41 | E41 | E41 | |
| 1x38 | V42 | V42 | V42 | |
| 1x39 | F43 | F43 | F43 | |
| 1x40 | L44 | L44 | L44 | |
| 1x41 | T45 | T45 | T45 | |
| 1x42 | L46 | L46 | L46 | |
| 1x43 | G47 | G47 | G47 | |
| 1x44 | V48 | L48 | L48 | |
| 1x45 | I49 | V49 | V49 | |
| 1x46 | S50 | S50 | S50 | |
| 1x47 | L51 | L51 | L51 | |
| 1x48 | L52 | L52 | L52 | |
| 1x49 | E53 | E53 | E53 | |
| 1x50 | N54 | N54 | N54 | |
| 1x51 | I55 | I55 | I55 | |
| 1x52 | L56 | L56 | L56 | |
| 1x53 | V57 | V57 | V57 | |
| 1x54 | I58 | I58 | I58 | |
| 1x55 | G59 | G59 | G59 | |
| 1x56 | A60 | A60 | A60 | |
| 1x57 | I61 | I61 | I61 | |
| 1x58 | V62 | V62 | V62 | |
| 1x59 | K63 | K63 | K63 | |
| 1x60 | N64 | N64 | N64 | |
| ICL1 | ||||
| 12x48 | K65 | K65 | K65 | |
| 12x49 | N66 | N66 | N66 | |
| 12x50 | L67 | L67 | L67 | |
| 12x51 | H68 | H68 | H68 | |
| TM2 | ||||
| 2x37 | S69 | S69 | S69 | |
| 2x38 | P70 | P70 | P70 | |
| 2x39 | M71 | M71 | M71 | |
| 2x40 | Y72 | Y72 | Y72 | |
| 2x41 | F73 | F73 | F73 | |
| 2x42 | F74 | F74 | F74 | |
| 2x43 | V75 | V75 | V75 | |
| 2x44 | C76 | G76 | G76 | |
| 2x45 | S77 | S77 | S77 | |
| 2x46 | L78 | L78 | L78 | |
| 2x47 | A79 | A79 | A79 | |
| 2x48 | V80 | V80 | V80 | |
| 2x49 | A81 | A81 | A81 | |
| 2x50 | D82 | D82 | D82 | |
| 2x51 | M83 | M83 | M83 | |
| 2x52 | L84 | L84 | L84 | |
| 2x53 | V85 | V85 | V85 | |
| 2x54 | S86 | S86 | S86 | |
| 2x55 | M87 | M87 | M87 | |
| 2x56 | S88 | S88 | S88 | |
| 2x57 | S89 | N89 | N89 | |
| 2x58 | A90 | A90 | A90 | |
| 2x59 | W91 | W91 | W91 | |
| 2x60 | E92 | E92 | E92 | |
| 2x61 | T93 | T93 | T93 | |
| 2x62 | I94 | V94 | I94 | |
| 2x63 | T95 | T95 | T95 | |
| 2x64 | I96 | I96 | I96 | |
| 2x65 | Y97 | Y97 | Y97 | |
| 2x66 | L98 | L98 | L98 | |
| 2x67 | L99 | L99 | I99 | |
| 2x68 | N100 | N100 | N100 | |
| 2x69 | N101 | N101 | N101 | |
| TM3 | ||||
| 3x17 | A107 | A107 | A107 | |
| 3x18 | D108 | D108 | D108 | |
| 3x19 | A109 | T109 | T109 | |
| 3x20 | F110 | F110 | F110 | |
| 3x21 | V111 | V111 | V111 | |
| 3x22 | R112 | R112 | R112 | |
| 3x23 | H113 | H113 | H113 | |
| 3x24 | I114 | I114 | I114 | |
| 3x25 | D115 | D115 | D115 | |
| 3x26 | N116 | N116 | N116 | |
| 3x27 | V117 | V117 | V117 | |
| 3x28 | F118 | F118 | F118 | |
| 3x29 | D119 | D119 | D119 | |
| 3x30 | S120 | S120 | S120 | |
| 3x31 | M121 | M121 | M121 | |
| 3x32 | I122 | I122 | I122 | |
| 3x33 | C123 | C123 | C123 | |
| 3x34 | I124 | I124 | I124 | |
| 3x35 | S125 | S125 | S125 | |
| 3x36 | V126 | V126 | V126 | |
| 3x37 | V127 | V127 | V127 | |
| 3x38 | A128 | A128 | A128 | |
| 3x39 | S129 | S129 | S129 | |
| 3x40 | M130 | M130 | M130 | |
| 3x41 | C131 | C131 | C131 | |
| 3x42 | S132 | S132 | S132 | |
| 3x43 | L133 | L133 | L133 | |
| 3x44 | L134 | L134 | L134 | |
| 3x45 | A135 | A135 | A135 | |
| 3x46 | I136 | I136 | I136 | |
| 3x47 | A137 | A137 | A137 | |
| 3x48 | V138 | V138 | V138 | |
| 3x49 | D139 | D139 | D139 | |
| 3x50 | R140 | R140 | R140 | |
| 3x51 | Y141 | Y141 | Y141 | |
| 3x52 | V142 | I142 | I142 | |
| 3x53 | T143 | T143 | T143 | |
| 3x54 | I144 | I144 | I144 | |
| 3x55 | F145 | F145 | F145 | |
| 3x56 | Y146 | Y146 | Y146 | |
| ICL2 | ||||
| 34x50 | A147 | A147 | A147 | |
| 34x51 | L148 | L148 | L148 | |
| 34x52 | R149 | R149 | R149 | |
| 34x53 | Y150 | Y150 | Y150 | |
| 34x54 | H151 | H151 | H151 | |
| 34x55 | H152 | H152 | H152 | |
| 34x56 | I153 | I153 | I153 | |
| 34x57 | M154 | M154 | M154 | |
| TM4 | ||||
| 4x38 | T155 | T155 | T155 | |
| 4x39 | A156 | A156 | A156 | |
| 4x40 | R157 | R157 | R157 | |
| 4x41 | R158 | R158 | R158 | |
| 4x42 | S159 | S159 | S159 | |
| 4x43 | G160 | G160 | G160 | |
| 4x44 | A161 | V161 | V161 | |
| 4x45 | I162 | I162 | I162 | |
| 4x46 | I163 | I163 | I163 | |
| 4x47 | A164 | A164 | A164 | |
| 4x48 | G165 | C165 | C165 | |
| 4x49 | I166 | I166 | I166 | |
| 4x50 | W167 | W167 | W167 | |
| 4x51 | A168 | T168 | T168 | |
| 4x52 | F169 | F169 | F169 | |
| 4x53 | C170 | C170 | C170 | |
| 4x54 | T171 | I171 | I171 | |
| 4x55 | G172 | S172 | S172 | |
| 4x56 | C173 | C173 | C173 | |
| 4x57 | G174 | G174 | G174 | |
| 4x58 | I175 | I175 | I175 | |
| 4x59 | V176 | V176 | V176 | |
| 4x60 | F177 | F177 | F177 | |
| 4x61 | I178 | I178 | I178 | |
| 4x62 | L179 | I179 | I179 | |
| 4x63 | Y180 | Y180 | Y180 | |
| 4x64 | S181 | Y181 | Y181 | |
| TM5 | ||||
| 5x36 | S183 | S183 | S183 | |
| 5x37 | T184 | K184 | K184 | |
| 5x38 | Y185 | Y185 | Y185 | |
| 5x39 | V186 | V186 | V186 | |
| 5x40 | I187 | I187 | I187 | |
| 5x41 | L188 | I188 | V188 | |
| 5x42 | C189 | C189 | C189 | |
| 5x43 | L190 | L190 | L190 | |
| 5x44 | I191 | I191 | I191 | |
| 5x45 | S192 | S192 | S192 | |
| 5x46 | M193 | M193 | M193 | |
| 5x47 | F194 | F194 | F194 | |
| 5x48 | F195 | F195 | F195 | |
| 5x49 | A196 | T196 | T196 | |
| 5x50 | M197 | M197 | M197 | |
| 5x51 | L198 | L198 | L198 | |
| 5x52 | F199 | F199 | F199 | |
| 5x53 | L200 | F200 | F200 | |
| 5x54 | L201 | M201 | M201 | |
| 5x55 | V202 | V202 | V202 | |
| 5x56 | S203 | S203 | S203 | |
| 5x57 | L204 | L204 | L204 | |
| 5x58 | Y205 | Y205 | Y205 | |
| 5x59 | I206 | I206 | I206 | |
| 5x60 | H207 | H207 | H207 | |
| 5x61 | M208 | M208 | M208 | |
| 5x62 | F209 | F209 | F209 | |
| 5x63 | L210 | L210 | L210 | |
| 5x64 | L211 | L211 | L211 | |
| 5x65 | A212 | A212 | A212 | |
| 5x66 | R213 | R213 | R213 | |
| 5x67 | T214 | N214 | N214 | |
| 5x68 | H215 | H215 | H215 | |
| 5x69 | V216 | V216 | V216 | |
| 5x70 | K217 | K217 | K217 | |
| 5x71 | R218 | R218 | R218 | |
| 5x72 | I219 | I219 | I219 | |
| 5x73 | A220 | A220 | A220 | |
| 5x74 | A221 | A221 | A221 | |
| TM6 | ||||
| 6x27 | Q230 | Q230 | Q230 | |
| 6x28 | R231 | R231 | R231 | |
| 6x29 | T232 | T232 | A232 | |
| 6x30 | S233 | S233 | S233 | |
| 6x31 | M234 | M234 | M234 | |
| 6x32 | Q235 | K235 | K235 | |
| 6x33 | G236 | G236 | G236 | |
| 6x34 | A237 | A237 | A237 | |
| 6x35 | V238 | I238 | I238 | |
| 6x36 | T239 | T239 | T239 | |
| 6x37 | V240 | L240 | L240 | |
| 6x38 | T241 | T241 | T241 | |
| 6x39 | M242 | M242 | M242 | |
| 6x40 | L243 | L243 | L243 | |
| 6x41 | L244 | L244 | L244 | |
| 6x42 | G245 | G245 | G245 | |
| 6x43 | V246 | I246 | I246 | |
| 6x44 | F247 | F247 | F247 | |
| 6x45 | T248 | I248 | I248 | |
| 6x46 | V249 | V249 | V249 | |
| 6x47 | C250 | C250 | C250 | |
| 6x48 | W251 | W251 | W251 | |
| 6x49 | A252 | S252 | S252 | |
| 6x50 | P253 | P253 | P253 | |
| 6x51 | F254 | F254 | F254 | |
| 6x52 | F255 | F255 | F255 | |
| 6x53 | L256 | L256 | L256 | |
| 6x54 | H257 | H257 | H257 | |
| 6x55 | L258 | L258 | L258 | |
| 6x56 | T259 | I259 | I259 | |
| 6x57 | L260 | L260 | L260 | |
| 6x58 | M261 | M261 | M261 | |
| 6x59 | L262 | I262 | I262 | |
| 6x60 | S263 | S263 | S263 | |
| 6x61 | C264 | C264 | C264 | |
| TM7 | ||||
| 7x33 | H276 | Y276 | Y276 | |
| 7x34 | F277 | F277 | F277 | |
| 7x35 | N278 | N278 | N278 | |
| 7x36 | M279 | M279 | M279 | |
| 7x37 | Y280 | Y280 | Y280 | |
| 7x38 | L281 | L281 | L281 | |
| 7x39 | I282 | I282 | I282 | |
| 7x40 | L283 | L283 | L283 | |
| 7x41 | I284 | I284 | I284 | |
| 7x42 | M285 | M285 | M285 | |
| 7x43 | C286 | C286 | C286 | |
| 7x45 | N287 | N287 | N287 | |
| 7x46 | S288 | S288 | S288 | |
| 7x47 | V289 | V289 | V289 | |
| 7x48 | M290 | I290 | I290 | |
| 7x49 | D291 | D291 | D291 | |
| 7x50 | P292 | P292 | P292 | |
| 7x51 | L293 | L293 | L293 | |
| 7x52 | I294 | I294 | I294 | |
| 7x53 | Y295 | Y295 | Y295 | |
| 7x54 | A296 | A296 | A296 | |
| 7x55 | F297 | L297 | L297 | |
| 7x56 | R298 | R298 | R298 | |
| H8 | ||||
| 8x47 | S299 | S299 | S299 | |
| 8x48 | Q300 | Q300 | Q300 | |
| 8x49 | E301 | E301 | E301 | |
| 8x50 | M302 | M302 | M302 | |
| 8x51 | R303 | R303 | R303 | |
| 8x52 | K304 | R304 | R304 | |
| 8x53 | T305 | T305 | T305 | |
| 8x54 | F306 | F306 | F306 | |
| 8x55 | K307 | K307 | K307 | |
| 8x56 | E308 | E308 | E308 | |
| 8x57 | I309 | I309 | I309 | |
| 8x58 | I310 | V310 | I310 | |
| 8x59 | C311 | C311 | C311 | |
| 8x60 | C312 | C312 | C312 | |
| 8x61 | R313 | H313 | H313 | |