ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	46780481	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3151	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	216239	23795	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23795	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23795	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	2176	49645	81	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1566249	49645	81	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	72106	78192	60	None	-3	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL2105059	78192	60	None	-3	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	45138674	16646	50	None	-5	6	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16646	50	None	-5	6	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	439280	120019	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	6971044	120019	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL350221	120019	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	432824	78264	13	None	-1	4	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	CHEMBL2106996	78264	13	None	-1	4	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	242	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	123606	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	5994	4641	88	None	-3	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4641	88	None	-3	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	2335	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	3149	12614	15	None	-30	26	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12614	15	None	-30	26	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	56959	31556	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31556	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31556	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	4034	55822	55	None	-8	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55822	55	None	-8	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	71398	106439	44	None	-1548	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106439	44	None	-1548	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	180	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1890	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	3316	31760	71	None	17	4	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31760	71	None	17	4	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	4993	122357	110	None	-5	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122357	110	None	-5	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	441074	19414	82	None	1	11	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19414	82	None	1	11	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	3658	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	191	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	1613	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4640	78266	30	None	1	11	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78266	30	None	1	11	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	3158	56267	27	None	-323	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56267	27	None	-323	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	4011	82408	49	None	-75	26	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82408	49	None	-75	26	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2520	204008	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	204008	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	204008	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	5906	14495	23	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14495	23	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	72093	35061	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35061	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35061	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4746	204891	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204891	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204891	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	1012	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1013	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1057	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	5757	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	CHEMBL135	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	DB00783	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1224	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	202	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	2419	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5077	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	2855	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5029	15545	92	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	CHEMBL1219	15545	92	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	2162	41514	100	None	-6	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41514	100	None	-6	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	47510	172546	39	None	-7	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	CHEMBL448416	172546	39	None	-7	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	22323	15299	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15299	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15299	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2895	203592	41	None	-60	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203592	41	None	-60	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2713	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2543	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	443955	204370	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204370	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	5357	98736	41	None	-117	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL277945	98736	41	None	-117	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	16351	102730	47	None	-208	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102730	47	None	-208	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	57469	18866	125	None	-10	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18866	125	None	-10	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	2286	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2393	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	4046	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	104850	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	1056	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	24776445	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	4227	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	6975	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	CHEMBL473417	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	DB08828	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	3081361	93934	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93934	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	2372	106468	40	None	-537	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106468	40	None	-537	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	71731823	111705	61	None	-11	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	CHEMBL3286830	111705	61	None	-11	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	3074	17958	26	None	-12	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL126075	17958	26	None	-12	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL508338	188966	0	None	-218	15	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	2105	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	11658860	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	124087	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2165	203783	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	203783	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	203783	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3108	207287	116	None	-7	7	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	207287	116	None	-7	7	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	1209	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	260	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2775	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	656665	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL56564	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB11699	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	4497	34404	99	None	-9	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL1428	34404	99	None	-9	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	3823	50221	42	None	-38	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	76973198	50221	42	None	-38	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL157101	50221	42	None	-38	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	10831	116963	25	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL338667	116963	25	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	3488	179136	115	None	-120	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL472	179136	115	None	-120	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	636403	188268	22	None	-6	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188268	22	None	-6	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	31703	194717	63	None	-23	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194717	63	None	-23	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194717	63	None	-23	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	2333	142335	97	None	-1	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	-1	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2169	44847	35	None	-26	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44847	35	None	-26	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	5453	203619	102	None	-36	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203619	102	None	-36	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	19861	207523	50	None	-75	10	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207523	50	None	-75	10	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	137	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2541	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	587	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	6907	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1016	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB00796	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB13919	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	4942	5718	50	None	-19	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5718	50	None	-19	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	10102	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	1824	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	65906	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	CHEMBL94454	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	DB12523	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	41684	31221	105	None	-38	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31221	105	None	-38	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4499	59775	99	None	-8	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL1726	59775	99	None	-8	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	37367	8651	14	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1095282	8651	14	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	11954369	189083	24	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	CHEMBL509924	189083	24	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	5991	203919	72	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL691	203919	72	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	4760	204249	84	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL711	204249	84	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	4452	2762	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	3294	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	214	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	37	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	57469	18866	125	None	-10	6	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18866	125	None	-10	6	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	46220502	112583	84	None	-61	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL3301610	112583	84	None	-61	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	44112	121290	48	None	-478	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121290	48	None	-478	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	2099	9307	55	None	52	5	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1110	9307	55	None	52	5	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	68867	78173	38	None	1	13	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78173	38	None	1	13	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	43815	186920	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186920	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186920	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	60606	61560	73	None	1	8	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61560	73	None	1	8	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	5591	157531	90	None	1	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157531	90	None	1	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	4046	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	108000	56853	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	135418340	56853	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1643895	56853	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	445643	97389	69	None	-2	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97389	69	None	-2	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	5639	98895	75	None	-398	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98895	75	None	-398	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	198	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	82148	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	99	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	CHEMBL10878	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	DB06594	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	2726	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2473	163183	47	None	-2454	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	CHEMBL418134	163183	47	None	-2454	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	168871	89130	14	None	-630	13	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	-630	13	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	3752	27031	82	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	CHEMBL136497	27031	82	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	6010	30698	44	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	CHEMBL1395	30698	44	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	146570	43454	67	None	-6	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1508	43454	67	None	-6	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1400	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	4150	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	2865	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	4940	14470	35	None	-7	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14470	35	None	-7	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	2202	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	3689	102771	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102771	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102771	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	4762	14469	27	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201208	14469	27	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	445643	97389	69	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97389	69	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	53232	188625	95	None	-3548	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL503	188625	95	None	-3548	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	448537	160250	89	None	-28	31	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160250	89	None	-28	31	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	4756	16649	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1201022	16649	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1242	16649	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	27812	66991	43	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1868702	66991	43	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	1153	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	150	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	31101	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	4046	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	10007	14484	38	None	1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201269	14484	38	None	1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	54841	203127	52	None	-14	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL641	203127	52	None	-14	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	1201549	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	68873	43564	64	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43564	64	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	319	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	4209	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL508338	188966	0	None	-218	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	8730	195891	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	90657408	195891	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL559	195891	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	4612	205980	39	None	-3	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	CHEMBL847	205980	39	None	-3	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	102	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	26987	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	21722	17992	31	None	-2	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17992	31	None	-2	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	4450	178228	69	None	-4	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178228	69	None	-4	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	100	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	124	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2995	204405	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204405	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204405	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2220	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	11626560	200937	94	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200937	94	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	213	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2402	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10531	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2274	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3926	207241	40	None	-4	18	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207241	40	None	-4	18	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	25271887	5160	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	5486971	5160	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1059	5160	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	2351	4300	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4300	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4300	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	50922675	112584	54	None	-3	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	CHEMBL3301612	112584	54	None	-3	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	154257	178619	67	None	-6	19	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178619	67	None	-6	19	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	6127	14499	8	None	-177	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14499	8	None	-177	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	5833	30484	74	None	-2	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30484	74	None	-2	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	4413	98073	57	None	-9	15	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98073	57	None	-9	15	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	5467	205928	43	None	-46	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL84158	205928	43	None	-46	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	5732	206935	59	None	-138	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL911	206935	59	None	-138	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	37	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	135	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	168871	89130	14	None	-630	13	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	-630	13	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	242	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	54477	84653	36	None	-33	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	CHEMBL22242	84653	36	None	-33	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	72093	35061	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35061	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35061	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4066	204626	78	None	-194	16	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204626	78	None	-194	16	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2342	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	24826799	10798	104	None	-10	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10798	104	None	-10	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	5411	204033	89	None	-11220	11	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL698	204033	89	None	-11220	11	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	135409453	3773	41	None	-28	35	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	41	None	-28	35	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	41	None	-28	35	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	1481	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	3749	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	589	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	6908	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1513	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	DB01029	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	1343	1889	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	1440	2027	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1909	2027	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	3715	2027	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL6	2027	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB00328	2027	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	60198	14412	83	None	-15	3	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	0	2	4.0	C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)C=CC(=O)C=C12	10.1038/s41467-023-40064-9
	CHEMBL1200374	14412	83	None	-15	3	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	0	2	4.0	C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)C=CC(=O)C=C12	10.1038/s41467-023-40064-9
	5284550	41721	15	None	-190	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41721	15	None	-190	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	240	944	43	None	-79	22	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	2769	944	43	None	-79	22	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	44279790	944	43	None	-79	22	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	660	944	43	None	-79	22	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL1729	944	43	None	-79	22	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL560739	944	43	None	-79	22	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	DB00604	944	43	None	-79	22	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	55645	84370	8	None	-389	11	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84370	8	None	-389	11	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	4993	122357	110	None	-5	5	Human	4.4	pAC50	=	4.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122357	110	None	-5	5	Human	4.4	pAC50	=	4.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	54454	5258	88	None	-1	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5258	88	None	-1	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	4976	203579	29	None	-426	15	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203579	29	None	-426	15	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	134	2514	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2514	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2514	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2514	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2514	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	67462786	120517	56	None	2	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	CHEMBL3545376	120517	56	None	2	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	2337	3256	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	2407	3372	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	1782	2518	84	None	-45	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	241	2518	84	None	-45	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	4168	2518	84	None	-45	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	CHEMBL86	2518	84	None	-45	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	DB01233	2518	84	None	-45	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	2600	3779	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3779	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3779	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3779	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3779	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	392622	56312	95	None	-3	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56312	95	None	-3	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	25382	9157	37	None	-117	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9157	37	None	-117	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	441243	9836	58	None	-288	11	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	CHEMBL114	9836	58	None	-288	11	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	3463	175146	107	None	3	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	250	6	1	2	3.6	Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1	10.1038/s41467-023-40064-9
	CHEMBL457	175146	107	None	3	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	250	6	1	2	3.6	Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1	10.1038/s41467-023-40064-9
	2389	3331	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	17676	7072	29	None	-1023	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7072	29	None	-1023	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7072	29	None	-1023	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	16362	3125	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3125	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3125	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3125	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3125	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	11561674	189611	83	None	-	1	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	460	8	1	7	2.4	CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL514800	189611	83	None	-	1	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	460	8	1	7	2.4	CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC	10.1038/s41467-023-40064-9
	135398737	958	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1222	1664	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1664	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1664	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1664	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1664	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	228	445	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	19675	51670	43	None	-363	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51670	43	None	-363	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	49806720	60080	99	None	1	4	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1738797	60080	99	None	1	4	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	212	3806	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2318	154856	29	None	3	15	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154856	29	None	3	15	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	1427	2013	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2013	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2013	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2013	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2013	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2303	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3187	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	5329102	194726	86	None	-8	37	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194726	86	None	-8	37	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	2470	3653	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3704	78189	41	None	3	5	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	CHEMBL2105022	78189	41	None	3	5	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	2585	803	103	None	-64	33	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	103	None	-64	33	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	103	None	-64	33	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	103	None	-64	33	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	103	None	-64	33	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	31101	729	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	135398745	2914	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2267	559	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3042	1414	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1414	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1414	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1414	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1414	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	4199	98845	42	None	-9	3	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL278819	98845	42	None	-9	3	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	2398	954	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	954	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	954	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	954	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	954	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2284	3182	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3182	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3182	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3182	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3182	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	5803	162227	84	None	-1	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162227	84	None	-1	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	1170	1633	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	3348	1633	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	4819	1633	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	74685737	1633	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL914	1633	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	DB00950	1633	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	2601	3780	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	25102847	78221	93	None	-4	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78221	93	None	-4	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	3949	100614	50	None	-6	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100614	50	None	-6	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	2435	3590	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3590	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3590	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3590	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3590	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	2136	3095	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	2367	964	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	6167	964	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	726	964	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	CHEMBL107	964	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	DB01394	964	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	2247	505	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	3157	1470	71	None	-1318	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	71	None	-1318	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	71	None	-1318	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	71	None	-1318	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	71	None	-1318	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL4743867	214033	14	None	-20	15	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	3062316	33575	121	None	-1	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33575	121	None	-1	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	2583	3776	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	4153	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	129211	3749	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3749	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3749	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3749	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3749	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	16363	596	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	92727	204552	77	None	-1	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	628	15	4	5	4.3	Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL729	204552	77	None	-1	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	628	15	4	5	4.3	Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O	10.1038/s41467-023-40064-9
	11504295	2923	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2782	32000	67	None	-199	8	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL1407943	32000	67	None	-199	8	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL3216363	32000	67	None	-199	8	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	1353	1911	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2771	195017	74	None	-5	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	195017	74	None	-5	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	195017	74	None	-5	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1816	2540	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4485	69379	118	None	-42	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL193	69379	118	None	-42	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	4567	9948	34	None	-41	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9948	34	None	-41	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	179	400	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	2159	400	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	963	400	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	CHEMBL243712	400	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	DB06288	400	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	213046	2385	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	1971	2866	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2448	99323	70	None	-331	15	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99323	70	None	-331	15	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	1830	2590	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2590	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2590	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2590	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2590	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	2477	745	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	36	745	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	437	745	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL49	745	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	DB00490	745	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	5906	14495	23	None	1	4	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14495	23	None	1	4	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	54682461	84686	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84686	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	68617	205527	62	None	-14	30	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205527	62	None	-14	30	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205527	62	None	-14	30	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	20628	96548	28	None	1	13	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96548	28	None	1	13	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	209	3057	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2113	3057	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748	3057	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL567	3057	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00850	3057	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2540	4401	111	None	-1122	28	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4401	111	None	-1122	28	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	1212	1662	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1662	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1662	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1662	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1662	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	71496458	115564	87	None	-2	16	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115564	87	None	-2	16	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	4418	34222	85	None	-3	18	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34222	85	None	-3	18	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	2880	98008	49	None	-8	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL27289	98008	49	None	-8	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	4178	195803	63	None	3	2	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	CHEMBL558	195803	63	None	3	2	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	1234	189221	56	None	9	10	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189221	56	None	9	10	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189221	56	None	9	10	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	6018	11065	96	None	2	3	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	CHEMBL117785	11065	96	None	2	3	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	118422671	2757	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	11980903	14492	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14492	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14492	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14492	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	138106885	166911	75	None	-4	8	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	36314	166911	75	None	-4	8	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	CHEMBL428647	166911	75	None	-4	8	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	5282175	14432	36	None	6	4	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1200661	14432	36	None	6	4	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	1530	2182	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2182	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2182	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2182	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2182	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	5311507	194815	41	None	-10	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194815	41	None	-10	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	216416	111581	48	None	-19	23	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111581	48	None	-19	23	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	65700	78260	28	None	-2	8	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78260	28	None	-2	8	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	2291	3184	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2561	3184	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932	3184	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL631	3184	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB01182	3184	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	5472	205818	75	None	-16	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	205818	75	None	-16	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	205818	75	None	-16	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2780	110529	36	None	-9	11	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110529	36	None	-9	11	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	43815	186920	64	None	-125	20	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186920	64	None	-125	20	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186920	64	None	-125	20	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	5	139	72	None	-2	26	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5202	139	72	None	-2	26	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	CHEMBL39	139	72	None	-2	26	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	DB08839	139	72	None	-2	26	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	72	None	-2	26	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5202	139	72	None	-2	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	CHEMBL39	139	72	None	-2	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	DB08839	139	72	None	-2	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	4376990	193009	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193009	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193009	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4376990	193009	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193009	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193009	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	26	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5202	139	72	None	-2	26	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	CHEMBL39	139	72	None	-2	26	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	DB08839	139	72	None	-2	26	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	5202	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	CHEMBL39	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	DB08839	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	439280	120019	107	None	-25	9	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120019	107	None	-25	9	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120019	107	None	-25	9	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	5	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	72	None	-2	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	439280	120019	107	None	-25	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120019	107	None	-25	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120019	107	None	-25	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	168293874	192179	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192179	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168293874	192179	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192179	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	72	None	-2	26	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	166	3359	18	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	3045227	3359	18	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	CHEMBL76781	3359	18	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	4407909	192866	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192866	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192866	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44315993	172877	0	None	2	3	Human	8.0	pEC50	=	8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172877	0	None	2	3	Human	8.0	pEC50	=	8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	4407909	192866	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192866	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192866	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	16115269	138129	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	138129	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9881885	64109	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180815	64109	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63938	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL180668	63938	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	10465263	64332	63	None	-89	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL181172	64332	63	None	-89	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11938	2412	7	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2412	7	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2412	7	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	59312249	111672	0	None	-8	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286565	111672	0	None	-8	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	122442324	138350	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11658860	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	2941	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	4374	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360328	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	DB04871	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	10379910	63301	0	None	-6	2	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179329	63301	0	None	-6	2	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63938	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180668	63938	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	122442324	138350	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11493484	89070	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	89070	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	89070	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	46230097	199366	0	None	-6	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	199366	0	None	-6	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	122442251	138360	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	4312735	192874	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192874	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192874	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4312735	192874	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192874	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192874	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	122442251	138360	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573155	189159	0	None	6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL511044	189159	0	None	6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	168282202	192884	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192884	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192884	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168282202	192884	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192884	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192884	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	44412404	77768	6	None	2	3	Human	7.0	pEC50	=	7.0	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209106	77768	6	None	2	3	Human	7.0	pEC50	=	7.0	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	70693928	74485	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2022192	74485	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2028036	74485	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	162652937	183662	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183662	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183662	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-2	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	5202	139	72	None	-2	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	CHEMBL39	139	72	None	-2	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	DB08839	139	72	None	-2	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	168	3982	15	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3982	15	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3982	15	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	157	2069	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	9840090	2069	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	CHEMBL134519	2069	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	157	2069	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	9840090	2069	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	CHEMBL134519	2069	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	10465263	64332	63	None	-89	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181172	64332	63	None	-89	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	162652937	183662	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183662	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183662	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265627	164013	0	None	-602	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	CHEMBL4208452	164013	0	None	-602	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	53324327	56850	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643857	56850	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	44572176	12560	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL1186735	12560	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL475641	12560	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	44572207	12702	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL1187556	12702	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL508680	12702	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	11492162	72053	3	None	-11	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197646	72053	3	None	-11	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	53317924	56851	0	None	-6	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643858	56851	0	None	-6	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	44572180	12562	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL1186737	12562	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL475643	12562	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	11151653	91101	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	91101	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	54587668	61459	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770378	61459	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	1355	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	142	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	CHEMBL478	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	DB12110	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	44573156	187297	0	None	-2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492949	187297	0	None	-2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1355	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	142	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL478	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	DB12110	2011	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	168285159	192914	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192914	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192914	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	23652278	62631	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL178365	62631	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11608308	64309	4	None	-407	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL181076	64309	4	None	-407	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	162658803	183692	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183692	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183692	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168285159	192914	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192914	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192914	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162658803	183692	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183692	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183692	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265732	163807	0	None	-1000	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4206126	163807	0	None	-1000	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	134265665	164799	0	None	-1047	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4218374	164799	0	None	-1047	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44572751	12499	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12499	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12499	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	53321948	56804	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643677	56804	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	189	3492	39	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	5163	3492	39	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	CHEMBL297784	3492	39	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	44431699	88289	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234837	88289	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	10015414	63485	0	None	-32	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179915	63485	0	None	-32	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	16115271	79108	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	79108	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	44572168	12484	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL1186458	12484	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL464475	12484	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	10036629	64637	0	None	-9	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL181787	64637	0	None	-9	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	23652278	62631	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178365	62631	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	25084025	12701	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL1187522	12701	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL506727	12701	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	45484687	198464	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577410	198464	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	53323196	56849	0	None	-23	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643856	56849	0	None	-23	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	118736623	118996	7	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425755	118996	7	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118733808	120656	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416056	120656	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546908	120656	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	44573231	187294	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492911	187294	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	216	2860	32	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	9815618	2860	32	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	CHEMBL253811	2860	32	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	162653458	183666	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183666	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183666	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	10331841	169204	6	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL440752	169204	6	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	44412389	78096	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210215	78096	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	162653458	183666	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183666	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183666	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11447552	62528	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178231	62528	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	54585653	61465	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770385	61465	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11427139	84687	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84687	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53325937	56805	0	None	-53	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643678	56805	0	None	-53	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	25070581	61461	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770380	61461	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	134265616	164411	0	None	-1548	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4213447	164411	0	None	-1548	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	122442286	138351	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733798	120649	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416051	120649	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546894	120649	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44573220	187451	0	None	4	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493951	187451	0	None	4	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	162658689	183690	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183690	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183690	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	138348	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572371	12527	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL1186608	12527	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL472678	12527	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	162658689	183690	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183690	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183690	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	138348	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115652	83491	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83491	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	54580776	61462	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770381	61462	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	118736624	118997	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425756	118997	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573229	172676	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	CHEMBL449999	172676	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	42601405	192654	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL521805	192654	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	11221167	84680	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84680	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	162657053	183681	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183681	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183681	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	10401602	123069	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360968	123069	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	11447552	62528	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178231	62528	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	25070907	61457	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770376	61457	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	44572369	12458	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186108	12458	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL450178	12458	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	46228438	199985	0	None	-1862	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595195	199985	0	None	-1862	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	45485742	197823	0	None	-18	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572228	197823	0	None	-18	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	44412405	77781	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209155	77781	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	11777150	62605	0	None	-63	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178313	62605	0	None	-63	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	11414184	83498	0	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83498	0	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	122442324	138350	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442324	138350	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573216	187338	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493151	187338	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572759	12462	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186135	12462	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL451368	12462	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	24773650	154697	2	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	CHEMBL399750	154697	2	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	118733818	120665	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416061	120665	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546956	120665	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168294162	193011	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	193011	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	193011	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10331841	169204	6	None	-158	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	CHEMBL440752	169204	6	None	-158	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	168294162	193011	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	193011	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	193011	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	135453290	133606	33	None	1	7	Rat	8.7	pEC50	=	8.7	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133606	33	None	1	7	Rat	8.7	pEC50	=	8.7	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	166	3359	18	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	3045227	3359	18	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	CHEMBL76781	3359	18	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	36906	104880	75	None	1	3	Rat	8.6	pEC50	=	8.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	CHEMBL31115	104880	75	None	1	3	Rat	8.6	pEC50	=	8.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	44572367	12543	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL1186673	12543	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL474230	12543	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	168291130	192976	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192976	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192976	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168291130	192976	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192976	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192976	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	11290492	138001	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL376456	138001	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	11499800	89107	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	89107	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	89107	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	122442254	138345	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442254	138345	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572810	12655	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12655	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12655	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	150	2509	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	1764	2509	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	8226	2509	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	CHEMBL1201356	2509	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	DB00353	2509	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	134265663	163679	0	None	-19	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4204710	163679	0	None	-19	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	53317923	56846	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643853	56846	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	53325936	56802	0	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643675	56802	0	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	122442293	138342	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	122442293	138342	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	11658860	2344	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2344	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2344	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2344	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2344	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	16115381	83443	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83443	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	44572166	12460	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12460	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12460	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	118736626	118998	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425758	118998	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	18735305	204933	0	None	2	3	Human	7.7	pEC50	=	7.7	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	204933	0	None	2	3	Human	7.7	pEC50	=	7.7	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	54583742	61456	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770375	61456	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	44389645	64181	0	None	-72	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180867	64181	0	None	-72	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733790	120671	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416047	120671	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546973	120671	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44572753	12703	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187565	12703	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL509418	12703	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	53321947	56798	0	None	-2	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643671	56798	0	None	-2	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	44431701	88144	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234682	88144	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	44409290	74651	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203013	74651	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	10017556	161878	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL415029	161878	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733760	120638	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416032	120638	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546869	120638	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11630623	89099	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	89099	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	89099	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	58911653	91116	0	None	-25	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397911	91116	0	None	-25	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	168291896	192985	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192985	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192985	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	145	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	1832	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	CHEMBL7257	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	DB14010	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	25070911	111671	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	CHEMBL3286564	111671	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	168291564	192983	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192983	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192983	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	168291896	192985	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192985	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192985	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442250	138344	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	5	139	72	None	-2	26	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	5202	139	72	None	-2	26	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	CHEMBL39	139	72	None	-2	26	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	DB08839	139	72	None	-2	26	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	168291564	192983	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192983	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192983	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442250	138344	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773816	94856	0	None	-31	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253805	94856	0	None	-31	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773814	94859	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253809	94859	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11264345	130399	5	None	-120	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL368016	130399	5	None	-120	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	122442300	138349	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	122442300	138349	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	146025684	183635	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183663	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183663	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183663	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025684	183635	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183663	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183663	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183663	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	45484673	198958	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL585012	198958	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11595191	89060	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	89060	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	89060	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	162658153	183685	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183685	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183685	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183685	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183685	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183685	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	118736627	118999	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425759	118999	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118736631	119002	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425763	119002	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	122442270	138346	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442270	138346	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11952353	199860	0	None	-1905	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	199860	0	None	-1905	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	11171955	91093	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397888	91093	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	44573002	12686	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL1187408	12686	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL501854	12686	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	16115511	84837	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84837	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	162643473	183615	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183615	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183615	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162643473	183615	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183615	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183615	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11300712	141686	0	None	-2	3	Human	7.6	pEC50	=	7.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141686	0	None	-2	3	Human	7.6	pEC50	=	7.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44573018	12644	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL1187169	12644	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL492306	12644	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	24826869	91102	0	None	-7	3	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	91102	0	None	-7	3	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	16115654	136974	0	None	-46	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	136974	0	None	-46	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53324629	56799	0	None	-4	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643672	56799	0	None	-4	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	1355	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	1355	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	2011	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	46937339	74209	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2023357	74209	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	46937339	74209	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL2023357	74209	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	16115392	84797	0	None	-5	2	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223292	84797	0	None	-5	2	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	16115388	137366	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	137366	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	11209786	137240	0	None	-208	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	137240	0	None	-208	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	9859257	205123	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	205123	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	168268877	189970	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189970	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168268877	189970	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189970	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	230	4119	25	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	3045225	4119	25	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	CHEMBL407909	4119	25	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	5	139	72	None	-7	26	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	5202	139	72	None	-7	26	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	CHEMBL39	139	72	None	-7	26	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	DB08839	139	72	None	-7	26	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	44572798	12650	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL1187187	12650	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL492926	12650	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	46933845	16162	0	None	-18	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16162	0	None	-18	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	54583743	61463	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770382	61463	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	118736630	119001	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425762	119001	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	122442263	138357	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44389646	64883	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL182184	64883	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	122442263	138357	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442260	138354	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11949712	202161	0	None	-3019	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL609306	202161	0	None	-3019	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	118733764	120645	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416034	120645	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546890	120645	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	118733776	120651	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416040	120651	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546903	120651	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	70687695	74478	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022186	74478	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027987	74478	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	134265675	164367	0	None	-40	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4212834	164367	0	None	-40	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162645074	183624	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183624	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183624	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162645074	183624	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183624	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183624	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11400855	12454	7	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186092	12454	7	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL449134	12454	7	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	57799306	89109	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	89109	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	89109	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	122442260	138354	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44315697	205505	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	205505	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	168268736	192789	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192789	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192789	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	9990808	122772	0	None	-51	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	CHEMBL360492	122772	0	None	-51	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	168268736	192789	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192789	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192789	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	11652452	89126	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	89126	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	89126	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	44572749	12437	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL1185954	12437	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL443128	12437	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	44412150	77733	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL208936	77733	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	11658860	2344	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	122442250	138344	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115644	136960	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	136960	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	118736628	119000	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425760	119000	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573230	187293	0	None	-3	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492910	187293	0	None	-3	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	3356430	193046	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193046	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193046	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	70683433	74458	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022185	74458	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027895	74458	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	122442250	138344	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138343	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138343	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573016	12670	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL1187322	12670	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL498863	12670	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	168272608	192793	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192793	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192793	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162657053	183681	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183681	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183681	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168272608	192793	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192793	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192793	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	3356430	193046	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193046	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193046	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44573222	174312	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL455039	174312	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	118733766	120639	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416035	120639	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546870	120639	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	146025686	183759	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183759	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183759	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	146025686	183759	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183759	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183759	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	44572757	12649	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL1187186	12649	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL492917	12649	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	45484742	198518	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	CHEMBL577903	198518	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	122442286	138351	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	138351	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573221	193080	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL522514	193080	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	44622848	193347	0	None	-11	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL524778	193347	0	None	-11	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	9881119	205473	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	205473	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	9990808	122772	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL360492	122772	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	44573012	12643	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL1187168	12643	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL492305	12643	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	11206703	91092	0	None	-12	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	91092	0	None	-12	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	44572657	12467	6	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186169	12467	6	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL452719	12467	6	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	44573004	12520	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL1186590	12520	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL471202	12520	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	53325938	56806	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643679	56806	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	10105208	62499	0	None	-83	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178124	62499	0	None	-83	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	1355	2011	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	142	2011	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	CHEMBL478	2011	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	DB12110	2011	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	24773649	94827	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253591	94827	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773651	154857	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	CHEMBL400600	154857	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	46228437	199984	1	None	-39	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595194	199984	1	None	-39	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	24773895	94857	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL253806	94857	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	122442270	138346	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773979	130169	21	None	-12	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	CHEMBL367796	130169	21	None	-12	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	11264955	204961	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	204961	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	152	364	29	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	2107	364	29	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	CHEMBL275854	364	29	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	11708275	72712	3	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	CHEMBL199775	72712	3	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	166	3359	18	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3359	18	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3359	18	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	5	139	72	None	-2	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	5202	139	72	None	-2	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	CHEMBL39	139	72	None	-2	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	DB08839	139	72	None	-2	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	16047544	12648	8	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12648	8	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12648	8	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	44572172	12546	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL1186686	12546	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL474633	12546	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	16115267	84793	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84793	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9994008	166149	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL426235	166149	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	122442270	138346	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	22368315	63766	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180166	63766	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	134265618	164055	0	None	-323	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4209052	164055	0	None	-323	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	46884138	8443	0	None	-812	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093699	8443	0	None	-812	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	44572812	12514	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL1186561	12514	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL469729	12514	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	54587669	61460	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770379	61460	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11609026	89127	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	89127	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	89127	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	44573014	12521	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL1186595	12521	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL471802	12521	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	3568128	192933	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192933	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192933	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	3568128	192933	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192933	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192933	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	44420682	137608	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137608	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	118733802	120653	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416053	120653	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546905	120653	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168284548	192911	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	192911	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	192911	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	168284548	192911	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	192911	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	192911	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	118733788	120664	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416046	120664	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546955	120664	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11658860	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183717	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183717	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183717	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11658860	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183717	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183717	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183717	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733792	120672	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416048	120672	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546974	120672	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	162659286	183695	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183695	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183695	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	122442266	138343	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138343	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162659286	183695	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183695	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183695	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	146025687	183715	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	118733804	120654	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416054	120654	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546906	120654	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	162668367	183739	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183739	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183739	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442309	138347	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138347	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138347	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	168294156	193005	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193005	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193005	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	162668367	183739	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183739	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183739	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	168294156	193005	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193005	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193005	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442254	138345	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442309	138347	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138347	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138347	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572164	12683	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL1187390	12683	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL501526	12683	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	146025687	183715	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	46230099	199312	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	199312	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	118733794	120673	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416049	120673	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546975	120673	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	122442254	138345	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	138351	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	45484682	198371	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL576651	198371	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11658860	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	44573153	187197	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492348	187197	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44573157	187298	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492950	187298	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	134265622	164753	0	None	-81	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4217787	164753	0	None	-81	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44412388	78185	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210484	78185	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	145966293	164454	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4213971	164454	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	18735309	205433	0	None	2	3	Human	7.3	pEC50	=	7.3	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	205433	0	None	2	3	Human	7.3	pEC50	=	7.3	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	118733814	120658	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416059	120658	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546910	120658	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	44572761	12680	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL1187377	12680	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL501117	12680	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	11302765	84248	4	None	-309	3	Human	5.3	pEC50	=	5.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	84248	4	None	-309	3	Human	5.3	pEC50	=	5.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11448649	83433	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83433	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	50878551	90745	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90745	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	50878551	90745	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90745	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	44572808	12706	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL1187585	12706	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL510383	12706	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	44431688	152740	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL397321	152740	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	5	139	72	None	-2	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	5202	139	72	None	-2	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	CHEMBL39	139	72	None	-2	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	DB08839	139	72	None	-2	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	135509961	136132	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	CHEMBL373245	136132	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	9991444	62632	1	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL178366	62632	1	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	154699445	177426	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	177426	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	11737032	85016	0	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	85016	0	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	162674022	183221	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	183221	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	22292784	64594	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	CHEMBL181672	64594	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	24773809	94882	0	None	-63	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254009	94882	0	None	-63	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	122442300	138349	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	24773900	123432	8	None	-6	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	CHEMBL361742	123432	8	None	-6	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	118733778	120660	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416041	120660	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546951	120660	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	50942111	56847	0	None	-5	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643854	56847	0	None	-5	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	45485725	197827	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572252	197827	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	122442300	138349	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572698	12552	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL1186700	12552	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL474885	12552	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	162652562	183657	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183657	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183657	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	11658860	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	11666237	89112	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	89112	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	89112	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	162652562	183657	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183657	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183657	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	44572755	12459	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186115	12459	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL450599	12459	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	22292784	64594	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181672	64594	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	118733780	120640	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416042	120640	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546871	120640	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	3572096	192898	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192898	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192898	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	3572096	192898	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192898	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192898	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	162670523	183750	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183750	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183750	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025688	183694	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	146025688	183694	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	11313985	91083	0	None	-18	3	Human	7.3	pEC50	=	7.3	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	91083	0	None	-18	3	Human	7.3	pEC50	=	7.3	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	11949710	199902	0	None	-50	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	199902	0	None	-50	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	118733772	120648	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416038	120648	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546893	120648	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11737939	84227	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL220900	84227	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	11291	3220	26	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	4980	3220	26	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	CHEMBL65547	3220	26	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	162670523	183750	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183750	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183750	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	168283046	192892	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192892	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192892	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162676809	183792	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183792	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183792	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	192934	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192934	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192934	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	162676809	183792	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183792	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183792	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	192934	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192934	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192934	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	44431689	87249	0	None	-13	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL232995	87249	0	None	-13	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	44572800	12653	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL1187194	12653	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL493128	12653	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	168283046	192892	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192892	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192892	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	44412403	77798	0	None	7	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209254	77798	0	None	7	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	135399866	72055	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	CHEMBL197653	72055	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	44431705	145126	0	None	6	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL391196	145126	0	None	6	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	18735313	204934	1	None	6	3	Human	8.2	pEC50	=	8.2	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	204934	1	None	6	3	Human	8.2	pEC50	=	8.2	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	162650400	183649	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183649	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183649	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	54581791	61464	0	None	3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770383	61464	0	None	3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	162650400	183649	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183649	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183649	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	53324165	56801	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643674	56801	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	122442263	138357	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442263	138357	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733800	120652	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416052	120652	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546904	120652	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	46230098	199329	0	None	-30	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	199329	0	None	-30	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	134265705	164091	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4209572	164091	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	54584721	61458	0	None	-1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770377	61458	0	None	-1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	118733812	120642	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416058	120642	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546873	120642	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	24849050	78300	2	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210802	78300	2	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	10036629	64637	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	CHEMBL181787	64637	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	24773728	94860	0	None	-31	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253810	94860	0	None	-31	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	118733806	120655	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416055	120655	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546907	120655	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	10064386	63317	4	None	-32	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179378	63317	4	None	-32	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44572802	12444	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12444	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12444	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	11983273	77996	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209714	77996	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	118733796	120641	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416050	120641	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546872	120641	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	44572747	12705	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL1187580	12705	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL510308	12705	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	44573217	187339	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493152	187339	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572174	12547	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186687	12547	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL474634	12547	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	44316017	205452	0	None	4	3	Human	8.1	pEC50	=	8.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	205452	0	None	4	3	Human	8.1	pEC50	=	8.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	11644842	89097	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337105	89097	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365394	89097	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	53321865	56848	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643855	56848	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	122442273	138356	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44316027	205522	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	205522	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	162644827	183623	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183623	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183623	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162660358	183704	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183704	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183704	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442273	138356	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162644827	183623	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183623	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183623	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	53317925	56852	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643859	56852	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	162660358	183704	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183704	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183704	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	118733816	120659	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416060	120659	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546911	120659	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	10624	70300	19	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	138543650	70300	19	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194378	70300	19	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	46228422	200036	0	None	-33	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595553	200036	0	None	-33	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44572806	12654	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1187195	12654	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL493129	12654	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	44573218	193057	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL522349	193057	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1534	103040	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103040	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103040	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	1534	103040	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103040	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103040	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	162659049	183693	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183693	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183693	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265620	164406	0	None	-6456	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4213379	164406	0	None	-6456	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162659049	183693	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183693	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183693	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	44572804	12623	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL1187088	12623	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL490064	12623	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	162669436	183745	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183745	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183745	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265590	164758	0	None	-2	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4217846	164758	0	None	-2	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	9991444	62632	1	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178366	62632	1	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	24773900	123432	8	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL361742	123432	8	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	162669436	183745	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183745	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183745	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11658860	2344	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	2941	2344	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	4374	2344	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL360328	2344	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	DB04871	2344	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	10105208	62499	0	None	-83	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL178124	62499	0	None	-83	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	11160564	63304	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	CHEMBL179337	63304	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	23395431	94913	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254215	94913	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	16115517	84838	0	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84838	0	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44572178	12561	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL1186736	12561	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL475642	12561	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	135520431	72609	9	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL199385	72609	9	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	135414348	72809	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL200104	72809	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	44573154	187198	0	None	-17	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492349	187198	0	None	-17	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	45484662	198491	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577691	198491	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11231392	84894	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84894	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	71682217	91118	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397913	91118	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44572170	12465	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL1186164	12465	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL452458	12465	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	118733810	120657	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416057	120657	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546909	120657	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	162657367	183682	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183682	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183682	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	45484700	197303	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL568692	197303	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11160564	63304	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179337	63304	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	53320653	56800	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643673	56800	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	135399666	168763	7	None	1	6	Rat	7.1	pEC50	=	7.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168763	7	None	1	6	Rat	7.1	pEC50	=	7.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	12370465	12674	18	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL1187354	12674	18	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL500093	12674	18	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	162657367	183682	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183682	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183682	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733762	120644	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416033	120644	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546889	120644	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	11437171	83490	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83490	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	168286640	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168294430	193007	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193007	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193007	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168294430	193007	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193007	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193007	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	24826868	91082	1	None	1	3	Human	8.1	pEC50	=	8.1	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	91082	1	None	1	3	Human	8.1	pEC50	=	8.1	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	11695000	89071	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89071	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89071	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	122461343	138362	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138362	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138362	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	7153	98020	77	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	CHEMBL272942	98020	77	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	154699445	177426	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	177426	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	122461343	138362	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138362	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138362	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11514226	89110	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	89110	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	89110	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	45484661	198881	0	None	-2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL584210	198881	0	None	-2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	53325935	56797	0	None	-17	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643670	56797	0	None	-17	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	53324630	56803	0	None	-18	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643676	56803	0	None	-18	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	11658860	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	2941	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	4374	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL360328	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	DB04871	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	11658860	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2344	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	122442275	138361	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	122442275	138361	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	168288743	192947	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192947	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192947	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	4543677	192790	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192790	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192790	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	4543677	192790	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192790	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192790	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168288743	192947	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192947	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192947	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	118733774	120650	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416039	120650	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546902	120650	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	46228430	199738	0	None	-8	3	Human	6.0	pEC50	=	6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL593545	199738	0	None	-8	3	Human	6.0	pEC50	=	6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44138039	179289	10	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	179289	10	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565847	180569	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	180569	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565831	180436	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	180436	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565608	179268	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	179268	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	188	3391	80	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3391	80	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3391	80	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	44565850	179733	0	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179733	0	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	4366334	80409	8	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214554	80409	8	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565638	189629	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189629	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3743171	80134	13	None	-	1	Human	7.0	pIC50	=	7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213329	80134	13	None	-	1	Human	7.0	pIC50	=	7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	145976085	163665	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204576	163665	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	145972374	164674	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4216860	164674	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	44565828	179198	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	179198	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	127035063	136486	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	CHEMBL3736149	136486	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	127037093	136508	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736252	136508	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	118464427	138334	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	138334	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	752565	138289	8	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770770	138289	8	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	44565849	179295	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473235	179295	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565805	189634	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189634	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416247	141458	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384255	141458	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44156863	8078	0	None	-21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091206	8078	0	None	-21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	44565827	179197	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472415	179197	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565636	179267	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472986	179267	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	171120	8	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	171120	8	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565606	179240	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	179240	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565806	180108	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	180108	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168295984	192220	0	None	-8	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5204813	192220	0	None	-8	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	127034715	136394	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735261	136394	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035064	136471	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735911	136471	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	127034730	136439	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735643	136439	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	46830134	8217	0	None	-37	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1092241	8217	0	None	-37	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	3781561	138598	6	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL377562	138598	6	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	10449757	3495	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3495	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3495	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	71528206	86971	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323581	86971	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	3830738	141646	7	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL385346	141646	7	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565831	180436	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	180436	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	145988313	167235	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	167235	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	4203621	138988	14	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL378541	138988	14	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	3898525	139579	8	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL379734	139579	8	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565635	179266	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	179266	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565641	179318	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	CHEMBL473391	179318	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	44565829	179218	2	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472589	179218	2	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	53327611	69754	0	None	-154	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	CHEMBL1935601	69754	0	None	-154	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	44416290	141384	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL383860	141384	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	44565824	179293	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	179293	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44155109	8174	4	None	-21	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091919	8174	4	None	-21	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	732268	138296	33	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770837	138296	33	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	44565635	179266	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	179266	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3716424	81050	6	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215380	81050	6	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3826158	79927	12	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212506	79927	12	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	118464428	138261	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770512	138261	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	145988313	167235	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	167235	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	136020618	163914	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4207302	163914	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	3736302	138918	7	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL378357	138918	7	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	188	3391	80	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3391	80	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3391	80	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	145979048	166658	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL4281546	166658	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	44565846	180568	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	180568	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	171120	8	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	171120	8	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565830	179722	2	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179722	2	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189693	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189693	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416309	141441	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384160	141441	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	145993660	167369	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4294723	167369	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	44565637	179290	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473187	179290	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	71528204	86969	0	None	-15	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323579	86969	0	None	-15	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	118464429	167117	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4290245	167117	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	26694436	162912	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4173963	162912	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	44565807	180110	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474840	180110	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416259	138203	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL376978	138203	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3649661	138219	7	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	138219	7	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	11502243	189506	48	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	189506	48	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11949710	199902	0	None	-50	3	Human	7.6	pIC50	=	7.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	199902	0	None	-50	3	Human	7.6	pIC50	=	7.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	5093797	81073	7	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215461	81073	7	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	895660	32393	8	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL1411080	32393	8	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	118464425	138309	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	138309	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5113614	80061	7	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213005	80061	7	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565808	180911	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	180911	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11502243	189506	48	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	189506	48	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11957541	1459	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	1229	1459	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	147	1459	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	170617	1459	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	CHEMBL6616	1459	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	3723094	79964	10	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212656	79964	10	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565608	179268	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	179268	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565846	180568	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	180568	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168284710	191593	0	None	-18	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5195241	191593	0	None	-18	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	136020617	57323	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL1651095	57323	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	44565805	189634	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189634	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416260	79991	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212755	79991	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565847	180569	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	180569	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565808	180911	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	180911	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11248240	2664	4	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	5601	2664	4	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	CHEMBL175543	2664	4	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	752521	198737	8	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	198737	8	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	118464420	138245	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	138245	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	44565634	179241	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472791	179241	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565850	179733	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179733	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	118464420	138245	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770342	138245	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	118464426	138246	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770351	138246	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	3751272	80596	13	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215024	80596	13	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	71528205	86970	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323580	86970	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	145963830	164123	0	None	3	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4209942	164123	0	None	3	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	127035065	136500	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	CHEMBL3736207	136500	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	44565606	179240	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	179240	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	73389570	162002	38	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	CHEMBL4159471	162002	38	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	2884131	166908	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286420	166908	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	44155107	8079	4	None	-60	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091207	8079	4	None	-60	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	4297073	81301	7	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215883	81301	7	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	46933845	16162	0	None	-18	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16162	0	None	-18	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	135753059	190718	5	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5182403	190718	5	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	135753074	191108	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5187824	191108	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	135753056	191175	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5188949	191175	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	156208582	192033	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	CHEMBL5202029	192033	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	3765560	141545	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384745	141545	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4518239	81057	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215404	81057	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	879244	28199	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL1373650	28199	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	4322819	80423	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL214594	80423	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	118464421	167292	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4293638	167292	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	44247568	82174	55	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	CHEMBL2170062	82174	55	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	44565806	180108	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	180108	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	2267399	138341	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771373	138341	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	136928971	138229	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770185	138229	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5128094	79857	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212228	79857	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	5167627	80062	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213006	80062	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44416351	80135	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	CHEMBL213332	80135	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	3802375	80317	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214184	80317	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4657811	80519	8	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214802	80519	8	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	5165122	81051	20	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215386	81051	20	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	3757038	81473	11	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215991	81473	11	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	3773677	138985	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	CHEMBL378540	138985	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	3410378	141462	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384270	141462	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	4679720	165977	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	CHEMBL425260	165977	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	4148445	138301	9	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770873	138301	9	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	3391669	141841	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL386459	141841	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	44565607	189565	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	189565	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	179294	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	179294	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565826	179196	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472414	179196	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44476436	82347	6	None	-7413	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	CHEMBL2172186	82347	6	None	-7413	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	162674022	183221	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	183221	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	127037059	136537	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736516	136537	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	10449757	3495	35	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3495	35	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3495	35	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	44565639	179317	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	179317	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	44565640	189505	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL513993	189505	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44138039	179289	10	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	179289	10	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189693	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189693	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565639	179317	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	179317	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	145989393	167223	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4292168	167223	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	3473601	140129	6	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL380167	140129	6	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44565830	179722	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179722	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	57495353	125040	38	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	CHEMBL3643413	125040	38	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	3400827	79913	11	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212457	79913	11	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	127035062	136451	0	None	6	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	136451	0	None	6	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035066	136421	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735434	136421	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	44565828	179198	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	179198	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	145964159	164329	0	None	8	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	164329	0	None	8	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44565638	189629	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189629	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3499360	141520	7	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384579	141520	7	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	104697662	145405	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	CHEMBL3914002	145405	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	11536299	183286	8	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	CHEMBL479683	183286	8	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	109052212	162547	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4168125	162547	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	44565607	189565	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	189565	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3442850	169561	20	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL443570	169561	20	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	4895014	80000	7	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212780	80000	7	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565824	179293	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	179293	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	179294	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	179294	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	12611598	60437	6	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60437	6	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	221	3491	71	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	3277600	3491	71	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	CHEMBL323356	3491	71	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	44385952	62208	5	None	-	0	Rat	7.9	pKd	=	7.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	CHEMBL177800	62208	5	None	-	0	Rat	7.9	pKd	=	7.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	135398737	958	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	38	958	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	722	958	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	CHEMBL42	958	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	DB00363	958	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	10022745	119969	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	CHEMBL349832	119969	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	44327167	9378	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL111393	9378	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL544319	9378	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	12611606	60378	9	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	CHEMBL174723	60378	9	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	12611609	60436	6	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	CHEMBL175204	60436	6	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	12611617	60355	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174563	60355	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	12611598	60437	6	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60437	6	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	10356829	59691	0	None	-	0	Rat	7.8	pKd	=	7.8	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	CHEMBL172269	59691	0	None	-	0	Rat	7.8	pKd	=	7.8	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	10693836	9337	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL111189	9337	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL545488	9337	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10715378	15518	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	CHEMBL121744	15518	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	9979654	207919	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL96781	207919	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611613	60460	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	CHEMBL175328	60460	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	10473483	8650	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL109528	8650	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL544318	8650	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	135398737	958	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	38	958	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	722	958	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	CHEMBL42	958	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	DB00363	958	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	10710246	121127	0	None	-	0	Rat	5.7	pKd	=	5.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL357517	121127	0	None	-	0	Rat	5.7	pKd	=	5.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34687	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143022	34687	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34687	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143022	34687	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	11760018	53365	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL160019	53365	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	44326982	8659	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL109548	8659	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL545727	8659	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	10090486	53272	0	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL159929	53272	0	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	10090424	34697	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143027	34697	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	10090424	34697	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143027	34697	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm011014y
	12611604	60447	4	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)c(O)c1	10.1021/jm00183a006
	CHEMBL175272	60447	4	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)c(O)c1	10.1021/jm00183a006
	10645469	110557	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL325253	110557	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL542428	110557	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611615	60335	1	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174449	60335	1	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	12611617	60355	3	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174563	60355	3	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	10024430	207613	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL95098	207613	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611613	60460	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	CHEMBL175328	60460	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	44327153	109210	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	CHEMBL321682	109210	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	CHEMBL558817	109210	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	10804995	35581	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143937	35581	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm0009890
	10804995	35581	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143937	35581	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm011014y
	197139	25072	26	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	CHEMBL1347	25072	26	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	12611606	60378	9	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	CHEMBL174723	60378	9	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	12611596	60304	6	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	CHEMBL174380	60304	6	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	12611615	60335	1	None	-	0	Rat	5.4	pKd	=	5.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174449	60335	1	None	-	0	Rat	5.4	pKd	=	5.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	9951008	206397	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87717	206397	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm011014y
	126769	206042	42	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	CHEMBL536255	206042	42	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	CHEMBL85194	206042	42	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	9930475	206290	0	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87026	206290	0	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm011014y
	10597019	34267	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	CHEMBL142668	34267	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	10597019	34267	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL142668	34267	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10249506	8805	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL109673	8805	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL544091	8805	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	11141324	53093	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	307	3	0	4	2.6	O=C1CC(CN2CCN(c3ccccn3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL159771	53093	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	307	3	0	4	2.6	O=C1CC(CN2CCN(c3ccccn3)CC2)c2ccccc21	10.1021/jm011014y
	9866660	114422	2	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	417	3	1	4	5.1	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	CHEMBL333174	114422	2	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	417	3	1	4	5.1	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	10061837	120740	0	None	-	0	Rat	7.3	pKd	=	7.3	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	273	2	2	4	3.8	Cc1cc(NC(=O)Nc2ccc3sccc3c2)on1	10.1021/jm00006a001
	CHEMBL354951	120740	0	None	-	0	Rat	7.3	pKd	=	7.3	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	273	2	2	4	3.8	Cc1cc(NC(=O)Nc2ccc3sccc3c2)on1	10.1021/jm00006a001
	10022781	57054	0	None	-	0	Rat	6.3	pKd	=	6.3	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	382	4	0	5	4.6	O=C1c2ccoc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL164471	57054	0	None	-	0	Rat	6.3	pKd	=	6.3	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	382	4	0	5	4.6	O=C1c2ccoc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	44326751	108615	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL320572	108615	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL539544	108615	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	10693017	33837	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	CHEMBL142316	33837	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	10367486	9294	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL110948	9294	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL543613	9294	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	10693017	33837	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL142316	33837	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10069784	14983	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	404	4	1	3	4.6	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	CHEMBL120903	14983	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	404	4	1	3	4.6	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	15021876	103410	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm011014y
	CHEMBL308480	103410	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm011014y
	10809188	9275	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL110847	9275	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL540822	9275	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	10497359	121737	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm0009890
	CHEMBL358895	121737	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm0009890
	10497359	121737	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm011014y
	CHEMBL358895	121737	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm011014y
	197139	25072	26	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	CHEMBL1347	25072	26	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	11023903	52755	0	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	327	3	0	5	2.7	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL159466	52755	0	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	327	3	0	5	2.7	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2sccc21	10.1021/jm011014y
	10015954	165239	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	270	2	2	4	3.1	Cc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)on1	10.1021/jm00006a001
	CHEMBL422923	165239	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	270	2	2	4	3.1	Cc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)on1	10.1021/jm00006a001
	9886130	206430	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87943	206430	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	10622347	54404	0	None	-	0	Rat	5.1	pKd	=	5.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	426	8	0	4	4.0	O=C(CCCN1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL160907	54404	0	None	-	0	Rat	5.1	pKd	=	5.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	426	8	0	4	4.0	O=C(CCCN1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10044334	207121	18	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL92145	207121	18	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	12611596	60304	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	CHEMBL174380	60304	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	44385952	62208	5	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	CHEMBL177800	62208	5	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	9951964	206358	0	None	-	0	Rat	6.1	pKd	=	6.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87458	206358	0	None	-	0	Rat	6.1	pKd	=	6.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm011014y
	12611609	60436	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	CHEMBL175204	60436	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	2148	3890	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	2150	3890	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	2784	3890	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	5610	3890	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	CHEMBL11608	3890	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	DB08841	3890	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	10022123	53316	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL159969	53316	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL92673	53316	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	10544858	170028	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	CHEMBL444269	170028	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	CHEMBL542181	170028	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	11121409	56402	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	341	4	0	5	3.1	O=C1c2ccsc2CCC1CCN1CCN(c2ccccn2)CC1	10.1021/jm011014y
	CHEMBL163180	56402	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	341	4	0	5	3.1	O=C1c2ccsc2CCC1CCN1CCN(c2ccccn2)CC1	10.1021/jm011014y
	10710246	121127	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL357517	121127	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm011014y
	10017554	4341	29	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandAntagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	CHEMBL101008	4341	29	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandAntagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	10017554	4341	29	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligandAgonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	CHEMBL101008	4341	29	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligandAgonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	134143752	150649	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3955519	150649	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	49836525	18807	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278202	18807	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836524	18806	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278201	18806	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	46933091	15763	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222695	15763	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836526	18648	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276859	18648	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836411	18725	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277585	18725	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	44516817	57663	5	None	-1023	2	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilizationAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	CHEMBL1668584	57663	5	None	-1023	2	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilizationAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	185	4006	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	5311271	4006	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	CHEMBL74355	4006	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	DB16351	4006	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	49836412	18724	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277584	18724	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836294	18779	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278020	18779	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836522	18795	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	CHEMBL1278113	18795	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	52944115	18798	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	CHEMBL1278116	18798	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	49833883	15761	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222693	15761	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	44156754	6510	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	CHEMBL1082763	6510	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	49836299	18744	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277770	18744	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49833886	15778	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222764	15778	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	49836639	18684	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277216	18684	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	46933089	15733	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222554	15733	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	46867519	6508	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2cc3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	CHEMBL1082761	6508	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2cc3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	44156752	6580	4	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.4	CNc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	CHEMBL1083075	6580	4	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.4	CNc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	10609802	107192	2	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	CHEMBL316527	107192	2	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	155531067	171619	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4465512	171619	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	134141831	146687	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3923870	146687	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	49833882	15760	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15760	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	46933090	15776	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222762	15776	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836635	18667	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277035	18667	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836409	18736	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277679	18736	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836300	18743	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277769	18743	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	134154065	152361	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3970041	152361	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	11957541	1459	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	1229	1459	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	147	1459	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	170617	1459	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	CHEMBL6616	1459	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	10609802	107192	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	CHEMBL316527	107192	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	1530	2182	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	3827	2182	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	7206	2182	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	CHEMBL534	2182	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	DB00920	2182	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	10440	2680	20	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2680	20	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2680	20	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	10751567	4539	3	None	-	1	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	CHEMBL102347	4539	3	None	-	1	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	49864841	15731	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	CHEMBL1222552	15731	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	49834053	15777	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222763	15777	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836634	18666	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277034	18666	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49833882	15760	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15760	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	25110703	189720	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	360	2	1	4	3.2	O=S(=O)(c1ccccc1)n1cc(Cl)c2cc3c(cc21)CCNCC3	10.1016/j.bmcl.2008.08.010
	CHEMBL515624	189720	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	360	2	1	4	3.2	O=S(=O)(c1ccccc1)n1cc(Cl)c2cc3c(cc21)CCNCC3	10.1016/j.bmcl.2008.08.010
	49836528	18658	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	CHEMBL1276947	18658	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	134152052	153083	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3976121	153083	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	44156628	6714	4	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	328	3	1	6	2.1	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	CHEMBL1083654	6714	4	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	328	3	1	6	2.1	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	10751567	4539	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	CHEMBL102347	4539	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	38240	107999	22	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	CHEMBL319415	107999	22	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	49833884	15762	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	CHEMBL1222694	15762	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	49864886	15745	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222624	15745	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	155558626	174761	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4561016	174761	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	49836633	18659	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276948	18659	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	25184832	18695	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277312	18695	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	13139	2491	29	None	-	2	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	4076	2491	29	None	-	2	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	CHEMBL26687	2491	29	None	-	2	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	2995	204405	53	None	-154	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204405	53	None	-154	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204405	53	None	-154	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	1225	1471	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1471	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1471	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1471	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1471	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	2105	3054	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3054	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3054	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3054	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3054	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	439280	120019	107	None	-25	9	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	6971044	120019	107	None	-25	9	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	CHEMBL350221	120019	107	None	-25	9	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	11658860	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	2941	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	4374	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	CHEMBL360328	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	DB04871	2344	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	30699	217704	0	None	-1	14	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	423	7	2	8	0.5	CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O	None
	5215	168967	102	None	1	3	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	250	3	2	5	0.9	Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1	None
	CHEMBL439	168967	102	None	1	3	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	250	3	2	5	0.9	Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1	None
	4421	217717	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	232	2	1	4	1.4	CCN1C=C(C(O)=O)C(=O)C2=CC=C(C)N=C12	None
	14052	172578	51	None	1	5	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	204	9	4	4	-0.3	CC[C@@H](CO)NCCN[C@@H](CC)CO	None
	CHEMBL44884	172578	51	None	1	5	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	204	9	4	4	-0.3	CC[C@@H](CO)NCCN[C@@H](CC)CO	None
	33613	217696	0	None	-1	3	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	365	4	4	6	0.0	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)C3=CC=C(O)C=C3)C(=O)N2[C@H]1C(O)=O	None
	2337	3256	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3256	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3256	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3256	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3256	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		2585	803	103	None	-18	21	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	803	103	None	-18	21	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	803	103	None	-18	21	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	803	103	None	-18	21	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	803	103	None	-18	21	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		1343	1889	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3519	1889	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		522	1889	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		CHEMBL862	1889	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		DB01018	1889	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		54477	84653	36	None	-	23	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
		CHEMBL22242	84653	36	None	-	23	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
		43815	186920	64	None	-1995	25	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL1708	186920	64	None	-1995	25	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL490	186920	64	None	-1995	25	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		1353	1911	93	None	-295	83	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-295	83	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-295	83	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-295	83	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-295	83	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		2247	505	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		4034	55822	55	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	55822	55	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		43815	186920	64	None	-1995	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL1708	186920	64	None	-1995	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL490	186920	64	None	-1995	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		2435	3590	83	None	-2	48	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		60149	3590	83	None	-2	48	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		98	3590	83	None	-2	48	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		CHEMBL12713	3590	83	None	-2	48	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		DB06144	3590	83	None	-2	48	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		1830	2590	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		207	2590	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		23897	2590	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL460	2590	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		DB01618	2590	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		2393	3334	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		5078	3334	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		51	3334	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		CHEMBL905	3334	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		DB00953	3334	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		1605	2342	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		3957	2342	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		7216	2342	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		CHEMBL998	2342	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		DB00455	2342	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		228	445	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		33	445	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		6005	445	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		CHEMBL53	445	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		DB00714	445	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		2865	4143	73	None	-12	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-12	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-12	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-12	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-12	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		3547	141373	71	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL38380	141373	71	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL541388	141373	71	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		5210	33338	48	None	-123	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		CHEMBL1200765	33338	48	None	-123	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		CHEMBL1419	33338	48	None	-123	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		1343	1889	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3519	1889	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		522	1889	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		CHEMBL862	1889	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		DB01018	1889	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		2402	3370	62	None	-9	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		5095	3370	62	None	-9	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		7295	3370	62	None	-9	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		CHEMBL589	3370	62	None	-9	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		DB00268	3370	62	None	-9	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		1201549	597	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		333	597	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7601	597	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201203	597	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL438151	597	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00245	597	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4199	98845	42	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL278819	98845	42	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
		5311507	194815	41	None	-	1	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL53904	194815	41	None	-	1	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		37	778	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	778	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	778	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	778	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	778	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		3158	56267	27	None	-389	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-389	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		2543	3707	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		5358	3707	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		54	3707	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		CHEMBL128	3707	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		DB00669	3707	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		5411	204033	89	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL698	204033	89	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
		3658	4107	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		517	4107	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		5709	4107	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL312448	4107	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		DB06694	4107	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		1400	1957	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3658	1957	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		7199	1957	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		91513	1957	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL896	1957	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00557	1957	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		5329102	194726	86	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	194726	86	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		1971	2866	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2404	2866	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		4543	2866	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL445	2866	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		DB00540	2866	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		1613	2348	53	None	-	44	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-	44	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-	44	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-	44	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-	44	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		2351	3286	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		2820	3286	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		5035	3286	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		CHEMBL81	3286	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		DB00481	3286	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		1357	2485	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
		1672	2485	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
		224	2485	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
		896	2485	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
		CHEMBL45	2485	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
		DB01065	2485	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
		119570	3159	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
		2233	3159	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
		953	3159	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
		CHEMBL301265	3159	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
		DB00413	3159	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
		176	398	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2157	398	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2566	398	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		CHEMBL633	398	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		DB01118	398	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		240	944	43	None	-6	24	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		2769	944	43	None	-6	24	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		44279790	944	43	None	-6	24	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		660	944	43	None	-6	24	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		CHEMBL1729	944	43	None	-6	24	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		CHEMBL560739	944	43	None	-6	24	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		DB00604	944	43	None	-6	24	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		2284	3182	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	3182	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	3182	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	3182	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	3182	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		5280343	188275	124	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
		CHEMBL1520590	188275	124	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
		CHEMBL50	188275	124	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
		10831	116963	25	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL338667	116963	25	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
		68867	78173	38	None	-	0	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2104523	78173	38	None	-	0	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
		134	2514	24	None	-2	67	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1775	2514	24	None	-2	67	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		9681	2514	24	None	-2	67	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		CHEMBL1065	2514	24	None	-2	67	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		DB00247	2514	24	None	-2	67	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		2105	3054	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	3054	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	3054	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	3054	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	3054	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		135409453	3773	41	None	2	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	2	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	2	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		20628	96548	28	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
		CHEMBL26291	96548	28	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
		441074	19414	82	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL1294	19414	82	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		2303	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		4946	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		564	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		63	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		91536	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		CHEMBL27	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		CHEMBL452861	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		DB00571	3187	68	None	-158	26	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-5	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-5	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-5	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-5	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		103	4153	61	None	1	53	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	4153	61	None	1	53	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	4153	61	None	1	53	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	4153	61	None	1	53	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	4153	61	None	1	53	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5666	102992	35	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
		CHEMBL306700	102992	35	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
		16362	3125	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	3125	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	3125	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	3125	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	3125	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		4209	3163	75	None	-758	33	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	3163	75	None	-758	33	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	3163	75	None	-758	33	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	3163	75	None	-758	33	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	3163	75	None	-758	33	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	3163	75	None	-758	33	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		319	1324	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		321	1324	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		444031	1324	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		784	1324	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		CHEMBL1346	1324	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		DB00496	1324	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		2402	3370	62	None	-9	24	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		5095	3370	62	None	-9	24	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		7295	3370	62	None	-9	24	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		CHEMBL589	3370	62	None	-9	24	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		DB00268	3370	62	None	-9	24	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		3316	31760	71	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
		CHEMBL1405973	31760	71	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
		216416	111581	48	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL328190	111581	48	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		2771	195017	74	None	1	27	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	195017	74	None	1	27	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	195017	74	None	1	27	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		2337	3256	77	None	-15	62	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-15	62	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-15	62	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-15	62	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-15	62	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		10007	14484	38	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201269	14484	38	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		150	2509	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		1764	2509	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		8226	2509	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		CHEMBL1201356	2509	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		DB00353	2509	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		2771	195017	74	None	1	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	195017	74	None	1	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	195017	74	None	1	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		2099	9307	55	None	-	1	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
		CHEMBL1110	9307	55	None	-	1	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
		1782	2518	84	None	-3	22	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		241	2518	84	None	-3	22	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		4168	2518	84	None	-3	22	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		CHEMBL86	2518	84	None	-3	22	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		DB01233	2518	84	None	-3	22	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		11626560	200937	94	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL601719	200937	94	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		1427	2013	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		357	2013	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		3696	2013	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL11	2013	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00458	2013	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		124087	1389	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	1389	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	1389	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	1389	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	1389	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		1530	2182	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		3827	2182	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		7206	2182	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		CHEMBL534	2182	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		DB00920	2182	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		55645	84370	8	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
		CHEMBL2218861	84370	8	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
		11658860	2344	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		2941	2344	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		4374	2344	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		CHEMBL360328	2344	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		DB04871	2344	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		48041	107081	46	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
		CHEMBL315838	107081	46	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
		1209	1658	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		203	1658	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		3386	1658	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL41	1658	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00472	1658	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		134	2514	24	None	-2	67	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1775	2514	24	None	-2	67	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		9681	2514	24	None	-2	67	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		CHEMBL1065	2514	24	None	-2	67	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		DB00247	2514	24	None	-2	67	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1210	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		1213	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		2725	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		33036	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		4411	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		616	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		6976	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		716121	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1201353	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1554789	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL505	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB01114	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB13679	918	51	None	-10	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		11693	1827	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	1827	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	1827	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	1827	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	1827	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	1827	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		21722	17992	31	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		CHEMBL126224	17992	31	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		242	470	124	None	-1	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-1	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-1	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-1	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-1	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		31101	729	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	729	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	729	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	729	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	729	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		2162	41514	100	None	-	6	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1491	41514	100	None	-	6	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		3337	206367	27	None	-75	40	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		65801	206367	27	None	-75	40	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		66264	206367	27	None	-75	40	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		91452	206367	27	None	-75	40	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		CHEMBL87493	206367	27	None	-75	40	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		3157	1470	71	None	-37	10	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	1470	71	None	-37	10	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	1470	71	None	-37	10	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	1470	71	None	-37	10	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	1470	71	None	-37	10	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		10531	1420	21	None	-15	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	1420	21	None	-15	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	1420	21	None	-15	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	1420	21	None	-15	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	1420	21	None	-15	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		2142	3096	58	None	-43	36	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4920903	3096	58	None	-43	36	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		502	3096	58	None	-43	36	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		5775	3096	58	None	-43	36	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL597	3096	58	None	-43	36	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		DB00692	3096	58	None	-43	36	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4418	34222	85	None	-	6	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		CHEMBL142635	34222	85	None	-	6	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		150	2509	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		1764	2509	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		8226	2509	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		CHEMBL1201356	2509	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		DB00353	2509	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		2520	204008	70	None	-4	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	204008	70	None	-4	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	204008	70	None	-4	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		123606	352	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
		128	352	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
		7110	352	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
		CHEMBL1505	352	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
		DB00918	352	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
		1209	1658	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		203	1658	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		3386	1658	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL41	1658	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00472	1658	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		1212	1662	50	None	-27	65	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		204	1662	50	None	-27	65	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		3372	1662	50	None	-27	65	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL726	1662	50	None	-27	65	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00623	1662	50	None	-27	65	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		16231	207509	57	None	-	17	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
		CHEMBL945	207509	57	None	-	17	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
		5360696	1406	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		6953	1406	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		842	1406	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		CHEMBL52440	1406	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		DB00514	1406	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		4452	2762	19	None	-208	19	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		983	2762	19	None	-208	19	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL20734	2762	19	None	-208	19	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		10531	1420	21	None	-15	23	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	1420	21	None	-15	23	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	1420	21	None	-15	23	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	1420	21	None	-15	23	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	1420	21	None	-15	23	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		27447	59803	63	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	3	5	0.4	CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1	10.1038/s41467-023-40064-9
		6560168	59803	63	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	3	5	0.4	CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1	10.1038/s41467-023-40064-9
		CHEMBL1727	59803	63	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	3	5	0.4	CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1	10.1038/s41467-023-40064-9
		154257	178619	67	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		CHEMBL46740	178619	67	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		2470	3653	50	None	-14125	59	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3300	3653	50	None	-14125	59	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		5265	3653	50	None	-14125	59	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		99	3653	50	None	-14125	59	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL267930	3653	50	None	-14125	59	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		2600	3779	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	3779	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	3779	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	3779	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	3779	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		1224	1432	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	1432	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	1432	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	1432	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	1432	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	1432	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		2286	3183	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		2713	205271	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353524	205271	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5360566	205271	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		88536661	205271	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		9552079	205271	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1330113	205271	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL790	205271	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		2389	3331	118	None	-66	67	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-66	67	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-66	67	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-66	67	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-66	67	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		3639	168446	106	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	1	3	5	-0.4	NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O	10.1038/s41467-023-40064-9
		CHEMBL435	168446	106	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	1	3	5	-0.4	NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O	10.1038/s41467-023-40064-9
		191	403	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	403	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	403	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	403	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	403	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		135	2532	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		2780	110529	36	None	-	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL325109	110529	36	None	-	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
		72093	35061	9	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL1433361	35061	9	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL2103773	35061	9	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		4212	198679	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
		CHEMBL1417019	198679	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
		CHEMBL58	198679	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
		4567	9948	34	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL114655	9948	34	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		3062316	33575	121	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
		CHEMBL1421	33575	121	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
		213	3853	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2717	3853	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		5533	3853	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL621	3853	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00656	3853	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		135398737	958	93	None	-2	89	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-2	89	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-2	89	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-2	89	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-2	89	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		2105	3054	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	3054	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	3054	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	3054	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	3054	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		37	778	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	778	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	778	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	778	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	778	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		1234	189221	56	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1256940	189221	56	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL51149	189221	56	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		180	401	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		3152	188411	103	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	188411	103	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		1890	2759	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		4449	2759	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		7247	2759	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		CHEMBL623	2759	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		DB01149	2759	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		214	3860	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	3860	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	3860	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	3860	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	3860	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	3860	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		212	3806	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	3806	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	3806	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	3806	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	3806	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		102	4127	48	None	-93	49	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	4127	48	None	-93	49	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	4127	48	None	-93	49	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	4127	48	None	-93	49	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	4127	48	None	-93	49	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		198	313	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
		82148	313	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
		99	313	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
		CHEMBL10878	313	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
		DB06594	313	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
		8249	59405	65	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1528839	59405	65	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL170988	59405	65	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		1222	881	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		2678	881	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		581	881	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1000	881	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00341	881	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		1016	3747	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		2561	3747	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		2733526	3747	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		5384	3747	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL83	3747	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		DB00675	3747	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		3686	94667	108	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	338	12	1	5	3.5	COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O	10.1038/s41467-023-40064-9
		CHEMBL252556	94667	108	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	338	12	1	5	3.5	COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O	10.1038/s41467-023-40064-9
		6989	100952	115	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	150	1	1	1	2.8	Cc1ccc(C(C)C)c(O)c1	10.1038/s41467-023-40064-9
		CHEMBL29411	100952	115	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	150	1	1	1	2.8	Cc1ccc(C(C)C)c(O)c1	10.1038/s41467-023-40064-9
		4886	14110	28	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1198	14110	28	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
		2318	154856	29	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL400599	154856	29	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		2726	919	68	None	-19	72	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	919	68	None	-19	72	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	919	68	None	-19	72	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	919	68	None	-19	72	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	919	68	None	-19	72	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		441074	19414	82	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL1294	19414	82	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		10198431	73905	0	None	-7	3	Human	9.0	pEC50	=	9.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201930	73905	0	None	-7	3	Human	9.0	pEC50	=	9.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		5	139	72	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		5202	139	72	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		CHEMBL39	139	72	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		DB08839	139	72	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		44407335	73094	0	None	-7	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
		CHEMBL201117	73094	0	None	-7	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
		44407440	139306	0	None	-4	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL379223	139306	0	None	-4	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		18715554	74424	0	None	-10	3	Human	6.8	pEC50	=	6.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL202656	74424	0	None	-10	3	Human	6.8	pEC50	=	6.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
		18715564	73380	0	None	-7	3	Human	8.7	pEC50	=	8.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201454	73380	0	None	-7	3	Human	8.7	pEC50	=	8.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
		18715555	74375	0	None	-8	3	Human	7.7	pEC50	=	7.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
		CHEMBL202458	74375	0	None	-8	3	Human	7.7	pEC50	=	7.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
		135398737	958	93	None	-2	89	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-2	89	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-2	89	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-2	89	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-2	89	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		44407398	74418	0	None	-8	3	Human	7.6	pEC50	=	7.6	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
		CHEMBL202616	74418	0	None	-8	3	Human	7.6	pEC50	=	7.6	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
		5	139	72	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
		5202	139	72	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
		CHEMBL39	139	72	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
		DB08839	139	72	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
		166	3359	18	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
		3045227	3359	18	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
		CHEMBL76781	3359	18	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
		44407453	74403	0	None	-9	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
		CHEMBL202538	74403	0	None	-9	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
		18715561	73044	0	None	-4	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201062	73044	0	None	-4	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
		44407327	141247	0	None	-5	3	Human	6.3	pEC50	=	6.3	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL383042	141247	0	None	-5	3	Human	6.3	pEC50	=	6.3	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		18715558	73882	0	None	-5	3	Human	7.2	pEC50	=	7.2	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201897	73882	0	None	-5	3	Human	7.2	pEC50	=	7.2	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
		9901086	187631	33	None	-	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm5019274
		CHEMBL494947	187631	33	None	-	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm5019274
		44407337	74204	0	None	-5	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL202324	74204	0	None	-5	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		44407460	140350	0	None	-6	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
		CHEMBL380763	140350	0	None	-6	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
		CHEMBL5081637	214757	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CN(CCc1cn(C)c2cccc(O)c12)CC1CC1	10.1021/acsmedchemlett.1c00578
		133	2496	52	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		134	2514	24	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	2514	24	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	2514	24	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	2514	24	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	2514	24	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		11291	3220	26	None	-	5	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
		4980	3220	26	None	-	5	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
		CHEMBL65547	3220	26	None	-	5	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
		150	2509	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	2509	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	2509	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	2509	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	2509	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		191	403	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2099	9307	55	None	-	1	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
		CHEMBL1110	9307	55	None	-	1	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
		11518143	89066	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
		CHEMBL2322611	89066	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
		CHEMBL2365004	89066	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
		2274	3173	58	None	-10	31	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-10	31	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-10	31	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-10	31	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-10	31	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		25060119	104315	0	None	-9332	7	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
		CHEMBL3099899	104315	0	None	-9332	7	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
		3033538	1319	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		7155	1319	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		781	1319	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		CHEMBL1201216	1319	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		DB00298	1319	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		213	3853	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	3853	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	3853	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	3853	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	3853	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		12488	1657	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		135398737	958	93	None	-2	89	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-2	89	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-2	89	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-2	89	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-2	89	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		73453	29616	24	None	-9	17	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	29616	24	None	-9	17	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		25070577	111666	4	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
		CHEMBL3286557	111666	4	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
		240	944	43	None	-6	24	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		2769	944	43	None	-6	24	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		44279790	944	43	None	-6	24	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		660	944	43	None	-6	24	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL1729	944	43	None	-6	24	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL560739	944	43	None	-6	24	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		DB00604	944	43	None	-6	24	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		146159245	188450	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		451415	188450	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		86289437	188450	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		CHEMBL502620	188450	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		1224	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		4178	195803	63	None	-	1	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
		CHEMBL558	195803	63	None	-	1	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
		44190762	176880	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		CHEMBL461571	176880	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		222757	99376	73	None	-1	3	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
		CHEMBL282575	99376	73	None	-1	3	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
		2812	4779	101	None	-40	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-40	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		2247	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		23027035	198547	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		CHEMBL578170	198547	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		78319901	159234	35	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2BSelectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2B	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
		CHEMBL4098877	159234	35	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2BSelectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2B	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
		54764239	68866	0	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL1922537	68866	0	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		2726	919	68	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		76072441	153947	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	7	0	4	3.4	C=CCN1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
		CHEMBL3983539	153947	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	7	0	4	3.4	C=CCN1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
		100	3805	58	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		134551	358	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	358	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	358	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	358	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		23027211	197250	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL568400	197250	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		100951644	169634	16	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	411	7	2	9	2.3	CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1	10.1021/acs.jmedchem.9b00260
		CHEMBL4437106	169634	16	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	411	7	2	9	2.3	CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1	10.1021/acs.jmedchem.9b00260
		3042	1414	35	None	-39	14	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		355	1414	35	None	-39	14	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		868	1414	35	None	-39	14	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		CHEMBL1123	1414	35	None	-39	14	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		DB00804	1414	35	None	-39	14	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		5591	157531	90	None	1	2	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
		CHEMBL408	157531	90	None	1	2	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
		3168	9262	92	None	-107	21	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-107	21	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		127048333	140680	1	None	38	3	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3815112	140680	1	None	38	3	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		1971	2866	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		1548953	207679	27	None	-4	17	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	207679	27	None	-4	17	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		5870	31660	92	None	-	1	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
		CHEMBL1405	31660	92	None	-	1	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
		6319	23475	95	None	-	1	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
		CHEMBL1333512	23475	95	None	-	1	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
		1305	511	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		9934033	511	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL182150	511	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		121318543	177567	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	560	6	0	6	4.7	COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2Cl)C1	10.1016/j.bmcl.2020.127214
		CHEMBL4640428	177567	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	560	6	0	6	4.7	COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2Cl)C1	10.1016/j.bmcl.2020.127214
		16665072	98538	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	449	8	1	6	3.6	CN(C)CCN(C)c1nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc2n1C	10.1016/j.bmcl.2006.11.092
		CHEMBL276393	98538	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	449	8	1	6	3.6	CN(C)CCN(C)c1nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc2n1C	10.1016/j.bmcl.2006.11.092
		155558726	174808	0	None	-19	4	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		CHEMBL4562303	174808	0	None	-19	4	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		667590	67794	12	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
		CHEMBL1909048	67794	12	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
		44112	121290	48	None	-11	7	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
		CHEMBL357995	121290	48	None	-11	7	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
		17683252	67796	3	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
		CHEMBL1909051	67796	3	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
		155565189	175565	0	None	-6	4	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		CHEMBL4579120	175565	0	None	-6	4	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		3525815	74146	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
		CHEMBL2022867	74146	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
		2520	204008	70	None	-4	12	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL1280	204008	70	None	-4	12	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL6966	204008	70	None	-4	12	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		23027245	197128	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL567791	197128	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		10660	14416	58	None	-29	12	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	-29	12	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		2333	142335	97	None	1	2	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
		CHEMBL388590	142335	97	None	1	2	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
		2771	195017	74	None	1	27	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL1200781	195017	74	None	1	27	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL549	195017	74	None	1	27	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		104903	56344	17	None	-4	6	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
		CHEMBL1630578	56344	17	None	-4	6	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
		2723	154046	108	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
		CHEMBL398440	154046	108	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
		1379258	67795	13	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
		CHEMBL1909050	67795	13	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
		76072442	146388	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	407	5	0	4	4.0	CC(C)(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
		CHEMBL3921628	146388	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	407	5	0	4	4.0	CC(C)(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
		11277147	106341	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092759	106341	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3139188	106341	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		76072471	153537	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	405	6	0	4	3.8	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCC1	nan
		CHEMBL3980023	153537	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	405	6	0	4	3.8	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCC1	nan
		11452268	81573	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	396	5	1	5	4.2	Cc1nc(N2CCCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2006.11.092
		CHEMBL216228	81573	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	396	5	1	5	4.2	Cc1nc(N2CCCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2006.11.092
		11957541	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
		1229	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
		147	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
		170617	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
		CHEMBL6616	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
		11957541	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
		1229	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
		147	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
		170617	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
		CHEMBL6616	1459	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
		9881053	120245	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [3H]5-HT from 5-hydroxytryptamine 2B receptorAbility to displace [3H]5-HT from 5-hydroxytryptamine 2B receptor	ChEMBL	339	5	1	4	4.1	CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1	10.1021/jm020954v
		CHEMBL35226	120245	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [3H]5-HT from 5-hydroxytryptamine 2B receptorAbility to displace [3H]5-HT from 5-hydroxytryptamine 2B receptor	ChEMBL	339	5	1	4	4.1	CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1	10.1021/jm020954v
		1201549	597	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		5510	205852	100	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
		CHEMBL83668	205852	100	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
		44393396	127297	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.6	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3cccc(Cl)c3Cl)cc12	10.1016/j.bmcl.2004.05.051
		CHEMBL365882	127297	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.6	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3cccc(Cl)c3Cl)cc12	10.1016/j.bmcl.2004.05.051
		4122	207625	108	None	-3	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
		CHEMBL9514	207625	108	None	-3	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
		1353	1911	93	None	-295	83	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-295	83	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-295	83	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-295	83	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-295	83	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		1016	3747	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL1909069	209076	0	None	-1	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL		None	None	None		None	nan
		1343	1889	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		3519	1889	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		522	1889	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		CHEMBL862	1889	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		DB01018	1889	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		2337	3256	77	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		122196341	124273	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
		CHEMBL3634745	124273	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
		2585	803	103	None	-18	21	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	803	103	None	-18	21	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	803	103	None	-18	21	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	803	103	None	-18	21	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	803	103	None	-18	21	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		2389	3331	118	None	-66	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-66	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-66	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-66	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-66	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		2398	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		1605	2342	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		3957	2342	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		7216	2342	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		CHEMBL998	2342	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		DB00455	2342	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		45482789	198925	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		CHEMBL584554	198925	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		122185011	122564	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	339	3	0	3	5.0	COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC	10.1039/C4MD00113C
		CHEMBL3601563	122564	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	339	3	0	3	5.0	COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC	10.1039/C4MD00113C
		11080	29085	79	None	-6	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	29085	79	None	-6	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		3151	1462	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	1462	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	1462	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	1462	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	1462	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		5818	3793	47	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
		5886965	3793	47	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
		CHEMBL1368005	3793	47	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
		76072440	149350	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	393	6	0	4	3.6	CC(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
		CHEMBL3945224	149350	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	393	6	0	4	3.6	CC(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
		1227	2489	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	2489	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	2489	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	2489	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	2489	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	2489	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		42636941	178949	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		CHEMBL470432	178949	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		1524	2181	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		197	2181	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		3822	2181	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		88	2181	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		CHEMBL51	2181	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		DB12465	2181	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		119584	2595	102	None	1	5	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		1848	2595	102	None	1	5	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		242	2595	102	None	1	5	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		CHEMBL60889	2595	102	None	1	5	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		DB11675	2595	102	None	1	5	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		76072443	151578	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	6	0	4	3.4	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CC1	nan
		CHEMBL3963333	151578	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	6	0	4	3.4	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CC1	nan
		11957541	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
		1229	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
		147	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
		170617	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
		CHEMBL6616	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
		11957541	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		1229	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		147	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		170617	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		CHEMBL6616	1459	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		72548703	161567	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysisDisplacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	161567	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysisDisplacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		1043	1582	14	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	1582	14	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	1582	14	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	1582	14	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	1582	14	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		23027527	196792	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL565551	196792	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		23027411	198520	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577912	198520	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		5318	15576	49	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	15576	49	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	15576	49	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		1531	2266	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		3869	2266	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		7207	2266	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		CHEMBL429	2266	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		DB00598	2266	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		124	2981	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2032	2981	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		4636	2981	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL762	2981	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		DB00935	2981	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		45485062	197168	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		CHEMBL567993	197168	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		44404883	72062	32	None	-2	4	Human	7.5	pIC50	=	7.5	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
		CHEMBL197664	72062	32	None	-2	4	Human	7.5	pIC50	=	7.5	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
		15987265	196887	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL566075	196887	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		3191	102858	97	None	-7	25	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-7	25	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		448537	160250	89	None	-21	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	160250	89	None	-21	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		5897	105211	80	None	-1	3	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		CHEMBL311469	105211	80	None	-1	3	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		72197486	102503	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL2393245	102503	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL3040361	102503	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		45484995	198519	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577904	198519	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		127048335	140592	1	None	15	3	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3813726	140592	1	None	15	3	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		196129	67798	17	None	-26	15	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	67798	17	None	-26	15	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		4011	82408	49	None	-20	24	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-20	24	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		4601	206747	35	None	-4	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-4	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-4	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		68617	205527	62	None	-15	26	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	205527	62	None	-15	26	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	205527	62	None	-15	26	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		2303	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		4946	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		564	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		63	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		91536	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL27	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL452861	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		DB00571	3187	68	None	-158	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		2353	101112	82	None	-7	4	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
		CHEMBL12089	101112	82	None	-7	4	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
		CHEMBL295124	101112	82	None	-7	4	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
		3117	207841	103	None	-8	16	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	207841	103	None	-8	16	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		2284	3182	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		11304816	66279	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	424	5	1	5	4.0	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2004.05.051
		CHEMBL184717	66279	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	424	5	1	5	4.0	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2004.05.051
		11536844	115122	0	None	1	2	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343672	115122	0	None	1	2	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		2351	3286	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	3286	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	3286	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	3286	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	3286	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		444795	139999	105	None	3	2	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
		CHEMBL38	139999	105	None	3	2	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
		26987	949	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		72734860	103957	0	None	6	5	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092753	103957	0	None	6	5	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		3973	208180	110	None	-44	3	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
		CHEMBL98350	208180	110	None	-44	3	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
		3157	1470	71	None	-37	10	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		7170	1470	71	None	-37	10	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		954	1470	71	None	-37	10	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		CHEMBL707	1470	71	None	-37	10	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		DB00590	1470	71	None	-37	10	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		58438464	3065	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		9060	3065	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		CHEMBL3287218	3065	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		DB14870	3065	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		6726	1280	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		118112300	155994	18	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at 5HT2B (unknown origin)Antagonist activity at 5HT2B (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
		CHEMBL4061793	155994	18	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at 5HT2B (unknown origin)Antagonist activity at 5HT2B (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
		2142	3096	58	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		4920903	3096	58	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		502	3096	58	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		5775	3096	58	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		CHEMBL597	3096	58	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		DB00692	3096	58	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		1212	1662	50	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		11957541	1459	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		1229	1459	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		147	1459	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		170617	1459	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		CHEMBL6616	1459	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		1042	1581	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	1581	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	1581	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	1581	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	1581	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		44393215	66663	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	417	6	2	4	5.4	Cc1cc(NC(C)C)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
		CHEMBL185376	66663	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	417	6	2	4	5.4	Cc1cc(NC(C)C)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
		78243717	137350	53	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Selectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2BSelectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2B	ChEMBL	321	4	1	5	2.4	O=C(/C=C/N1C[C@H]2C[C@@H]1CN2c1ccccn1)c1ccccc1O	10.6019/CHEMBL5212743
		CHEMBL3752911	137350	53	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Selectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2BSelectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2B	ChEMBL	321	4	1	5	2.4	O=C(/C=C/N1C[C@H]2C[C@@H]1CN2c1ccccn1)c1ccccc1O	10.6019/CHEMBL5212743
		74538762	143541	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	419	6	0	4	4.2	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCCC1	nan
		CHEMBL3898995	143541	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	419	6	0	4	4.2	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCCC1	nan
		1599	2341	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		3955	2341	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		7215	2341	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		CHEMBL841	2341	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		DB00836	2341	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		2303	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		4946	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		564	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		63	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		91536	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL27	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL452861	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		DB00571	3187	68	None	-158	26	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		4209	3163	75	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		4893	3163	75	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		503	3163	75	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		5385	3163	75	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		CHEMBL2	3163	75	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		DB00457	3163	75	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		CHEMBL5079070	214604	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CC(C)N(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
		124087	1389	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		72198754	90880	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
		CHEMBL2392349	90880	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
		58438475	92273	0	None	-	2	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
		CHEMBL2426677	92273	0	None	-	2	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
		21138	98451	39	None	-6	7	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
		CHEMBL275742	98451	39	None	-6	7	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
		10389430	125951	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.3	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
		CHEMBL364863	125951	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.3	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
		1530	2182	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		5353853	17986	47	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	17986	47	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	17986	47	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		2600	3779	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	3779	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	3779	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	3779	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	3779	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		4211	57822	83	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		CHEMBL1670	57822	83	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		6761	67799	19	None	-7	18	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-7	18	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		1588	2325	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		206	2493	16	None	-1	25	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
		68848	2493	16	None	-1	25	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
		CHEMBL12314	2493	16	None	-1	25	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
		44516817	57663	5	None	-4365	2	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
		CHEMBL1668584	57663	5	None	-4365	2	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
		6075	150108	42	None	-8	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	-8	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		5624	32693	14	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL1203324	32693	14	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL141343	32693	14	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		11694810	120539	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3310123	120539	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3545474	120539	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		44592109	179087	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	6	0	5	4.4	CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		CHEMBL471663	179087	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	6	0	5	4.4	CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		56645363	121490	12	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	Selectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2BSelectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
		CHEMBL3582478	121490	12	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	Selectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2BSelectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
		169713	80161	20	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
		CHEMBL21343	80161	20	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
		4943	193417	105	None	1	2	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
		CHEMBL526	193417	105	None	1	2	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
		11500509	120581	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343670	120581	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545812	120581	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		4189	206922	96	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		2683	102888	25	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	102888	25	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	102888	25	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		3598	187821	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	187821	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		135398745	2914	112	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		107715	200945	22	None	-14	19	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	200945	22	None	-14	19	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	200945	22	None	-14	19	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		122196341	124273	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to human 5HT2bBinding affinity to human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
		CHEMBL3634745	124273	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to human 5HT2bBinding affinity to human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
		10531	1420	21	None	-15	23	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	1420	21	None	-15	23	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	1420	21	None	-15	23	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	1420	21	None	-15	23	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	1420	21	None	-15	23	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		1836	2592	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	2592	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	2592	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	2592	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	2592	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		14049689	198443	11	None	20	2	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
		CHEMBL577294	198443	11	None	20	2	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
		72198756	90882	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	478	8	0	5	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3c(Cl)nc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
		CHEMBL2392351	90882	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	478	8	0	5	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3c(Cl)nc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
		1782	2518	84	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		241	2518	84	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		4168	2518	84	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		CHEMBL86	2518	84	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		DB01233	2518	84	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		72713752	103743	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	396	5	2	7	3.0	Cc1csc(C(C)(O)c2nnc(NC(=O)Cc3c(F)cccc3F)s2)n1	10.1021/jm4012033
		CHEMBL3088176	103743	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	396	5	2	7	3.0	Cc1csc(C(C)(O)c2nnc(NC(=O)Cc3c(F)cccc3F)s2)n1	10.1021/jm4012033
		90644511	111665	18	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
		CHEMBL3286556	111665	18	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
		2406	100404	89	None	-27	12	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	100404	89	None	-27	12	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		2286	3183	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		3198	205513	76	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		135	2532	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		180	401	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		4595	176715	106	None	2	15	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
		CHEMBL46	176715	106	None	2	15	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
		11536843	115123	0	None	1	2	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343673	115123	0	None	1	2	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		1547484	940	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	940	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	940	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	940	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	940	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		102	4127	48	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		3659	4127	48	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		8969	4127	48	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		CHEMBL15245	4127	48	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		DB01392	4127	48	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		2477	745	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		36	745	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		437	745	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		CHEMBL49	745	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		DB00490	745	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		71499384	111149	41	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	448	8	1	5	4.5	COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OC	10.1021/jm401431x
		CHEMBL3264204	111149	41	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	448	8	1	5	4.5	COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OC	10.1021/jm401431x
		2105	3054	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	3054	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	3054	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	3054	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	3054	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		67406727	117192	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		CHEMBL3394201	117192	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		11957735	200021	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
		CHEMBL595449	200021	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
		2028	2979	80	None	-40	10	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		359	2979	80	None	-40	10	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		4634	2979	80	None	-40	10	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		CHEMBL1231	2979	80	None	-40	10	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		DB01062	2979	80	None	-40	10	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		31101	729	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	729	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	729	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	729	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	729	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		161	754	6	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
		4284720	754	6	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
		CHEMBL1255834	754	6	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
		54764240	68868	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL1922539	68868	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL5085055	214946	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CCN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
		4098	32505	30	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		54764241	68867	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL1922538	68867	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		5282379	194984	69	None	1	3	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
		CHEMBL547	194984	69	None	1	3	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
		146420029	184762	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	379	3	1	3	4.2	CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1	10.1016/j.ejmech.2021.113782
		CHEMBL4851044	184762	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	379	3	1	3	4.2	CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1	10.1016/j.ejmech.2021.113782
		3158	56267	27	None	-389	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-389	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		72197484	102494	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
		CHEMBL2393243	102494	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
		CHEMBL3040324	102494	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
		277	1301	62	None	-4	50	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-4	50	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-4	50	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-4	50	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-4	50	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		1305	511	14	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		9934033	511	14	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL182150	511	14	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		9861687	189199	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	315	4	0	5	3.7	CCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		CHEMBL511312	189199	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	315	4	0	5	3.7	CCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		2291	3184	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		2561	3184	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		4932	3184	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		CHEMBL631	3184	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		DB01182	3184	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		176	398	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		657255	199084	34	None	-9	15	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	199084	34	None	-9	15	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		3952	1888	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5353646	1888	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5443	1888	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5702063	1888	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL1331786	1888	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL420	1888	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		24360	203344	106	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
		CHEMBL65	203344	106	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
		127048334	140600	1	None	13	3	Human	7.0	pIC50	=	7	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3813796	140600	1	None	13	3	Human	7.0	pIC50	=	7	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		10851262	40559	0	None	1	2	Rat	8.9	pKd	=	8.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	293	1	1	3	3.7	Cc1coc2cc3c(cc12)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		CHEMBL148346	40559	0	None	1	2	Rat	8.9	pKd	=	8.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	293	1	1	3	3.7	Cc1coc2cc3c(cc12)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		9972439	40611	0	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	2	1	3	3.7	CCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		CHEMBL148385	40611	0	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	2	1	3	3.7	CCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		10851406	119264	1	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	295	1	1	3	3.9	O=C(Nc1cccnc1)N1CCc2cc3sccc3cc21	10.1021/jm960571v
		CHEMBL343666	119264	1	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	295	1	1	3	3.9	O=C(Nc1cccnc1)N1CCc2cc3sccc3cc21	10.1021/jm960571v
		141	1427	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
		6089	1427	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
		CHEMBL12420	1427	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
		DB01488	1427	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
		12281266	31832	5	None	-	1	Rat	7.0	pKd	=	7.0	Binding	Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.	ChEMBL	187	3	0	1	3.7	CC(C)CCn1ccc2ccccc21	10.1021/jm00367a008
		CHEMBL140663	31832	5	None	-	1	Rat	7.0	pKd	=	7.0	Binding	Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.	ChEMBL	187	3	0	1	3.7	CC(C)CCn1ccc2ccccc21	10.1021/jm00367a008
		6088	119842	56	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1021/jm00343a013
		CHEMBL348588	119842	56	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1021/jm00343a013
		10637557	36271	0	None	5	2	Rat	7.9	pKd	=	7.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	294	1	1	3	2.7	CN1CCc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		CHEMBL144567	36271	0	None	5	2	Rat	7.9	pKd	=	7.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	294	1	1	3	2.7	CN1CCc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		152234	56023	22	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1cccc(CC(C)N)c1	10.1021/jm00144a009
		CHEMBL16247	56023	22	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1cccc(CC(C)N)c1	10.1021/jm00144a009
		44359526	116631	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2c(ccn2CCC(C)C)c1	10.1021/jm00367a008
		CHEMBL336928	116631	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2c(ccn2CCC(C)C)c1	10.1021/jm00367a008
		44359525	28871	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
		CHEMBL137933	28871	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
		805647	30811	12	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	189	3	0	3	1.6	CN(C)CCn1cnc2ccccc21	10.1021/jm00367a008
		CHEMBL139655	30811	12	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	189	3	0	3	1.6	CN(C)CCn1cnc2ccccc21	10.1021/jm00367a008
		143435	99694	6	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(CC(C)N)cc1OC	10.1021/jm00144a009
		CHEMBL284589	99694	6	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(CC(C)N)cc1OC	10.1021/jm00144a009
		62787	206188	21	None	-3	10	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	10.1021/jm00144a009
		CHEMBL8642	206188	21	None	-3	10	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	10.1021/jm00144a009
		9904139	106993	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm960571v
		CHEMBL315223	106993	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm960571v
		31014	205891	20	None	2	3	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(OC)cc1CC(C)N	10.1021/jm00144a009
		CHEMBL8389	205891	20	None	2	3	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(OC)cc1CC(C)N	10.1021/jm00144a009
		144891	107387	8	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	241	5	1	4	2.3	COc1cc(OC)c(SC)cc1CC(C)N	10.1021/jm00144a009
		CHEMBL31787	107387	8	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	241	5	1	4	2.3	COc1cc(OC)c(SC)cc1CC(C)N	10.1021/jm00144a009
		9904139	106993	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm00014a004
		CHEMBL315223	106993	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm00014a004
		141685	107048	6	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(CC(C)N)cc1OC	10.1021/jm00144a009
		CHEMBL31557	107048	6	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(CC(C)N)cc1OC	10.1021/jm00144a009
		11806221	120222	1	None	-	1	Rat	6.7	pKd	=	6.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)C(CCN(C)C)CN2	10.1021/jm00343a013
		CHEMBL352140	120222	1	None	-	1	Rat	6.7	pKd	=	6.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)C(CCN(C)C)CN2	10.1021/jm00343a013
		10757038	119234	0	None	1	2	Rat	7.7	pKd	=	7.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	1	1	3	3.5	Cc1cc2cc3c(cc2n1C)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		CHEMBL343455	119234	0	None	1	2	Rat	7.7	pKd	=	7.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	1	1	3	3.5	Cc1cc2cc3c(cc2n1C)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		10690384	120956	0	None	-3	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	368	3	1	3	4.7	O=C(Nc1cccnc1)N1CCc2cc3c(ccn3Cc3ccccc3)cc21	10.1021/jm960571v
		CHEMBL356146	120956	0	None	-3	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	368	3	1	3	4.7	O=C(Nc1cccnc1)N1CCc2cc3c(ccn3Cc3ccccc3)cc21	10.1021/jm960571v
		44359444	29129	0	None	-	1	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
		CHEMBL138144	29129	0	None	-	1	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
		12655251	119309	58	None	-	1	Rat	5.7	pKd	=	5.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	162	2	2	2	1.5	NCCC1CNc2ccccc21	10.1021/jm00367a008
		CHEMBL344028	119309	58	None	-	1	Rat	5.7	pKd	=	5.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	162	2	2	2	1.5	NCCC1CNc2ccccc21	10.1021/jm00367a008
		11074217	52807	4	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	190	3	1	2	2.1	CN(C)CCC1CNc2ccccc21	10.1021/jm00343a013
		CHEMBL159503	52807	4	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	190	3	1	2	2.1	CN(C)CCC1CNc2ccccc21	10.1021/jm00343a013
		547452	54791	2	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	187	3	0	1	2.6	CN(C)CCC1=CCc2ccccc21	10.1021/jm00343a013
		CHEMBL161241	54791	2	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	187	3	0	1	2.6	CN(C)CCC1=CCc2ccccc21	10.1021/jm00343a013
		12451869	55184	5	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
		CHEMBL161751	55184	5	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
		144889	99324	6	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(OC)c(CC(C)N)cc1C	10.1021/jm00144a009
		CHEMBL282183	99324	6	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(OC)c(CC(C)N)cc1C	10.1021/jm00144a009
		34677	102219	88	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	147	0	1	1	1.5	NC1CCc2ccccc2C1	10.1021/jm00343a013
		CHEMBL30294	102219	88	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	147	0	1	1	1.5	NC1CCc2ccccc2C1	10.1021/jm00343a013
		141047	99406	20	None	1	3	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)c(OC)c1	10.1021/jm00144a009
		CHEMBL282734	99406	20	None	1	3	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)c(OC)c1	10.1021/jm00144a009
		31016	102287	15	None	-11	5	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	10.1021/jm00144a009
		CHEMBL30336	102287	15	None	-11	5	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	10.1021/jm00144a009
		15011362	52646	24	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	161	2	1	1	2.1	NCCC1CCc2ccccc21	10.1021/jm00343a013
		CHEMBL159346	52646	24	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	161	2	1	1	2.1	NCCC1CCc2ccccc21	10.1021/jm00343a013
		744368	164929	18	None	-	1	Rat	6.6	pKd	=	6.6	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	190	3	0	2	1.6	CN(C)CCN1CCc2ccccc21	10.1021/jm00367a008
		CHEMBL422471	164929	18	None	-	1	Rat	6.6	pKd	=	6.6	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	190	3	0	2	1.6	CN(C)CCN1CCc2ccccc21	10.1021/jm00367a008
		159755	57095	61	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccccc1CC(C)N	10.1021/jm00144a009
		CHEMBL16451	57095	61	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccccc1CC(C)N	10.1021/jm00144a009
		91255	99111	11	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(CC(C)N)c1OC	10.1021/jm00144a009
		CHEMBL280855	99111	11	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(CC(C)N)c1OC	10.1021/jm00144a009
		189	3492	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
		5163	3492	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
		CHEMBL297784	3492	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
		189	3492	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
		5163	3492	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
		CHEMBL297784	3492	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
		10683987	121278	1	None	3	2	Rat	7.5	pKd	=	7.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	278	1	2	2	3.2	O=C(Nc1cccnc1)N1CCc2cc3[nH]ccc3cc21	10.1021/jm960571v
		CHEMBL357870	121278	1	None	3	2	Rat	7.5	pKd	=	7.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	278	1	2	2	3.2	O=C(Nc1cccnc1)N1CCc2cc3[nH]ccc3cc21	10.1021/jm960571v
		1614	203655	24	None	-2	10	Rat	6.5	pKd	=	6.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	10.1021/jm00144a009
		CHEMBL6731	203655	24	None	-2	10	Rat	6.5	pKd	=	6.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	10.1021/jm00144a009
		8423	98689	30	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)cc1OC	10.1021/jm00144a009
		CHEMBL277540	98689	30	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)cc1OC	10.1021/jm00144a009
		126769	206042	42	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
		CHEMBL536255	206042	42	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
		CHEMBL85194	206042	42	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
		12451869	55184	5	None	-	1	Rat	5.4	pKd	=	5.4	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
		CHEMBL161751	55184	5	None	-	1	Rat	5.4	pKd	=	5.4	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
		155	728	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
		163	728	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
		62065	728	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
		CHEMBL6607	728	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
		DB01484	728	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
		44375004	53006	1	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	189	3	0	1	2.7	CN(C)CCC1CCc2ccccc21	10.1021/jm00343a013
		CHEMBL159689	53006	1	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	189	3	0	1	2.7	CN(C)CCC1CCc2ccccc21	10.1021/jm00343a013
		44359477	116434	0	None	-	1	Rat	7.3	pKd	=	7.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2ccn(CCC(C)C)c12	10.1021/jm00367a008
		CHEMBL336042	116434	0	None	-	1	Rat	7.3	pKd	=	7.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2ccn(CCC(C)C)c12	10.1021/jm00367a008
		77042	188357	58	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	177	4	0	2	1.8	CN(C)CCC(=O)c1ccccc1	10.1021/jm00343a013
		CHEMBL50115	188357	58	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	177	4	0	2	1.8	CN(C)CCC(=O)c1ccccc1	10.1021/jm00343a013
		31015	118415	16	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(CC(C)N)c(OC)c1	10.1021/jm00144a009
		CHEMBL34108	118415	16	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(CC(C)N)c(OC)c1	10.1021/jm00144a009
		10335310	206003	0	None	75	2	Rat	7.3	pKd	=	7.3	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2cc3c(cc21)CCCN3C(=O)Nc1cccnc1	10.1021/jm00014a004
		CHEMBL84888	206003	0	None	75	2	Rat	7.3	pKd	=	7.3	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2cc3c(cc21)CCCN3C(=O)Nc1cccnc1	10.1021/jm00014a004
		33984	29641	40	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	192	5	0	2	2.1	CCN(CCN(C)C)c1ccccc1	10.1021/jm00367a008
		CHEMBL138604	29641	40	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	192	5	0	2	2.1	CCN(CCN(C)C)c1ccccc1	10.1021/jm00367a008
		1150	3878	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
		125	3878	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
		CHEMBL6640	3878	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
		DB08653	3878	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
		3007	155685	27	None	-1	6	Rat	5.3	pKd	=	5.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	ChEMBL	135	2	1	1	1.6	CC(N)Cc1ccccc1	10.1021/jm00144a009
		CHEMBL405	155685	27	None	-1	6	Rat	5.3	pKd	=	5.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	ChEMBL	135	2	1	1	1.6	CC(N)Cc1ccccc1	10.1021/jm00144a009
		127035062	136451	0	None	-4	19	Human	6.3	pKd	=	6.3	Binding	Non-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot methodNon-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	136451	0	None	-4	19	Human	6.3	pKd	=	6.3	Binding	Non-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot methodNon-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		10591799	39950	0	None	1	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	2	1	3	4.2	CC(C)n1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		CHEMBL147820	39950	0	None	1	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	2	1	3	4.2	CC(C)n1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		44363813	40560	0	None	19	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	305	1	1	2	4.1	Cc1cn(C)c2cc3c(cc12)N(C(=O)Nc1ccccc1)CC3	10.1021/jm960571v
		CHEMBL148347	40560	0	None	19	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	305	1	1	2	4.1	Cc1cn(C)c2cc3c(cc12)N(C(=O)Nc1ccccc1)CC3	10.1021/jm960571v
		10335309	206046	0	None	-	1	Rat	7.2	pKd	=	7.2	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CCC3	10.1021/jm00014a004
		CHEMBL85247	206046	0	None	-	1	Rat	7.2	pKd	=	7.2	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CCC3	10.1021/jm00014a004
		31721	98822	42	None	-	1	Rat	5.2	pKd	=	5.2	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccc(CC(C)N)cc1	10.1021/jm00144a009
		CHEMBL278663	98822	42	None	-	1	Rat	5.2	pKd	=	5.2	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccc(CC(C)N)cc1	10.1021/jm00144a009
		10495940	78858	0	None	1	2	Rat	8.1	pKd	=	8.1	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	3	1	3	4.0	CCCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		CHEMBL2112859	78858	0	None	1	2	Rat	8.1	pKd	=	8.1	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	3	1	3	4.0	CCCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
		44359524	28869	1	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2c1ccn2CCC(C)C	10.1021/jm00367a008
		CHEMBL137932	28869	1	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2c1ccn2CCC(C)C	10.1021/jm00367a008
		164	1460	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
		85875	1460	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
		CHEMBL8600	1460	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
		DB01528	1460	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
		141048	102869	9	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(OC)c1CC(C)N	10.1021/jm00144a009
		CHEMBL30577	102869	9	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(OC)c1CC(C)N	10.1021/jm00144a009
		25187	100299	28	None	-	1	Rat	5.1	pKd	=	5.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	163	4	0	1	2.2	CN(C)CCCc1ccccc1	10.1021/jm00343a013
		CHEMBL289199	100299	28	None	-	1	Rat	5.1	pKd	=	5.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	163	4	0	1	2.2	CN(C)CCCc1ccccc1	10.1021/jm00343a013
		44359556	119428	0	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)NCC2CCN(C)C	10.1021/jm00367a008
		CHEMBL344878	119428	0	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)NCC2CCN(C)C	10.1021/jm00367a008
		145	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
		1832	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
		CHEMBL7257	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
		DB14010	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
		31012	103118	17	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1ccc(CC(C)N)c(OC)c1OC	10.1021/jm00144a009
		CHEMBL30777	103118	17	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1ccc(CC(C)N)c(OC)c1OC	10.1021/jm00144a009
		81206	29650	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00367a008
		CHEMBL138614	29650	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00367a008
		81206	29650	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00343a013
		CHEMBL138614	29650	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00343a013
		CHEMBL5270056	193617	0	None	100	2	Rat	10.1	pKi	=	10.1	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	428	4	2	3	5.0	COc1ccc(CC2NCCc3c2[nH]c2c(C)c(C)ccc32)c(Br)c1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL5277645	193941	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	368	5	2	4	4.3	COc1ccc(CC2NCCc3c2[nH]c2cccc(SC)c32)cc1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL5279881	194041	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	5	2	3	4.2	CCc1cccc2[nH]c3c(c12)CCNC3Cc1ccc(OC)c(OC)c1	10.1021/acs.jmedchem.0c01887
		CHEMBL5280131	194052	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	448	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2cccc(I)c32)cc1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL5284094	194243	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	336	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2cccc(C)c32)cc1OC	10.1021/acs.jmedchem.0c01887
		11666595	120532	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310115	120532	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545467	120532	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
		9839057	41394	4	None	-9	3	Human	9.7	pKi	=	9.7	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	293	2	1	3	3.8	CC(N)Cc1c2ccoc2c(Br)c2ccoc12	10.1021/jm9803525
		CHEMBL149024	41394	4	None	-9	3	Human	9.7	pKi	=	9.7	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	293	2	1	3	3.8	CC(N)Cc1c2ccoc2c(Br)c2ccoc12	10.1021/jm9803525
		9953185	207619	4	None	1	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human 5-HT2B assessed as inhibition constantBinding affinity to human 5-HT2B assessed as inhibition constant	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.2c00633
		CHEMBL95121	207619	4	None	1	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human 5-HT2B assessed as inhibition constantBinding affinity to human 5-HT2B assessed as inhibition constant	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.2c00633
		10597927	207531	0	None	93	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	414	4	2	3	4.7	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Br)c1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL94644	207531	0	None	93	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	414	4	2	3	4.7	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Br)c1OC	10.1021/acs.jmedchem.0c01887
		10618362	207534	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	358	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2c(F)cc(F)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL94655	207534	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	358	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2c(F)cc(F)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
		9953185	207619	4	None	-1	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL95121	207619	4	None	-1	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.0c01887
		10760338	207846	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2c(C)cc(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL96427	207846	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2c(C)cc(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
		10569875	207862	0	None	15	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2cc(C)c(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
		CHEMBL96480	207862	0	None	15	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2cc(C)c(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
		133	2496	52	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		188	3391	80	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
		196968	3391	80	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
		CHEMBL473186	3391	80	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
		70772974	191489	6	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysisBinding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysis	ChEMBL	369	3	2	3	3.8	Cc1c(C(=O)N2CCC(c3ncc[nH]3)CC2)n[nH]c1-c1ccc(Cl)cc1	10.1021/acs.jmedchem.2c00633
		CHEMBL5193649	191489	6	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysisBinding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysis	ChEMBL	369	3	2	3	3.8	Cc1c(C(=O)N2CCC(c3ncc[nH]3)CC2)n[nH]c1-c1ccc(Cl)cc1	10.1021/acs.jmedchem.2c00633
		134	2514	24	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	2514	24	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	2514	24	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	2514	24	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	2514	24	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		242	470	124	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		34	470	124	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		60795	470	124	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		CHEMBL1112	470	124	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		DB01238	470	124	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		11393666	192986	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5201983	192986	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5222597	192986	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		11978813	721	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		5014	721	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		7672	721	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		CHEMBL2105760	721	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		DB09128	721	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		11465618	102398	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL3039528	102398	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL5191141	102398	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		10686579	112363	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	312	2	2	1	4.8	c1ccc2c(CC3NCCc4c3[nH]c3ccccc43)cccc2c1	10.1021/acs.jmedchem.0c01887
		CHEMBL329479	112363	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	312	2	2	1	4.8	c1ccc2c(CC3NCCc4c3[nH]c3ccccc43)cccc2c1	10.1021/acs.jmedchem.0c01887
		23151734	103958	0	None	467	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092758	103958	0	None	467	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		11687730	120585	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343668	120585	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545816	120585	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		71528206	86971	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
		CHEMBL2323581	86971	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
		56597938	3940	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
		7651	3940	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
		CHEMBL2165126	3940	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
		56597090	81983	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	7	0	4	6.6	Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl	10.1021/jm300603y
		CHEMBL2165137	81983	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	7	0	4	6.6	Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl	10.1021/jm300603y
		56597938	3940	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		7651	3940	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL2165126	3940	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		118706290	120533	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310116	120533	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545468	120533	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
		118706734	120526	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3310714	120526	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3545444	120526	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		150	2509	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
		1764	2509	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
		8226	2509	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
		CHEMBL1201356	2509	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
		DB00353	2509	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
		118706282	120530	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3310111	120530	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3545465	120530	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		118706299	120537	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310121	120537	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545472	120537	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		118706284	120524	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310112	120524	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545440	120524	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
		150	2509	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	2509	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	2509	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	2509	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	2509	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		71528205	86970	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
		CHEMBL2323580	86970	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
		71528204	86969	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
		CHEMBL2323579	86969	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
		11358099	180406	0	None	3	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4752099	180406	0	None	3	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		11460460	182362	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4784845	182362	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		9954003	71700	24	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
		CHEMBL196514	71700	24	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
		16062782	97833	0	None	2	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	307	2	1	3	3.8	Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL272082	97833	0	None	2	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	307	2	1	3	3.8	Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		59757163	106342	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092760	106342	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3139189	106342	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		118706732	120527	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3310713	120527	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3545445	120527	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		56593482	3941	3	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		7650	3941	3	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL2165119	3941	3	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		10568771	102789	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
		CHEMBL305275	102789	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
		CHEMBL6710	102789	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
		242	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		34	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		60795	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		CHEMBL1112	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		DB01238	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		11658860	2344	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
		2941	2344	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
		4374	2344	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
		CHEMBL360328	2344	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
		DB04871	2344	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
		37	778	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
		460	778	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
		54746	778	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
		CHEMBL1201087	778	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
		DB00248	778	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
		242	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		34	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		60795	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL1112	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		DB01238	470	124	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		118706278	120523	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310109	120523	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545439	120523	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
		2865	4143	73	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		59	4143	73	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		60854	4143	73	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		CHEMBL708	4143	73	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		DB00246	4143	73	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		9888211	21416	13	None	-1	10	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
		CHEMBL131495	21416	13	None	-1	10	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
		10568771	102789	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
		CHEMBL305275	102789	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
		CHEMBL6710	102789	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
		10017554	4341	29	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm9803525
		CHEMBL101008	4341	29	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm9803525
		11957541	1459	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		1229	1459	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		147	1459	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		170617	1459	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		CHEMBL6616	1459	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
		118706285	112888	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3310113	112888	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		135399866	72055	2	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
		CHEMBL197653	72055	2	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
		118464429	167117	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
		CHEMBL4290245	167117	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
		127048333	140680	1	None	38	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3815112	140680	1	None	38	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		118706280	120529	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310110	120529	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545464	120529	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
		118717220	120580	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343669	120580	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545811	120580	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		72734860	103957	0	None	6	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092753	103957	0	None	6	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		11277147	106341	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092759	106341	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3139188	106341	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		11277147	106341	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3092759	106341	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3139188	106341	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		134	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
		1775	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
		9681	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
		CHEMBL1065	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
		DB00247	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
		206	2493	16	None	-1	25	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
		68848	2493	16	None	-1	25	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
		CHEMBL12314	2493	16	None	-1	25	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
		192	3502	54	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
		443390	3502	54	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
		CHEMBL14276	3502	54	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
		10573762	98783	0	None	1	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)cc1)CC2	10.1021/jm990388c
		CHEMBL278267	98783	0	None	1	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)cc1)CC2	10.1021/jm990388c
		10670813	162591	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	4	1	3	5.9	CCc1cc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc(-c2cccnc2)c1	10.1021/jm990388c
		CHEMBL416896	162591	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	4	1	3	5.9	CCc1cc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc(-c2cccnc2)c1	10.1021/jm990388c
		44397929	67181	0	None	-6	3	Human	8.0	pKi	=	8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL187739	67181	0	None	-6	3	Human	8.0	pKi	=	8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		10808965	100331	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	367	3	1	3	4.8	CCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		CHEMBL289436	100331	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	367	3	1	3	4.8	CCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		46230098	199329	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
		CHEMBL590580	199329	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
		18931422	207392	0	None	-50	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	435	8	2	5	3.4	COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		CHEMBL93862	207392	0	None	-50	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	435	8	2	5	3.4	COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		10740494	35139	0	None	-12	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL14345	35139	0	None	-12	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		10764263	40886	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccncc3)c1)CC2	10.1021/jm990388c
		CHEMBL14863	40886	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccncc3)c1)CC2	10.1021/jm990388c
		10740495	98629	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)nc1)CC2	10.1021/jm990388c
		CHEMBL277111	98629	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)nc1)CC2	10.1021/jm990388c
		122178705	121371	0	None	2	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3581250	121371	0	None	2	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		59395105	106340	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
		CHEMBL3092755	106340	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
		CHEMBL3139187	106340	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
		118729272	120710	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402680	120710	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547158	120710	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
		44214724	194986	0	None	-19	3	Human	8.0	pKi	=	8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cnccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL54707	194986	0	None	-19	3	Human	8.0	pKi	=	8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cnccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		5	139	72	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		5202	139	72	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		CHEMBL39	139	72	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		DB08839	139	72	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		24841480	183899	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	183899	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		193	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
		3644637	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
		CHEMBL14563	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
		194	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
		443391	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
		CHEMBL14460	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
		193	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
		3644637	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
		CHEMBL14563	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
		194	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
		443391	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
		CHEMBL14460	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
		CHEMBL5285512	194299	0	None	1	3	Human	7.0	pKi	=	7	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	327	2	1	3	4.9	COc1ccc2[nH]c3c(-c4cn(C)c5ccccc45)nccc3c2c1	10.1021/acs.jmedchem.0c01887
		193	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
		3644637	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
		CHEMBL14563	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
		194	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
		443391	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
		CHEMBL14460	3507	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
		44298230	194602	0	None	-79	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	492	3	1	4	6.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL53152	194602	0	None	-79	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	492	3	1	4	6.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
		44298022	195558	0	None	-63	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	5	1	4	5.8	CCCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL55472	195558	0	None	-63	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	5	1	4	5.8	CCCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		18931133	168031	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	465	9	2	6	3.4	COc1cc(OC)c(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		CHEMBL432217	168031	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	465	9	2	6	3.4	COc1cc(OC)c(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		145977338	163717	0	None	19	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
		CHEMBL4205064	163717	0	None	19	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
		145963830	164123	0	None	7	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
		CHEMBL4209942	164123	0	None	7	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
		193	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
		3644637	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
		CHEMBL14563	3506	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
		11419526	88056	0	None	-100	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3ccc(Cl)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234533	88056	0	None	-100	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3ccc(Cl)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		16215237	88175	0	None	-39	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(Cl)c(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234738	88175	0	None	-39	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(Cl)c(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		10503674	98825	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3c(F)cccc3F)c1)CC2	10.1021/jm990388c
		CHEMBL278685	98825	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3c(F)cccc3F)c1)CC2	10.1021/jm990388c
		9813197	96535	6	None	-11	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	1	1	2.7	Clc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		CHEMBL262862	96535	6	None	-11	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	1	1	2.7	Clc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		25122651	200249	0	None	-23	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm901674f
		CHEMBL597002	200249	0	None	-23	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm901674f
		67268994	163968	2	None	-3	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207884	163968	2	None	-3	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		44298108	100924	0	None	-39	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL293937	100924	0	None	-39	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		44298092	101969	0	None	-19	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	400	4	1	5	4.7	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccs3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL301409	101969	0	None	-19	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	400	4	1	5	4.7	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccs3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		162663486	181999	0	None	-	1	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2cccc(C(F)(F)F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		CHEMBL4780527	181999	0	None	-	1	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2cccc(C(F)(F)F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		162672422	183181	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
		CHEMBL4795598	183181	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
		24888181	80124	0	None	-158	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL213272	80124	0	None	-158	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		24887525	80369	1	None	-199	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL214398	80369	1	None	-199	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		9888494	98171	0	None	-446	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determinedBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determined	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL273921	98171	0	None	-446	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determinedBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determined	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		11168182	3534	25	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		264	3534	25	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		CHEMBL1181770	3534	25	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		6918648	101559	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
		CHEMBL29846	101559	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
		145972374	164674	0	None	-3	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		CHEMBL4216860	164674	0	None	-3	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		136054961	57319	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
		CHEMBL1651091	57319	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
		153287535	174900	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	0	1	3	2.0	CN1CC[C@H]2c3ccc(O)cc3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		CHEMBL4564308	174900	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	0	1	3	2.0	CN1CC[C@H]2c3ccc(O)cc3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		23462894	157231	3	None	-15	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	240	1	0	3	2.3	CN1CCc2ccc([N+](=O)[O-])c(Cl)c2CC1	10.1016/j.bmc.2007.12.009
		CHEMBL407636	157231	3	None	-15	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	240	1	0	3	2.3	CN1CCc2ccc([N+](=O)[O-])c(Cl)c2CC1	10.1016/j.bmc.2007.12.009
		9934284	90296	0	None	-2511	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238520	90296	0	None	-2511	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		76325517	105732	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	272	3	1	4	3.3	O=c1cc(CCc2cccs2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		CHEMBL3126302	105732	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	272	3	1	4	3.3	O=c1cc(CCc2cccs2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		118278480	122011	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2ccc(O)cc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		CHEMBL3593950	122011	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2ccc(O)cc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		44453877	155616	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	305	2	1	3	3.6	Fc1ccc(-c2nc(-c3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL404582	155616	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	305	2	1	3	3.6	Fc1ccc(-c2nc(-c3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		44298151	100865	0	None	-31	2	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Cl)ccc21	10.1016/s0960-894x(00)00365-6
		CHEMBL293597	100865	0	None	-31	2	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Cl)ccc21	10.1016/s0960-894x(00)00365-6
		44298158	193974	0	None	-12	3	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2c(Cl)cccc21	10.1016/s0960-894x(00)00365-6
		CHEMBL52783	193974	0	None	-12	3	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2c(Cl)cccc21	10.1016/s0960-894x(00)00365-6
		6918648	101559	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
		CHEMBL29846	101559	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
		3233	3512	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		3247	3512	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		6604889	3512	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		CHEMBL282199	3512	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		DB13988	3512	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		16063047	95383	0	None	-77	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL256811	95383	0	None	-77	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCCC3)cc1	10.1016/j.bmcl.2008.01.090
		122483292	138111	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764335	138111	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765876	138111	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		141	1427	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
		6089	1427	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
		CHEMBL12420	1427	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
		DB01488	1427	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
		136054961	57319	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/np100588c
		CHEMBL1651091	57319	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/np100588c
		73213196	104460	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		CHEMBL3104093	104460	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		73213196	104460	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	104460	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		73213196	104460	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	104460	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		142601343	185603	0	None	-36	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863868	185603	0	None	-36	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		71455083	81830	0	None	-173	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		CHEMBL2164354	81830	0	None	-173	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		2520	204008	70	None	-4	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL1280	204008	70	None	-4	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL6966	204008	70	None	-4	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		118055295	178072	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	242	0	1	2	2.2	FC(F)(F)c1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4647417	178072	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	242	0	1	2	2.2	FC(F)(F)c1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		11324968	91085	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397880	91085	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		168285382	191520	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5194057	191520	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		44582707	186998	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490634	186998	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		13091359	113539	0	None	-1479	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321790	113539	0	None	-1479	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		53251189	130894	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2B	ChEMBL	452	5	3	7	5.1	Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1	10.6019/CHEMBL5212743
		CHEMBL3685796	130894	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2B	ChEMBL	452	5	3	7	5.1	Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1	10.6019/CHEMBL5212743
		135367405	164196	0	None	-2	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4210782	164196	0	None	-2	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		122179556	121488	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2B	ChEMBL	303	2	0	3	4.5	FC(F)(F)c1ccc2c(c1)nc(-c1cccnc1)n2C1CC1	10.6019/CHEMBL5212743
		CHEMBL3582461	121488	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2B	ChEMBL	303	2	0	3	4.5	FC(F)(F)c1ccc2c(c1)nc(-c1cccnc1)n2C1CC1	10.6019/CHEMBL5212743
		15560577	185341	9	None	1	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL4859858	185341	9	None	1	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		123683	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
		422	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
		CHEMBL119709	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
		DB05511	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
		123683	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		422	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		CHEMBL119709	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		DB05511	3121	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		16115652	83491	0	None	-27	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL220211	83491	0	None	-27	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		71061724	145552	0	None	1	5	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
		CHEMBL3915107	145552	0	None	1	5	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
		10660	14416	58	None	-29	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	-29	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		134138168	147691	0	None	1	10	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		CHEMBL3931889	147691	0	None	1	10	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		44397832	123109	0	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	256	0	1	2	2.4	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N12	10.1016/j.bmcl.2005.05.074
		CHEMBL361079	123109	0	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	256	0	1	2	2.4	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N12	10.1016/j.bmcl.2005.05.074
		118706287	120531	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310114	120531	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545466	120531	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
		10131066	21603	0	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	2	1	3	2.4	CC(N)Cc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL131736	21603	0	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	2	1	3	2.4	CC(N)Cc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL5286886	194361	0	None	7	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	6	4	8	1.4	OC[C@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1039/D1MD00167A
		134141831	146687	0	None	2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3923870	146687	0	None	2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		45486902	196946	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
		CHEMBL566396	196946	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
		118729270	120702	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402678	120702	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547139	120702	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
		145965628	164047	0	None	-4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4208914	164047	0	None	-4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		146025727	171685	0	None	-40	27	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	171685	0	None	-40	27	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		132060743	162236	0	None	-4	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4163428	162236	0	None	-4	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		10541003	103119	0	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@H]3CO2	10.1021/jm980076u
		CHEMBL307770	103119	0	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@H]3CO2	10.1021/jm980076u
		136118640	76318	0	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058700	76318	0	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
		21044391	76631	0	None	-21	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	2	4	0.3	C[C@@H]1CNC[C@H]2Cc3ccc(CO)nc3N12	10.1016/j.bmcl.2005.11.083
		CHEMBL206386	76631	0	None	-21	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	2	4	0.3	C[C@@H]1CNC[C@H]2Cc3ccc(CO)nc3N12	10.1016/j.bmcl.2005.11.083
		2333	142335	97	None	1	2	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
		CHEMBL388590	142335	97	None	1	2	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
		11313985	91083	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397878	91083	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		18715561	73044	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201062	73044	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
		46914774	15442	0	None	21	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		CHEMBL1215037	15442	0	None	21	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		16115269	138129	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
		CHEMBL376676	138129	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
		21786603	134863	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	259	3	2	3	1.7	CN1CCN(CCc2c[nH]c3cccc(O)c23)CC1	10.1016/j.bmcl.2005.06.104
		CHEMBL371899	134863	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	259	3	2	3	1.7	CN1CCN(CCc2c[nH]c3cccc(O)c23)CC1	10.1016/j.bmcl.2005.06.104
		127051592	140878	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818710	140878	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819742	140878	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		2771	195017	74	None	1	27	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL1200781	195017	74	None	1	27	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL549	195017	74	None	1	27	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		127051592	140878	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818710	140878	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819742	140878	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		104903	56344	17	None	-4	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
		CHEMBL1630578	56344	17	None	-4	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
		58911534	91109	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397904	91109	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		2723	154046	108	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
		CHEMBL398440	154046	108	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
		1379258	67795	13	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
		CHEMBL1909050	67795	13	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
		16754	85574	50	None	-2	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL228082	85574	50	None	-2	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		5	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
		5202	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
		CHEMBL39	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
		DB08839	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
		CHEMBL5081379	214746	0	None	-1	9	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		58405183	110697	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
		CHEMBL3260336	110697	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
		11380477	179682	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4743582	179682	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		5	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		5202	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		CHEMBL39	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		DB08839	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
		10198431	73905	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201930	73905	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		189	3492	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
		5163	3492	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
		CHEMBL297784	3492	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
		11625624	113088	0	None	-17	7	Human	7.9	pKi	=	7.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	406	4	4	8	0.9	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL331291	113088	0	None	-17	7	Human	7.9	pKi	=	7.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	406	4	4	8	0.9	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		189	3492	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
		5163	3492	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
		CHEMBL297784	3492	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
		10741816	98190	0	None	-5	3	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3c(C)ccnc3C)c1)CC2	10.1021/jm990388c
		CHEMBL274066	98190	0	None	-5	3	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3c(C)ccnc3C)c1)CC2	10.1021/jm990388c
		10549658	98283	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3ccncc3)cc1)CC2	10.1021/jm990388c
		CHEMBL274692	98283	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3ccncc3)cc1)CC2	10.1021/jm990388c
		18475509	101947	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	3	3.9	CN1CCc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
		CHEMBL301209	101947	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	3	3.9	CN1CCc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
		191	3498	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
		443389	3498	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
		CHEMBL276140	3498	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
		44298172	101771	0	None	-6	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cncnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL299938	101771	0	None	-6	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cncnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		44298163	195401	0	None	-25	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL55207	195401	0	None	-25	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
		191	3498	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
		443389	3498	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
		CHEMBL276140	3498	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
		9887537	84345	43	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
		CHEMBL221692	84345	43	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
		CHEMBL4751170	84345	43	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
		44298246	195609	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	397	4	1	5	4.0	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL55597	195609	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	397	4	1	5	4.0	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
		56658155	65663	0	None	13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccccc1CCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834252	65663	0	None	13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccccc1CCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
		145972796	164596	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
		CHEMBL4215741	164596	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
		71212556	143562	0	None	-24	6	Human	6.9	pKi	=	6.9	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		CHEMBL3899169	143562	0	None	-24	6	Human	6.9	pKi	=	6.9	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		155561439	175666	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	411	4	4	7	3.5	Oc1ccc(CCNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)cc1O	10.1039/C8MD00317C
		CHEMBL4581568	175666	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	411	4	4	7	3.5	Oc1ccc(CCNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)cc1O	10.1039/C8MD00317C
		44404899	70432	2	None	-70	4	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	190	2	2	2	1.9	CN(C)Cc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL194588	70432	2	None	-70	4	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	190	2	2	2	1.9	CN(C)Cc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		44404904	133011	1	None	-11	3	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	2	1	3	1.9	CN(C)Cc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL370221	133011	1	None	-11	3	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	2	1	3	1.9	CN(C)Cc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		127050699	140872	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819082	140872	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819726	140872	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		117209918	186410	1	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4876036	186410	1	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		135508617 136016503	10630	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL1170237	10630	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
		9869628	72043	0	None	-199	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	440	7	0	4	4.8	COc1cc2c(cc1OCCN1CCCCC1)N(C(=O)/C=C/c1ccccc1Cl)CC2	10.1016/j.bmcl.2005.08.004
		CHEMBL197630	72043	0	None	-199	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	440	7	0	4	4.8	COc1cc2c(cc1OCCN1CCCCC1)N(C(=O)/C=C/c1ccccc1Cl)CC2	10.1016/j.bmcl.2005.08.004
		10127968	72219	0	None	-15	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	479	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL198109	72219	0	None	-15	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	479	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
		10479409	78063	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(C2=CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL210007	78063	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(C2=CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		49850874	56462	0	None	-398	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632210	56462	0	None	-398	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		44298243	100662	0	None	-100	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
		CHEMBL292228	100662	0	None	-100	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
		44298254	194535	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	442	4	1	4	5.8	CCc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL52919	194535	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	442	4	1	4	5.8	CCc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		22619858	199074	1	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL58765	199074	1	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
		18931348	104741	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	389	8	2	6	1.7	COc1ccc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)c1	10.1016/S0960-894X(96)00503-3
		CHEMBL310656	104741	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	389	8	2	6	1.7	COc1ccc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)c1	10.1016/S0960-894X(96)00503-3
		44324011	111611	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	562	11	3	8	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(F)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL328375	111611	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	562	11	3	8	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(F)cc1	10.1016/S0960-894X(96)00503-3
		148302367	173521	0	None	15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	2	1	2	4.0	CC[C@H]1c2cc(-c3ccccc3)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4530979	173521	0	None	15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	2	1	2	4.0	CC[C@H]1c2cc(-c3ccccc3)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		149396365	176004	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	295	3	1	3	3.5	C[C@@]12COc3cc(OCc4ccccc4)ccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4589450	176004	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	295	3	1	3	3.5	C[C@@]12COc3cc(OCc4ccccc4)ccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		44430976	88041	0	None	-50	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCC(C)C1	10.1016/j.bmcl.2006.10.029
		CHEMBL234492	88041	0	None	-50	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCC(C)C1	10.1016/j.bmcl.2006.10.029
		11236301	88054	0	None	-63	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	450	6	0	4	4.9	COc1ccc(N2Cc3c(F)c(F)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234531	88054	0	None	-63	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	450	6	0	4	4.9	COc1ccc(N2Cc3c(F)c(F)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		11475519	152075	0	None	-79	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	414	6	0	4	4.6	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL396747	152075	0	None	-79	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	414	6	0	4	4.6	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		44430979	153192	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.8	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1[C@@H](C)CCC[C@H]1C	10.1016/j.bmcl.2006.10.029
		CHEMBL397709	153192	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.8	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1[C@@H](C)CCC[C@H]1C	10.1016/j.bmcl.2006.10.029
		162654275	180680	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
		CHEMBL4755344	180680	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
		10287730	3536	40	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		77	3536	40	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		CHEMBL425190	3536	40	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		10217208	72213	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3cccc(Cl)c3Cl)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL198097	72213	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3cccc(Cl)c3Cl)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		44404608	72252	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	346	6	1	4	2.7	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCO	10.1016/j.bmcl.2005.08.004
		CHEMBL198192	72252	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	346	6	1	4	2.7	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCO	10.1016/j.bmcl.2005.08.004
		10309622	141374	0	None	-1000	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	395	7	0	4	4.0	COc1ccc(N2CCN(c3ccccc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL383800	141374	0	None	-1000	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	395	7	0	4	4.0	COc1ccc(N2CCN(c3ccccc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		44414209	81236	0	None	-398	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	424	7	0	4	4.4	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		CHEMBL215864	81236	0	None	-398	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	424	7	0	4	4.4	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		9891002	107408	0	None	-1258	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligandBinding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
		CHEMBL318018	107408	0	None	-1258	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligandBinding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
		11304596	56396	0	None	-7943	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631542	56396	0	None	-7943	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		9827938	11771	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		CHEMBL1181680	11771	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		CHEMBL188486	11771	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		2470	3653	50	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
		3300	3653	50	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
		5265	3653	50	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
		99	3653	50	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
		CHEMBL267930	3653	50	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
		10008294	206827	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	574	12	3	9	2.5	COc1ccc(S(=O)(=O)Nc2cc(C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O)c(OC)cc2OC)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL90467	206827	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	574	12	3	9	2.5	COc1ccc(S(=O)(=O)Nc2cc(C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O)c(OC)cc2OC)cc1	10.1016/S0960-894X(96)00503-3
		10371119	207007	0	None	-794	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	8	3.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL91454	207007	0	None	-794	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	8	3.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/S0960-894X(96)00503-3
		127050699	140872	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819082	140872	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819726	140872	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		122182283	122010	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2cccc(O)c2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		CHEMBL3593949	122010	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2cccc(O)c2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		9935387	99442	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL282971	99442	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
		9913554	100992	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL29433	100992	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
		136030693	57320	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/np100588c
		CHEMBL1651092	57320	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/np100588c
		13149	2545	36	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
		3034396	2545	36	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL299031	2545	36	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
		1201549	597	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		118055293	177245	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	252	0	1	2	1.9	Brc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4635854	177245	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	252	0	1	2	1.9	Brc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		58911604	91106	1	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397901	91106	1	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		135846982	93055	0	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cc(Br)ccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2442268	93055	0	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cc(Br)ccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		5510	205852	100	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
		CHEMBL83668	205852	100	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
		135846955	189483	4	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)N/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL513803	189483	4	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)N/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
		4122	207625	108	None	-3	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
		CHEMBL9514	207625	108	None	-3	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
		71682216	91114	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	260	3	1	3	1.4	CCCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397909	91114	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	260	3	1	3	1.4	CCCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL4754103	214039	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000328a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000328a HTR2B	ChEMBL		None	None	None		CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O	10.6019/CHEMBL5212743
		92042876	151336	0	None	-2	10	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL3961059	151336	0	None	-2	10	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		9920815	67249	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL188033	67249	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		5	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
		5202	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
		CHEMBL39	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
		DB08839	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
		152	364	29	None	1	18	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
		2107	364	29	None	1	18	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
		CHEMBL275854	364	29	None	1	18	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
		24826790	91094	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397889	91094	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		46230095	199291	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	271	0	2	3	1.2	O=C1NC2CNCCN2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2009.12.014
		CHEMBL590333	199291	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	271	0	2	3	1.2	O=C1NC2CNCCN2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2009.12.014
		127048336	140605	1	None	5	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2I)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3813855	140605	1	None	5	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2I)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		5	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
		5202	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
		CHEMBL39	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
		DB08839	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
		152	364	29	None	1	18	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
		2107	364	29	None	1	18	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
		CHEMBL275854	364	29	None	1	18	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
		9856041	24114	3	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL133868	24114	3	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		5	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
		5202	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
		CHEMBL39	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
		DB08839	139	72	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
		156013985	177175	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter methodDisplacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
		CHEMBL4634785	177175	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter methodDisplacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
		45486824	197377	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
		CHEMBL569251	197377	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
		CHEMBL5094234	215573	0	None	-61	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096019	215573	0	None	-61	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5090884	215577	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096072	215577	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		24771120	184100	0	None	-56	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
		CHEMBL482562	184100	0	None	-56	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
		136020618	163914	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4207302	163914	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		135753074	191108	9	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
		CHEMBL5187824	191108	9	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
		136030693	57320	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
		CHEMBL1651092	57320	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
		11739217	137040	0	None	-8	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL374660	137040	0	None	-8	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		16063039	155615	0	None	-147	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCCNC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL404581	155615	0	None	-147	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCCNC3)cc1	10.1016/j.bmcl.2008.01.090
		1353	1911	93	None	-295	83	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-295	83	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-295	83	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-295	83	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-295	83	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL4537673	213989	29	None	-	1	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000305b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000305b HTR2B	ChEMBL		None	None	None		C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(N(C)C)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1	10.6019/CHEMBL5212743
		44409332	76730	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL206618	76730	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		162661262	181852	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	432	6	4	7	2.7	OC[C@@]12C[C@@H]1[C@@H](n1ccc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1016/j.bmcl.2020.127599
		CHEMBL4778636	181852	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	432	6	4	7	2.7	OC[C@@]12C[C@@H]1[C@@H](n1ccc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1016/j.bmcl.2020.127599
		1016	3747	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		71061585	160497	0	None	3	2	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	367	6	0	5	2.8	Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
		CHEMBL4112090	160497	0	None	3	2	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	367	6	0	5	2.8	Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
		CHEMBL1909069	209076	0	None	-1	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL		None	None	None		None	nan
		117209971	186485	1	None	-26	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4877051	186485	1	None	-26	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		1343	1889	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		3519	1889	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		522	1889	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		CHEMBL862	1889	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		DB01018	1889	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		CHEMBL4780458	214048	0	None	-5	4	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000540a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000540a HTR2B	ChEMBL		None	None	None		O=C(Nc1cccnn1)N1CC(C/C=C/c2cncc(Oc3ccc(C(F)(F)F)cn3)n2)C1	10.6019/CHEMBL5212743
		58911681	90985	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
		CHEMBL2396668	90985	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
		136118639	76317	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058699	76317	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		2337	3256	77	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		71455625	82964	0	None	-3388	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
		CHEMBL2181170	82964	0	None	-3388	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
		44407398	74418	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
		CHEMBL202616	74418	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
		136030596	57318	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/np100588c
		CHEMBL1651090	57318	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/np100588c
		168277287	190150	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	426	7	2	3	7.8	CCCC(CCC)c1nc2c(Nc3ccc(Cl)c(Cl)c3)nc3ccccc3c2[nH]1	10.1021/acs.jmedchem.2c01170
		CHEMBL5173661	190150	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	426	7	2	3	7.8	CCCC(CCC)c1nc2c(Nc3ccc(Cl)c(Cl)c3)nc3ccccc3c2[nH]1	10.1021/acs.jmedchem.2c01170
		25123011	201193	0	None	-74	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccc5ccccc5c4)c3c2)CC1	10.1021/jm901674f
		CHEMBL603483	201193	0	None	-74	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccc5ccccc5c4)c3c2)CC1	10.1021/jm901674f
		46230046	199247	0	None	14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
		CHEMBL590077	199247	0	None	14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
		135846958	76245	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
		CHEMBL2058408	76245	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
		18715555	74375	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
		CHEMBL202458	74375	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
		168286940	192281	0	None	-691	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysisDisplacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysis	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
		CHEMBL5205903	192281	0	None	-691	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysisDisplacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysis	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
		76518514	113537	0	None	-147	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321788	113537	0	None	-147	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		58911582	91099	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397894	91099	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		59012632	87738	0	None	91	2	Human	7.9	pKi	=	7.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	388	2	1	3	4.6	COc1ccc(-c2cc3c4c(c2)[C@@H]2CNCC[C@@H]2N4CCC3)c(C(F)(F)F)c1	10.1016/j.bmcl.2012.10.091
		CHEMBL2337102	87738	0	None	91	2	Human	7.9	pKi	=	7.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	388	2	1	3	4.6	COc1ccc(-c2cc3c4c(c2)[C@@H]2CNCC[C@@H]2N4CCC3)c(C(F)(F)F)c1	10.1016/j.bmcl.2012.10.091
		127051482	140654	1	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccc(F)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3814737	140654	1	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccc(F)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		127050282	140673	1	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2cccc(Br)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3815066	140673	1	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2cccc(Br)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		10353268	97770	1	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL27173	97770	1	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		24893978	1010	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
		8872	1010	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
		CHEMBL495075	1010	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
		10176869	166027	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@@H]1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL425545	166027	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@@H]1C2	10.1016/j.bmcl.2005.05.074
		11595191	89060	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337488	89060	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2364960	89060	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		854531	152994	30	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	244	1	1	1	4.4	c1ccc(-c2nccc3c2[nH]c2ccccc23)cc1	10.1021/acs.jmedchem.0c01887
		CHEMBL3975325	152994	30	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	244	1	1	1	4.4	c1ccc(-c2nccc3c2[nH]c2ccccc23)cc1	10.1021/acs.jmedchem.0c01887
		145978819	163881	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2cccs2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4206939	163881	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2cccs2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		145975226	163933	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		CHEMBL4207529	163933	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		145976983	164006	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4208376	164006	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		136030596	57318	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
		CHEMBL1651090	57318	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
		44537940	18774	0	None	-18	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	482	5	1	6	4.5	O=S(=O)(c1cccc2ccccc12)c1nn(Cc2ccccc2)c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
		CHEMBL1278001	18774	0	None	-18	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	482	5	1	6	4.5	O=S(=O)(c1cccc2ccccc12)c1nn(Cc2ccccc2)c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
		16115513	136402	0	None	-23	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		CHEMBL373531	136402	0	None	-23	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		136118732	76246	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2c(Br)cccc12	10.1016/j.bmc.2013.09.011
		CHEMBL2058409	76246	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2c(Br)cccc12	10.1016/j.bmc.2013.09.011
		122187383	123030	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(CC1CC1)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3609148	123030	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(CC1CC1)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		72549033	110693	0	None	-660	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometryDisplacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometry	ChEMBL	367	3	0	5	3.3	CN1CCC(c2cccc3cc(S(=O)(=O)c4ccccn4)cnc23)CC1	10.1021/ml500045k
		CHEMBL3260311	110693	0	None	-660	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometryDisplacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometry	ChEMBL	367	3	0	5	3.3	CN1CCC(c2cccc3cc(S(=O)(=O)c4ccccn4)cnc23)CC1	10.1021/ml500045k
		155536080	172114	0	None	2	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4472703	172114	0	None	2	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		142601333	185763	0	None	-63	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4866412	185763	0	None	-63	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		71062646	149543	0	None	-2398	12	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		CHEMBL3946661	149543	0	None	-2398	12	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		56675412	65666	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	334	6	0	3	4.2	c1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834255	65666	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	334	6	0	3	4.2	c1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		134141050	147304	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.4	O=C(O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3928983	147304	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.4	O=C(O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		21302483	87739	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	246	0	1	3	2.4	c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCCS2	10.1016/j.bmcl.2012.10.091
		CHEMBL2337103	87739	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	246	0	1	3	2.4	c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCCS2	10.1016/j.bmcl.2012.10.091
		CHEMBL5094680	215510	0	None	3	8	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		46914487	15410	0	None	144	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		CHEMBL1214830	15410	0	None	144	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		CHEMBL5288004	194404	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1039/D1MD00167A
		71461603	78538	1	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
		CHEMBL2112055	78538	1	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
		2585	803	103	None	-18	21	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	803	103	None	-18	21	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	803	103	None	-18	21	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	803	103	None	-18	21	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	803	103	None	-18	21	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		2389	3331	118	None	-66	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-66	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-66	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-66	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-66	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		135520431	72609	9	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
		CHEMBL199385	72609	9	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
		24873257	180256	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4750414	180256	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		168274008	190196	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5174366	190196	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		134143752	150649	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3955519	150649	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		134143752	150649	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL3955519	150649	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		24824726	161109	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4060529	161109	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4117079	161109	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5282336	161109	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286389	161109	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		10550406	31953	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3C)c1)CC2	10.1021/jm990388c
		CHEMBL14076	31953	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3C)c1)CC2	10.1021/jm990388c
		10718089	98556	0	None	-31	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	443	4	1	4	5.4	COc1ccc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc1-c1cccnc1	10.1021/jm990388c
		CHEMBL276571	98556	0	None	-31	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	443	4	1	4	5.4	COc1ccc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc1-c1cccnc1	10.1021/jm990388c
		10767350	99042	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	489	4	1	3	7.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL280297	99042	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	489	4	1	3	7.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		18475610	196796	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	327	3	2	3	4.5	COc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1Cl	10.1016/s0960-894x(01)00343-2
		CHEMBL56557	196796	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	327	3	2	3	4.5	COc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1Cl	10.1016/s0960-894x(01)00343-2
		10714852	163150	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	381	4	1	3	5.2	CCCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		CHEMBL41792	163150	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	381	4	1	3	5.2	CCCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		44298082	194964	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ncccc3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL54484	194964	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ncccc3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
		118055289	177899	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.7	Cc1cc2c3c(c1Cl)C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4644872	177899	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.7	Cc1cc2c3c(c1Cl)C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
		10421236	188733	1	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	226	1	3	4	1.9	Nc1nccc(-c2c[nH]c3cccc(O)c23)n1	10.1016/j.bmc.2011.08.033
		CHEMBL50498	188733	1	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	226	1	3	4	1.9	Nc1nccc(-c2c[nH]c3cccc(O)c23)n1	10.1016/j.bmc.2011.08.033
		135367857	164604	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4215875	164604	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL5280298	194059	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	294	1	1	1	5.5	c1ccc2cc(-c3nccc4c3[nH]c3ccccc34)ccc2c1	10.1021/acs.jmedchem.0c01887
		145967795	164823	0	None	5	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4218679	164823	0	None	5	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		136259032	164640	17	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	205	2	1	4	2.3	O=Cc1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
		CHEMBL4216337	164640	17	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	205	2	1	4	2.3	O=Cc1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
		CHEMBL4802045	214059	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
		732268	138296	33	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
		CHEMBL3770837	138296	33	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
		127051843	140751	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818200	140751	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		1222	1664	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
		3396	1664	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
		85	1664	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
		CHEMBL46516	1664	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
		DB04842	1664	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
		CHEMBL4802045	214059	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
		2398	954	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		127051843	140751	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818200	140751	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		155543832	173211	0	None	-134	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	451	6	3	7	3.4	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL4522864	173211	0	None	-134	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	451	6	3	7	3.4	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		11952353	199860	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
		CHEMBL594469	199860	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
		168274751	190638	0	None	2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5181312	190638	0	None	2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		11302765	84248	4	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL221113	84248	4	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		10235	2674	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
		137553161	2674	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
		CHEMBL4470080	2674	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
		CHEMBL4545807	213994	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000748a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000748a HTR2B	ChEMBL		None	None	None		Cn1c(-c2csc(C3CCN(CC4=NC5N=CC=CC5N4)CC3)n2)nc2ccccc21	10.6019/CHEMBL5212743
		56645363	121490	12	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
		CHEMBL3582478	121490	12	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
		136118650	76323	0	None	6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058705	76323	0	None	6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
		44581972	175600	0	None	-5	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL458001	175600	0	None	-5	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		136020620	57324	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	219	2	1	4	2.6	Cc1sc(-c2ccccc2O)nc1C=O	10.1021/np100588c
		CHEMBL1651096	57324	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	219	2	1	4	2.6	Cc1sc(-c2ccccc2O)nc1C=O	10.1021/np100588c
		142601325	185869	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4868035	185869	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		16117151	60087	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1642882	60087	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1739102	60087	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		25263297	184337	0	None	-19	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
		CHEMBL484345	184337	0	None	-19	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
		53483975	65614	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		CHEMBL1833977	65614	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		1605	2342	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		3957	2342	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		7216	2342	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		CHEMBL998	2342	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		DB00455	2342	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		168282554	190866	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OC(C)C)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL5184659	190866	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OC(C)C)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		155530292	171494	0	None	-3548	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	458	5	4	8	1.6	O=C(NC1CC1)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL4463802	171494	0	None	-3548	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	458	5	4	8	1.6	O=C(NC1CC1)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		10151289	133583	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	434	6	0	4	4.7	O=C1N(c2ccc(OCCN3CCCCC3)nc2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2005.08.004
		CHEMBL371211	133583	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	434	6	0	4	4.7	O=C1N(c2ccc(OCCN3CCCCC3)nc2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2005.08.004
		49850872	56458	0	None	-630	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632206	56458	0	None	-630	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		10830245	101424	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	329	1	1	2	4.6	CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		CHEMBL297445	101424	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	329	1	1	2	4.6	CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		10408409	193163	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL52308	193163	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
		44298226	196485	0	None	-100	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	378	3	1	4	4.6	Cc1cc2c(cc1F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL56336	196485	0	None	-100	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	378	3	1	4	4.6	Cc1cc2c(cc1F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		153287542	169534	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4435237	169534	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		11237290	87957	0	None	-199	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	458	6	0	4	4.7	COc1ccc(N2Cc3cccc(Br)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234109	87957	0	None	-199	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	458	6	0	4	4.7	COc1ccc(N2Cc3cccc(Br)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		10413268	152667	0	None	-31	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	453	6	0	5	4.9	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
		CHEMBL397259	152667	0	None	-31	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	453	6	0	5	4.9	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
		44420682	137608	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
		CHEMBL375642	137608	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
		162647275	179562	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
		CHEMBL4741776	179562	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
		10150393	71909	0	None	-398	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	373	7	0	4	3.2	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN(C)C	10.1016/j.bmcl.2005.08.004
		CHEMBL197170	71909	0	None	-398	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	373	7	0	4	3.2	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN(C)C	10.1016/j.bmcl.2005.08.004
		10479309	79747	0	None	-79	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	458	8	0	5	4.7	COc1ccc(N2CCC(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1Cl	10.1016/j.bmcl.2006.05.034
		CHEMBL211719	79747	0	None	-79	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	458	8	0	5	4.7	COc1ccc(N2CCC(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1Cl	10.1016/j.bmcl.2006.05.034
		44414217	80143	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	516	7	0	4	6.3	O=C1C(c2ccc(Cl)c(Cl)c2)CCN1c1ccc(OC(F)(F)F)c(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.05.034
		CHEMBL213368	80143	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	516	7	0	4	6.3	O=C1C(c2ccc(Cl)c(Cl)c2)CCN1c1ccc(OC(F)(F)F)c(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.05.034
		24887284	141746	0	None	-125	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL385921	141746	0	None	-125	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		24888183	141819	0	None	-1000	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	420	7	0	4	4.5	COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		CHEMBL386332	141819	0	None	-1000	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	420	7	0	4	4.5	COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		10296414	3531	15	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		76	3531	15	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		CHEMBL183460	3531	15	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		11248705	90295	0	None	-630	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238519	90295	0	None	-630	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		91826739	122013	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	4	1	4	3.2	O=c1cc(COCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		CHEMBL3593952	122013	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	4	1	4	3.2	O=c1cc(COCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		168271856	190561	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5180016	190561	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		44572166	12460	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
		CHEMBL1186133	12460	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
		CHEMBL451232	12460	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
		44572751	12499	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
		CHEMBL1186509	12499	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
		CHEMBL467736	12499	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
		127026052	137553	0	None	4	19	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754496	137553	0	None	4	19	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		145989551	167138	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	297	3	0	2	4.1	CN(C)CC/C=C1\c2ccc(F)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
		CHEMBL4290607	167138	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	297	3	0	2	4.1	CN(C)CC/C=C1\c2ccc(F)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
		70687202	77978	0	None	-10	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
		CHEMBL2096809	77978	0	None	-10	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
		11231392	84894	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		CHEMBL223628	84894	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		11080	29085	79	None	-6	6	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	29085	79	None	-6	6	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		59652086	114592	0	None	-85	2	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2B	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
		CHEMBL3337895	114592	0	None	-85	2	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2B	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
		49865833	16164	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.2	O=C(Nc1ccccc1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224036	16164	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.2	O=C(Nc1ccccc1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		14702424	18564	69	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	176	2	2	2	1.6	COc1ccc2[nH]cc(CN)c2c1	10.1021/jm100600y
		CHEMBL1276050	18564	69	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	176	2	2	2	1.6	COc1ccc2[nH]cc(CN)c2c1	10.1021/jm100600y
		71462776	82963	0	None	-134	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181169	82963	0	None	-134	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
		136118659	76255	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058427	76255	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		21527771	70156	1	None	-645	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940404	70156	1	None	-645	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		134135745	144379	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		CHEMBL3905850	144379	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		134156506	154063	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		CHEMBL3984645	154063	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		58911666	91091	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397886	91091	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
		25120700	81239	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	369	7	1	5	3.0	COc1ccc(N2CCN(CC[C@@H](OC(N)=O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.02.023
		CHEMBL2158704	81239	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	369	7	1	5	3.0	COc1ccc(N2CCN(CC[C@@H](OC(N)=O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.02.023
		45486820	196934	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
		CHEMBL1237149	196934	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
		CHEMBL566356	196934	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
		45279963	80909	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
		CHEMBL2152944	80909	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
		71062768	143736	0	None	-4	4	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3900699	143736	0	None	-4	4	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
		3151	1462	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	1462	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	1462	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	1462	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	1462	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		44409317	141358	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@@H]2Cc3ccc(Br)nc3N21	10.1016/j.bmcl.2005.11.083
		CHEMBL383694	141358	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@@H]2Cc3ccc(Br)nc3N21	10.1016/j.bmcl.2005.11.083
		46884102	8062	1	None	-912	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
		CHEMBL1091106	8062	1	None	-912	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
		135501716	76313	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
		CHEMBL2058695	76313	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
		49783419	17749	0	None	-79	12	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258671	17749	0	None	-79	12	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
		118055288	177036	0	None	-58	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	2	3.0	CC1CN2CCNCc3cc(Cl)c(Cl)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4632473	177036	0	None	-58	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	2	3.0	CC1CN2CCNCc3cc(Cl)c(Cl)c1c32	10.1016/j.bmcl.2019.126929
		25209356	179785	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	544	7	2	8	4.0	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1	10.1021/jm800962k
		CHEMBL474473	179785	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	544	7	2	8	4.0	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1	10.1021/jm800962k
		127051015	140874	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818128	140874	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819731	140874	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		24826957	91117	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397912	91117	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		127049983	140662	1	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(Cl)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3814821	140662	1	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(Cl)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		127037093	136508	0	None	40	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3736252	136508	0	None	40	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		44435193	91225	0	None	1	7	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	331	2	0	2	5.6	CC(C(=O)N1c2ccccc2Sc2ccccc21)c1ccccc1	10.1016/j.bmcl.2013.04.082
		CHEMBL240045	91225	0	None	1	7	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	331	2	0	2	5.6	CC(C(=O)N1c2ccccc2Sc2ccccc21)c1ccccc1	10.1016/j.bmcl.2013.04.082
		CHEMBL5083607	214873	0	None	-14	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		CHEMBL5093342	215564	0	None	-19	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095971	215564	0	None	-19	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		10334023	112882	5	None	1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	283	1	2	1	4.9	c1ccc2c(-c3nccc4c3[nH]c3ccccc34)c[nH]c2c1	10.1021/acs.jmedchem.0c01887
		CHEMBL3309924	112882	5	None	1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	283	1	2	1	4.9	c1ccc2c(-c3nccc4c3[nH]c3ccccc34)c[nH]c2c1	10.1021/acs.jmedchem.0c01887
		CHEMBL5268604	193574	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	299	1	3	2	4.6	Oc1ccc2[nH]c3c(-c4c[nH]c5ccccc45)nccc3c2c1	10.1021/acs.jmedchem.0c01887
		162647063	179648	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	499	6	4	8	1.6	CC(C)[C@@H](Nc1nc(I)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
		CHEMBL4743059	179648	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	499	6	4	8	1.6	CC(C)[C@@H](Nc1nc(I)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
		162646751	179742	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	419	7	4	9	1.7	CSc1nc(N[C@H](C(C)C)C2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@]4(CO)C[C@H]34)c2n1	10.1016/j.bmcl.2020.127599
		CHEMBL4744176	179742	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	419	7	4	9	1.7	CSc1nc(N[C@H](C(C)C)C2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@]4(CO)C[C@H]34)c2n1	10.1016/j.bmcl.2020.127599
		90469115	185842	4	None	-56	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		CHEMBL4867565	185842	4	None	-56	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		67978437	120677	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402657	120677	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547010	120677	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
		44404887	134429	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	340	8	2	4	3.0	CCCCn1cc(CCN(C)C)c2c(OP(=O)(O)O)cccc21	10.1016/j.bmcl.2005.06.104
		CHEMBL371753	134429	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	340	8	2	4	3.0	CCCCn1cc(CCN(C)C)c2c(OP(=O)(O)O)cccc21	10.1016/j.bmcl.2005.06.104
		127051015	140874	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818128	140874	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819731	140874	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		11652359	89128	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2337502	89128	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2365706	89128	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
		45279963	80909	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
		CHEMBL2152944	80909	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
		45279963	80909	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL5212743
		CHEMBL2152944	80909	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL5212743
		46884101	8060	0	None	-87	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	310	6	2	3	2.6	O=C(NCc1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		CHEMBL1091104	8060	0	None	-87	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	310	6	2	3	2.6	O=C(NCc1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		25263302	191984	0	None	-134	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
		CHEMBL520129	191984	0	None	-134	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
		44409290	74651	0	None	-45	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
		CHEMBL203013	74651	0	None	-45	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
		16117279	60136	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		CHEMBL1642886	60136	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		CHEMBL1739606	60136	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		57799326	89108	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337104	89108	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365468	89108	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		145988693	167166	0	None	-7	17	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4291048	167166	0	None	-7	17	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		153287572	173422	0	None	11	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	205	1	1	2	2.6	CC[C@H]1c2cc(C)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4528651	173422	0	None	11	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	205	1	1	2	2.6	CC[C@H]1c2cc(C)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		49865887	16181	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	302	1	1	3	3.0	O=C(NC1CCCCC1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224103	16181	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	302	1	1	3	3.0	O=C(NC1CCCCC1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		1227	2489	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	2489	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	2489	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	2489	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	2489	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	2489	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		118055202	177194	0	None	-12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.5	CC1(C)CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4635105	177194	0	None	-12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.5	CC1(C)CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
		118055282	178014	0	None	-22	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	334	1	1	2	3.4	FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4646572	178014	0	None	-22	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	334	1	1	2	3.4	FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
		157	2069	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
		9840090	2069	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
		CHEMBL134519	2069	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
		46230049	201545	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
		CHEMBL605402	201545	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
		18715564	73380	0	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201454	73380	0	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
		127053028	140642	1	None	8	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(I)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3814559	140642	1	None	8	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(I)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		127049982	140666	1	None	9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2cccc(F)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3815000	140666	1	None	9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2cccc(F)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		16115517	84838	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL223468	84838	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		23151712	120536	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310120	120536	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545471	120536	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		157	2069	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
		9840090	2069	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
		CHEMBL134519	2069	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
		49862237	15007	0	None	-11	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
		CHEMBL1209157	15007	0	None	-11	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
		1524	2181	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		197	2181	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		3822	2181	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		88	2181	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		CHEMBL51	2181	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		DB12465	2181	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
		118055199	177955	0	None	-33	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	1.9	CC1(C)CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4645774	177955	0	None	-33	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	1.9	CC1(C)CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
		44409124	74469	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	214	0	1	4	0.7	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)nc3N12	10.1016/j.bmcl.2005.11.083
		CHEMBL202795	74469	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	214	0	1	4	0.7	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)nc3N12	10.1016/j.bmcl.2005.11.083
		46914777	15443	0	None	18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		CHEMBL1215038	15443	0	None	18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		33630	178957	99	None	-6	28	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL47050	178957	99	None	-6	28	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		44582677	181573	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476838	181573	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		71061729	160943	0	None	-1	4	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL4115493	160943	0	None	-1	4	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		25117679	200604	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
		CHEMBL599263	200604	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
		142601318	185545	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863036	185545	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		134138183	147811	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		CHEMBL3932820	147811	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		155567457	175949	0	None	-158	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	359	2	3	6	2.8	O[C@H]1CCC[C@@H]1Nc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
		CHEMBL4587951	175949	0	None	-158	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	359	2	3	6	2.8	O[C@H]1CCC[C@@H]1Nc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
		46914926	15431	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		CHEMBL1214960	15431	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		11579853	89085	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2337504	89085	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2365200	89085	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		119584	2595	102	None	1	5	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		1848	2595	102	None	1	5	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		242	2595	102	None	1	5	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		CHEMBL60889	2595	102	None	1	5	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		DB11675	2595	102	None	1	5	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		CHEMBL4750687	214037	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000312b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000312b HTR2B	ChEMBL		None	None	None		Cc1ncc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(CC(N)=O)c2cnccc21	10.6019/CHEMBL5212743
		CHEMBL4741904	214032	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000710a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000710a HTR2B	ChEMBL		None	None	None		Cc1ncc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(CC(N)=O)c2ccccc21	10.6019/CHEMBL5212743
		44316027	205522	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
		CHEMBL80862	205522	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
		11658860	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
		2941	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
		4374	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
		CHEMBL360328	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
		DB04871	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
		CHEMBL5074880	214339	0	None	-1	9	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		9899500	67889	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
		CHEMBL191054	67889	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
		11391654	180525	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4753511	180525	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		24873384	182601	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4788223	182601	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		134154065	152361	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3970041	152361	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		11020695	25514	1	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL135076	25514	1	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		879244	28199	8	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
		CHEMBL1373650	28199	8	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
		10791286	35317	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	491	3	1	3	6.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(Br)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL14368	35317	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	491	3	1	3	6.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(Br)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		10526616	39506	0	None	-15	3	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	430	4	1	5	4.9	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3)nc1)CC2	10.1021/jm990388c
		CHEMBL14726	39506	0	None	-15	3	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	430	4	1	5	4.9	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3)nc1)CC2	10.1021/jm990388c
		44298229	101924	0	None	-31	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL301012	101924	0	None	-31	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
		147653864	171561	0	None	19	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4464697	171561	0	None	19	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		153061504	172810	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4513930	172810	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		2389	3331	118	None	-66	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		5073	3331	118	None	-66	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		96	3331	118	None	-66	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		CHEMBL85	3331	118	None	-66	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		DB00734	3331	118	None	-66	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		2267	559	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
		271	559	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
		7121	559	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
		CHEMBL639	559	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
		DB00972	559	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
		44298118	193411	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	5	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL52592	193411	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	5	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		12017599	195784	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	426	4	1	3	5.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(CCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL55784	195784	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	426	4	1	3	5.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(CCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		72698088	103989	0	None	-954	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	421	6	0	4	5.4	Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
		CHEMBL3093187	103989	0	None	-954	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	421	6	0	4	5.4	Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
		11175045	136541	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.9	CC(C)c1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL373695	136541	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.9	CC(C)c1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		135474338	189271	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL511879	189271	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
		54761054	138081	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Positive allosteric modulation of 5-HT2B receptor (unknown origin)Positive allosteric modulation of 5-HT2B receptor (unknown origin)	ChEMBL	367	3	1	5	4.0	Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C	10.1016/j.bmcl.2016.01.021
		CHEMBL3765778	138081	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Positive allosteric modulation of 5-HT2B receptor (unknown origin)Positive allosteric modulation of 5-HT2B receptor (unknown origin)	ChEMBL	367	3	1	5	4.0	Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C	10.1016/j.bmcl.2016.01.021
		134149168	148246	0	None	-2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	297	2	0	2	3.6	CN1CC[C@H]2CC(=O)[C@H](Cc3ccccc3)[C@H]3CCC[C@@H]1[C@H]23	10.1016/j.bmcl.2016.10.065
		CHEMBL3936289	148246	0	None	-2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	297	2	0	2	3.6	CN1CC[C@H]2CC(=O)[C@H](Cc3ccccc3)[C@H]3CCC[C@@H]1[C@H]23	10.1016/j.bmcl.2016.10.065
		11499800	89107	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2337503	89107	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2365465	89107	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		25117680	200635	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	434	4	1	6	4.1	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
		CHEMBL599466	200635	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	434	4	1	6	4.1	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
		155536619	172201	0	None	-75	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	254	3	4	7	-2.3	NC(=O)c1ncn([C@H]2[C@H](O)[C@H](O)[C@]3(CO)C[C@H]23)n1	10.1021/acs.jmedchem.8b01662
		CHEMBL4473739	172201	0	None	-75	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	254	3	4	7	-2.3	NC(=O)c1ncn([C@H]2[C@H](O)[C@H](O)[C@]3(CO)C[C@H]23)n1	10.1021/acs.jmedchem.8b01662
		122178710	121376	0	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		CHEMBL3581255	121376	0	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		11290492	138001	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		CHEMBL376456	138001	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		5318	15576	49	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	15576	49	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	15576	49	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		1531	2266	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		3869	2266	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		7207	2266	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		CHEMBL429	2266	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		DB00598	2266	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
		124	2981	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2032	2981	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		4636	2981	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL762	2981	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		DB00935	2981	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		11416698	91107	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397902	91107	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		73349359	92543	0	None	-2	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2432051	92543	0	None	-2	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
		44582708	186838	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		CHEMBL489408	186838	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		3191	102858	97	None	-7	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-7	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		44414251	78073	0	None	-158	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	470	7	0	4	4.8	COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL210053	78073	0	None	-158	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	470	7	0	4	4.8	COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		44414070	79920	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	474	7	0	4	5.7	COc1ccc(C2=C(C)CN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL212482	79920	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	474	7	0	4	5.7	COc1ccc(C2=C(C)CN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		49850672	56386	0	None	-794	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1631532	56386	0	None	-794	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		44298021	194759	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	4	1	4	5.9	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C(C)C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL53793	194759	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	4	1	4	5.9	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C(C)C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		18931377	206475	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1cccc(Cl)c1	10.1016/S0960-894X(96)00503-3
		CHEMBL88193	206475	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1cccc(Cl)c1	10.1016/S0960-894X(96)00503-3
		18931150	206828	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1cc(Cl)ccc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		CHEMBL90470	206828	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1cc(Cl)ccc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		153287566	171180	0	None	-74	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
		CHEMBL4459009	171180	0	None	-74	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
		11292350	87941	0	None	-79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	394	6	0	4	4.3	COc1ccc(N2Cc3cccc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234006	87941	0	None	-79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	394	6	0	4	4.3	COc1ccc(N2Cc3cccc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		11775262	88055	0	None	-125	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234532	88055	0	None	-125	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		11430311	150047	0	None	-158	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	428	6	0	4	5.2	COc1ccc(N2C(=O)c3c(Cl)cccc3C2C)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL395059	150047	0	None	-158	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	428	6	0	4	5.2	COc1ccc(N2C(=O)c3c(Cl)cccc3C2C)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		11453704	150066	0	None	-79	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.4	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1	10.1016/j.bmcl.2006.10.029
		CHEMBL395072	150066	0	None	-79	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.4	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1	10.1016/j.bmcl.2006.10.029
		11282335	150323	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)c(Cl)cc3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL395297	150323	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)c(Cl)cc3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		11753782	12806	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
		CHEMBL1188213	12806	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
		CHEMBL535626	12806	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
		10458785	86762	0	None	-50	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		CHEMBL232045	86762	0	None	-50	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		10346749	88407	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	487	6	0	5	5.5	COc1ccc(N2Cc3c(c4cc(Cl)c(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
		CHEMBL234947	88407	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	487	6	0	5	5.5	COc1ccc(N2Cc3c(c4cc(Cl)c(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
		10390089	142361	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	436	6	0	5	5.2	COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		CHEMBL388882	142361	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	436	6	0	5	5.2	COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		44298138	195501	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(COc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL55344	195501	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(COc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		162660908	181420	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
		CHEMBL4763861	181420	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
		162669225	182764	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2cccc(Cl)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		CHEMBL4790230	182764	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2cccc(Cl)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		10812577	99045	1	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3cccnc3)ccc1F)CC2	10.1021/jm990388c
		CHEMBL280322	99045	1	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3cccnc3)ccc1F)CC2	10.1021/jm990388c
		10249573	207593	0	None	-199	11	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL94984	207593	0	None	-199	11	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		10237852	72404	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	411	7	0	6	3.6	COc1ccc(-n2ccn(-c3cccc(F)c3)c2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL198712	72404	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	411	7	0	6	3.6	COc1ccc(-n2ccn(-c3cccc(F)c3)c2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		24887517	169039	0	None	-158	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		CHEMBL439504	169039	0	None	-158	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		11191906	11767	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		CHEMBL1181665	11767	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		CHEMBL187928	11767	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		44298079	196323	0	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	346	3	1	4	4.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccccc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL56232	196323	0	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	346	3	1	4	4.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccccc32)cn1	10.1016/s0960-894x(00)00364-4
		44298193	199378	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL59097	199378	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		10433930	51089	0	None	-999	5	Human	5.7	pKi	=	5.7	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		CHEMBL157910	51089	0	None	-999	5	Human	5.7	pKi	=	5.7	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		118278424	122012	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	256	3	1	4	2.9	O=c1cc(CCc2ccco2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		CHEMBL3593951	122012	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	256	3	1	4	2.9	O=c1cc(CCc2ccco2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		24865725	188084	0	None	-3981	12	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human cloned 5HT2B receptorDisplacement of radioligand from human cloned 5HT2B receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL497963	188084	0	None	-3981	12	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human cloned 5HT2B receptorDisplacement of radioligand from human cloned 5HT2B receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		9892409	100950	0	None	-398	9	Human	5.7	pKi	=	5.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL29410	100950	0	None	-398	9	Human	5.7	pKi	=	5.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
		448537	160250	89	None	-21	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	160250	89	None	-21	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		11957541	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		1229	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		147	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		170617	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		CHEMBL6616	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
		11957541	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
		1229	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
		147	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
		170617	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
		CHEMBL6616	1459	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
		24826867	91095	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397890	91095	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		11323169	179967	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4746737	179967	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		2220	3134	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		27400	3134	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		93	3134	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		CHEMBL294951	3134	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		DB06153	3134	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		118717217	120576	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343667	120576	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545762	120576	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		72734862	106306	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
		CHEMBL3092754	106306	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
		CHEMBL3139079	106306	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
		44269058	31366	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/ml3003814
		CHEMBL14022	31366	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/ml3003814
		157	2069	7	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
		9840090	2069	7	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL134519	2069	7	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
		1043	1582	14	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	1582	14	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	1582	14	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	1582	14	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	1582	14	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		10251906	2743	18	None	-186	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1021/acs.jmedchem.2c00633
		13550	2743	18	None	-186	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1021/acs.jmedchem.2c00633
		CHEMBL1908863	2743	18	None	-186	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1021/acs.jmedchem.2c00633
		72734867	106366	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
		CHEMBL3092757	106366	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
		CHEMBL3139241	106366	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
		230	4119	25	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
		3045225	4119	25	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
		CHEMBL407909	4119	25	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
		67781610	166954	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	0	2	4.7	CN(C)CC/C=C1\c2ccc(Br)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
		CHEMBL4287193	166954	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	0	2	4.7	CN(C)CC/C=C1\c2ccc(Br)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
		16062910	97428	0	None	-6	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	329	3	1	3	3.7	Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL269974	97428	0	None	-6	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	329	3	1	3	3.7	Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		9839920	101708	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	316	2	2	3	4.4	Cn1ccc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
		CHEMBL299498	101708	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	316	2	2	3	4.4	Cn1ccc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
		146709966	175779	0	None	338	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4583909	175779	0	None	338	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		1042	1581	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	1581	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	1581	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	1581	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	1581	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		11536844	115122	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343672	115122	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		206	2493	16	None	-1	25	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
		68848	2493	16	None	-1	25	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
		CHEMBL12314	2493	16	None	-1	25	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
		4376990	193009	5	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5207529	193009	5	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5222754	193009	5	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		153061504	172810	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4513930	172810	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		59752538	181152	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4760784	181152	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		11414582	181338	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4762886	181338	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		59752638	182397	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4785470	182397	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		189	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
		5163	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
		CHEMBL297784	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
		3037629	184572	18	None	1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL4848517	184572	18	None	1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		66647021	120676	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402656	120676	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547009	120676	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
		118729256	120709	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402670	120709	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547156	120709	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
		16062785	95121	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	2	1	3	3.1	CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
		CHEMBL255543	95121	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	2	1	3	3.1	CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
		16062784	95167	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	318	2	1	4	3.4	N#Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL255802	95167	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	318	2	1	4	3.4	N#Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		752521	198737	8	None	12	9	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
		CHEMBL582877	198737	8	None	12	9	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
		118729260	120688	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402672	120688	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547044	120688	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
		118729274	120711	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402681	120711	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547175	120711	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
		44435219	91792	0	None	-6	4	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	367	2	0	2	6.2	O=C(Cc1ccc2ccccc2c1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL241115	91792	0	None	-6	4	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	367	2	0	2	6.2	O=C(Cc1ccc2ccccc2c1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		155556618	174477	0	None	-1905	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL4554295	174477	0	None	-1905	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		5897	105211	80	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		CHEMBL311469	105211	80	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		9926401	140875	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819556	140875	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819732	140875	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		71459553	83696	10	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
		CHEMBL2205360	83696	10	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
		9926401	140875	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819556	140875	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819732	140875	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		155554410	174394	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	331	2	2	5	0.6	Cc1cccc(C)c1N1C(=O)[C@H](CO)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
		CHEMBL4552298	174394	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	331	2	2	5	0.6	Cc1cccc(C)c1N1C(=O)[C@H](CO)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
		11615459	199248	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
		CHEMBL590078	199248	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
		122186881	122981	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3608451	122981	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		11209786	137240	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
		CHEMBL375170	137240	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
		155558626	174761	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		CHEMBL4561016	174761	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		11336079	83476	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	280	0	1	2	1.8	C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL220115	83476	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	280	0	1	2	1.8	C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		11264955	204961	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
		CHEMBL76474	204961	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
		20824945	67588	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL190124	67588	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		196129	67798	17	None	-26	15	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	67798	17	None	-26	15	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		118055334	177470	0	None	-34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	266	0	1	2	2.5	CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4639090	177470	0	None	-34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	266	0	1	2	2.5	CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
		24826963	91115	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397910	91115	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		71681897	91119	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
		CHEMBL2397914	91119	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
		25123014	200431	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		CHEMBL598229	200431	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		126769	206042	42	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
		CHEMBL536255	206042	42	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
		CHEMBL85194	206042	42	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
		189	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
		5163	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
		CHEMBL297784	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
		127037059	136537	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3736516	136537	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL4777443	214046	0	None	11	14	Human	7.7	pKi	=	7.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR2B	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	10.6019/CHEMBL5212743
		70687202	77978	0	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
		CHEMBL2096809	77978	0	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
		18715558	73882	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL201897	73882	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
		44451390	155750	2	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	210	1	2	2	2.1	CNc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		CHEMBL405717	155750	2	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	210	1	2	2	2.1	CNc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		118729246	120687	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402663	120687	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547043	120687	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
		16062143	97694	0	None	-19	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	283	2	1	3	3.2	Fc1ccc(-c2nc(C3CCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL271318	97694	0	None	-19	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	283	2	1	3	3.2	Fc1ccc(-c2nc(C3CCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		134146585	148909	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	366	3	3	8	-0.4	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3941738	148909	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	366	3	3	8	-0.4	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		117209911	186329	1	None	-26	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4874854	186329	1	None	-26	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		24826786	91086	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397881	91086	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		10330266	21403	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2ccsc12	10.1021/jm980692q
		CHEMBL13147	21403	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2ccsc12	10.1021/jm980692q
		4011	82408	49	None	-20	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-20	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		155512086	169621	0	None	-407	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	399	6	4	8	1.5	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL4436786	169621	0	None	-407	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	399	6	4	8	1.5	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		137645406	157902	0	None	-269	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4084262	157902	0	None	-269	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4526351	213983	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000703a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000703a HTR2B	ChEMBL		None	None	None		Cc1cc(NC(=O)c2cccc(S(F)(F)(F)(F)F)c2)cc(-n2ccn3nc(-c4cccnc4)cc23)c1	10.6019/CHEMBL5212743
		117209857	185138	1	None	-5	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4856702	185138	1	None	-5	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		4601	206747	35	None	-4	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-4	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-4	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		68617	205527	62	None	-15	26	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	205527	62	None	-15	26	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	205527	62	None	-15	26	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		104697662	145405	1	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
		CHEMBL3914002	145405	1	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
		71682217	91118	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397913	91118	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		44409032	75022	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@@H]2Cc3ccc(Cl)nc3N21	10.1016/j.bmcl.2005.11.083
		CHEMBL203396	75022	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@@H]2Cc3ccc(Cl)nc3N21	10.1016/j.bmcl.2005.11.083
		2303	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		4946	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		564	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		63	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		91536	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL27	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL452861	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		DB00571	3187	68	None	-158	26	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		2353	101112	82	None	-7	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
		CHEMBL12089	101112	82	None	-7	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
		CHEMBL295124	101112	82	None	-7	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
		10440	2680	20	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		139030523	2680	20	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		CHEMBL4449712	2680	20	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		3117	207841	103	None	-8	16	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	207841	103	None	-8	16	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		145992489	166977	0	None	-6	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4287623	166977	0	None	-6	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		118055195	178017	0	None	-9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	2.0	Cc1ccc2c3c1C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4646618	178017	0	None	-9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	2.0	Cc1ccc2c3c1C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
		122178704	121370	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3581249	121370	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		16047544	12648	8	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
		CHEMBL1187185	12648	8	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
		CHEMBL492916	12648	8	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
		16062911	97711	0	None	-27	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	383	3	1	3	4.4	FC(F)(F)c1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL271418	97711	0	None	-27	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	383	3	1	3	4.4	FC(F)(F)c1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		189	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
		5163	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
		CHEMBL297784	3492	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
		11658860	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
		2941	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
		4374	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
		CHEMBL360328	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
		DB04871	2344	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
		11187156	136354	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL373483	136354	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		16062270	97673	0	None	-100	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	297	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL271212	97673	0	None	-100	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	297	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		16062266	97693	0	None	-169	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	337	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL271317	97693	0	None	-169	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	337	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		2284	3182	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		9837204	74693	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	209	0	1	3	1.1	Clc1ccc2c(n1)N1CCNCC1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL203025	74693	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	209	0	1	3	1.1	Clc1ccc2c(n1)N1CCNCC1C2	10.1016/j.bmcl.2005.11.083
		49865829	16159	0	None	22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	330	1	1	3	4.1	O=C(Nc1ccccc1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224031	16159	0	None	22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	330	1	1	3	4.1	O=C(Nc1ccccc1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		51352628	82827	10	None	-1	3	Human	5.7	pKi	=	5.7	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		CHEMBL2180408	82827	10	None	-1	3	Human	5.7	pKi	=	5.7	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		16062139	157667	0	None	-204	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.4	CCC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		CHEMBL408154	157667	0	None	-204	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.4	CCC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		71463061	83795	0	None	-3	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
		CHEMBL2205813	83795	0	None	-3	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
		2351	3286	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	3286	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	3286	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	3286	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	3286	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		156012918	177448	0	None	-7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.2	Clc1ccc2c3c1CCCN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4638807	177448	0	None	-7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.2	Clc1ccc2c3c1CCCN3CCNC2	10.1016/j.bmcl.2019.126929
		24826870	91103	0	None	-4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397898	91103	0	None	-4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		444795	139999	105	None	3	2	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
		CHEMBL38	139999	105	None	3	2	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
		136118613	93063	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL2442275	93063	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
		51352628	82827	10	None	-1	3	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		CHEMBL2180408	82827	10	None	-1	3	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		CHEMBL5271021	193667	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1039/D1MD00167A
		26987	949	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		46230099	199312	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
		CHEMBL590483	199312	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
		11514226	89110	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337494	89110	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365470	89110	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		15560577	185341	9	None	1	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL4859858	185341	9	None	1	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		134152052	153083	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3976121	153083	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		134152052	153083	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL3976121	153083	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL5094493	215499	0	None	-11	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		72698087	103988	0	None	-2089	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	407	5	0	4	5.0	Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
		CHEMBL3093186	103988	0	None	-2089	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	407	5	0	4	5.0	Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
		10251906	2743	18	None	-186	8	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1016/j.bmc.2008.04.050
		13550	2743	18	None	-186	8	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1016/j.bmc.2008.04.050
		CHEMBL1908863	2743	18	None	-186	8	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1016/j.bmc.2008.04.050
		155539605	172845	0	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		CHEMBL4514672	172845	0	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		127034730	136439	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735643	136439	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		46914927	15419	0	None	14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		CHEMBL1214893	15419	0	None	14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		91864602	140738	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818047	140738	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		135514796	93058	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	226	1	4	2	1.2	N=C1NC(=O)/C(=C\c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2442270	93058	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	226	1	4	2	1.2	N=C1NC(=O)/C(=C\c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
		142601323	185841	0	None	-9	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4867560	185841	0	None	-9	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
		3973	208180	110	None	-44	3	Human	4.6	pKi	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
		CHEMBL98350	208180	110	None	-44	3	Human	4.6	pKi	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
		3157	1470	71	None	-37	10	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		7170	1470	71	None	-37	10	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		954	1470	71	None	-37	10	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		CHEMBL707	1470	71	None	-37	10	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		DB00590	1470	71	None	-37	10	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
		91864602	140738	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818047	140738	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		16115388	137366	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
		CHEMBL375302	137366	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
		11185858	84792	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
		CHEMBL223271	84792	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
		71061785	160496	0	None	-6	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
		CHEMBL4112056	160496	0	None	-6	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
		10430623	18675	24	None	-213	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
		CHEMBL1277105	18675	24	None	-213	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
		72901200	119777	25	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2BSelectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2B	ChEMBL	322	7	2	4	3.8	Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1	10.6019/CHEMBL5212743
		CHEMBL3480577	119777	25	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2BSelectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2B	ChEMBL	322	7	2	4	3.8	Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1	10.6019/CHEMBL5212743
		11587397	89056	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337489	89056	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2364893	89056	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		6726	1280	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		44579715	193252	0	None	-2238	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	4	3	7	2.7	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Cl)c3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
		CHEMBL523797	193252	0	None	-2238	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	4	3	7	2.7	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Cl)c3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
		46230048	199290	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
		CHEMBL590332	199290	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
		118055215	177456	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	216	0	1	2	2.2	Cc1ccc2c3c1C(C)(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4638879	177456	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	216	0	1	2	2.2	Cc1ccc2c3c1C(C)(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
		1355	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
		142	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
		CHEMBL478	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
		DB12110	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
		11652452	89126	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337492	89126	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365703	89126	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
		162668650	182673	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4789085	182673	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		3251	4072	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
		5684	4072	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
		80	4072	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
		CHEMBL31354	4072	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
		1355	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
		142	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
		CHEMBL478	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
		DB12110	2011	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
		16115381	83443	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
		CHEMBL219837	83443	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
		10015055	2104	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
		1212	2104	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
		CHEMBL3402679	2104	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
		46884100	8017	0	None	-104	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		CHEMBL1090757	8017	0	None	-104	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		145978665	163518	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4202582	163518	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		2142	3096	58	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		4920903	3096	58	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		502	3096	58	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		5775	3096	58	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		CHEMBL597	3096	58	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		DB00692	3096	58	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		56678761	65668	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1cccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834257	65668	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1cccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
		46914773	15429	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		CHEMBL1214958	15429	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		9921064	127178	25	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
		CHEMBL365751	127178	25	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
		22254068	65970	32	None	-173	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	423	5	2	6	4.0	CS(=O)(=O)NC[C@H]1CC[C@H](Nc2nc3c(s2)CCSc2ccccc2-3)CC1	10.1016/j.bmcl.2011.06.124
		CHEMBL1836317	65970	32	None	-173	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	423	5	2	6	4.0	CS(=O)(=O)NC[C@H]1CC[C@H](Nc2nc3c(s2)CCSc2ccccc2-3)CC1	10.1016/j.bmcl.2011.06.124
		11536299	183286	8	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
		CHEMBL479683	183286	8	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
		145990586	166843	0	None	-19	11	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		CHEMBL4285281	166843	0	None	-19	11	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		136118660	76256	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058428	76256	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
		135367816	164835	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4218801	164835	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		11483068	84812	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		CHEMBL223440	84812	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		11414184	83498	0	None	-13	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
		CHEMBL220274	83498	0	None	-13	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
		43922	114765	10	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	250	4	2	2	2.0	COc1cc2c(CCNC(C)=O)c[nH]c2cc1F	10.1021/jm100600y
		CHEMBL333886	114765	10	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	250	4	2	2	2.0	COc1cc2c(CCNC(C)=O)c[nH]c2cc1F	10.1021/jm100600y
		1212	1662	50	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		9856509	95967	4	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	259	0	1	1	2.8	Clc1c(Br)ccc2c1CCNCC2	10.1016/j.bmc.2007.12.009
		CHEMBL259480	95967	4	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	259	0	1	1	2.8	Clc1c(Br)ccc2c1CCNCC2	10.1016/j.bmc.2007.12.009
		168293016	192110	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5203303	192110	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		10599545	36402	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL14469	36402	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		10436045	3516	4	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
		782	3516	4	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
		CHEMBL432713	3516	4	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
		189	3492	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
		5163	3492	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
		CHEMBL297784	3492	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
		11391654	180525	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4753511	180525	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		189	3492	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
		5163	3492	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
		CHEMBL297784	3492	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
		10835537	38627	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2	10.1021/jm990388c
		CHEMBL14652	38627	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2	10.1021/jm990388c
		10574607	40644	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3ccncc3)c1)CC2	10.1021/jm990388c
		CHEMBL14841	40644	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3ccncc3)c1)CC2	10.1021/jm990388c
		44298249	194584	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3cccnc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL53063	194584	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3cccnc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		44298121	194828	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cccc(COc2ccc(NC(=O)N3CCc4cc(C)c(C(F)(F)F)cc43)cn2)n1	10.1016/s0960-894x(00)00365-6
		CHEMBL53939	194828	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cccc(COc2ccc(NC(=O)N3CCc4cc(C)c(C(F)(F)F)cc43)cn2)n1	10.1016/s0960-894x(00)00365-6
		44214723	195494	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	427	4	1	3	5.6	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)cc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL55335	195494	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	427	4	1	3	5.6	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)cc1)CC2	10.1016/s0960-894x(00)00365-6
		1225	1471	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
		3958	1471	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
		667477	1471	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
		CHEMBL860	1471	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
		DB01142	1471	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
		20824946	123643	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	218	1	2	3	0.9	C[C@@H]1CNC[C@H]2Cc3ccc(CO)cc3N12	10.1016/j.bmcl.2005.05.074
		CHEMBL361929	123643	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	218	1	2	3	0.9	C[C@@H]1CNC[C@H]2Cc3ccc(CO)cc3N12	10.1016/j.bmcl.2005.05.074
		118729244	120686	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402662	120686	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547029	120686	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
		122188579	123184	0	None	-1479	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	471	4	4	8	2.0	CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.5b00150
		CHEMBL3612940	123184	0	None	-1479	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	471	4	4	8	2.0	CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.5b00150
		16062137	97712	0	None	-125	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL271419	97712	0	None	-125	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		44298186	101711	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	458	4	1	5	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cc1C)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL299506	101711	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	458	4	1	5	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cc1C)CC2	10.1016/s0960-894x(00)00364-4
		44298120	195000	0	None	-158	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1ccc2c(c1Br)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
		CHEMBL54775	195000	0	None	-158	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1ccc2c(c1Br)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
		44323840	206572	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	9	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)=O)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL88809	206572	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	9	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)=O)cc1	10.1016/S0960-894X(96)00503-3
		155519891	170393	0	None	2	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		CHEMBL4447975	170393	0	None	2	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		155526977	171121	0	None	10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	221	2	1	3	2.3	CC[C@H]1c2cc(OC)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4458099	171121	0	None	10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	221	2	1	3	2.3	CC[C@H]1c2cc(OC)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		153287541	172195	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		CHEMBL4473697	172195	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		153287539	176074	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4591008	176074	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		11465413	88043	0	None	-125	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.7	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234494	88043	0	None	-125	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.7	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.10.029
		11305844	88176	0	None	-630	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	466	6	0	4	5.1	COc1ccc(N2Cc3cc(F)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL234739	88176	0	None	-630	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	466	6	0	4	5.1	COc1ccc(N2Cc3cc(F)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		10368204	86764	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4ccc(F)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		CHEMBL232047	86764	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4ccc(F)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		2337	3256	77	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		50	3256	77	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		5002	3256	77	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		CHEMBL716	3256	77	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		DB01224	3256	77	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		76325516	105731	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	280	4	1	3	3.7	O=c1cc(CCCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		CHEMBL3126299	105731	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	280	4	1	3	3.7	O=c1cc(CCCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
		18357724	196597	0	None	-31	3	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2ccc(C(F)(F)F)cc21	10.1016/s0960-894x(00)00365-6
		CHEMBL56405	196597	0	None	-31	3	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2ccc(C(F)(F)F)cc21	10.1016/s0960-894x(00)00365-6
		162645563	179690	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2ccc(C(F)(F)F)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		CHEMBL4743625	179690	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2ccc(C(F)(F)F)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		162648564	179921	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2ccc(Cl)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		CHEMBL4746138	179921	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2ccc(Cl)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		162666438	182270	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	298	4	1	3	3.8	O=c1cc(CCCc2cccc(F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		CHEMBL4783824	182270	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	298	4	1	3	3.8	O=c1cc(CCCc2cccc(F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
		44298126	101595	0	None	-158	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c(Cl)cccc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL298696	101595	0	None	-158	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c(Cl)cccc32)cn1	10.1016/s0960-894x(00)00364-4
		10085260	170627	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
		CHEMBL445106	170627	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
		71086303	160810	0	None	1	2	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL4114493	160810	0	None	1	2	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		117209965	185247	1	None	-10	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4858338	185247	1	None	-10	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		46914775	15430	0	None	3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		CHEMBL1214959	15430	0	None	3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		127035062	136451	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3735756	136451	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		127035062	136451	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	136451	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		15011385	161552	4	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL412876	161552	4	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		45378936	199506	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	448	5	1	6	4.2	CC(C)Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
		CHEMBL591940	199506	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	448	5	1	6	4.2	CC(C)Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
		70695555	77961	1	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@H]1CNC[C@@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
		CHEMBL2096711	77961	1	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@H]1CNC[C@@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
		168286277	191615	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	468	3	2	3	6.5	Ic1ccc(Nc2nc3ccccc3c3[nH]c(C4CCCCC4)nc23)cc1	10.1021/acs.jmedchem.2c01170
		CHEMBL5195535	191615	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	468	3	2	3	6.5	Ic1ccc(Nc2nc3ccccc3c3[nH]c(C4CCCCC4)nc23)cc1	10.1021/acs.jmedchem.2c01170
		1599	2341	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		3955	2341	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		7215	2341	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		CHEMBL841	2341	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		DB00836	2341	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
		46914771	15411	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		CHEMBL1214831	15411	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		2303	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		4946	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		564	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		63	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		91536	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL27	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		CHEMBL452861	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		DB00571	3187	68	None	-158	26	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	nan
		4209	3163	75	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		4893	3163	75	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		503	3163	75	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		5385	3163	75	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		CHEMBL2	3163	75	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		DB00457	3163	75	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		10085260	170627	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
		CHEMBL445106	170627	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
		135433933	177038	1	None	-2	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL463249	177038	1	None	-2	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
		136118728	93061	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2442273	93061	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
		90181059	160231	0	None	-1	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
		CHEMBL4109801	160231	0	None	-1	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
		10472143	119277	0	None	-60	16	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL343755	119277	0	None	-60	16	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		59757153	106343	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
		CHEMBL3092762	106343	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
		CHEMBL3139190	106343	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
		118464427	138334	0	None	15	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3771331	138334	0	None	15	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		118709750	113540	0	None	-24	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321791	113540	0	None	-24	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
		44453652	155455	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	1	1	3	2.8	Cc1nc2c(c(-c3ccc(Cl)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
		CHEMBL403902	155455	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	1	1	3	2.8	Cc1nc2c(c(-c3ccc(Cl)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
		73349361	92548	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		CHEMBL2432058	92548	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		136118636	76314	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
		CHEMBL2058696	76314	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
		43229249	140817	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818989	140817	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		25067564	201300	0	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		CHEMBL604102	201300	0	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		56658157	65669	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	348	7	0	3	4.6	c1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834258	65669	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	348	7	0	3	4.6	c1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		43229249	140817	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818989	140817	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		44582706	186997	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	417	10	1	5	4.0	COc1ccc(CCN2CCC(C(O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		CHEMBL490633	186997	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	417	10	1	5	4.0	COc1ccc(CCN2CCC(C(O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		3035850	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
		457	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
		CHEMBL431733	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
		DB12885	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
		3035850	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		457	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		CHEMBL431733	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		DB12885	951	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
		145973771	164719	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		CHEMBL4217398	164719	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		21138	98451	39	None	-6	7	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
		CHEMBL275742	98451	39	None	-6	7	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
		46914486	15420	0	None	13	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		CHEMBL1214894	15420	0	None	13	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		124087	1389	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		118055191	177315	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	280	0	1	2	2.7	CC1(C)CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4636977	177315	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	280	0	1	2	2.7	CC1(C)CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL5074190	214314	0	None	-112	9	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		11701315	199289	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
		CHEMBL590331	199289	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
		44554393	18547	0	None	-61	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	448	5	1	6	4.1	CC(C)Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		CHEMBL1275630	18547	0	None	-61	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	448	5	1	6	4.1	CC(C)Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		CHEMBL4748908	214035	1	None	-3	12	Human	6.6	pKi	=	6.6	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		49783415	17678	0	None	-1202	12	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
		CHEMBL1258452	17678	0	None	-1202	12	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
		136118647	76320	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.2	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058702	76320	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.2	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
		1530	2182	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		122178707	121373	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		CHEMBL3581252	121373	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		11233293	84162	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
		CHEMBL220833	84162	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
		16115267	84793	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
		CHEMBL223272	84793	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
		71461049	82975	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181187	82975	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
		56665074	65664	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1cccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834253	65664	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1cccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
		CHEMBL4748908	214035	1	None	-3	12	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		155534799	176512	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
		CHEMBL4471059	176512	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
		CHEMBL4596904	176512	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
		155535203	172041	0	None	-7	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		CHEMBL4471712	172041	0	None	-7	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		5353853	17986	47	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	17986	47	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	17986	47	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		44409327	76632	0	None	-128	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL206394	76632	0	None	-128	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		155531067	171619	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		CHEMBL4465512	171619	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		71459604	83793	0	None	-5	14	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205811	83793	0	None	-5	14	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		122187378	123026	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3609143	123026	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		44455426	155149	0	None	-4	12	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL402143	155149	0	None	-4	12	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		11288612	182611	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4788327	182611	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		145981805	166710	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	313	3	0	2	4.6	CN(C)CC/C=C1\c2ccc(Cl)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
		CHEMBL4282729	166710	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	313	3	0	2	4.6	CN(C)CC/C=C1\c2ccc(Cl)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
		127048334	140600	1	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3813796	140600	1	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		135398737	958	93	None	-2	89	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		38	958	93	None	-2	89	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		722	958	93	None	-2	89	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		CHEMBL42	958	93	None	-2	89	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		DB00363	958	93	None	-2	89	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		29943048	67663	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL190699	67663	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		29943048	67663	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL190699	67663	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		1588	2325	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		11637931	120583	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343665	120583	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545814	120583	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		145993540	167334	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting method	ChEMBL	503	12	3	11	2.2	NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1	10.1039/C7MD00247E
		CHEMBL4294350	167334	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting method	ChEMBL	503	12	3	11	2.2	NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1	10.1039/C7MD00247E
		127048335	140592	1	None	15	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3813726	140592	1	None	15	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		11502243	189506	48	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmc.2019.02.044
		CHEMBL513994	189506	48	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmc.2019.02.044
		146709966	175779	0	None	338	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4583909	175779	0	None	338	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		72734865	106315	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
		CHEMBL3092756	106315	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
		CHEMBL3139103	106315	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
		135509961	136132	2	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
		CHEMBL373245	136132	2	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
		10623020	32400	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2	10.1021/jm990388c
		CHEMBL14111	32400	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2	10.1021/jm990388c
		18475630	101896	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	330	2	2	3	4.7	Cc1cc2cc(NC(=O)Nc3ccnc4ccccc34)ccc2n1C	10.1016/s0960-894x(01)00343-2
		CHEMBL300835	101896	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	330	2	2	3	4.7	Cc1cc2cc(NC(=O)Nc3ccnc4ccccc34)ccc2n1C	10.1016/s0960-894x(01)00343-2
		10690185	161754	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	365	3	1	3	4.5	CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		CHEMBL41389	161754	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	365	3	1	3	4.5	CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		1621	2429	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		17	2429	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		5761	2429	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		CHEMBL263881	2429	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		DB04829	2429	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		2600	3779	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	3779	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	3779	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	3779	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	3779	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		118729264	120699	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402675	120699	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547136	120699	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
		118729248	120703	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402664	120703	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547150	120703	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
		16062788	97473	0	None	-50	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.6	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL270188	97473	0	None	-50	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.6	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		16062781	155179	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	311	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL402357	155179	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	311	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		127036932	137348	0	None	1	22	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752900	137348	0	None	1	22	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		44581973	175601	0	None	-14	10	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL458002	175601	0	None	-14	10	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		73346042	91834	5	None	-3019	17	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		CHEMBL2413153	91834	5	None	-3019	17	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		44451429	155767	3	None	-21	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	226	1	1	3	1.9	O=[N+]([O-])c1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		CHEMBL405829	155767	3	None	-21	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	226	1	1	3	1.9	O=[N+]([O-])c1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		89901929	120704	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402665	120704	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547151	120704	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
		89901938	120713	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402684	120713	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547177	120713	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
		145978113	163837	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4206418	163837	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		11312820	136334	1	None	-8	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
		CHEMBL373402	136334	1	None	-8	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
		46914621	15421	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		CHEMBL1214895	15421	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
		122187375	123023	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	443	5	0	5	5.6	CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3609140	123023	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	443	5	0	5	5.6	CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		4211	57822	83	None	-2	4	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		CHEMBL1670	57822	83	None	-2	4	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		11737032	85016	0	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
		CHEMBL223896	85016	0	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
		44316017	205452	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
		CHEMBL80366	205452	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
		6761	67799	19	None	-7	18	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-7	18	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		59752584	181495	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4764808	181495	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
		118717213	120579	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343664	120579	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545802	120579	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		10244831	194887	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	309	3	2	3	4.6	CSc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
		CHEMBL54062	194887	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	309	3	2	3	4.6	CSc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
		9888804	194991	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/j.bmcl.2005.08.004
		CHEMBL54719	194991	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/j.bmcl.2005.08.004
		10811153	169119	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	403	3	1	3	5.1	CSc1cc2c(cc1C(F)(F)C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		CHEMBL44015	169119	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	403	3	1	3	5.1	CSc1cc2c(cc1C(F)(F)C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
		44298173	195493	0	None	-31	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL55331	195493	0	None	-31	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		44298236	195962	0	None	-19	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	3	1	4	5.4	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(C)c1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL55964	195962	0	None	-19	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	3	1	4	5.4	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(C)c1)CC2	10.1016/s0960-894x(00)00364-4
		10435572	150100	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cccc(F)c4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		CHEMBL395098	150100	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cccc(F)c4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		50878551	90745	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	90745	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		9888804	194991	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL54719	194991	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		11121216	30139	0	None	-154	14	Human	6.5	pKi	=	6.5	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL138989	30139	0	None	-154	14	Human	6.5	pKi	=	6.5	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		3845148	65662	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	320	5	0	3	3.8	c1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834251	65662	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	320	5	0	3	3.8	c1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		16063181	155433	0	None	-34	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL403764	155433	0	None	-34	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNC3)cc1	10.1016/j.bmcl.2008.01.090
		142601337	185970	0	None	-97	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4869695	185970	0	None	-97	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		145990659	166925	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	273	1	4	6	1.7	NC1=NC2(CCCCC2)NC(Nc2cccc(O)c2)=N1	10.1021/acsmedchemlett.8b00300
		CHEMBL4286819	166925	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	273	1	4	6	1.7	NC1=NC2(CCCCC2)NC(Nc2cccc(O)c2)=N1	10.1021/acsmedchemlett.8b00300
		9906447	195577	2	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031738	195577	2	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL555146	195577	2	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		9909089	186968	0	None	-2511	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL490417	186968	0	None	-2511	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		10217207	72112	0	None	-398	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL197807	72112	0	None	-398	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		10288601	72184	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	465	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL198007	72184	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	465	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
		50898777	56440	0	None	-2951	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		CHEMBL1632158	56440	0	None	-2951	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		44414105	138185	0	None	-79	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	488	7	0	4	5.9	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.05.034
		CHEMBL376962	138185	0	None	-79	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	488	7	0	4	5.9	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.05.034
		19356259	102029	0	None	-158	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL301784	102029	0	None	-158	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		44298192	168150	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	472	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(I)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL433060	168150	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	472	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(I)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		187	3388	18	None	-288	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
		3693566	3388	18	None	-288	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
		CHEMBL88402	3388	18	None	-288	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
		11766873	206742	0	None	-31	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	558	11	3	8	2.8	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL89967	206742	0	None	-31	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	558	11	3	8	2.8	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C)cc1	10.1016/S0960-894X(96)00503-3
		18931123	207229	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	601	12	4	9	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(NC(C)=O)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL92809	207229	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	601	12	4	9	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(NC(C)=O)cc1	10.1016/S0960-894X(96)00503-3
		153287567	172384	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
		CHEMBL4476396	172384	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
		153287557	176079	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4591108	176079	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		11463745	151788	0	None	-79	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	400	6	0	4	4.4	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.029
		CHEMBL396505	151788	0	None	-79	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	400	6	0	4	4.4	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.029
		11750162	151813	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	408	6	0	4	4.6	COc1ccc(N2Cc3cc(C)cc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL396527	151813	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	408	6	0	4	4.6	COc1ccc(N2Cc3cc(C)cc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		179	400	115	None	-17	49	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		2159	400	115	None	-17	49	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		963	400	115	None	-17	49	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		CHEMBL243712	400	115	None	-17	49	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		DB06288	400	115	None	-17	49	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		10440	2680	20	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		139030523	2680	20	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		CHEMBL4449712	2680	20	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
		155531067	171619	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		CHEMBL4465512	171619	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		155558626	174761	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		CHEMBL4561016	174761	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
		44243470	89098	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
		CHEMBL2334981	89098	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
		CHEMBL2365395	89098	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
		18931217	206790	0	None	-39	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	623	12	4	10	1.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(S(N)(=O)=O)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL90267	206790	0	None	-39	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	623	12	4	10	1.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(S(N)(=O)=O)cc1	10.1016/S0960-894X(96)00503-3
		44439167	90557	0	None	-316	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238732	90557	0	None	-316	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		71062790	160053	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ncccc1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
		CHEMBL4108274	160053	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ncccc1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
		44420683	84133	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
		CHEMBL220789	84133	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
		1355	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
		142	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
		CHEMBL478	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
		DB12110	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
		11151653	91101	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397896	91101	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		1355	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
		142	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
		CHEMBL478	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
		DB12110	2011	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
		CHEMBL5084249	214905	0	None	-38	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		1704	3522	85	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		4331799	3522	85	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		CHEMBL1334465	3522	85	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		118055337	177371	0	None	-28	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	220	0	1	2	2.0	CC1(C)CN2CCNCc3ccc(F)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4637882	177371	0	None	-28	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	220	0	1	2	2.0	CC1(C)CN2CCNCc3ccc(F)c1c32	10.1016/j.bmcl.2019.126929
		44582675	189701	0	None	-5	15	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL515472	189701	0	None	-5	15	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		3336	95001	30	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
		CHEMBL1405922	95001	30	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
		CHEMBL254832	95001	30	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
		16573	177619	34	None	-16	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL464099	177619	34	None	-16	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		168273532	190185	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	450	3	2	3	7.8	Clc1ccc(Nc2nc3ccccc3c3[nH]c([C@@H]4C[C@@H]5CCC[C@@H](C5)C4)nc23)cc1Cl	10.1021/acs.jmedchem.2c01170
		CHEMBL5174205	190185	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	450	3	2	3	7.8	Clc1ccc(Nc2nc3ccccc3c3[nH]c([C@@H]4C[C@@H]5CCC[C@@H](C5)C4)nc23)cc1Cl	10.1021/acs.jmedchem.2c01170
		23290944	81826	0	None	-213	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		CHEMBL2164350	81826	0	None	-213	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		6075	150108	42	None	-8	16	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	-8	16	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		44247568	82174	55	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
		CHEMBL2170062	82174	55	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
		16118923	60146	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
		CHEMBL1642866	60146	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
		CHEMBL1739656	60146	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
		11695000	89071	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337490	89071	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365083	89071	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		122178706	121372	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3581251	121372	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		3038495	708	37	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
		7625	708	37	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
		CHEMBL25236	708	37	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
		11948707	166167	0	None	-83	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		CHEMBL426317	166167	0	None	-83	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		5624	32693	14	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL1203324	32693	14	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL141343	32693	14	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		56675413	65670	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccccc1CCCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834259	65670	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccccc1CCCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
		134143302	145316	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	503	9	5	9	0.6	CC(=O)NCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3913293	145316	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	503	9	5	9	0.6	CC(=O)NCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		90181065	160812	0	None	5	2	Mouse	6.5	pKi	=	6.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@@H](COc2cccc(Cl)c2)C1	nan
		CHEMBL4114519	160812	0	None	5	2	Mouse	6.5	pKi	=	6.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@@H](COc2cccc(Cl)c2)C1	nan
		155566272	175788	0	None	4	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	543	8	3	8	5.1	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CSc2ccccc2F)[C@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL4584140	175788	0	None	4	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	543	8	3	8	5.1	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CSc2ccccc2F)[C@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL5089613	215216	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL		None	None	None		C=C[C@H]1CN2CCc3c([nH]c4cccc(O)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		16115654	136974	0	None	-38	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL374562	136974	0	None	-38	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		44451373	96335	1	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2ccc3c(c2o1)CCNCC3	10.1016/j.bmc.2007.12.009
		CHEMBL261490	96335	1	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2ccc3c(c2o1)CCNCC3	10.1016/j.bmc.2007.12.009
		50878551	90745	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	90745	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		118706296	120525	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3310119	120525	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3545441	120525	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		134143536	145517	0	None	8	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3914843	145517	0	None	8	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		71459269	82960	0	None	-1479	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
		CHEMBL2181166	82960	0	None	-1479	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
		58911532	91104	0	None	-4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397899	91104	0	None	-4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		11176570	91120	1	None	-8	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397915	91120	1	None	-8	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		56661666	65671	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1cccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834260	65671	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1cccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
		11150514	84877	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
		CHEMBL223584	84877	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
		16071847	60145	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
		CHEMBL1642865	60145	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
		CHEMBL1739655	60145	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
		11195293	91088	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397883	91088	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
		90181070	160537	0	None	1	3	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ccnc(OC[C@H]2CN(CC(=O)N3c4ccccc4CC3C)CCO2)c1	nan
		CHEMBL4112412	160537	0	None	1	3	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ccnc(OC[C@H]2CN(CC(=O)N3c4ccccc4CC3C)CCO2)c1	nan
		136118621	76253	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL2058420	76253	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
		4943	193417	105	None	1	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
		CHEMBL526	193417	105	None	1	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
		135399666	168763	7	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		CHEMBL437314	168763	7	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		46884034	7929	0	None	-870	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	347	3	2	2	3.3	O=C(NCc1ccc(-c2ccc(Cl)cc2)cc1F)N1CCNCC1	10.1016/j.bmcl.2010.01.107
		CHEMBL1090397	7929	0	None	-870	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	347	3	2	2	3.3	O=C(NCc1ccc(-c2ccc(Cl)cc2)cc1F)N1CCNCC1	10.1016/j.bmcl.2010.01.107
		118055294	177474	0	None	-24	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	204	1	1	3	1.2	COc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4639115	177474	0	None	-24	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	204	1	1	3	1.2	COc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		56682068	65672	0	None	16	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834261	65672	0	None	16	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		4189	206922	96	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		136118651	76324	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058706	76324	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
		127052458	140740	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818056	140740	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		9881119	205473	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
		CHEMBL80482	205473	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
		117209864	186034	1	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4870675	186034	1	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		127052458	140740	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818056	140740	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		168284710	191593	0	None	-17	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL5195241	191593	0	None	-17	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		135398745	2914	112	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		127035066	136421	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
		CHEMBL3735434	136421	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
		156021327	178133	0	None	-33	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	224	0	1	3	1.6	Clc1ccc2c3c1OCCN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4648457	178133	0	None	-33	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	224	0	1	3	1.6	Clc1ccc2c3c1OCCN3CCNC2	10.1016/j.bmcl.2019.126929
		132075278	162644	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		CHEMBL4169752	162644	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		2683	102888	25	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	102888	25	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	102888	25	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		3598	187821	76	None	-2	7	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	187821	76	None	-2	7	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		136118635	76312	0	None	5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
		CHEMBL2058694	76312	0	None	5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
		16115148	84839	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
		CHEMBL223469	84839	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
		156014235	177178	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	240	0	1	3	2.4	Clc1ccc2c3c1SCCN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4634836	177178	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	240	0	1	3	2.4	Clc1ccc2c3c1SCCN3CCNC2	10.1016/j.bmcl.2019.126929
		53324045	57071	0	None	-9	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644980	57071	0	None	-9	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		11253485	141978	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
		CHEMBL387344	141978	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
		44409101	141250	0	None	-23	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	2	1	4	1.0	COCc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL383051	141250	0	None	-23	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	2	1	4	1.0	COCc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		18735305	204933	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
		CHEMBL76301	204933	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
		44404883	72062	32	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL197664	72062	32	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		44364215	39628	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1ccc2[nH]cc(C3CC3N)c2c1	10.1021/jm980318q
		CHEMBL147434	39628	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1ccc2[nH]cc(C3CC3N)c2c1	10.1021/jm980318q
		118464425	138309	0	None	3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770981	138309	0	None	3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		145976085	163665	0	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4204576	163665	0	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		44407453	74403	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
		CHEMBL202538	74403	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
		11163458	136568	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	2	1	2	2.8	CCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL373905	136568	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	2	1	2	2.8	CCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		49865831	16161	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	2	1	3	3.0	CCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224033	16161	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	2	1	3	3.0	CCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		132060720	162489	0	None	2	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		CHEMBL4167315	162489	0	None	2	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		11206703	91092	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397887	91092	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
		10528314	171881	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	469	3	1	3	6.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C(C)(C)C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL446942	171881	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	469	3	1	3	6.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C(C)(C)C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		240	944	43	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		2769	944	43	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		44279790	944	43	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		660	944	43	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		CHEMBL1729	944	43	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		CHEMBL560739	944	43	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		DB00604	944	43	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		18005120	194968	0	None	-100	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	460	4	1	5	5.9	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL54560	194968	0	None	-100	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	460	4	1	5	5.9	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		44298086	195219	0	None	-39	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(Cl)c(C)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL55079	195219	0	None	-39	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(Cl)c(C)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
		44298234	196735	0	None	-25	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	462	3	1	4	6.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL56508	196735	0	None	-25	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	462	3	1	4	6.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
		10255548	86763	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		CHEMBL232046	86763	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		2726	919	68	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		621	919	68	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		83	919	68	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		CHEMBL71	919	68	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		DB00477	919	68	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		25235287	177716	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	302	0	1	2	4.5	Cc1nccc2c1C(C)(C)Nc1cc(Br)ccc1-2	10.1021/acs.jnatprod.9b01107
		CHEMBL4642292	177716	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	302	0	1	2	4.5	Cc1nccc2c1C(C)(C)Nc1cc(Br)ccc1-2	10.1021/acs.jnatprod.9b01107
		136188797	57322	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
		CHEMBL1651094	57322	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
		136030744	57321	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
		CHEMBL1651093	57321	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
		11288140	84769	0	None	-12	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		CHEMBL223090	84769	0	None	-12	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		46830177	8061	30	None	-4365	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		CHEMBL1091105	8061	30	None	-4365	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		118055319	177526	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	1	1	2	2.6	FC(F)(F)CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4639970	177526	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	1	1	2	2.6	FC(F)(F)CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
		10050022	166356	0	None	-39	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(C2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL427398	166356	0	None	-39	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(C2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		49850870	56389	0	None	-3162	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631535	56389	0	None	-3162	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		49850570	56472	0	None	-2511	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632220	56472	0	None	-2511	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		44298140	100559	0	None	-79	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL291510	100559	0	None	-79	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
		18931172	106174	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1Cl	10.1016/S0960-894X(96)00503-3
		CHEMBL313745	106174	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1Cl	10.1016/S0960-894X(96)00503-3
		18931163	206775	0	None	-50	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	569	11	3	9	2.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C#N)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL90175	206775	0	None	-50	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	569	11	3	9	2.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C#N)cc1	10.1016/S0960-894X(96)00503-3
		18931420	206846	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	628	12	3	9	3.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL90565	206846	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	628	12	3	9	3.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1	10.1016/S0960-894X(96)00503-3
		127052465	140731	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		CHEMBL3817911	140731	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		10835585	101861	0	None	-63	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(C(F)(F)F)ccc21	10.1016/s0960-894x(00)00365-6
		CHEMBL300618	101861	0	None	-63	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(C(F)(F)F)ccc21	10.1016/s0960-894x(00)00365-6
		1836	2592	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	2592	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	2592	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	2592	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	2592	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		10597140	63045	0	None	-251	6	Human	5.4	pKi	=	5.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL1788231	63045	0	None	-251	6	Human	5.4	pKi	=	5.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		1703	3519	97	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
		6604926	3519	97	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
		CHEMBL291536	3519	97	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
		44343212	9838	0	None	-100	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL114012	9838	0	None	-100	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		49865890	16182	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	1	1	3	3.5	Cc1ccccc1NC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224106	16182	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	1	1	3	3.5	Cc1ccccc1NC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		57799324	89092	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337501	89092	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365359	89092	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		11312173	182111	0	None	-3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4782005	182111	0	None	-3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		127034715	136394	0	None	35	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735261	136394	0	None	35	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		107715	200945	22	None	-14	19	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	200945	22	None	-14	19	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	200945	22	None	-14	19	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		189	3492	39	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
		5163	3492	39	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
		CHEMBL297784	3492	39	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
		11694810	120539	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3310123	120539	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3545474	120539	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		11694810	120539	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3310123	120539	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545474	120539	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		10531	1420	21	None	-15	23	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	1420	21	None	-15	23	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	1420	21	None	-15	23	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	1420	21	None	-15	23	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	1420	21	None	-15	23	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		118706301	120538	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3310122	120538	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3545473	120538	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		168293874	192179	0	None	5	11	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		CHEMBL5204071	192179	0	None	5	11	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		145988313	167235	0	None	104	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
		CHEMBL4292326	167235	0	None	104	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
		168268877	189970	0	None	1	12	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		CHEMBL5170784	189970	0	None	1	12	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		127035064	136471	0	None	23	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
		CHEMBL3735911	136471	0	None	23	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
		135	2532	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		11681111	120584	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343666	120584	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545815	120584	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		16062783	155022	0	None	2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	323	3	1	4	3.5	COc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL401509	155022	0	None	2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	323	3	1	4	3.5	COc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		14049689	198443	11	None	20	2	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
		CHEMBL577294	198443	11	None	20	2	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
		58911653	91116	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397911	91116	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		57799306	89109	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337493	89109	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365469	89109	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
		9899500	67889	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.11.083
		CHEMBL191054	67889	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.11.083
		168281367	190901	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OCC3CC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL5185086	190901	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OCC3CC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		118729232	120675	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402655	120675	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547008	120675	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
		90188146	120698	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402674	120698	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547135	120698	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
		16062912	155152	0	None	-56	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	351	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL402164	155152	0	None	-56	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	351	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
		71461050	82977	0	None	-13	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181189	82977	0	None	-13	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
		45486891	196940	0	None	-83	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
		CHEMBL566379	196940	0	None	-83	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
		145974750	164755	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4217810	164755	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		127052465	140731	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		CHEMBL3817911	140731	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		89901924	120706	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402667	120706	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547153	120706	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
		16062651	95645	0	None	-13	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.1	CC(C)Cc1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		CHEMBL257944	95645	0	None	-13	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.1	CC(C)Cc1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		132007291	148945	0	None	-33	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	395	3	2	4	4.3	Fc1ccc(C#Cc2nc(NCc3cccc(Cl)c3)c3nc[nH]c3n2)cc1F	10.1021/acs.jmedchem.6b01183
		CHEMBL3941980	148945	0	None	-33	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	395	3	2	4	4.3	Fc1ccc(C#Cc2nc(NCc3cccc(Cl)c3)c3nc[nH]c3n2)cc1F	10.1021/acs.jmedchem.6b01183
		1782	2518	84	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		241	2518	84	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		4168	2518	84	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		CHEMBL86	2518	84	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		DB01233	2518	84	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		11171955	91093	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397888	91093	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
		16115515	137596	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
		CHEMBL375575	137596	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
		2775690	93011	53	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		CHEMBL2441619	93011	53	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		11848624	89146	0	None	2	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		CHEMBL236587	89146	0	None	2	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		46230100	199319	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
		CHEMBL590531	199319	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
		118717211	120578	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343663	120578	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545801	120578	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		44451422	167425	2	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	199	0	1	1	2.2	Fc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		CHEMBL429689	167425	2	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	199	0	1	1	2.2	Fc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		75201901	166425	19	None	-301	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	166425	19	None	-301	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		118729238	120679	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402659	120679	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547012	120679	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
		118729240	120680	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402660	120680	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547013	120680	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
		46884098	8187	0	None	-954	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	286	4	2	2	3.1	O=C(NCc1ccc(C2CCCCC2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		CHEMBL1092029	8187	0	None	-954	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	286	4	2	2	3.1	O=C(NCc1ccc(C2CCCCC2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
		142601329	186517	5	None	-63	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4877603	186517	5	None	-63	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		122187379	123027	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	441	5	0	5	5.3	C=CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3609144	123027	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	441	5	0	5	5.3	C=CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		122483223	138109	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764650	138109	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765874	138109	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		122187382	123029	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCN1CC(c2ccccc2)c2cc(OC)c(OC)c3c2C1Cc1cc2c(cc1-3)OCO2	10.1016/j.bmcl.2015.07.012
		CHEMBL3609147	123029	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCN1CC(c2ccccc2)c2cc(OC)c(OC)c3c2C1Cc1cc2c(cc1-3)OCO2	10.1016/j.bmcl.2015.07.012
		137646281	157806	0	None	-95	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4083252	157806	0	None	-95	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
		122178711	121377	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		CHEMBL3581256	121377	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		46933845	16162	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224034	16162	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		11957541	1459	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
		1229	1459	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
		147	1459	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
		170617	1459	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
		CHEMBL6616	1459	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
		25117676	200459	0	None	-831	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		CHEMBL598444	200459	0	None	-831	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		53325242	57070	0	None	-2	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644978	57070	0	None	-2	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		21854226	124604	5	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	230	3	2	2	2.5	Oc1cccc2[nH]cc(CCN3CCCC3)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL364061	124604	5	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	230	3	2	2	2.5	Oc1cccc2[nH]cc(CCN3CCCC3)c12	10.1016/j.bmcl.2005.06.104
		2286	3183	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		59752589	179826	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4745055	179826	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
		11425677	182335	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4784424	182335	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		145975946	163920	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	307	8	1	4	3.9	CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
		CHEMBL4207355	163920	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	307	8	1	4	3.9	CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
		2406	100404	89	None	-27	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	100404	89	None	-27	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		3198	205513	76	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		118055192	177033	0	None	-46	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	188	0	1	2	1.7	CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4632419	177033	0	None	-46	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	188	0	1	2	1.7	CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
		10947658	28702	0	None	-39	16	Human	7.4	pKi	=	7.4	Binding	Binding affinities against 5-hydroxytryptamine 2B receptorBinding affinities against 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL137781	28702	0	None	-39	16	Human	7.4	pKi	=	7.4	Binding	Binding affinities against 5-hydroxytryptamine 2B receptorBinding affinities against 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		44409095	76030	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	1	4	0.8	COc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL205671	76030	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	1	4	0.8	COc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		71618702	143382	0	None	1	4	Mouse	6.4	pKi	=	6.4	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1	nan
		CHEMBL3897835	143382	0	None	1	4	Mouse	6.4	pKi	=	6.4	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1	nan
		156014421	177205	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	3	1.4	[O-][S+]1CCN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4635293	177205	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	3	1.4	[O-][S+]1CCN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
		25122654	200528	0	None	-54	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	390	3	2	5	3.0	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc(Cl)c4)c3c2)CC1	10.1021/jm901674f
		CHEMBL598851	200528	0	None	-54	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	390	3	2	5	3.0	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc(Cl)c4)c3c2)CC1	10.1021/jm901674f
		135476741	155525	11	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.8	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL404232	155525	11	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.8	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
		117209962	184869	1	None	-16	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4852622	184869	1	None	-16	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		136118716	93059	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2442271	93059	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
		180	401	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		122178703	121369	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		CHEMBL3581248	121369	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		127049980	140634	1	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccc(Br)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3814485	140634	1	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccc(Br)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		134144970	150773	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	461	8	3	9	2.3	CCCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3956531	150773	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	461	8	3	9	2.3	CCCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		12901777	137998	32	None	-7	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
		CHEMBL376455	137998	32	None	-7	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
		44407337	74204	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL202324	74204	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		45378934	201646	0	None	-8	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
		CHEMBL605971	201646	0	None	-8	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
		135449090	189314	4	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	268	1	1	2	1.9	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL512332	189314	4	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	268	1	1	2	1.9	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
		4595	176715	106	None	2	15	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
		CHEMBL46	176715	106	None	2	15	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
		136118729	93062	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2442274	93062	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
		10150497	4074	47	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
		3240	4074	47	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
		CHEMBL392760	4074	47	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
		168	3982	15	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
		6604042	3982	15	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
		CHEMBL309760	3982	15	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
		10430183	205628	0	None	-457	7	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
		CHEMBL81728	205628	0	None	-457	7	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
		118055338	177185	0	None	-57	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.4	CC1CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
		CHEMBL4634942	177185	0	None	-57	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.4	CC1CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
		56852956	112043	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		71618636	148885	0	None	-7	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
		CHEMBL3941579	148885	0	None	-7	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
		56665075	65665	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834254	65665	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
		1547484	940	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	940	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	940	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	940	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	940	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		44582678	181574	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476839	181574	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		136188797	57322	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
		CHEMBL1651094	57322	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
		102	4127	48	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		3659	4127	48	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		8969	4127	48	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		CHEMBL15245	4127	48	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		DB01392	4127	48	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		24826787	91097	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397892	91097	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		24826869	91102	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397897	91102	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		145964159	164329	0	None	3	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4212435	164329	0	None	3	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		168281307	190806	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5183799	190806	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		56852956	112043	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		11347858	137037	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	2	3	1.3	O=C1c2c(cc(CO)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
		CHEMBL374659	137037	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	2	3	1.3	O=C1c2c(cc(CO)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
		136030744	57321	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
		CHEMBL1651093	57321	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
		134149008	148461	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	353	3	3	8	-0.1	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)O)C[C@H]12	10.1021/acs.jmedchem.6b01183
		CHEMBL3938006	148461	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	353	3	3	8	-0.1	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)O)C[C@H]12	10.1021/acs.jmedchem.6b01183
		16115521	84665	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		CHEMBL222466	84665	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		155566338	175911	0	None	-446	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	405	4	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL4587144	175911	0	None	-446	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	405	4	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		134134668	144253	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	6	4	8	1.4	CCC(CC)Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
		CHEMBL3904817	144253	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	6	4	8	1.4	CCC(CC)Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
		2477	745	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		36	745	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		437	745	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		CHEMBL49	745	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		DB00490	745	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
		11666237	89112	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2337496	89112	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2365472	89112	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		11609026	89127	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337500	89127	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365705	89127	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
		44409031	74956	0	None	-30	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N12	10.1016/j.bmcl.2005.11.083
		CHEMBL203230	74956	0	None	-30	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N12	10.1016/j.bmcl.2005.11.083
		122178702	121368	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		CHEMBL3581247	121368	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		168295984	192220	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL5204813	192220	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		134155462	151109	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	339	3	3	8	-0.2	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
		CHEMBL3959210	151109	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	339	3	3	8	-0.2	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
		10058473	20655	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2sccc12	10.1021/jm980692q
		CHEMBL13086	20655	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2sccc12	10.1021/jm980692q
		71681898	91089	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
		CHEMBL2397884	91089	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
		49865832	16163	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	3	1	3	3.3	CCCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224035	16163	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	3	1	3	3.3	CCCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		136118618	76250	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058417	76250	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
		56707820	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
		9155	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
		CHEMBL4548689	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
		CHEMBL5306285	194583	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	486	7	2	9	3.2	C[C@H](NC(=O)c1cn(C2(C#N)CC2)cn1)C(=O)Nc1nc(-c2cccc(-c3ccn(C)n3)c2)cs1	10.6019/CHEMBL5303766
		9859257	205123	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
		CHEMBL77880	205123	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
		2105	3054	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	3054	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	3054	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	3054	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	3054	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		71028	84361	25	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	216	1	2	2	2.4	COc1ccc2[nH]c3c(c2c1)CCNC3C	10.1021/jm100600y
		CHEMBL221811	84361	25	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	216	1	2	2	2.4	COc1ccc2[nH]c3c(c2c1)CCNC3C	10.1021/jm100600y
		25122652	200662	0	None	-134	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	3	2	5	3.8	Cc1ccc(S(=O)(=O)c2n[nH]c3ccc(N4CCC(N)CC4)cc23)c2ccccc12	10.1021/jm901674f
		CHEMBL599663	200662	0	None	-134	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	3	2	5	3.8	Cc1ccc(S(=O)(=O)c2n[nH]c3ccc(N4CCC(N)CC4)cc23)c2ccccc12	10.1021/jm901674f
		11653679	181191	1	None	-75	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned 5HT2B receptorBinding affinity to human cloned 5HT2B receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL476108	181191	1	None	-75	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned 5HT2B receptorBinding affinity to human cloned 5HT2B receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		56707820	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
		9155	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
		CHEMBL4548689	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
		56707820	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5212743
		9155	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5212743
		CHEMBL4548689	2910	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5212743
		5009938	15409	1	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	306	4	0	3	3.8	c1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		CHEMBL1214829	15409	1	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	306	4	0	3	3.8	c1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		11393128	182861	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4791646	182861	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		10527432	36286	0	None	1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1Cl)CC2	10.1021/jm990388c
		CHEMBL14458	36286	0	None	1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1Cl)CC2	10.1021/jm990388c
		10550405	38057	0	None	-5	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL14606	38057	0	None	-5	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		75306277	109254	0	None	-2	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	109254	0	None	-2	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		166	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
		3045227	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
		CHEMBL76781	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
		166	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
		3045227	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
		CHEMBL76781	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
		11536843	115123	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343673	115123	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		11500509	120581	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343670	120581	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545812	120581	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		31101	729	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	729	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	729	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	729	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	729	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		10331436	324	10	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		160	324	10	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		CHEMBL133455	324	10	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		242	470	124	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		34	470	124	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		60795	470	124	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		CHEMBL1112	470	124	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		DB01238	470	124	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		44364163	39788	1	None	-3	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	190	1	2	1	2.1	NC1CC1c1c[nH]c2ccc(F)cc12	10.1021/jm980318q
		CHEMBL147656	39788	1	None	-3	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	190	1	2	1	2.1	NC1CC1c1c[nH]c2ccc(F)cc12	10.1021/jm980318q
		118464420	138245	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
		CHEMBL3770342	138245	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
		127035063	136486	0	None	21	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
		CHEMBL3736149	136486	0	None	21	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
		44404886	72225	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
		CHEMBL198124	72225	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
		CHEMBL5077293	214491	0	None	-17	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		136118648	76321	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058703	76321	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
		118729266	120700	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402676	120700	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547137	120700	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
		10837002	35366	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1021/jm990388c
		CHEMBL14374	35366	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1021/jm990388c
		18475647	197712	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	334	5	2	3	4.7	CCN(CC)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
		CHEMBL57135	197712	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	334	5	2	3	4.7	CCN(CC)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
		10837002	35366	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL14374	35366	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		44298175	100940	0	None	-39	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL294030	100940	0	None	-39	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
		11742218	195793	0	None	-25	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	4	1	4	5.4	CCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL55792	195793	0	None	-25	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	4	1	4	5.4	CCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		18931202	206803	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1ccc(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		CHEMBL90346	206803	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1ccc(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		73350823	102530	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
		CHEMBL2424668	102530	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
		CHEMBL3040578	102530	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
		10257042	204361	0	None	-12	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	551	6	3	3	7.3	O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1	10.1016/s0960-894x(01)00397-3
		CHEMBL71707	204361	0	None	-12	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	551	6	3	3	7.3	O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1	10.1016/s0960-894x(01)00397-3
		9866423	72304	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	413	7	0	4	4.1	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL198330	72304	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	413	7	0	4	4.1	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		24887527	80026	0	None	-100	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	4.9	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		CHEMBL212886	80026	0	None	-100	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	4.9	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
		24887290	80249	0	None	-630	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL213839	80249	0	None	-630	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		44414051	166227	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	5.0	COc1ccc(C2=C(C)CN(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL426684	166227	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	5.0	COc1ccc(C2=C(C)CN(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		10454231	168961	0	None	-79	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(C2=CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL438963	168961	0	None	-79	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(C2=CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		11292933	56394	45	None	-2511	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631540	56394	45	None	-2511	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		44298100	196065	0	None	-158	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2ccc(Cl)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL56050	196065	0	None	-158	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2ccc(Cl)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
		153287551	169952	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	307	1	0	2	3.8	CC(=O)N1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		CHEMBL4441621	169952	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	307	1	0	2	3.8	CC(=O)N1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		153287553	171104	0	None	-79	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4457754	171104	0	None	-79	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		17989823	152076	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.0	COc1ccc(N2Cc3cccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL396748	152076	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.0	COc1ccc(N2Cc3cccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		10813396	98716	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cc(F)cc(F)c3)c1)CC2	10.1021/jm990388c
		CHEMBL277732	98716	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cc(F)cc(F)c3)c1)CC2	10.1021/jm990388c
		18357723	195520	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	424	4	1	4	4.4	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Br)ccc21	10.1016/s0960-894x(00)00365-6
		CHEMBL55388	195520	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	424	4	1	4	4.4	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Br)ccc21	10.1016/s0960-894x(00)00365-6
		44298129	195957	0	None	-125	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	364	3	1	4	4.3	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL55958	195957	0	None	-125	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	364	3	1	4	4.3	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		2028	2979	80	None	-40	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		359	2979	80	None	-40	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		4634	2979	80	None	-40	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		CHEMBL1231	2979	80	None	-40	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		DB01062	2979	80	None	-40	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		136020617	57323	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/np100588c
		CHEMBL1651095	57323	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/np100588c
		132060770	162639	0	None	-8	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4169689	162639	0	None	-8	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		135367820	164821	0	None	-9	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4218672	164821	0	None	-9	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		135846981	93052	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1/N/C(=C/c2c[nH]c3ccccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2442265	93052	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1/N/C(=C/c2c[nH]c3ccccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL5306285	194583	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	486	7	2	9	3.2	C[C@H](NC(=O)c1cn(C2(C#N)CC2)cn1)C(=O)Nc1nc(-c2cccc(-c3ccn(C)n3)c2)cs1	10.6019/CHEMBL5303766
		CHEMBL5072247	214275	5	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL		None	None	None		CC[C@H]1CN2CCc3c([nH]c4cccc(O)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		145980271	166492	0	None	1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4278465	166492	0	None	1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4475494	213951	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O	10.6019/CHEMBL4879554
		71452172	83518	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysis	ChEMBL	274	6	1	5	2.4	c1ccc(OCc2cc(OC[C@@H]3CCCN3)no2)cc1	10.1021/ml3002715
		CHEMBL2203551	83518	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysis	ChEMBL	274	6	1	5	2.4	c1ccc(OCc2cc(OC[C@@H]3CCCN3)no2)cc1	10.1021/ml3002715
		46230100	199319	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
		CHEMBL590531	199319	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
		127049981	140599	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(I)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3813789	140599	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(I)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		135464118	93060	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2442272	93060	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		155556596	174423	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT2B by radio-ligand binding displacement assayInhibition of human 5HT2B by radio-ligand binding displacement assay	ChEMBL	428	5	4	7	3.1	OC[C@@]12C[C@@H]1[C@@H](n1cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b00689
		CHEMBL4552895	174423	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT2B by radio-ligand binding displacement assayInhibition of human 5HT2B by radio-ligand binding displacement assay	ChEMBL	428	5	4	7	3.1	OC[C@@]12C[C@@H]1[C@@H](n1cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b00689
		161	754	6	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
		4284720	754	6	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
		CHEMBL1255834	754	6	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
		58911644	91100	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		CHEMBL2397895	91100	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
		136020617	57323	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL1651095	57323	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4475494	213951	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O	10.6019/CHEMBL4879554
		44407460	140350	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
		CHEMBL380763	140350	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
		90181061	160871	0	None	1	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
		CHEMBL4115017	160871	0	None	1	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
		145	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
		1832	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
		CHEMBL7257	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
		DB14010	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
		2726	919	68	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
		621	919	68	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
		83	919	68	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
		CHEMBL71	919	68	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
		DB00477	919	68	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
		72735042	106310	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092763	106310	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3139089	106310	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		127036953	137515	0	None	-5	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754166	137515	0	None	-5	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		118709751	113541	0	None	-407	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		CHEMBL3321792	113541	0	None	-407	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		136118653	93054	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2442267	93054	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		54764240	68868	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL1922539	68868	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL4592872	214020	0	None	-4	3	Human	5.3	pKi	=	5.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000340a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000340a HTR2B	ChEMBL		None	None	None		O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@H]1c1ccc(F)cc1	10.6019/CHEMBL5212743
		58405078	110696	0	None	-6	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
		CHEMBL3260335	110696	0	None	-6	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
		398712	77869	5	None	-52	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		CHEMBL209324	77869	5	None	-52	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		9859144	67361	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	208	0	1	2	1.7	Clc1ccc2c(c1)N1CCNCC1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL188605	67361	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	208	0	1	2	1.7	Clc1ccc2c(c1)N1CCNCC1C2	10.1016/j.bmcl.2005.05.074
		122178701	121367	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3581246	121367	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		122178708	121374	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		CHEMBL3581253	121374	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
		2884131	166908	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
		CHEMBL4286420	166908	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
		71655748	87825	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	359	5	1	4	4.8	CC(C)CCOc1ccc2c(c1)[C@H]1OCCC[C@H]1[C@@H](C1CCOCC1)N2	10.1021/jm400181k
		CHEMBL2338343	87825	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	359	5	1	4	4.8	CC(C)CCOc1ccc2c(c1)[C@H]1OCCC[C@H]1[C@@H](C1CCOCC1)N2	10.1021/jm400181k
		142601335	186421	0	None	-44	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4876193	186421	0	None	-44	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		134157367	153898	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	517	10	5	9	1.0	CC(=O)NCCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3983143	153898	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	517	10	5	9	1.0	CC(=O)NCCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		11644842	89097	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337105	89097	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365394	89097	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		4098	32505	30	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL4557026	214007	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000700a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000700a HTR2B	ChEMBL		None	None	None		C[C@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccn1	10.6019/CHEMBL5212743
		54764241	68867	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL1922538	68867	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		18735313	204934	1	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
		CHEMBL76307	204934	1	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
		24826868	91082	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397877	91082	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		127049979	140650	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(Cl)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		CHEMBL3814708	140650	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(Cl)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
		5282379	194984	69	None	1	3	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
		CHEMBL547	194984	69	None	1	3	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
		118729242	120685	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402661	120685	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547028	120685	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
		181743	178572	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL467094	178572	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2015.07.012
		181743	178572	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		CHEMBL467094	178572	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		16115511	84837	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		CHEMBL223466	84837	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		122178709	121375	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3581254	121375	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		4407909	192866	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5182943	192866	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5221893	192866	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		118055233	177268	0	None	-38	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	214	0	1	2	2.0	c1cc2c3c(c1)C1(CCC1)CN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4636196	177268	0	None	-38	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	214	0	1	2	2.0	c1cc2c3c(c1)C1(CCC1)CN3CCNC2	10.1016/j.bmcl.2019.126929
		11448649	83433	0	None	-27	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
		CHEMBL219734	83433	0	None	-27	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
		29101	72224	2	None	-10	2	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	298	5	2	4	1.8	CN(C)CCc1cn(C)c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL198123	72224	2	None	-10	2	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	298	5	2	4	1.8	CN(C)CCc1cn(C)c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
		71061709	149527	0	None	-3	11	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3946540	149527	0	None	-3	11	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		11222829	91111	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397906	91111	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		162669941	182655	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	4	8	1.8	CC(C)C(Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C(C)C	10.1016/j.bmcl.2020.127599
		CHEMBL4788883	182655	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	4	8	1.8	CC(C)C(Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C(C)C	10.1016/j.bmcl.2020.127599
		44404895	170809	0	None	-12	3	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	292	3	2	2	3.9	Oc1cccc2[nH]cc(CCN3CCCc4ccccc43)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL445331	170809	0	None	-12	3	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	292	3	2	2	3.9	Oc1cccc2[nH]cc(CCN3CCCc4ccccc43)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL4798829	214053	7	None	6	2	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000752a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000752a HTR2B	ChEMBL		None	None	None		c1ccc2oc(-c3csc(C4CCN(Cc5nc6ncccc6[nH]5)CC4)n3)cc2c1	10.6019/CHEMBL5212743
		44582705	186996	0	None	-3	13	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490632	186996	0	None	-3	13	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		3158	56267	27	None	-389	20	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-389	20	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		122178699	121366	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3581245	121366	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		216239	23795	118	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
		CHEMBL1200485	23795	118	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
		CHEMBL1336	23795	118	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
		73213195	104459	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		11808247	18075	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL126667	18075	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819366	18075	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		11808247	18075	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL126667	18075	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819366	18075	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		44456400	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		44456400	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	12834	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		49865830	16160	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.0	CC(C)NC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224032	16160	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.0	CC(C)NC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
		41305446	167252	1	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	398	5	1	2	4.5	O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
		CHEMBL4292719	167252	1	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	398	5	1	2	4.5	O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
		46914772	15441	0	None	56	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		CHEMBL1215036	15441	0	None	56	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		73213195	104459	0	None	-1	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-1	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		122178700	121305	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3580670	121305	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		71681899	91087	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397882	91087	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		2291	3184	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		2561	3184	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		4932	3184	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		CHEMBL631	3184	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		DB01182	3184	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
		44364514	121699	10	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	NC1CC1c1c[nH]c2ccccc12	10.1021/jm980318q
		CHEMBL358810	121699	10	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	NC1CC1c1c[nH]c2ccccc12	10.1021/jm980318q
		10103618	121526	4	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@@H]1C[C@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
		CHEMBL358522	121526	4	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@@H]1C[C@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
		50878551	90745	61	None	-1	18	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL2391541	90745	61	None	-1	18	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		11492300	89111	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337495	89111	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365471	89111	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
		68691189	91108	0	None	1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397903	91108	0	None	1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		25117677	200252	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		CHEMBL597009	200252	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		176	398	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		127051844	140847	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819427	140847	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		127051844	140847	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819427	140847	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		136118620	76252	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL2058419	76252	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
		44397846	67645	0	None	-22	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL190584	67645	0	None	-22	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		127034729	136365	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	463	12	0	6	5.1	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
		CHEMBL3734894	136365	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	463	12	0	6	5.1	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
		127036910	136465	0	None	18	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	419	10	0	5	4.7	COc1ccc(CCN(CCc2ccc3c(c2)OCO3)Cc2ccccc2)cc1OC	10.1039/C4MD00418C
		CHEMBL3735862	136465	0	None	18	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	419	10	0	5	4.7	COc1ccc(CCN(CCc2ccc3c(c2)OCO3)Cc2ccccc2)cc1OC	10.1039/C4MD00418C
		136118615	93065	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL2442277	93065	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
		657255	199084	34	None	-9	15	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	199084	34	None	-9	15	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		45486824	197377	0	None	-14	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
		CHEMBL569251	197377	0	None	-14	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
		135427931	73120	2	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	317	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(I)c21	10.1021/jm050663x
		CHEMBL201132	73120	2	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	317	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(I)c21	10.1021/jm050663x
		58911579	91096	0	None	12	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397891	91096	0	None	12	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		277	1301	62	None	-4	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-4	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-4	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-4	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-4	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		118464420	138245	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770342	138245	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
		118464421	167292	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
		CHEMBL4293638	167292	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
		118706294	120535	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3310118	120535	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3545470	120535	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		44324142	206956	0	None	-25	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	427	7	2	5	3.0	COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		CHEMBL91221	206956	0	None	-25	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	427	7	2	5	3.0	COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
		10670191	40897	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	428	3	1	4	5.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2	10.1021/jm990388c
		CHEMBL14864	40897	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	428	3	1	4	5.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2	10.1021/jm990388c
		135398745	2914	112	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		47	2914	112	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		CHEMBL715	2914	112	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		DB00334	2914	112	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		44298080	195970	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	431	4	1	5	4.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL55969	195970	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	431	4	1	5	4.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
		191	403	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		118706292	120534	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310117	120534	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545469	120534	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
		127035065	136500	0	None	30	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
		CHEMBL3736207	136500	0	None	30	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
		73453	29616	24	None	-9	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	29616	24	None	-9	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		118729258	120696	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402671	120696	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547133	120696	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
		127036186	137414	0	None	-1	19	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3753318	137414	0	None	-1	19	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		71062829	160134	0	None	1	3	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	339	6	0	5	2.2	c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1	nan
		CHEMBL4108986	160134	0	None	1	3	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	339	6	0	5	2.2	c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1	nan
		10659364	120714	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
		CHEMBL3402685	120714	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
		CHEMBL3547178	120714	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
		122187376	123024	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	457	6	0	5	5.9	CCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3609141	123024	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	457	6	0	5	5.9	CCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		9978683	18674	0	None	-380	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
		CHEMBL1277104	18674	0	None	-380	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
		53325861	56856	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		CHEMBL1643902	56856	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		53325861	56856	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmcl.2010.11.075
		CHEMBL1643902	56856	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmcl.2010.11.075
		117209858	184554	1	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4848305	184554	1	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		46230047	199250	0	None	16	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
		CHEMBL590089	199250	0	None	16	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
		24839550	137315	14	None	1	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752576	137315	14	None	1	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		45486891	196940	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
		CHEMBL566379	196940	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
		27620	140818	13	None	-269	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818994	140818	13	None	-269	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		24360	203344	106	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
		CHEMBL65	203344	106	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
		44315697	205505	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
		CHEMBL80731	205505	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
		3952	1888	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5353646	1888	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5443	1888	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5702063	1888	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL1331786	1888	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL420	1888	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		145967771	164787	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4218231	164787	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
		57396813	71545	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		CHEMBL1949930	71545	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		CHEMBL1963007	71545	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		44407335	73094	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
		CHEMBL201117	73094	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
		57799321	89061	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337491	89061	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2364961	89061	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		71462777	82965	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	335	5	0	4	4.3	CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1	10.1021/jm300943r
		CHEMBL2181171	82965	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	335	5	0	4	4.3	CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1	10.1021/jm300943r
		56658156	65667	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccccc1CCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
		CHEMBL1834256	65667	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccccc1CCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
		168281486	191034	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(OCCF)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL5187013	191034	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(OCCF)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		11630147	91113	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397908	91113	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		44298209	194591	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL53113	194591	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		44298225	195478	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	456	3	1	5	5.1	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(C(F)(F)F)c2c3CCO2)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL55292	195478	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	456	3	1	5	5.1	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(C(F)(F)F)c2c3CCO2)cn1	10.1016/s0960-894x(00)00364-4
		44298244	200075	0	None	-79	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1cc2c(cc1Br)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL59584	200075	0	None	-79	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1cc2c(cc1Br)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
		17989871	150325	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(C)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		CHEMBL395298	150325	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(C)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
		10693974	35665	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccc(F)cc3)c1)CC2	10.1021/jm990388c
		CHEMBL14401	35665	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccc(F)cc3)c1)CC2	10.1021/jm990388c
		10458193	86842	0	None	-25	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cc(F)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		CHEMBL232254	86842	0	None	-25	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cc(F)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
		44568347	191651	0	None	-30	15	Human	6.2	pKi	=	6.2	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL519609	191651	0	None	-30	15	Human	6.2	pKi	=	6.2	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		18475581	199599	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	4	4.3	Cc1nc2ccc(NC(=O)Nc3ccnc4ccccc34)cc2o1	10.1016/s0960-894x(01)00343-2
		CHEMBL59266	199599	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	4	4.3	Cc1nc2ccc(NC(=O)Nc3ccnc4ccccc34)cc2o1	10.1016/s0960-894x(01)00343-2
		24888180	79868	0	None	-251	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	426	7	0	4	4.6	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL212270	79868	0	None	-251	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	426	7	0	4	4.6	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		24887518	80284	0	None	-794	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		CHEMBL213987	80284	0	None	-794	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
		44298091	101719	0	None	-99	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	398	3	1	4	5.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL299530	101719	0	None	-99	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	398	3	1	4	5.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		10476876	194976	0	None	-158	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C(F)(F)F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL54610	194976	0	None	-158	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C(F)(F)F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		44298182	194997	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	424	3	1	4	4.9	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL54769	194997	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	424	3	1	4	4.9	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)ccc32)cn1	10.1016/s0960-894x(00)00364-4
		10413595	161841	0	None	-1995	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		CHEMBL414628	161841	0	None	-1995	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		6918647	100746	2	None	-125	14	Human	6.2	pKi	=	6.2	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
		CHEMBL292759	100746	2	None	-125	14	Human	6.2	pKi	=	6.2	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
		18931344	206534	0	None	-19	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	544	11	3	8	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1	10.1016/S0960-894X(96)00503-3
		CHEMBL88571	206534	0	None	-19	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	544	11	3	8	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1	10.1016/S0960-894X(96)00503-3
		155557042	174557	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
		CHEMBL4556297	174557	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
		15124	141135	7	None	1	4	Human	5.2	pKi	=	5.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	3	2	2	2.0	CN(C)CCc1c[nH]c2cc(O)ccc12	10.1016/j.bmcl.2005.06.104
		CHEMBL382750	141135	7	None	1	4	Human	5.2	pKi	=	5.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	3	2	2	2.0	CN(C)CCc1c[nH]c2cc(O)ccc12	10.1016/j.bmcl.2005.06.104
		118055308	177762	0	None	-2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	208	0	1	2	1.8	Clc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		CHEMBL4642763	177762	0	None	-2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	208	0	1	2	1.8	Clc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
		2099	9307	55	None	-	1	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
		CHEMBL1110	9307	55	None	-	1	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
		25209050	181590	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	479	6	2	6	3.9	Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL477008	181590	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	479	6	2	6	3.9	Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		11820166	40275	0	None	-5	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1cccc2[nH]cc(C3CC3N)c12	10.1021/jm980318q
		CHEMBL148091	40275	0	None	-5	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1cccc2[nH]cc(C3CC3N)c12	10.1021/jm980318q
		70695812	73284	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		CHEMBL2012686	73284	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		71062560	153428	0	None	-1	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	352	5	0	4	2.4	O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21	nan
		CHEMBL3979116	153428	0	None	-1	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	352	5	0	4	2.4	O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21	nan
		59511191	185523	3	None	-8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4862745	185523	3	None	-8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		44276349	100004	0	None	-288	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	325	3	4	8	-0.2	CNc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
		CHEMBL286739	100004	0	None	-288	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	325	3	4	8	-0.2	CNc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
		11427139	84687	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL222566	84687	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		2274	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		132060812	162036	0	None	-16	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		CHEMBL4160064	162036	0	None	-16	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		44215629	156342	1	None	-12	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	206	0	1	2	1.9	N#Cc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		CHEMBL406585	156342	1	None	-12	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	206	0	1	2	1.9	N#Cc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		118729236	120678	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402658	120678	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547011	120678	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
		CHEMBL4513786	213967	7	None	-1174	8	Human	5.2	pKi	=	5.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2B	ChEMBL		None	None	None		CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC	10.6019/CHEMBL5212743
		CHEMBL4796803	213967	7	None	-1174	8	Human	5.2	pKi	=	5.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2B	ChEMBL		None	None	None		CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC	10.6019/CHEMBL5212743
		46914776	15418	0	None	7	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		CHEMBL1214892	15418	0	None	7	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		71062708	154306	0	None	-3	12	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3986651	154306	0	None	-3	12	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		49865886	16180	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	262	2	1	3	2.1	CCCNC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		CHEMBL1224102	16180	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	262	2	1	3	2.1	CCCNC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
		11198145	9815	2	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL113830	9815	2	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		49783209	17609	0	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	17609	0	None	-33	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		10539928	120707	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402668	120707	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547154	120707	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
		136118619	76251	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058418	76251	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
		25060119	104315	0	None	-9332	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
		CHEMBL3099899	104315	0	None	-9332	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
		122187377	123025	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	485	8	0	5	6.7	CCCCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3609142	123025	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	485	8	0	5	6.7	CCCCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL5071978	214272	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		44397752	125269	0	None	-7	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
		CHEMBL364534	125269	0	None	-7	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
		46230097	199366	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
		CHEMBL590816	199366	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
		130442480	175270	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	175270	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		134150123	152090	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	4	2	9	0.4	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3967613	152090	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	4	2	9	0.4	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		3033538	1319	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		7155	1319	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		781	1319	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		CHEMBL1201216	1319	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		DB00298	1319	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
		16118795	60096	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1642851	60096	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1739215	60096	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		16117153	60139	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1642889	60139	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1739616	60139	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		70695812	73284	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
		CHEMBL2012686	73284	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
		44352308	117487	0	None	-83	12	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		CHEMBL339980	117487	0	None	-83	12	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		122442272	138348	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	138348	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	138348	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		213	3853	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	3853	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	3853	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	3853	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	3853	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		44409097	76606	0	None	-4	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	257	0	1	3	1.8	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)nc3N12	10.1016/j.bmcl.2005.11.083
		CHEMBL206333	76606	0	None	-4	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	257	0	1	3	1.8	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)nc3N12	10.1016/j.bmcl.2005.11.083
		44626329	197408	0	None	-20	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
		CHEMBL569513	197408	0	None	-20	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
		11148641	91090	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
		CHEMBL2397885	91090	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
		CHEMBL5091373	215567	0	None	-33	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095981	215567	0	None	-33	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		2351	3286	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
		2820	3286	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
		5035	3286	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
		CHEMBL81	3286	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
		DB00481	3286	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
		122442272	138348	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	138348	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	138348	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		9909648	205573	3	None	-22	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm100600y
		CHEMBL81330	205573	3	None	-22	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm100600y
		145977799	163643	0	None	1	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4204036	163643	0	None	1	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4778870	214047	8	None	-1	5	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1	10.6019/CHEMBL4800732
		12488	1657	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		53324553	56855	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		CHEMBL1643900	56855	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		53324553	56855	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		CHEMBL1643900	56855	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		CHEMBL4778870	214047	8	None	-1	5	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1	10.6019/CHEMBL4800732
		16115271	79108	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
		CHEMBL2113264	79108	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
		71720492	86968	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	493	8	2	5	3.0	C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/ml3003814
		CHEMBL2323578	86968	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	493	8	2	5	3.0	C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/ml3003814
		135398737	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		9803032	191453	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5193178	191453	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
		3649661	138219	7	None	23	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770106	138219	7	None	23	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		2247	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		11708275	72712	3	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
		CHEMBL199775	72712	3	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
		134	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		1775	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		9681	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		CHEMBL1065	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		DB00247	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		134	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		1775	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		9681	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		CHEMBL1065	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		DB00247	2514	24	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
		11949710	199902	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
		CHEMBL594717	199902	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
		36906	104880	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
		CHEMBL31115	104880	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
		36906	104880	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm030205t
		CHEMBL31115	104880	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm030205t
		44573547	187632	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assayBinding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assay	ChEMBL	348	5	1	5	2.6	C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F	10.1021/acs.jmedchem.2c00633
		CHEMBL494948	187632	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assayBinding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assay	ChEMBL	348	5	1	5	2.6	C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F	10.1021/acs.jmedchem.2c00633
		9931534	34109	0	None	-7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL14255	34109	0	None	-7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		10623205	99067	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	445	3	1	3	5.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL280465	99067	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	445	3	1	3	5.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
		10837468	162708	0	None	-15	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	455	3	1	4	5.3	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2	10.1021/jm990388c
		CHEMBL417082	162708	0	None	-15	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	455	3	1	4	5.3	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2	10.1021/jm990388c
		10622480	167036	0	None	-5	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		CHEMBL428879	167036	0	None	-5	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
		44298176	100628	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL291949	100628	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
		18357730	195909	0	None	-19	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL55914	195909	0	None	-19	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2	10.1016/s0960-894x(00)00365-6
		44453103	98061	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	296	4	1	4	2.9	CCN(CC)c1nc2c(c(-c3ccc(C)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		CHEMBL273173	98061	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	296	4	1	4	2.9	CCN(CC)c1nc2c(c(-c3ccc(C)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		240	944	43	None	-6	24	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		2769	944	43	None	-6	24	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		44279790	944	43	None	-6	24	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		660	944	43	None	-6	24	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL1729	944	43	None	-6	24	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL560739	944	43	None	-6	24	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		DB00604	944	43	None	-6	24	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		11737939	84227	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
		CHEMBL220900	84227	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
		118729268	120701	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402677	120701	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547138	120701	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
		118729254	120708	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402669	120708	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547155	120708	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
		16062136	157668	4	None	-13	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	1	1	3	3.2	CC(C)(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		CHEMBL408155	157668	4	None	-13	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	1	1	3	3.2	CC(C)(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
		146159245	188450	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		451415	188450	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		86289437	188450	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		CHEMBL502620	188450	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
		12613159	187326	11	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL493054	187326	11	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		10517285	120712	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402683	120712	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547176	120712	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
		1224	1432	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		122187381	123028	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	401	2	1	5	4.5	COc1cc2c3c(c1O)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3609146	123028	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	401	2	1	5	4.5	COc1cc2c3c(c1O)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		135465870	188991	8	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL508657	188991	8	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
		155565326	175585	0	None	-467	7	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	462	6	5	9	0.5	O=C(NCCO)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL4579650	175585	0	None	-467	7	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	462	6	5	9	0.5	O=C(NCCO)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		46914620	15433	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		CHEMBL1214962	15433	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		46230094	199311	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
		CHEMBL590482	199311	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
		57403525	70154	0	None	-478	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940402	70154	0	None	-478	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		127051845	140729	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3817898	140729	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		4178	195803	63	None	-	1	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
		CHEMBL558	195803	63	None	-	1	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
		127051845	140729	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3817898	140729	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		145986752	167276	0	None	-1	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		CHEMBL4293307	167276	0	None	-1	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		11695000	89071	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337490	89071	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365083	89071	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
		118729276	120689	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402682	120689	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547045	120689	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
		134152157	153139	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		CHEMBL3976579	153139	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
		21830793	91835	10	None	-489	45	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		CHEMBL2413154	91835	10	None	-489	45	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		16115392	84797	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		CHEMBL223292	84797	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		11665991	199344	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CNCCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
		CHEMBL590721	199344	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CNCCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
		222757	99376	73	None	-1	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
		CHEMBL282575	99376	73	None	-1	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
		2812	4779	101	None	-40	34	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-40	34	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		44407440	139306	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL379223	139306	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		24740863	89158	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
		CHEMBL236610	89158	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
		46214153	110695	0	None	-6	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
		CHEMBL3260334	110695	0	None	-6	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
		11221167	84680	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
		CHEMBL222514	84680	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
		CHEMBL4520788	213975	10	None	-3	25	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR2B	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		155535754	172075	0	None	13	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	301	1	1	4	1.2	Cc1cccc(C)c1N1C(=O)CNC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
		CHEMBL4472251	172075	0	None	13	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	301	1	1	4	1.2	Cc1cccc(C)c1N1C(=O)CNC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
		44404906	70270	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	2	2	2.4	CC(Cc1c[nH]c2cccc(O)c12)N(C)C	10.1016/j.bmcl.2005.06.104
		CHEMBL194202	70270	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	2	2	2.4	CC(Cc1c[nH]c2cccc(O)c12)N(C)C	10.1016/j.bmcl.2005.06.104
		24873261	183194	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4795756	183194	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		16115644	136960	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL374436	136960	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		145964150	164306	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
		CHEMBL4212246	164306	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
		118567543	171368	0	None	-7	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	463	4	0	4	4.2	O=C1N(c2cccnc2C(F)(F)F)CC2(CCN(CCc3ccccc3F)CC2)OC12CC2	10.1021/acs.jmedchem.9b01256
		CHEMBL4461774	171368	0	None	-7	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	463	4	0	4	4.2	O=C1N(c2cccnc2C(F)(F)F)CC2(CCN(CCc3ccccc3F)CC2)OC12CC2	10.1021/acs.jmedchem.9b01256
		88912137	110698	0	None	-245	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
		CHEMBL3260337	110698	0	None	-245	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
		122188580	123185	0	None	-19	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	485	5	4	8	2.4	CCCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.9b00637
		CHEMBL3612941	123185	0	None	-19	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	485	5	4	8	2.4	CCCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.9b00637
		71062889	148274	0	None	-41	5	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
		CHEMBL3936595	148274	0	None	-41	5	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
		44409096	76775	0	None	-28	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	203	0	1	3	1.1	Cc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL206845	76775	0	None	-28	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	203	0	1	3	1.1	Cc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		134138769	147671	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		CHEMBL3931747	147671	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
		132559161	173022	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2b (unknown origin)Binding affinity to 5HT2b (unknown origin)	ChEMBL	538	7	2	7	1.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccoc2)N(C)C(=O)[C@H](Cc2ccoc2)NC(=O)[C@H](Cc2ccoc2)N(C)C1=O	10.1039/C9MD00050J
		CHEMBL4518571	173022	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2b (unknown origin)Binding affinity to 5HT2b (unknown origin)	ChEMBL	538	7	2	7	1.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccoc2)N(C)C(=O)[C@H](Cc2ccoc2)NC(=O)[C@H](Cc2ccoc2)N(C)C1=O	10.1039/C9MD00050J
		90181066	160163	0	None	9	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	380	5	0	4	3.1	Cc1ccccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
		CHEMBL4109218	160163	0	None	9	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	380	5	0	4	3.1	Cc1ccccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
		136118652	93053	0	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cccc(Br)c23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2442266	93053	0	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cccc(Br)c23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		11673842	89088	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2337498	89088	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2365254	89088	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		11361103	91105	1	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397900	91105	1	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		18715554	74424	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL202656	74424	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
		24826871	91112	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397907	91112	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		25122653	200527	0	None	-17	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	440	3	2	5	4.1	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5c(Cl)cccc45)c3c2)CC1	10.1021/jm901674f
		CHEMBL598850	200527	0	None	-17	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	440	3	2	5	4.1	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5c(Cl)cccc45)c3c2)CC1	10.1021/jm901674f
		136118638	76316	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058698	76316	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
		136118730	76244	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
		CHEMBL2058407	76244	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
		71062567	160415	0	None	2	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL4111349	160415	0	None	2	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		54764239	68866	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		CHEMBL1922537	68866	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
		11630623	89099	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2337499	89099	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2365399	89099	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		56649649	67857	0	None	-93	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910140	67857	0	None	-93	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		86221574	166687	2	None	9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	375	5	2	2	3.4	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1	10.1039/C8MD00204E
		CHEMBL4282117	166687	2	None	9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	375	5	2	2	3.4	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1	10.1039/C8MD00204E
		162674022	183221	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
		CHEMBL4796102	183221	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
		44299663	163126	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	306	3	2	3	3.9	CN(C)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
		CHEMBL417753	163126	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	306	3	2	3	3.9	CN(C)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
		10127939	72242	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	477	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL198171	72242	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	477	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
		49850772	56399	0	None	-501	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631545	56399	0	None	-501	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		44298208	194686	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cn1)CC2	10.1016/s0960-894x(00)00364-4
		CHEMBL53308	194686	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cn1)CC2	10.1016/s0960-894x(00)00364-4
		18931357	206588	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(Cl)cc1	10.1016/S0960-894X(96)00503-3
		CHEMBL88894	206588	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(Cl)cc1	10.1016/S0960-894X(96)00503-3
		153287568	170985	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		CHEMBL4456195	170985	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		12017598	168117	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nn1)CC2	10.1016/s0960-894x(00)00365-6
		CHEMBL432879	168117	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nn1)CC2	10.1016/s0960-894x(00)00365-6
		21533446	70155	0	None	-213	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940403	70155	0	None	-213	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		117209964	186134	1	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4871980	186134	1	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		10194524	72552	0	None	-63	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	415	7	0	5	3.0	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
		CHEMBL199177	72552	0	None	-63	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	415	7	0	5	3.0	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
		49850567	56469	0	None	-3981	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632217	56469	0	None	-3981	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		44298142	101745	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		CHEMBL299726	101745	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
		153287574	175247	0	None	-10	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4572167	175247	0	None	-10	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		10368126	86719	0	None	-25	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	449	7	0	6	4.2	COc1ccc2c(c1)c1c(n2C)CN(c2ccc(OC)c(OCCN3CCCCC3)c2)C1=O	10.1016/j.bmcl.2006.10.034
		CHEMBL231833	86719	0	None	-25	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	449	7	0	6	4.2	COc1ccc2c(c1)c1c(n2C)CN(c2ccc(OC)c(OCCN3CCCCC3)c2)C1=O	10.1016/j.bmcl.2006.10.034
		25164129	161160	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
		CHEMBL4088036	161160	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
		CHEMBL4117406	161160	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
		25056080	65690	0	None	-407	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	342	3	1	3	2.3	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC(C)(C)C=N1	10.1021/jm200466r
		CHEMBL1834345	65690	0	None	-407	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	342	3	1	3	2.3	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC(C)(C)C=N1	10.1021/jm200466r
		24826788	91098	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		CHEMBL2397893	91098	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
		71657836	120697	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402673	120697	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547134	120697	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
		135453290	133606	33	None	-2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		CHEMBL371300	133606	33	None	-2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		134551	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		30241	42044	16	None	-8	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	204	3	2	2	2.2	COc1ccc2[nH]cc(C(C)CN)c2c1	10.1021/jm980318q
		CHEMBL149564	42044	16	None	-8	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	204	3	2	2	2.2	COc1ccc2[nH]cc(C(C)CN)c2c1	10.1021/jm980318q
		11492162	72053	3	None	10	4	Human	8.1	pKi	=	8.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL197646	72053	3	None	10	4	Human	8.1	pKi	=	8.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
		11615459	199248	0	None	10	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
		CHEMBL590078	199248	0	None	10	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
		135414348	72809	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
		CHEMBL200104	72809	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
		CHEMBL5082177	214792	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCN(CCC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		2726	919	68	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		122178698	121365	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL3581244	121365	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		10827035	120705	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3402666	120705	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
		CHEMBL3547152	120705	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
		118729281	120684	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
		CHEMBL3402686	120684	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
		CHEMBL3547018	120684	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
		44409316	75021	0	None	-102	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@H]2Cc3ccc(Br)nc3N12	10.1016/j.bmcl.2005.11.083
		CHEMBL203393	75021	0	None	-102	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@H]2Cc3ccc(Br)nc3N12	10.1016/j.bmcl.2005.11.083
		145965940	164198	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	2	2	4	2.8	C[C@@H]1SC(c2cc3ccccc3cc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4210787	164198	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	2	2	4	2.8	C[C@@H]1SC(c2cc3ccccc3cc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		100	3805	58	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		168277348	190299	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5175973	190299	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		155558726	174808	0	None	-19	4	Human	5.1	pKi	=	5.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		CHEMBL4562303	174808	0	None	-19	4	Human	5.1	pKi	=	5.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		3042	1414	35	None	-39	14	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		355	1414	35	None	-39	14	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		868	1414	35	None	-39	14	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		CHEMBL1123	1414	35	None	-39	14	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		DB00804	1414	35	None	-39	14	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		122483275	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764133	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765875	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		11949706	200055	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
		CHEMBL595645	200055	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
		3037629	184572	18	None	1	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL4848517	184572	18	None	1	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		130442572	171908	0	None	-17	24	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-17	24	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		5591	157531	90	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
		CHEMBL408	157531	90	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
		21044398	141084	0	None	-21	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	1	2	4	0.9	C[C@H](O)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		CHEMBL382618	141084	0	None	-21	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	1	2	4	0.9	C[C@H](O)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
		46945446	17762	0	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 5-HT2B receptorInhibition of 5-HT2B receptor	ChEMBL	408	9	0	5	4.6	CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1	10.1016/j.bmcl.2010.07.135
		CHEMBL1258723	17762	0	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 5-HT2B receptorInhibition of 5-HT2B receptor	ChEMBL	408	9	0	5	4.6	CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1	10.1016/j.bmcl.2010.07.135
		136118657	93056	0	None	12	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3c(Br)cccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2442269	93056	0	None	12	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3c(Br)cccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		44451393	156672	1	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	211	1	1	2	2.0	COc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		CHEMBL406957	156672	1	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	211	1	1	2	2.0	COc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
		11437171	83490	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		CHEMBL220207	83490	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
		155558968	174818	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	432	3	2	5	3.2	Cc1cccc(C)c1N1C(=O)[C@H](CC2CNc3ccccc32)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
		CHEMBL4562437	174818	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	432	3	2	5	3.2	Cc1cccc(C)c1N1C(=O)[C@H](CC2CNc3ccccc32)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
		44572802	12444	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
		CHEMBL1186019	12444	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
		CHEMBL445747	12444	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
		136016509 136118731	10961	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
		CHEMBL1173331	10961	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
		3168	9262	92	None	-107	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-107	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		71450550	83807	0	None	-1	16	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	83807	0	None	-1	16	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		1971	2866	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		11300712	141686	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		CHEMBL385577	141686	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
		59757162	106304	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
		CHEMBL3092761	106304	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
		CHEMBL3139074	106304	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
		1548953	207679	27	None	-4	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	207679	27	None	-4	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		5870	31660	92	None	-	1	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
		CHEMBL1405	31660	92	None	-	1	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
		6452095	40703	18	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	174	2	2	1	2.2	CC(CN)c1c[nH]c2ccccc12	10.1021/jm980318q
		CHEMBL148463	40703	18	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	174	2	2	1	2.2	CC(CN)c1c[nH]c2ccccc12	10.1021/jm980318q
		11493484	89070	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2337106	89070	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		CHEMBL2365079	89070	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
		21509921	104458	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	104458	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		44554395	18723	0	None	-54	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		CHEMBL1277565	18723	0	None	-54	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		21509921	104458	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	104458	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		155565189	175565	0	None	-6	4	Human	6.1	pKi	=	6.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		CHEMBL4579120	175565	0	None	-6	4	Human	6.1	pKi	=	6.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		18735309	205433	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
		CHEMBL80246	205433	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
		53381002	65465	0	None	15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
		CHEMBL1829959	65465	0	None	15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
		56649650	67858	0	None	-100	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910141	67858	0	None	-100	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		71062530	160092	0	None	-3	2	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
		CHEMBL4108620	160092	0	None	-3	2	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
		44407327	141247	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		CHEMBL383042	141247	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
		136118617	76249	0	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058416	76249	0	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		44315993	172877	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
		CHEMBL451543	172877	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
		44572810	12655	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
		CHEMBL1187196	12655	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
		CHEMBL493130	12655	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
		11346775	83481	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		CHEMBL220157	83481	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
		CHEMBL5094181	215480	22	None	-2	5	Human	6.1	pKi	=	6.1	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		132060776	162402	0	None	-3	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		CHEMBL4165863	162402	0	None	-3	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		136118658	76254	0	None	2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058426	76254	0	None	2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL5094181	215480	22	None	-2	5	Human	6.1	pKi	=	6.1	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		13091356	113538	0	None	-218	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321789	113538	0	None	-218	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		118717223	120582	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343671	120582	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545813	120582	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		46914485	15432	0	None	83	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		CHEMBL1214961	15432	0	None	83	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
		44397731	67218	0	None	-23	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	213	0	1	3	1.3	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)cc3N12	10.1016/j.bmcl.2005.05.074
		CHEMBL187888	67218	0	None	-23	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	213	0	1	3	1.3	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)cc3N12	10.1016/j.bmcl.2005.05.074
		6319	23475	95	None	-	1	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
		CHEMBL1333512	23475	95	None	-	1	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
		44451369	96334	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2c3c(ccc2o1)CCNCC3	10.1016/j.bmc.2007.12.009
		CHEMBL261489	96334	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2c3c(ccc2o1)CCNCC3	10.1016/j.bmc.2007.12.009
		135753056	191175	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
		CHEMBL5188949	191175	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
		16062145	97658	0	None	-223	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	269	2	1	3	2.8	Fc1ccc(-c2nc(C3CC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		CHEMBL271111	97658	0	None	-223	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	269	2	1	3	2.8	Fc1ccc(-c2nc(C3CC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
		11716185	89064	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2337497	89064	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		CHEMBL2364998	89064	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
		10028436	3532	5	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		3237	3532	5	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		CHEMBL95104	3532	5	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		25209705	181060	28	None	-144	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	510	7	2	8	3.3	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1	10.1021/jm800962k
		CHEMBL475965	181060	28	None	-144	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	510	7	2	8	3.3	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1	10.1021/jm800962k
		168294400	192480	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC)-c1c(OC)c(OC3CCCCC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		CHEMBL5208882	192480	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC)-c1c(OC)c(OC3CCCCC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
		118055296	177951	0	None	-58	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	264	2	1	2	2.7	c1ccc(Cc2ccc3c4c2CCN4CCNC3)cc1	10.1016/j.bmcl.2019.126929
		CHEMBL4645736	177951	0	None	-58	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	264	2	1	2	2.7	c1ccc(Cc2ccc3c4c2CCN4CCNC3)cc1	10.1016/j.bmcl.2019.126929
		122483281	138108	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763779	138108	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765873	138108	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		136118649	76322	0	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058704	76322	0	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		11819486	121149	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@H]1C[C@@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
		CHEMBL357702	121149	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@H]1C[C@@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
		58911668	91110	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		CHEMBL2397905	91110	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
		162652711	180380	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	3	7	2.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CF)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
		CHEMBL4751718	180380	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	3	7	2.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CF)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
		71452341	83697	7	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
		CHEMBL2205361	83697	7	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
		11848625	5792	0	None	2	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
		CHEMBL1078745	5792	0	None	2	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
		136118614	93064	0	None	13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL2442276	93064	0	None	13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
		10106214	2103	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
		1207	2103	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
		1209	2103	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
		CHEMBL127307	2103	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
		6604117	187847	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL2062340	187847	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL49623	187847	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		49864027	15417	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	400	8	0	4	4.8	FC(F)CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		CHEMBL1214891	15417	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	400	8	0	4	4.8	FC(F)CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
		168279369	191133	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		CHEMBL5188171	191133	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
		122186880	122980	0	None	4	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3608450	122980	0	None	4	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		44554227	18750	0	None	-33	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	434	4	1	6	4.0	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		CHEMBL1277837	18750	0	None	-33	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	434	4	1	6	4.0	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		20824949	67196	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	245	1	2	3	1.4	CC(=O)Nc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		CHEMBL187787	67196	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	245	1	2	3	1.4	CC(=O)Nc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
		667590	67794	12	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
		CHEMBL1909048	67794	12	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
		44582676	189779	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	189779	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		135511529 135555540	10988	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccccc12	10.1016/j.bmc.2013.09.011
		CHEMBL1173525	10988	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccccc12	10.1016/j.bmc.2013.09.011
		136118661	76257	0	None	6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058429	76257	0	None	6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
		44112	121290	48	None	-11	7	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
		CHEMBL357995	121290	48	None	-11	7	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
		124247485	164069	8	None	1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4209274	164069	8	None	1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		155563428	175286	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	475	7	3	9	2.7	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		CHEMBL4572905	175286	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	475	7	3	9	2.7	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
		44581974	175704	0	None	-1	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL458220	175704	0	None	-1	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		25123013	200458	0	None	-27	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	378	3	2	5	2.7	NC1CN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		CHEMBL598443	200458	0	None	-27	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	378	3	2	5	2.7	NC1CN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		10383646	18762	0	None	-512	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
		CHEMBL1277917	18762	0	None	-512	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
		71450247	82976	0	None	-19	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181188	82976	0	None	-19	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
		44404905	72380	1	None	3	3	Human	7.0	pKi	=	7.0	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	4	2	2	2.4	CN(C)CCCc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		CHEMBL198617	72380	1	None	3	3	Human	7.0	pKi	=	7.0	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	4	2	2	2.4	CN(C)CCCc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
		17683252	67796	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
		CHEMBL1909051	67796	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
		142601328	185003	0	None	-63	5	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4854605	185003	0	None	-63	5	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		142601341	185372	0	None	-3	3	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4860503	185372	0	None	-3	3	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		56649648	67855	0	None	-301	8	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910139	67855	0	None	-301	8	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		136118616	76248	0	None	3	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058415	76248	0	None	3	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
		136118646	76319	0	None	2	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2058701	76319	0	None	2	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
		3007	155685	27	None	-1	6	Rat	8.3	pKd	=	8.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	Drug Central	135	2	1	1	1.6	CC(N)Cc1ccccc1	None
		CHEMBL405	155685	27	None	-1	6	Rat	8.3	pKd	=	8.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	Drug Central	135	2	1	1	1.6	CC(N)Cc1ccccc1	None
		10615	572	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
		46200932	572	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
		CHEMBL4297183	572	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
		DB14823	572	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
		136	3292	32	None	-8	15	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		223	3292	32	None	-8	15	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		643606	3292	32	None	-8	15	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		CHEMBL10347	3292	32	None	-8	15	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		134	2514	24	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		188	3391	80	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
		196968	3391	80	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
		CHEMBL473186	3391	80	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
		242	470	124	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	470	124	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		134	2514	24	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		5074	3332	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		None	216052	0	3H-5HT	-2	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		None	216052	0	3H-5HT	-2	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		107	141	121	3H-5HT	-4	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-4	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-4	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		None	216380	0	3H-MESULERGINE	5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
		4106	2502	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		134	2514	24	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		133	2496	52	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		133	2496	52	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		6437377	215954	0	3H-RAUWOLSCINE	5	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
		5	139	72	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2470	3653	50	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		None	216052	0	Functional	-2	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		1342	35	49	3H-RAUWOLSCINE	2	19	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-RAUWOLSCINE	2	19	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-RAUWOLSCINE	2	19	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		None	216380	0	Functional	5	4	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
		1621	2429	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5	139	72	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5074	3332	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		1588	2325	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		188	3391	80	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
		196968	3391	80	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
		CHEMBL473186	3391	80	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
		None	216450	0	Functional	1	28	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		5	139	72	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		None	216341	0	3H-MESULERGINE	-1	19	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
		103	4153	61	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5074	3332	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		189	3492	39	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	3492	39	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	3492	39	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		11954224	215953	0	3H-5HT	-66	58	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1588	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1588	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2435	3590	83	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		11957541	1459	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		206	2493	16	3H-5HT	-1	25	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-1	25	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-1	25	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		134	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		6437377	215954	0	3H-5HT	5	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
		277	1301	62	3H-5HT	-4	50	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5HT	-4	50	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5HT	-4	50	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5HT	-4	50	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5HT	-4	50	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		4106	2502	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		135	2532	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		134	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		6437377	215954	0	3H-5HT	5	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
		5074	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		134	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		5074	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		133	2496	52	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		11954224	215953	0	3H- LSD	-66	58	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		11954224	215953	0	3H-LSD	-66	58	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		206	2493	16	3H-RAUWOLSCINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-RAUWOLSCINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-RAUWOLSCINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		206	2493	16	3H-MESULERGINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-MESULERGINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-MESULERGINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		199	392	0	3H-5HT	1	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		9821951	392	0	3H-5HT	1	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		CHEMBL160293	392	0	3H-5HT	1	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		5	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		135398737	958	93	3H-5HT	-2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		152	364	29	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		2107	364	29	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		CHEMBL275854	364	29	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		152	364	29	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		2107	364	29	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		CHEMBL275854	364	29	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		7153	98020	77	3H-RAUWOLSCINE	-1	34	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-RAUWOLSCINE	-1	34	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		199	392	0	3H-5HT	-5	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		9821951	392	0	3H-5HT	-5	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		CHEMBL160293	392	0	3H-5HT	-5	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		11957541	1459	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1614	203655	24	Functional	2	10	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		CHEMBL6731	203655	24	Functional	2	10	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		24840389	115213	4	3H-MESULERGINE	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		CHEMBL334529	115213	4	3H-MESULERGINE	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		1809	134	32	3H-KETANSERIN	-109647	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-KETANSERIN	-109647	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-KETANSERIN	-109647	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1209	1658	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		1357	2485	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		13139	2491	29	3H-KETANSERIN	-66	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	None
		4076	2491	29	3H-KETANSERIN	-66	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	None
		CHEMBL26687	2491	29	3H-KETANSERIN	-66	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	None
		107992	2553	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		165	2553	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		CHEMBL269521	2553	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		DB12111	2553	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		208	2863	0	3H-5HT	-69	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		4541	2863	0	3H-5HT	-69	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL1494	2863	0	3H-5HT	-69	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		119570	3159	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		119570	3159	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		243	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		2	3261	23	3H-MESULERGINE	-363	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	3261	23	3H-MESULERGINE	-363	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	3261	23	3H-MESULERGINE	-363	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		128563	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		2470	3653	50	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2543	3707	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2543	3707	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		46882133	5808	0	UNDEFINED	-54	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
		CHEMBL1078896	5808	0	UNDEFINED	-54	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
		46882180	5841	0	UNDEFINED	-39	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
		CHEMBL1079180	5841	0	UNDEFINED	-39	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
		2662	11384	131	3H-LSD	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	11384	131	3H-LSD	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		10836	14467	14	3H-LSD	-3	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	14467	14	3H-LSD	-3	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		5090	15561	106	3H-LSD	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	3H-LSD	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		5210	33338	48	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
		CHEMBL1200765	33338	48	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
		CHEMBL1419	33338	48	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
		156391	46800	99	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	46800	99	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	46800	99	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		4771	50530	29	3H-5HT	1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	1	2.0	CC(C)(N)Cc1ccccc1	None
		CHEMBL1574	50530	29	3H-5HT	1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	1	2.0	CC(C)(N)Cc1ccccc1	None
		2244	94233	100	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	94233	100	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		104870	98880	47	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	98880	47	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	98880	47	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		43815	186920	64	3H-5HT	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	186920	64	3H-5HT	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	186920	64	3H-5HT	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		3672	192533	136	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	192533	136	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	193615	112	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	193615	112	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		4495	196535	92	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	196535	92	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	200551	115	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	200551	115	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	200551	115	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		5281600	203025	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	203025	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	203066	87	3H-5HT	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-5HT	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		3821	204718	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		CHEMBL742	204718	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		4158	205341	21	3H-5HT	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	205341	21	3H-5HT	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	205341	21	3H-5HT	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		4054	205501	72	3H-LSD	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	205501	72	3H-LSD	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	205501	72	3H-LSD	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		6852400	215937	0	3H-KETANSERIN	-25118	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-KETANSERIN	-25118	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		None	216342	0	3H-MESULERGINE	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
		135269	216389	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	216390	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	216391	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	216392	0	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		123619	216393	0	3H-LSD	-1412	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	216394	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	216395	0	3H-LSD	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	216451	0	3H-5HT	-1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	4	1	1	4.6	CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N.Cl	None
		None	216489	0	3H-LSD	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		1150	3878	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		185	4006	60	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		62787	206188	21	3H-5HT	-10	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
		CHEMBL8642	206188	21	3H-5HT	-10	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
		None	216135	0	3H-LSD	-1122	24	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		102	4127	48	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		141	1427	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	1427	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	1427	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	1427	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		3668	216122	0	3H-LSD	-977	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	510	5	4	9	0.4	CNC(=O)C1C(C(C(O1)N2C=NC3=C2N=CN=C3NCC4=CC(=CC=C4)I)O)O	None
		146	135	85	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
		164682	135	85	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
		CHEMBL275628	135	85	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
		1621	2429	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		15897	2862	0	3H-LSD	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-LSD	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-LSD	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		15897	2862	0	3H-5-HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		15897	2862	0	3H-5HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-5-HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-5HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-5-HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-5HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		5	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		152	364	29	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		2107	364	29	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		CHEMBL275854	364	29	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		135398745	2914	112	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		152	364	29	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		2107	364	29	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		CHEMBL275854	364	29	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		45486902	196946	0	UNDEFINED	-3	2	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
		CHEMBL566396	196946	0	UNDEFINED	-3	2	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
		1150	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		1150	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		77590	215955	0	3H-5HT	-15	6	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	124	4	0	2	0.8	COCCOCCl	None
		2389	3331	118	35S-GTPGammaS	-66	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	35S-GTPGammaS	-66	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	35S-GTPGammaS	-66	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	35S-GTPGammaS	-66	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	35S-GTPGammaS	-66	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		542051	206100	6	3H-5HT	-128	7	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
		CHEMBL8569	206100	6	3H-5HT	-128	7	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
		1809	134	32	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		5	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		199	392	0	3H-5HT	-5	5	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		9821951	392	0	3H-5HT	-5	5	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		CHEMBL160293	392	0	3H-5HT	-5	5	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
		135398745	2914	112	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135	2532	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		7153	98020	77	3H-MESULERGINE	-1	34	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-MESULERGINE	-1	34	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		134	2514	24	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		None	216450	0	Functional	-1	28	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	216450	0	UNDEFINED	-1	28	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	215946	0	3H-KETANSERIN	-851	24	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		2202	3132	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	3132	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	3132	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	3132	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	3132	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		221	3491	71	3H-5HT	-4	14	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	3491	71	3H-5HT	-4	14	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	3491	71	3H-5HT	-4	14	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		5	139	72	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1809	134	32	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		173	3262	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		None	216214	0	3H-5HT	-120	14	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	438	5	1	4	4.8	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45	None
		179	400	115	3H-LSD	-17	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-LSD	-17	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-LSD	-17	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-LSD	-17	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-LSD	-17	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		77379	19046	75	3H-5HT	-2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
		CHEMBL1288716	19046	75	3H-5HT	-2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
		102	4127	48	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		5	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		77158	19047	56	3H-5HT	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
		CHEMBL1288717	19047	56	3H-5HT	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
		None	217469	0	UNDEFINED	-14	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	421	4	3	4	3.3	C1CC2=C(CC1CNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)C6=C(N2)C=CC(=C6)F	None
		145	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1150	3878	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		173	3262	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		25058166	215960	0	3H-MESULERGINE	-66	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-MESULERGINE	-66	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		2470	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		None	215946	0	3H-5HT	-33	24	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		130	3500	47	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3378093	3500	47	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL281350	3500	47	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		240	944	43	3H-5HT	-26	24	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	3H-5HT	-26	24	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	3H-5HT	-26	24	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	3H-5HT	-26	24	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	3H-5HT	-26	24	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	3H-5HT	-26	24	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	3H-5HT	-26	24	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2105	3054	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		138107169	215952	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		186	1807	52	3H-LSD	-426	17	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	1807	52	3H-LSD	-426	17	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	1807	52	3H-LSD	-426	17	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		1353	1911	93	3H-5HT	-295	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5HT	-295	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5HT	-295	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5HT	-295	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5HT	-295	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	215938	0	3H-5HT	-2398	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		1809	134	32	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		124	2981	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		15897	2862	0	3H-LSD	12	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-LSD	12	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-LSD	12	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		138107169	215952	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	215938	0	3H-LSD	-407	21	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		1809	134	32	Functional	-999	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	Functional	-999	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	Functional	-999	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		221	3491	71	UNDEFINED	4	14	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	3491	71	UNDEFINED	4	14	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	3491	71	UNDEFINED	4	14	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		6446436	216453	0	3H-MESULERGINE	-1	2	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	3	4	3.2	CC1=CC2=C(C=C1)C(C3=C2N(C=C3)CC(C)N)(C)C.C(=CC(=O)O)C(=O)O	None
		134	2514	24	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1614	203655	24	Functional	2	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		CHEMBL6731	203655	24	Functional	2	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		1809	134	32	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		107992	2553	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		165	2553	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		CHEMBL269521	2553	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		DB12111	2553	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		28	3496	46	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3292447	3496	46	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL20963	3496	46	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		2470	3653	50	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2389	3331	118	3H-LSD	-66	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-66	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-66	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-66	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-66	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		107	141	121	3H-5HT	-4	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-4	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-4	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		None	215946	0	3H-5HT	-12	24	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		None	217471	0	UNDEFINED	-12	3	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	432	3	2	4	3.8	C1CC2=C(CC1CN3CC4CC3CN4C5=CC=CC6=C5OC(=O)N6)C7=C(N2)C=CC(=C7)F	None
		105432	216025	0	3H-5HT	-30	4	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	240	5	1	5	1.5	CC(CC1=CC(=C(C=C1OC)[N+](=O)[O-])OC)N	None
		18971832	2418	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		21	2418	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		CHEMBL3186179	2418	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		37459	746	13	3H-KETANSERIN	-39	25	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-KETANSERIN	-39	25	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-KETANSERIN	-39	25	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		None	215946	0	3H-5HT	-12	24	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		5268	3656	40	3H-RAUWOLSCINE	-1047	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-RAUWOLSCINE	-1047	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-RAUWOLSCINE	-1047	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		173	3262	95	Functional	1	23	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	Functional	1	23	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	Functional	1	23	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		1353	1911	93	3H-5HT	-295	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5HT	-295	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5HT	-295	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5HT	-295	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5HT	-295	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		119607	206203	113	3H-LSD	97	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	206203	113	3H-LSD	97	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		1809	134	32	3H-5HT	-999	36	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-999	36	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-999	36	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		31016	102287	15	3H-5HT	-11	5	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
		CHEMBL30336	102287	15	3H-5HT	-11	5	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
		213	3853	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5	139	72	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		134	2514	24	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		11957541	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		7153	98020	77	3H-LSD	-1	34	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-LSD	-1	34	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		135	2532	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		3652	4097	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	4097	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	4097	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	4097	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	4097	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		5268	3656	40	3H-5HT	-616	18	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-5HT	-616	18	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-5HT	-616	18	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		1574	81	60	3H-5HT	-2	21	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	81	60	3H-5HT	-2	21	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	81	60	3H-5HT	-2	21	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		135	2532	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1150	3878	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		1150	3878	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		152	364	29	Functional	1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		2107	364	29	Functional	1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		CHEMBL275854	364	29	Functional	1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		5	139	72	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		4106	2502	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5074	3332	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		None	216052	0	3H-LSD	-2	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		133	2496	52	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1524	2181	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		None	216380	0	3H-5HT	5	4	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
		191	3498	52	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
		443389	3498	52	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
		CHEMBL276140	3498	52	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
		None	216379	0	3H-5HT	-2	11	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
		277	1301	62	3H-LSD	-4	50	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-LSD	-4	50	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-LSD	-4	50	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-LSD	-4	50	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-LSD	-4	50	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		135409468	2035	69	3H-LSD	1	39	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-LSD	1	39	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-LSD	1	39	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		5	139	72	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		155	728	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	728	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	728	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	728	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	728	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		1588	2325	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		None	216278	0	3H-LSD	-32	12	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	426	6	0	6	3.4	C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54	None
		11957541	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		11957541	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1615	167791	24	Functional	-2	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	Functional	-2	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		2389	3331	118	3H-5HT	-549	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-5HT	-549	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-5HT	-549	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-5HT	-549	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-5HT	-549	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1524	2181	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		189	3492	39	3H- LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		189	3492	39	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	3492	39	3H- LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	3492	39	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	3492	39	3H- LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	3492	39	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		155	728	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	728	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	728	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	728	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	728	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		202	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		2477	745	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		1524	2181	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		2176	3127	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		277	1301	62	125I-DOI	-26	50	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	125I-DOI	-26	50	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	125I-DOI	-26	50	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	125I-DOI	-26	50	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	125I-DOI	-26	50	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		189	3492	39	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	3492	39	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	3492	39	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		1220	187	55	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		6917970	3691	61	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	3691	61	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	3691	61	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		1524	2181	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		104911	216019	0	3H-LSD	-99	37	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		105432	216025	0	3H-5HT	-44	4	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	240	5	1	5	1.5	CC(CC1=CC(=C(C=C1OC)[N+](=O)[O-])OC)N	None
		1150	3878	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		7153	98020	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		7153	98020	77	UNDEFINED	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	UNDEFINED	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		None	216450	0	UNDEFINED	-1	28	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		198	313	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		82148	313	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		99	313	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		CHEMBL10878	313	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		DB06594	313	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		None	215946	0	Functional	-33	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		11957541	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		7153	98020	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		6166	216024	0	3H-5HT	-7	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
		155	728	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	728	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	728	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	728	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	728	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		7153	98020	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		57174031	215940	0	3H-KETANSERIN	-457	19	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
		185	4006	60	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		3294	2006	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		3337	206367	27	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		2865	4143	73	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		11957541	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		5	139	72	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		11957541	1459	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		7153	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		7153	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		138107169	215952	0	3H-5HT	-33	22	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-5HT	-33	22	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		1574	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		1574	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		115	3791	80	Functional	-1	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	3791	80	Functional	-1	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	3791	80	Functional	-1	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		2389	3331	118	3H-5HT	-66	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-5HT	-66	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-5HT	-66	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-5HT	-66	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-5HT	-66	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1150	3878	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		107992	2553	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		165	2553	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		CHEMBL269521	2553	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		DB12111	2553	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		11954224	215953	0	3H-5HT	-66	58	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		None	216450	0	3H-MESULERGINE	1	28	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		7153	98020	77	3H-5HT	-1	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		1342	35	49	3H-5HT	2	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	2	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	2	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		206	2493	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		135398737	958	93	3H-RAUWOLSCINE	-2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-RAUWOLSCINE	-2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-RAUWOLSCINE	-2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-RAUWOLSCINE	-2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-RAUWOLSCINE	-2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		206	2493	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		242	470	124	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		11954224	215953	0	3H-5HT	-66	58	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		206	2493	16	3H-5HT	-1	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-1	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-1	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		5074	3332	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		1342	35	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		1621	2429	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1342	35	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		1621	2429	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		None	215938	0	Functional	-407	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		6971132	216009	0	3H-LSD	-7	14	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	268	1	2	2	2.1	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O	None
		219050	3373	25	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		52	3373	25	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		CHEMBL431367	3373	25	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		2470	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2	3261	23	3H-5HT	-363	29	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	3261	23	3H-5HT	-363	29	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	3261	23	3H-5HT	-363	29	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		186	1807	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	1807	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	1807	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		31016	102287	15	3H-5HT	-5	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
		CHEMBL30336	102287	15	3H-5HT	-5	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
		135398737	958	93	3H-5HT	-36	89	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-36	89	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-36	89	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-36	89	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-36	89	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		102	4127	48	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		7153	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		None	215946	0	3H-5HT	-33	24	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		6166	216024	0	3H-5HT	-4	4	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
		1574	81	60	3H-5HT	-3	21	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	81	60	3H-5HT	-3	21	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	81	60	3H-5HT	-3	21	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		130	3500	47	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3378093	3500	47	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL281350	3500	47	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		2470	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1524	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		2470	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	3653	50	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		7153	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		1524	2181	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		2470	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		15760	113079	57	3H-5HT	-5	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	None
		CHEMBL331241	113079	57	3H-5HT	-5	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	None
		None	215938	0	3H-LSD	-407	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		186	1807	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	1807	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	1807	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		2470	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		138107169	215952	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		138107169	215952	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		206	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		1524	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		206	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		7153	98020	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		1353	1911	93	3H-5HT	-295	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5HT	-295	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5HT	-295	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5HT	-295	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5HT	-295	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1524	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	2181	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		2220	3134	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		27400	3134	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		93	3134	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		CHEMBL294951	3134	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		DB06153	3134	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		77158	19047	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
		CHEMBL1288717	19047	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
		2402	3370	62	3H-MESULERGINE	-9	24	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	3H-MESULERGINE	-9	24	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	3H-MESULERGINE	-9	24	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	3H-MESULERGINE	-9	24	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	3H-MESULERGINE	-9	24	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		145	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		77158	19047	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
		CHEMBL1288717	19047	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
		206	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		138107169	215952	0	3H-5HT	-117	22	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-5HT	-117	22	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		115	3791	80	3H-5HT	-1	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	3791	80	3H-5HT	-1	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	3791	80	3H-5HT	-1	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		3337	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		1524	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		102	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		102	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		1524	2181	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		5	139	72	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		135398737	958	93	3H-LSD	-2	89	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-2	89	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-2	89	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-2	89	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-2	89	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		138107169	215952	0	3H-RAUWOLSCINE	-33	22	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-RAUWOLSCINE	-33	22	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		135	2532	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2865	4143	73	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		1342	35	49	3H-5HT	-4	19	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	-4	19	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	-4	19	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3117	207841	103	None	-8	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		CHEMBL964	207841	103	None	-8	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		104903	56344	17	None	-4	6	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	None
		CHEMBL1630578	56344	17	None	-4	6	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	None
		7153	98020	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		102	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		7153	98020	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		164	1460	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
		85875	1460	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
		CHEMBL8600	1460	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
		DB01528	1460	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
		3337	206367	27	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		None	217468	0	UNDEFINED	-83	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	449	6	3	4	4.1	C1CC2=C(CC1CCCNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)NC6=C2C=C(C=C6)F	None
		107992	2553	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		165	2553	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		CHEMBL269521	2553	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		DB12111	2553	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		1220	187	55	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		11848624	89146	0	UNDEFINED	2	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
		CHEMBL236587	89146	0	UNDEFINED	2	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
		2389	3331	118	3H-LSD	-66	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-66	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-66	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-66	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-66	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1220	187	55	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		3337	206367	27	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		3337	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		90475904	216022	0	3H-RAUWOLSCINE	-5011	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		102	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		155	728	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	728	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	728	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	728	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	728	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		102	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		11954224	215953	0	3H-LSD	-66	58	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		11291	3220	26	3H-KETANSERIN	-44	5	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
		4980	3220	26	3H-KETANSERIN	-44	5	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
		CHEMBL65547	3220	26	3H-KETANSERIN	-44	5	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
		None	216450	0	3H-5HT	1	28	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		173	3262	95	3H-KETANSERIN	-5	23	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-KETANSERIN	-5	23	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-KETANSERIN	-5	23	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		2181	3128	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		15897	2862	0	3H-5-HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		15897	2862	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-5-HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-5-HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		186	1807	52	3H-5HT	-776	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	1807	52	3H-5HT	-776	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	1807	52	3H-5HT	-776	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		5268	3656	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		15897	2862	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		173	3262	95	3H-5HT	1	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-5HT	1	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-5HT	1	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		11653679	181191	1	UNDEFINED	-75	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL476108	181191	1	UNDEFINED	-75	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		10836	14467	14	None	-3	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	14467	14	None	-3	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		5475158	67213	25	3H-KETANSERIN	-1	14	Bovine	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		CHEMBL18786	67213	25	3H-KETANSERIN	-1	14	Bovine	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		5074	3332	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		5074	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		5870	31660	92	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	None
		CHEMBL1405	31660	92	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	None
		None	216380	0	3H-5HT	5	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
		5074	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		2812	4779	101	None	-40	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	4779	101	None	-40	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		222757	99376	73	None	-1	3	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	None
		CHEMBL282575	99376	73	None	-1	3	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	None
		1210	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	-10	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		5074	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		1357	2485	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1342	35	49	3H-5HT	-4	19	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	-4	19	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	-4	19	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		1209	1658	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3198	205513	76	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	205513	76	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	205513	76	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		2406	100404	89	None	-27	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		CHEMBL290106	100404	89	None	-27	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		None	216380	0	3H-5HT	5	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
		66265	94013	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL248702	94013	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		1836	2592	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		3340	2592	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		5281040	2592	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		CHEMBL787	2592	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		DB00471	2592	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		2402	3370	62	None	-9	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	None	-9	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	None	-9	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	None	-9	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	None	-9	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		3598	187821	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		CHEMBL496	187821	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		135	2532	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4189	206922	96	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	206922	96	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	206922	96	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		4943	193417	105	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	None
		CHEMBL526	193417	105	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	None
		3336	95001	30	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
		CHEMBL1405922	95001	30	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
		CHEMBL254832	95001	30	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
		135	2532	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		189	3492	39	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	3492	39	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	3492	39	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		4211	57822	83	None	-2	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
		CHEMBL1670	57822	83	None	-2	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
		5353853	17986	47	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		9556529	17986	47	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1262	17986	47	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		1599	2341	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		3955	2341	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		7215	2341	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		CHEMBL841	2341	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		DB00836	2341	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		4209	3163	75	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		2142	3096	58	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		146	135	85	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
		164682	135	85	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
		CHEMBL275628	135	85	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
		68617	205527	62	None	-15	26	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	None	-15	26	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	None	-15	26	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		4601	206747	35	None	-4	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	206747	35	None	-4	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	206747	35	None	-4	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		448537	160250	89	None	-21	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		CHEMBL411	160250	89	None	-21	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		2176	3127	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		1531	2266	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
		3869	2266	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
		7207	2266	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
		CHEMBL429	2266	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
		DB00598	2266	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
		5318	15576	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1200348	15576	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1221	15576	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		119607	206203	113	None	97	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	206203	113	None	97	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		1227	2489	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3151	1462	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	1462	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	1462	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	1462	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	1462	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		1343	1889	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		3519	1889	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		522	1889	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		CHEMBL862	1889	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		DB01018	1889	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		1016	3747	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	3747	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	3747	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	3747	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	3747	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	3747	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5510	205852	100	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	None
		CHEMBL83668	205852	100	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	None
		2202	3132	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	3132	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	3132	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	3132	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	3132	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		2723	154046	108	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	None
		CHEMBL398440	154046	108	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	None
		2771	195017	74	None	1	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	None	1	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	None	1	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2333	142335	97	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	None
		CHEMBL388590	142335	97	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	None
		135	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2470	3653	50	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		102	4127	48	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		102	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		135	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		221	3491	71	UNDEFINED	4	14	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	3491	71	UNDEFINED	4	14	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	3491	71	UNDEFINED	4	14	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		102	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		1615	167791	24	3H-LSD	-2	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	3H-LSD	-2	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		122	1437	9	3H-5HT	-100	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	1437	9	3H-5HT	-100	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	1437	9	3H-5HT	-100	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1209	1658	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		5268	3656	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		208	2863	0	3H-5HT	-69	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		4541	2863	0	3H-5HT	-69	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL1494	2863	0	3H-5HT	-69	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3337	206367	27	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		3337	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		221	3491	71	3H-MESULERGINE	-4	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	3491	71	3H-MESULERGINE	-4	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	3491	71	3H-MESULERGINE	-4	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3337	206367	27	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		108182	4131	22	3H-5HT	-1	16	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		245	4131	22	3H-5HT	-1	16	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		CHEMBL18041	4131	22	3H-5HT	-1	16	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		15897	2862	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		15897	2862	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		135	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		None	216026	0	3H-5HT	-5	4	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
		2105	3054	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		102	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		135398745	2914	112	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11957541	1459	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		102	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		542051	206100	6	3H-5HT	-61	7	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
		CHEMBL8569	206100	6	3H-5HT	-61	7	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
		1220	187	55	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		3337	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		11957541	1459	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		141	1427	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	1427	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	1427	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	1427	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		31101	729	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		2181	3128	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		3337	206367	27	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		3337	206367	27	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		3337	206367	27	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		1357	2485	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		115	3791	80	3H-5HT	-1	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	3791	80	3H-5HT	-1	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	3791	80	3H-5HT	-1	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		138107169	215952	0	3H-5HT	-117	22	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-5HT	-117	22	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		2470	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		283	3130	57	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		4847	3130	57	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		CHEMBL18331	3130	57	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		2726	919	68	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		None	217469	0	UNDEFINED	-14	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	421	4	3	4	3.3	C1CC2=C(CC1CNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)C6=C(N2)C=CC(=C6)F	None
		44112	121290	48	None	-11	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	None
		CHEMBL357995	121290	48	None	-11	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	None
		1548955	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2800	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		CHEMBL2355051	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		3168	9262	92	None	-107	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	9262	92	None	-107	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		3042	1414	35	None	-39	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	1414	35	None	-39	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	1414	35	None	-39	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	1414	35	None	-39	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	1414	35	None	-39	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		5591	157531	90	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	None
		CHEMBL408	157531	90	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	None
		1353	1911	93	None	-295	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-295	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-295	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-295	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-295	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		4452	2762	19	3H-LSD	-208	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		983	2762	19	3H-LSD	-208	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		CHEMBL20734	2762	19	3H-LSD	-208	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		4178	195803	63	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	None
		CHEMBL558	195803	63	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	None
		1224	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		146159245	188450	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
		451415	188450	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
		86289437	188450	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
		CHEMBL502620	188450	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
		12488	1657	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		941361	1657	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		CHEMBL30008	1657	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		DB04841	1657	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		3033538	1319	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
		7155	1319	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
		781	1319	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
		CHEMBL1201216	1319	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
		DB00298	1319	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
		77379	19046	75	3H-5HT	2	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
		CHEMBL1288716	19046	75	3H-5HT	2	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
		657255	199084	34	None	-9	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		CHEMBL588119	199084	34	None	-9	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		176	398	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2157	398	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2566	398	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		CHEMBL633	398	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		DB01118	398	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		4098	32505	30	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1255739	32505	30	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1411979	32505	30	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		5282379	194984	69	None	1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	None
		CHEMBL547	194984	69	None	1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	None
		134	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2028	2979	80	None	-40	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	2979	80	None	-40	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	2979	80	None	-40	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	2979	80	None	-40	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	2979	80	None	-40	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		134	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		6437377	215954	0	3H-5HT	-5	5	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
		1547484	940	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	940	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	940	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	940	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	940	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		4595	176715	106	None	2	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	176715	106	None	2	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		1782	2518	84	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	2518	84	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	2518	84	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	2518	84	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	2518	84	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		2477	745	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		5074	3332	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		6075	150108	42	None	-8	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		CHEMBL395110	150108	42	None	-8	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		2470	3653	50	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		198	313	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		82148	313	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		99	313	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		CHEMBL10878	313	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		DB06594	313	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
		210	3477	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
		2423	3477	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
		5160	3477	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
		CHEMBL52939	3477	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
		DB12163	3477	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
		133	2496	52	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		6726	1280	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		7151	1280	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		749	1280	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL648	1280	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB01176	1280	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		3157	1470	71	None	-37	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		7170	1470	71	None	-37	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		954	1470	71	None	-37	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		CHEMBL707	1470	71	None	-37	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		DB00590	1470	71	None	-37	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		444795	139999	105	None	3	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	None
		CHEMBL38	139999	105	None	3	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	None
		2284	3182	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		2303	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		4946	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		564	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		63	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		91536	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL27	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL452861	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		DB00571	3187	68	None	-158	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		4011	82408	49	None	-20	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	None	-20	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		3191	102858	97	None	-7	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	102858	97	None	-7	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		1524	2181	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		119584	2595	102	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		1848	2595	102	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		242	2595	102	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		CHEMBL60889	2595	102	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		DB11675	2595	102	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		33630	178957	99	None	-6	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	178957	99	None	-6	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		1605	2342	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		3957	2342	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		7216	2342	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		CHEMBL998	2342	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		DB00455	2342	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		2895	203592	41	None	1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		CHEMBL669	203592	41	None	1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		2398	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		1222	1664	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		11658860	2344	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
		2941	2344	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
		4374	2344	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
		CHEMBL360328	2344	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
		DB04871	2344	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
		124	2981	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		6437377	215954	0	3H-5HT	-5	5	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
		1201549	597	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	597	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	597	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	597	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	597	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	597	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		228	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		152	364	29	3H-5HT	1	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		2107	364	29	3H-5HT	1	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		CHEMBL275854	364	29	3H-5HT	1	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
		2520	204008	70	None	-4	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		CHEMBL1280	204008	70	None	-4	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		CHEMBL6966	204008	70	None	-4	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		15897	2862	0	Functional	12	36	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	Functional	12	36	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	Functional	12	36	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		None	215939	0	3H-KETANSERIN	-19	6	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	6	2	7	2.1	CC(C1=CC=CC2=NC3=C(C=CC=C3N=C21)C(=O)O)OC(=O)C(CO)OC	None
		10624	70300	19	3H-KETANSERIN	-46	33	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-KETANSERIN	-46	33	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-KETANSERIN	-46	33	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		71285	215985	0	Functional	1	2	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	209	3	2	4	1.3	CC(CC1=CC2=C(C=C1O)OCO2)NC	None
		283	3130	57	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		4847	3130	57	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		CHEMBL18331	3130	57	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		115237	55585	119	3H-LSD	-89	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-LSD	-89	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		None	217468	0	UNDEFINED	-83	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	449	6	3	4	4.1	C1CC2=C(CC1CCCNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)NC6=C2C=C(C=C6)F	None
		107992	2553	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		165	2553	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		CHEMBL269521	2553	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		DB12111	2553	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
		240	944	43	3H-5HT	-6	24	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	3H-5HT	-6	24	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	3H-5HT	-6	24	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	3H-5HT	-6	24	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	3H-5HT	-6	24	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	3H-5HT	-6	24	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	3H-5HT	-6	24	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		7153	98020	77	Functional	-1	34	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	Functional	-1	34	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		None	216450	0	Functional	1	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		107780	1844	54	3H-5HT	-676	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	1844	54	3H-5HT	-676	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	1844	54	3H-5HT	-676	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		1524	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		173	3262	95	3H-5HT	-3	23	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-5HT	-3	23	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-5HT	-3	23	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		1574	81	60	125I-DOI	-70	21	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	81	60	125I-DOI	-70	21	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	81	60	125I-DOI	-70	21	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		173	3262	95	125I-DOI	-75	23	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	125I-DOI	-75	23	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	125I-DOI	-75	23	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		1342	35	49	3H-5HT	-4	19	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	-4	19	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	-4	19	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		44626329	197408	0	UNDEFINED	-20	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
		CHEMBL569513	197408	0	UNDEFINED	-20	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
		3337	206367	27	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		62787	206188	21	3H-KETANSERIN	-67	10	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
		CHEMBL8642	206188	21	3H-KETANSERIN	-67	10	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
		90475904	216022	0	3H-5HT	-5011	6	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		2470	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5440	28724	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		CHEMBL1378	28724	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		4976	203579	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		CHEMBL668	203579	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		5022	1651	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
		6918248	1651	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
		8182	1651	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
		CHEMBL231068	1651	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
		DB04908	1651	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
		1971	2866	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		107	141	121	3H-5HT	-12	30	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-12	30	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-12	30	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		213	3853	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		11957541	1459	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	1459	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	1459	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	1459	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	1459	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		2105	3054	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2601	3780	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		100	3805	58	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		240	944	43	None	-6	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	None	-6	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	None	-6	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	None	-6	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	None	-6	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	None	-6	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	None	-6	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		135398737	958	93	3H-5HT	-2	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-2	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-2	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-2	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-2	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2351	3286	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2820	3286	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		5035	3286	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		CHEMBL81	3286	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		DB00481	3286	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2274	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2099	9307	55	None	-	1	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL1110	9307	55	None	-	1	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	None
		135398745	2914	112	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		3952	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5353646	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5443	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5702063	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL1331786	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL420	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		115237	55585	119	None	-89	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	None	-89	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		2291	3184	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
		2561	3184	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
		4932	3184	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
		CHEMBL631	3184	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
		DB01182	3184	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
		216239	23795	118	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
		CHEMBL1200485	23795	118	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
		CHEMBL1336	23795	118	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
		2726	919	68	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		31101	729	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		102	4127	48	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2181	3128	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		2286	3183	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		180	401	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2389	3331	118	None	-66	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-66	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-66	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-66	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-66	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		114948	60297	14	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		CHEMBL1743263	60297	14	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		6761	67799	19	None	-7	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL1909072	67799	19	None	-7	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1621	2429	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2600	3779	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	3779	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	3779	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	3779	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	3779	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		1530	2182	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		124087	1389	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		7157	1389	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		814	1389	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		CHEMBL1172	1389	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		DB00967	1389	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		2865	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		135398737	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1212	1662	50	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		26987	949	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	949	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	949	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	949	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	949	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		2267	559	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		271	559	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		7121	559	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		CHEMBL639	559	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		DB00972	559	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		3652	4097	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	4097	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	4097	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	4097	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	4097	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		2585	803	103	None	-18	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		522	803	103	None	-18	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		551	803	103	None	-18	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		CHEMBL723	803	103	None	-18	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		DB01136	803	103	None	-18	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		102	4127	48	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		135398745	2914	112	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		134	2514	24	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		3036864	202754	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		1615	167791	24	3H-LSD	-2	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	3H-LSD	-2	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		2470	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		90475904	216022	0	3H-5HT	-5011	6	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		1150	3878	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		213	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		21830793	91835	10	3H-8-OH-DPAT	-489	45	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	91835	10	3H-8-OH-DPAT	-489	45	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		45266826	217691	0	[3H] LSD	2	8	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	177	3	1	2	1.8	CC1=CC=C(C=C1)C(=O)C(C)NC	None
		179	400	115	3H-LSD	-17	49	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-LSD	-17	49	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-LSD	-17	49	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-LSD	-17	49	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-LSD	-17	49	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		24740863	89158	0	UNDEFINED	1	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
		CHEMBL236610	89158	0	UNDEFINED	1	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
		1524	2181	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		5	139	72	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		77590	215955	0	3H-5HT	-10	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	124	4	0	2	0.8	COCCOCCl	None
		221	3491	71	3H-5HT	-4	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	3491	71	3H-5HT	-4	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	3491	71	3H-5HT	-4	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		None	216450	0	UNDEFINED	1	28	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		206	2493	16	3H-KETANSERIN	-5	25	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-KETANSERIN	-5	25	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-KETANSERIN	-5	25	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		134551	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		271	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		885	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		CHEMBL1403281	358	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		135	2532	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2247	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		1385580	29276	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		4615	29276	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		CHEMBL13828	29276	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		191	403	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2601	3780	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		135398737	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		10531	1420	21	None	-15	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	1420	21	None	-15	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	1420	21	None	-15	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	1420	21	None	-15	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	1420	21	None	-15	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		107715	200945	22	None	-14	19	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL1255837	200945	22	None	-14	19	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL601773	200945	22	None	-14	19	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		135526515	217725	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	301	7	4	3	2.8	CCCCCNC(=N)NN=CC1=CNC2=C1C=C(OC)C=C2	None
		1588	2325	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		135398737	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-2	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1042	1581	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		148	1581	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		443884	1581	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		CHEMBL119443	1581	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		DB01253	1581	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		2220	3134	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		27400	3134	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		93	3134	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		CHEMBL294951	3134	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		DB06153	3134	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		3337	206367	27	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		11978813	721	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		5014	721	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		7672	721	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		CHEMBL2105760	721	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		DB09128	721	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		133	2496	52	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		277	1301	62	None	-4	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-4	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-4	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-4	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-4	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		37	778	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		460	778	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		54746	778	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		CHEMBL1201087	778	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		DB00248	778	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		11954224	215953	0	None	-66	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1621	2429	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		135	2532	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		None	215969	0	3H-KETANSERIN	-147	2	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	259	5	1	3	2.6	CCC1=CC(=C(C=C1OC)CC(C)N)OC.Cl	None
		3036864	202754	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		213	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		115	3791	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	3791	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	3791	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		173	3262	95	3H-5HT	1	23	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-5HT	1	23	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-5HT	1	23	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		115	3791	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	3791	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	3791	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		2337	3256	77	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		134	2514	24	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		119376	1841	48	3H-5HT	-3801	26	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		247	1841	48	3H-5HT	-3801	26	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		CHEMBL33884	1841	48	3H-5HT	-3801	26	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		71299720	215951	0	3H-5HT	-691	17	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		1220	187	55	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		150	2509	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		1764	2509	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		8226	2509	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		CHEMBL1201356	2509	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		DB00353	2509	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		134	2514	24	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		107	141	121	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		107	141	121	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		11154555	800	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5037	800	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		7671	800	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL2028019	800	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL3085826	800	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB06016	800	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		134	2514	24	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		242	470	124	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		135	2532	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		46780481	107531	20	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		5	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		11848625	5792	0	UNDEFINED	2	6	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
		CHEMBL1078745	5792	0	UNDEFINED	2	6	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
		62787	206188	21	3H-5HT	-3	10	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
		CHEMBL8642	206188	21	3H-5HT	-3	10	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
		7153	98020	77	3H-KETANSERIN	-50	34	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-KETANSERIN	-50	34	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		None	216026	0	3H-5HT	-10	4	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
		None	216452	0	3H-5HT	-43	3	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	419	6	1	4	3.4	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCOC4=CC=C(C=C4)F.Cl	None
		10624	70300	19	3H-LSD	-7	33	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-LSD	-7	33	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-LSD	-7	33	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		282	1419	0	None	-371	7	Human	7.5	pKi	=	7.5	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	23519215
		522609	1419	0	None	-371	7	Human	7.5	pKi	=	7.5	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	23519215
		1621	2429	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
		17	2429	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
		5761	2429	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
		CHEMBL263881	2429	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
		DB04829	2429	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
		10287037	626	0	None	31	2	Human	10.1	pKi	=	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	367	3	0	4	5.1	CCOc1ccc2c(c1)Sc1c(C2=C2CCN(CC2)C)c(OC)ccc1	25666387
		8424	626	0	None	31	2	Human	10.1	pKi	=	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	367	3	0	4	5.1	CCOc1ccc2c(c1)Sc1c(C2=C2CCN(CC2)C)c(OC)ccc1	25666387
		2	3261	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
		2	3261	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
		54562	3261	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
		54562	3261	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
		CHEMBL240773	3261	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
		CHEMBL240773	3261	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
		11658860	2344	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
		2941	2344	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
		4374	2344	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
		CHEMBL360328	2344	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
		DB04871	2344	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
		45275554	3312	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
		8427	3312	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
		CHEMBL3544975	3312	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
		DB12798	3312	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
		11957541	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		11957541	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
		1229	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		1229	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
		147	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		147	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
		170617	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		170617	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
		CHEMBL6616	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		CHEMBL6616	1459	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
		11957541	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
		11957541	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		11957541	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
		1229	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
		1229	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		1229	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
		147	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
		147	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		147	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
		170617	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
		170617	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		170617	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
		CHEMBL6616	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
		CHEMBL6616	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
		CHEMBL6616	1459	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
		161	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
		161	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
		161	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
		4284720	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
		4284720	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
		4284720	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
		CHEMBL1255834	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
		CHEMBL1255834	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
		CHEMBL1255834	754	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
		166	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
		3045227	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
		CHEMBL76781	3359	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
		135	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
		135	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
		135	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
		1796	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
		1796	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
		1796	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
		4184	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
		4184	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
		4184	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
		CHEMBL6437	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
		CHEMBL6437	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
		CHEMBL6437	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
		DB06148	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
		DB06148	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
		DB06148	2532	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
		134	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
		134	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
		134	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
		1775	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
		1775	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
		1775	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
		9681	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
		9681	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
		9681	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
		CHEMBL1065	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
		CHEMBL1065	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
		CHEMBL1065	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
		DB00247	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
		DB00247	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
		DB00247	2514	24	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
		176	1537	0	None	19	4	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
		9930789	1537	0	None	19	4	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
		CHEMBL1628720	1537	0	None	19	4	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
		188	3391	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
		188	3391	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
		196968	3391	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
		196968	3391	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
		CHEMBL473186	3391	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
		CHEMBL473186	3391	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
		3763	217713	0	None	-	1	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	184	2	0	1	2.4	FC(F)OC(Cl)C(F)(F)F	None
		202	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		3337	206367	27	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		4450	178228	69	None	-1	3	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	None
		CHEMBL465026	178228	69	None	-1	3	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	None
		6166	216024	0	None	-4	4	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
		179	400	115	None	-17	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	None	-17	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	None	-17	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	None	-17	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	None	-17	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		1357	2485	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
		1672	2485	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
		224	2485	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
		896	2485	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
		CHEMBL45	2485	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
		DB01065	2485	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
		1209	1658	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		203	1658	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		3386	1658	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		CHEMBL41	1658	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		DB00472	1658	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		208	2863	0	None	-69	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		4541	2863	0	None	-69	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		CHEMBL1494	2863	0	None	-69	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
		1220	187	55	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
		1220	187	55	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
		31	187	55	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
		31	187	55	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
		7	187	55	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
		7	187	55	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
		CHEMBL56	187	55	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
		CHEMBL56	187	55	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
		1524	2181	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
		197	2181	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
		3822	2181	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
		88	2181	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
		CHEMBL51	2181	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
		DB12465	2181	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
		186	1807	52	None	-426	17	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
		71781	1807	52	None	-426	17	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
		CHEMBL18972	1807	52	None	-426	17	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
		2470	3653	50	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
		3300	3653	50	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
		5265	3653	50	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
		99	3653	50	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
		CHEMBL267930	3653	50	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
		2176	3127	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
		4828	3127	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
		91	3127	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
		CHEMBL500	3127	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
		DB00960	3127	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
		29	792	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		9805719	792	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		CHEMBL2027925	792	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		18971832	2418	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		21	2418	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		CHEMBL3186179	2418	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		28	3496	46	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		3292447	3496	46	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		CHEMBL20963	3496	46	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		2202	3132	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		4850	3132	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		49	3132	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		CHEMBL1371770	3132	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		DB12478	3132	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		130	3500	47	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
		3378093	3500	47	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
		CHEMBL281350	3500	47	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
		143	3515	51	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
		5311096	3515	51	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
		CHEMBL85606	3515	51	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
		175	3655	44	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		68186	3655	44	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		CHEMBL79834	3655	44	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		185	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
		185	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
		5311271	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
		5311271	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
		CHEMBL74355	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
		CHEMBL74355	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
		DB16351	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
		DB16351	4006	60	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
		187	3388	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
		187	3388	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
		3693566	3388	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
		3693566	3388	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
		CHEMBL88402	3388	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
		CHEMBL88402	3388	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
		1353	1911	93	None	-295	83	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
		3559	1911	93	None	-295	83	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
		86	1911	93	None	-295	83	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
		CHEMBL54	1911	93	None	-295	83	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
		DB00502	1911	93	None	-295	83	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
		109	902	31	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
		2689	902	31	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
		CHEMBL27403	902	31	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
		2470	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		2470	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
		2470	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
		3300	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		3300	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
		3300	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
		5265	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		5265	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
		5265	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
		99	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		99	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
		99	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
		CHEMBL267930	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
		CHEMBL267930	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
		CHEMBL267930	3653	50	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
		107780	1844	54	None	-676	17	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		14	1844	54	None	-676	17	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		CHEMBL15928	1844	54	None	-676	17	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		133633	2241	53	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
		177	2241	53	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
		CHEMBL445102	2241	53	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
		177336	3120	50	None	-1412	2	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
		225	3120	50	None	-1412	2	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
		CHEMBL356359	3120	50	None	-1412	2	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
		DB04873	3120	50	None	-1412	2	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
		1524	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
		1524	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
		1524	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
		1524	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
		1524	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
		197	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
		197	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
		197	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
		197	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
		197	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
		3822	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
		3822	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
		3822	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
		3822	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
		3822	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
		88	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
		88	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
		88	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
		88	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
		88	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
		CHEMBL51	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
		CHEMBL51	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
		CHEMBL51	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
		CHEMBL51	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
		CHEMBL51	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
		DB12465	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
		DB12465	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
		DB12465	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
		DB12465	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
		DB12465	2181	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
		107992	2553	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
		165	2553	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
		CHEMBL269521	2553	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
		DB12111	2553	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
		107992	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
		107992	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
		165	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
		165	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
		CHEMBL269521	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
		CHEMBL269521	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
		DB12111	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
		DB12111	2553	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
		5268	3656	40	None	-1047	18	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
		53	3656	40	None	-1047	18	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
		CHEMBL300555	3656	40	None	-1047	18	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
		1574	81	60	None	-3	21	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
		218	81	60	None	-3	21	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
		CHEMBL266591	81	60	None	-3	21	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
		198	313	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
		82148	313	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
		99	313	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
		CHEMBL10878	313	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
		DB06594	313	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
		177336	3120	50	None	-1412	2	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
		225	3120	50	None	-1412	2	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
		CHEMBL356359	3120	50	None	-1412	2	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
		DB04873	3120	50	None	-1412	2	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
		210	3477	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
		2423	3477	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
		5160	3477	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
		CHEMBL52939	3477	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
		DB12163	3477	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
		195	3570	7	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
		9859407	3570	7	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
		CHEMBL316069	3570	7	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
		1809	134	32	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
		1809	134	32	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
		4	134	32	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
		4	134	32	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
		CHEMBL18840	134	32	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
		CHEMBL18840	134	32	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
		1809	134	32	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
		1809	134	32	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
		4	134	32	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
		4	134	32	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
		CHEMBL18840	134	32	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
		CHEMBL18840	134	32	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
		129	3440	10	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
		9868452	3440	10	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
		CHEMBL65280	3440	10	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
		193	3506	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
		193	3506	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
		3644637	3506	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
		3644637	3506	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
		CHEMBL14563	3506	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
		CHEMBL14563	3506	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
		228	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		33	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		6005	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		CHEMBL53	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		DB00714	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		173	3262	95	None	-3	23	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
		5011	3262	95	None	-3	23	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
		CHEMBL18772	3262	95	None	-3	23	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
		108029	3414	57	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
		23	3414	57	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
		CHEMBL18785	3414	57	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
		221	3491	71	None	-4	14	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
		3277600	3491	71	None	-4	14	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
		CHEMBL323356	3491	71	None	-4	14	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
		170	2962	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
		9796408	2962	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
		CHEMBL506999	2962	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
		194	3507	31	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
		443391	3507	31	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
		CHEMBL14460	3507	31	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
		1150	3878	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
		1150	3878	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
		125	3878	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
		125	3878	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
		CHEMBL6640	3878	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
		CHEMBL6640	3878	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
		DB08653	3878	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
		DB08653	3878	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
		173	3262	95	None	1	23	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
		5011	3262	95	None	1	23	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
		CHEMBL18772	3262	95	None	1	23	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
		115	3791	80	None	-2	27	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
		4296	3791	80	None	-2	27	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
		CHEMBL274866	3791	80	None	-2	27	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
		213	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
		213	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
		2717	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
		2717	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
		5533	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
		5533	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
		CHEMBL621	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
		CHEMBL621	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
		DB00656	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
		DB00656	3853	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
		115	3791	80	None	-1	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
		4296	3791	80	None	-1	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
		CHEMBL274866	3791	80	None	-1	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
		31101	729	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		35	729	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		403	729	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		CHEMBL493	729	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		DB01200	729	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		135	2532	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
		1796	2532	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
		4184	2532	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
		CHEMBL6437	2532	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
		DB06148	2532	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
		12895728	2861	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
		217	2861	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
		CHEMBL250881	2861	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
		15897	2862	0	None	12	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
		215	2862	0	None	12	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
		CHEMBL1979333	2862	0	None	12	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
		102	4127	48	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		3659	4127	48	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		8969	4127	48	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		CHEMBL15245	4127	48	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		DB01392	4127	48	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		157	2069	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
		157	2069	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
		9840090	2069	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
		9840090	2069	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
		CHEMBL134519	2069	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
		CHEMBL134519	2069	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
		10	723	28	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
		3654103	723	28	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
		CHEMBL534232	723	28	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
		206	2493	16	None	-26	25	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
		68848	2493	16	None	-26	25	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
		CHEMBL12314	2493	16	None	-26	25	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
		171	2964	0	None	-5	3	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	233	3	1	3	1.9	COc1ccc2c(c1O[C@@H]1CNCC1)CCC2	15322733
		9794656	2964	0	None	-5	3	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	233	3	1	3	1.9	COc1ccc2c(c1O[C@@H]1CNCC1)CCC2	15322733
		136	3292	32	None	-63	15	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		223	3292	32	None	-63	15	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		643606	3292	32	None	-63	15	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		CHEMBL10347	3292	32	None	-63	15	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
		155	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
		155	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
		163	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
		163	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
		62065	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
		62065	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
		CHEMBL6607	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
		CHEMBL6607	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
		DB01484	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
		DB01484	728	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
		219050	3373	25	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
		52	3373	25	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
		CHEMBL431367	3373	25	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
		168	3982	15	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
		6604042	3982	15	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
		CHEMBL309760	3982	15	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
		153	1458	9	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
		6603801	1458	9	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
		CHEMBL1434583	1458	9	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
		1355	2011	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
		142	2011	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
		CHEMBL478	2011	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
		DB12110	2011	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
		102	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
		102	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
		102	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		3659	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
		3659	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
		3659	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		8969	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
		8969	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
		8969	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		CHEMBL15245	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
		CHEMBL15245	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
		CHEMBL15245	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		DB01392	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
		DB01392	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
		DB01392	4127	48	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		157	2069	7	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
		9840090	2069	7	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
		CHEMBL134519	2069	7	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
		3652	4097	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		57	4097	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		60809	4097	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		CHEMBL21536	4097	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		DB15357	4097	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		108029	3414	57	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
		23	3414	57	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
		CHEMBL18785	3414	57	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
		13878025	2427	0	None	-19	3	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
		184	2427	0	None	-19	3	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
		CHEMBL52422	2427	0	None	-19	3	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
		1355	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
		1355	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
		1355	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
		1355	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
		1355	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
		142	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
		142	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
		142	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
		142	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
		142	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
		CHEMBL478	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
		CHEMBL478	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
		CHEMBL478	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
		CHEMBL478	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
		CHEMBL478	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
		DB12110	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
		DB12110	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
		DB12110	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
		DB12110	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
		DB12110	2011	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
		5	139	72	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
		5202	139	72	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
		CHEMBL39	139	72	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
		DB08839	139	72	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
		107	141	121	None	-12	30	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
		1833	141	121	None	-12	30	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
		CHEMBL8165	141	121	None	-12	30	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
		152	364	29	None	-1	18	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
		2107	364	29	None	-1	18	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
		CHEMBL275854	364	29	None	-1	18	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
		199	392	0	None	-5	5	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
		9821951	392	0	None	-5	5	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
		CHEMBL160293	392	0	None	-5	5	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
		216	2860	32	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
		9815618	2860	32	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
		CHEMBL253811	2860	32	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
		189	3492	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
		189	3492	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
		5163	3492	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
		5163	3492	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
		CHEMBL297784	3492	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
		CHEMBL297784	3492	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
		192	3502	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
		192	3502	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
		443390	3502	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
		443390	3502	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
		CHEMBL14276	3502	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
		CHEMBL14276	3502	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
		136	3292	32	None	-8	15	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		223	3292	32	None	-8	15	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		643606	3292	32	None	-8	15	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		CHEMBL10347	3292	32	None	-8	15	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
		152	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
		152	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
		152	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
		2107	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
		2107	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
		2107	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
		CHEMBL275854	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
		CHEMBL275854	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
		CHEMBL275854	364	29	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
		5	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
		5	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
		5	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
		5	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
		5	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
		5202	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
		5202	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
		5202	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
		5202	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
		5202	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
		CHEMBL39	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
		CHEMBL39	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
		CHEMBL39	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
		CHEMBL39	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
		CHEMBL39	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
		DB08839	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
		DB08839	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
		DB08839	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
		DB08839	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
		DB08839	139	72	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
		183	2425	0	None	-5	4	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
		3034814	2425	0	None	-5	4	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
		CHEMBL1356280	2425	0	None	-5	4	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
		133	2496	52	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
		1723	2496	52	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
		28693	2496	52	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
		CHEMBL19215	2496	52	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
		DB13520	2496	52	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
		134	2514	24	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
		1775	2514	24	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
		9681	2514	24	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
		CHEMBL1065	2514	24	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
		DB00247	2514	24	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
		2105	3054	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		47811	3054	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		48	3054	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		CHEMBL531	3054	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		DB01186	3054	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		2601	3780	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		443951	3780	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		56	3780	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL73151	3780	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB13399	3780	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		10331436	324	10	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
		160	324	10	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
		CHEMBL133455	324	10	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
		1621	2429	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
		17	2429	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
		5761	2429	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
		CHEMBL263881	2429	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
		DB04829	2429	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
		5074	3332	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
		97	3332	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
		CHEMBL267777	3332	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
		DB12693	3332	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
		10449757	3495	35	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
		190	3495	35	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
		CHEMBL2110371	3495	35	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
		1342	35	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
		1342	35	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
		3	35	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
		3	35	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
		CHEMBL277120	35	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
		CHEMBL277120	35	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
		135398737	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
		135398737	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
		135398737	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
		38	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
		38	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
		38	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
		722	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
		722	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
		722	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
		CHEMBL42	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
		CHEMBL42	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
		CHEMBL42	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
		DB00363	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
		DB00363	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
		DB00363	958	93	None	-2	89	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
		167	3431	0	None	-3	5	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	7	0	5	3.6	Fc1ccc(cc1)C(=O)CC1CCN(C1)CCOc1cccc2c1OCCO2	9732398
		9821498	3431	0	None	-3	5	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	7	0	5	3.6	Fc1ccc(cc1)C(=O)CC1CCN(C1)CCOc1cccc2c1OCCO2	9732398
		135409453	3773	41	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
		226	3773	41	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
		CHEMBL76370	3773	41	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
		191	3498	52	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
		443389	3498	52	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
		CHEMBL276140	3498	52	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
		206	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
		206	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
		206	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
		68848	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
		68848	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
		68848	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
		CHEMBL12314	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
		CHEMBL12314	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
		CHEMBL12314	2493	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
		1342	35	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
		1342	35	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
		3	35	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
		3	35	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
		CHEMBL277120	35	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
		CHEMBL277120	35	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
		1043	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
		1043	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
		149	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
		149	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
		8223	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
		8223	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
		CHEMBL442	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
		CHEMBL442	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
		DB00696	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
		DB00696	1582	14	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
		133	2496	52	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
		1723	2496	52	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
		28693	2496	52	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
		CHEMBL19215	2496	52	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
		DB13520	2496	52	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
		37	778	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		460	778	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		54746	778	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		CHEMBL1201087	778	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		DB00248	778	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		1588	2325	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		28864	2325	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		43	2325	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL157138	2325	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB00589	2325	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		4106	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
		4106	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
		5358812	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
		5358812	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
		89	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
		89	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
		CHEMBL93240	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
		CHEMBL93240	2502	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
		5074	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
		5074	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
		5074	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
		5074	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
		97	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
		97	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
		97	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
		97	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
		CHEMBL267777	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
		CHEMBL267777	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
		CHEMBL267777	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
		CHEMBL267777	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
		DB12693	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
		DB12693	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
		DB12693	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
		DB12693	3332	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
		183	2425	0	None	2	4	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
		3034814	2425	0	None	2	4	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
		CHEMBL1356280	2425	0	None	2	4	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
		154	2359	0	None	-1	4	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	15322733
		638252	2359	0	None	-1	4	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	15322733
		150	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
		150	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
		1764	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
		1764	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
		8226	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
		8226	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
		CHEMBL1201356	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
		CHEMBL1201356	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
		DB00353	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
		DB00353	2509	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733

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Ligand source activities (1 row/activity)