Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
| 49779990 | 135761 | 0 | None | - | 1 | Human | 10.2 | pEC50 | = | 10.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 499 | 8 | 2 | 3 | 4.6 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCCC1)C21CC1 | nan | |
| CHEMBL3730217 | 135761 | 0 | None | - | 1 | Human | 10.2 | pEC50 | = | 10.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 499 | 8 | 2 | 3 | 4.6 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCCC1)C21CC1 | nan | |
| 67496162 | 135529 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 485 | 8 | 2 | 3 | 4.2 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 | nan | |
| CHEMBL3728769 | 135529 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 485 | 8 | 2 | 3 | 4.2 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 | nan | |
| 67495697 | 135565 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 471 | 5 | 3 | 3 | 3.9 | NC[C@H]1CC[C@@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 | nan | |
| CHEMBL3729012 | 135565 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 471 | 5 | 3 | 3 | 3.9 | NC[C@H]1CC[C@@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 | nan | |
| 67495547 | 135329 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 445 | 8 | 3 | 3 | 3.5 | NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| CHEMBL3727613 | 135329 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 445 | 8 | 3 | 3 | 3.5 | NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| 67496555 | 135557 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 443 | 4 | 3 | 3 | 3.1 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 | nan | |
| CHEMBL3728932 | 135557 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 443 | 4 | 3 | 3 | 3.1 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 | nan | |
| 67495917 | 135599 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 416 | 5 | 2 | 2 | 4.0 | CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| CHEMBL3729214 | 135599 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 416 | 5 | 2 | 2 | 4.0 | CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| 124093849 | 183076 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay |
ChEMBL | 330 | 4 | 2 | 3 | 3.1 | COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 | 10.1016/j.ejmech.2021.113194 | |
| CHEMBL4794375 | 183076 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay |
ChEMBL | 330 | 4 | 2 | 3 | 3.1 | COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 | 10.1016/j.ejmech.2021.113194 | |
| 127024365 | 135733 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 503 | 8 | 2 | 3 | 4.5 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@H]1F)C21CC1 | nan | |
| CHEMBL3730056 | 135733 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 503 | 8 | 2 | 3 | 4.5 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@H]1F)C21CC1 | nan | |
| 67496467 | 135797 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 431 | 7 | 3 | 3 | 3.1 | NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| CHEMBL3730438 | 135797 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 431 | 7 | 3 | 3 | 3.1 | NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| 127024366 | 135748 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 503 | 8 | 2 | 3 | 4.5 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@@H]1F)C21CC1 | nan | |
| CHEMBL3730133 | 135748 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 503 | 8 | 2 | 3 | 4.5 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@@H]1F)C21CC1 | nan | |
| 67495052 | 136000 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 487 | 8 | 2 | 3 | 4.4 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 | nan | |
| CHEMBL3731671 | 136000 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 487 | 8 | 2 | 3 | 4.4 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 | nan | |
| 67495909 | 135633 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 471 | 8 | 2 | 3 | 3.8 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC1)C21CC1 | nan | |
| CHEMBL3729434 | 135633 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 471 | 8 | 2 | 3 | 3.8 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC1)C21CC1 | nan | |
| 67495424 | 136164 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 431 | 6 | 2 | 3 | 2.9 | CN(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| CHEMBL3732621 | 136164 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 431 | 6 | 2 | 3 | 2.9 | CN(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| 87422323 | 135909 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 454 | 8 | 3 | 5 | 3.1 | NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| CHEMBL3731107 | 135909 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 454 | 8 | 3 | 5 | 3.1 | NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| 87422349 | 135939 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 466 | 5 | 3 | 5 | 3.0 | O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCNC1)C21CC1 | nan | |
| CHEMBL3731259 | 135939 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 466 | 5 | 3 | 5 | 3.0 | O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCNC1)C21CC1 | nan | |
| 67496515 | 135869 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 433 | 6 | 3 | 3 | 2.4 | NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| CHEMBL3730874 | 135869 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 433 | 6 | 3 | 3 | 2.4 | NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| 87422373 | 135328 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 440 | 7 | 3 | 5 | 2.8 | NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| CHEMBL3727601 | 135328 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 440 | 7 | 3 | 5 | 2.8 | NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| 67496242 | 135512 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 501 | 8 | 2 | 4 | 3.4 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCOCC1)C21CC1 | nan | |
| CHEMBL3728644 | 135512 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 501 | 8 | 2 | 4 | 3.4 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCOCC1)C21CC1 | nan | |
| 67495587 | 135920 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 479 | 6 | 3 | 3 | 4.0 | NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 | nan | |
| CHEMBL3731166 | 135920 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 479 | 6 | 3 | 3 | 4.0 | NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 | nan | |
| 87422150 | 135440 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 452 | 8 | 3 | 5 | 2.9 | NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| CHEMBL3728245 | 135440 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 452 | 8 | 3 | 5 | 2.9 | NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 | nan | |
| 67495044 | 135635 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 499 | 9 | 2 | 3 | 4.6 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCCN1CCCC1)C21CC1 | nan | |
| CHEMBL3729460 | 135635 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 499 | 9 | 2 | 3 | 4.6 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCCN1CCCC1)C21CC1 | nan | |
| 67495611 | 136068 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 475 | 9 | 2 | 3 | 4.3 | CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| CHEMBL3732081 | 136068 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 475 | 9 | 2 | 3 | 4.3 | CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 | nan | |
| 67496319 | 135751 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 501 | 9 | 2 | 4 | 3.4 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCOCCN1CCCC1)C21CC1 | nan | |
| CHEMBL3730159 | 135751 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 501 | 9 | 2 | 4 | 3.4 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCOCCN1CCCC1)C21CC1 | nan | |
| 67495075 | 135911 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 457 | 5 | 3 | 3 | 3.3 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 | nan | |
| CHEMBL3731113 | 135911 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 457 | 5 | 3 | 3 | 3.3 | O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 | nan | |
| 67496410 | 136209 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 503 | 8 | 2 | 3 | 4.3 | O=C(Nc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 | nan | |
| CHEMBL3732902 | 136209 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay |
ChEMBL | 503 | 8 | 2 | 3 | 4.3 | O=C(Nc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 | nan | |
Showing 1 to 50 of 1,628 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
| CHEMBL5271637 | 193690 | 0 | None | - | 0 | Human | 10.7 | pEC50 | = | 10.7 | Binding | Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux |
ChEMBL | 420 | 4 | 2 | 5 | 3.0 | COc1cc(F)c([C@@H]2CN3CCON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 | 10.1016/j.ejmech.2021.113167 | ||
| 118132792 | 181668 | 0 | None | - | 0 | Human | 10.3 | pEC50 | = | 10.3 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 411 | 4 | 4 | 4 | 2.7 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4776349 | 181668 | 0 | None | - | 0 | Human | 10.3 | pEC50 | = | 10.3 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 411 | 4 | 4 | 4 | 2.7 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122583080 | 182809 | 0 | None | - | 0 | Human | 10.1 | pEC50 | = | 10.1 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 391 | 4 | 4 | 4 | 2.4 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4790836 | 182809 | 0 | None | - | 0 | Human | 10.1 | pEC50 | = | 10.1 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 391 | 4 | 4 | 4 | 2.4 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 118132866 | 179708 | 0 | None | - | 0 | Human | 10.1 | pEC50 | = | 10.1 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 343 | 4 | 3 | 3 | 2.2 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4743917 | 179708 | 0 | None | - | 0 | Human | 10.1 | pEC50 | = | 10.1 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 343 | 4 | 3 | 3 | 2.2 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122583049 | 180706 | 0 | None | - | 0 | Human | 10.1 | pEC50 | = | 10.1 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 395 | 4 | 4 | 4 | 2.2 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4755590 | 180706 | 0 | None | - | 0 | Human | 10.1 | pEC50 | = | 10.1 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 395 | 4 | 4 | 4 | 2.2 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 118132864 | 179734 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10.0 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 359 | 4 | 3 | 3 | 2.8 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4744094 | 179734 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10.0 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 359 | 4 | 3 | 3 | 2.8 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122582941 | 180999 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10.0 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 395 | 4 | 3 | 3 | 3.0 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4758920 | 180999 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10.0 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 395 | 4 | 3 | 3 | 3.0 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 135251225 | 182332 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10.0 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 373 | 4 | 3 | 3 | 3.1 | COc1ccc([C@@H]2CCNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4784400 | 182332 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10.0 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 373 | 4 | 3 | 3 | 3.1 | COc1ccc([C@@H]2CCNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL5288361 | 194419 | 0 | None | - | 0 | Human | 9.9 | pEC50 | = | 9.9 | Binding | Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 371 | 5 | 2 | 3 | 3.0 | CCN1C[C@@H](c2ccc(OC)cc2)[C@H](NC(=O)Nc2ccc(F)cc2)C1=O | 10.1016/j.ejmech.2021.113167 | ||
| CHEMBL5284349 | 194251 | 0 | None | - | 0 | Human | 9.9 | pEC50 | = | 9.9 | Binding | Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay |
ChEMBL | 512 | 6 | 3 | 4 | 4.7 | CS(=O)(=O)Nc1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)cc1 | 10.1016/j.ejmech.2021.113167 | ||
| 122583076 | 182083 | 1 | None | - | 0 | Human | 9.9 | pEC50 | = | 9.9 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 379 | 4 | 3 | 3 | 2.5 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4781596 | 182083 | 1 | None | - | 0 | Human | 9.9 | pEC50 | = | 9.9 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 379 | 4 | 3 | 3 | 2.5 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 118132901 | 179798 | 0 | None | - | 0 | Human | 9.8 | pEC50 | = | 9.8 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 379 | 4 | 3 | 3 | 2.5 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4744835 | 179798 | 0 | None | - | 0 | Human | 9.8 | pEC50 | = | 9.8 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 379 | 4 | 3 | 3 | 2.5 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F | 10.1021/acs.jmedchem.9b02101 | ||
| 122582993 | 181271 | 0 | None | - | 0 | Human | 9.8 | pEC50 | = | 9.8 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 397 | 4 | 3 | 3 | 2.7 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4762030 | 181271 | 0 | None | - | 0 | Human | 9.8 | pEC50 | = | 9.8 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 397 | 4 | 3 | 3 | 2.7 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL5281870 | 194135 | 0 | None | - | 0 | Human | 9.8 | pEC50 | = | 9.8 | Binding | Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 416 | 8 | 3 | 6 | 3.4 | COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2noc(CCO)n2)cc1 | 10.1016/j.ejmech.2021.113167 | ||
| 118132864 | 179734 | 0 | None | - | 0 | Human | 9.7 | pEC50 | = | 9.7 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 359 | 4 | 3 | 3 | 2.8 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4744094 | 179734 | 0 | None | - | 0 | Human | 9.7 | pEC50 | = | 9.7 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 359 | 4 | 3 | 3 | 2.8 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/acs.jmedchem.9b02101 | ||
| 162659259 | 181233 | 0 | None | - | 0 | Human | 9.7 | pEC50 | = | 9.7 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 439 | 4 | 3 | 3 | 3.1 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4761554 | 181233 | 0 | None | - | 0 | Human | 9.7 | pEC50 | = | 9.7 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 439 | 4 | 3 | 3 | 3.1 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL5270733 | 193649 | 0 | None | - | 0 | Human | 9.7 | pEC50 | = | 9.7 | Binding | Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay |
ChEMBL | 524 | 7 | 3 | 4 | 3.6 | CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1 | 10.1016/j.ejmech.2021.113167 | ||
| 124093849 | 183076 | 0 | None | - | 0 | Human | 9.6 | pEC50 | = | 9.6 | Binding | Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux |
ChEMBL | 330 | 4 | 2 | 3 | 3.1 | COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 | 10.1016/j.ejmech.2021.113167 | ||
| CHEMBL4794375 | 183076 | 0 | None | - | 0 | Human | 9.6 | pEC50 | = | 9.6 | Binding | Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux |
ChEMBL | 330 | 4 | 2 | 3 | 3.1 | COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 | 10.1016/j.ejmech.2021.113167 | ||
| CHEMBL5287715 | 194391 | 0 | None | - | 0 | Human | 9.6 | pEC50 | = | 9.6 | Binding | Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 416 | 8 | 3 | 7 | 2.4 | COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2nnn(CCO)n2)cc1 | 10.1016/j.ejmech.2021.113167 | ||
| CHEMBL5273168 | 193752 | 0 | None | - | 0 | Human | 9.6 | pEC50 | = | 9.6 | Binding | Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 450 | 8 | 4 | 6 | 2.2 | COc1ccc(NC(=O)N[C@@H]2/C(=N/OCCO)NC[C@H]2c2c(F)cc(OC)cc2F)cc1 | 10.1016/j.ejmech.2021.113167 | ||
| CHEMBL5275581 | 193863 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux |
ChEMBL | 398 | 4 | 2 | 5 | 2.3 | COc1ccc([C@@H]2CN3C(=O)CON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 | 10.1016/j.ejmech.2021.113167 | ||
| 122583133 | 181162 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 401 | 4 | 3 | 4 | 3.1 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4760897 | 181162 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 401 | 4 | 3 | 4 | 3.1 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122582929 | 181861 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 382 | 4 | 3 | 5 | 2.1 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4778725 | 181861 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 382 | 4 | 3 | 5 | 2.1 | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122582983 | 180537 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 362 | 4 | 3 | 4 | 1.8 | COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4753713 | 180537 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 362 | 4 | 3 | 4 | 1.8 | COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| 11024 | 688 | 19 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122583088 | 688 | 19 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4784510 | 688 | 19 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122583126 | 179823 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4745044 | 179823 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL5288386 | 194421 | 0 | None | - | 0 | Human | 9.3 | pEC50 | = | 9.3 | Binding | Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay |
ChEMBL | 561 | 5 | 2 | 3 | 6.0 | CP(C)(=O)c1ccccc1-c1ccc(N2CC3(CC3)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F | 10.1016/j.ejmech.2021.113167 | ||
| 11024 | 688 | 19 | None | - | 0 | Mouse | 9.3 | pEC50 | = | 9.3 | Binding | Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 | 10.1021/acs.jmedchem.9b02101 | ||
| 122583088 | 688 | 19 | None | - | 0 | Mouse | 9.3 | pEC50 | = | 9.3 | Binding | Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL4784510 | 688 | 19 | None | - | 0 | Mouse | 9.3 | pEC50 | = | 9.3 | Binding | Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay |
ChEMBL | 361 | 4 | 3 | 3 | 2.4 | COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 | 10.1021/acs.jmedchem.9b02101 | ||
| CHEMBL5274399 | 193815 | 0 | None | - | 0 | Human | 9.3 | pEC50 | = | 9.3 | Binding | Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay |
ChEMBL | 404 | 9 | 4 | 4 | 2.9 | CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)/C(N)=N/OCCO)cc1 | 10.1016/j.ejmech.2021.113167 | ||
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